CN108470585A - A kind of long-range mask method of interactive virtual sliced sheet and system - Google Patents
A kind of long-range mask method of interactive virtual sliced sheet and system Download PDFInfo
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- CN108470585A CN108470585A CN201810211140.1A CN201810211140A CN108470585A CN 108470585 A CN108470585 A CN 108470585A CN 201810211140 A CN201810211140 A CN 201810211140A CN 108470585 A CN108470585 A CN 108470585A
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T3/00—Geometric image transformation in the plane of the image
- G06T3/40—Scaling the whole image or part thereof
- G06T3/4038—Scaling the whole image or part thereof for image mosaicing, i.e. plane images composed of plane sub-images
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/40—Extraction of image or video features
- G06V10/46—Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
- G06V10/462—Salient features, e.g. scale invariant feature transforms [SIFT]
Abstract
The present invention relates to a kind of long-range mask methods of interactive virtual sliced sheet and system, method to include：By the image mosaic amplified by the low power of multiple collected slice parts of digitlization filming apparatus continuous scanning at one about the complete full width low power enlarged drawing of the slice；Full width low power enlarged drawing is given to higher level end by network transmission；The target area information of magnification at high multiple image need to be acquired by being sent out from higher level end to subordinate end, and coloring marks out the target area on the full width low power enlarged drawing at subordinate end；The magnification at high multiple image of scanning collection to target area is transferred to higher level end.By the long-range mask method of interactive virtual sliced sheet and system in the application present invention, it can ensure the remote transmission of the magnification at high multiple image in pathological section remote medical consultation with specialists to key area under the premise of network transfer speeds are conditional.It is specified that several key areas progress high magnification is taken pictures or scanned after higher level's clinical expert inspects low range scan image in checking software.
Description
Technical field
The present invention relates to digitlization pathology and pathological section remote medical consultation with specialists etc. fields, and in particular to a kind of interactive virtual
It is sliced long-range mask method and system.
Background technology
Pathology full slice scans (whole slide imaging) technology to be developed by ten several years, has been mature on the whole, but will
There is tripartite's surface technology defects in remote medical consultation with specialists for its virtual sliced sheet data application generated：
1, under high magnification, when carrying out full slice scanning and need to cover thousands of visuals field, thus needing the scanning grown very much
Between.It is difficult to meet to the higher applied field of requirement of real-time if even if it scans time-consuming using more advanced automatically scanning instrument
Scape, such as remote medical consultation with specialists is carried out to frozen section.
2, due to basic optical characteristic, the microscopical observation depth of field is extremely shallow under high magnification, it is out of focus to be easy, thus is sweeping
Frequent auto-focusing is needed during retouching.This process not only takes, but also encounters the thicker situation of sample and be difficult to ensure certainly
The stability of dynamicization operation.
3, it is scanned completely using high magnification, will produce several GB to the data volume of tens of GB, even if in high-speed dedicated net
It is transmitted in network, elapsed time still cannot be satisfied the scene high to requirement of real-time.In this huge data volume, the overwhelming majority
The details in the region for having no help to diagnosis is covered, is not necessarily to carry out high precision collecting, storage, transmission originally.However, to key
Dependent on the clinical expert for having abundant diagnostic experiences, general operation person and machine there is no method to differentiate for the division in region.
Invention content
The technical problem to be solved by the present invention is to：One kind is proposed under relatively low network transfer speeds environment, disclosure satisfy that remote
The long-range mask method of interactive virtual sliced sheet and system of needs are held a consultation to pathological section image transmitting and checked to journey.
The technical solution (one) that the present invention proposes to solve above-mentioned technical problem is：A kind of interactive virtual sliced sheet is remotely marked
Injecting method includes the following steps：
By by digitlization filming apparatus continuous scanning it is collected multiple slice part low powers amplification image mosaic at
One about the complete full width low power enlarged drawing of the slice；
The full width low power enlarged drawing is given to higher level end by network transmission；
The target area information of magnification at high multiple image need to be acquired by being sent out from higher level end to subordinate end, and described in subordinate end
Coloring marks out the target area on full width low power enlarged drawing；
The magnification at high multiple image of scanning collection to target area is given to higher level end by network transmission.
Further, the splicing refers to adjacent two images in the Relatively orientation based on multiple Feature Points Matchings
Afterwards, it includes full content new images in aforementioned two images the lap removal in two images to be regenerated a width again
Process；
The adjacent two images, which refer in two images, to partially overlap.
The Selection Strategy of the multiple characteristic point uses adaptive threshold.
Further, when carrying out characteristic point selection using the adaptive threshold strategy,
Use SURF or SIFT feature Processing Algorithm, the characteristic point for calculating each pixel notable in each image
Property, the mathematical sense of the conspicuousness is the determinant of the Hessian eigenmatrixes of this pixel；
Default feature is counted out upper limit value KmaxTo limit the calculated load upper limit and feature significance minimum threshold Tmin
To determine whether that there are any available feature minimum threshold Tmin；
Each image is segmented into several overlapped regions, each range test whether all pixels feature significance
Respectively less than Tmin, namely whether be white space；Remember that white space number in the ratio p of overall area number, and then calculates expected special
Levy the K that counts outexp=(1-p) Kmax；
The pixel coordinate that all feature significances in the full visual field of image are local maximum is arranged according to conspicuousness descending,
Take its preceding KexpA final set of characteristic points in the visual field thus, using feature point description vector record characteristic point adjacent pixels point when
Frequency domain characteristic.
Further, adjacent two images are in the Relatively orientation based on multiple Feature Points Matchings,
Characteristic point in the two images is first matched to and is calculated its coordinate difference value vector,
Mode is taken in the coordinate difference value vector of all characteristic points pair again, to exclude a small number of matching errors,
Finally calculate this relative displacement and relative position relation between this two images.
Further, after coloring marks out the target area on the full width low power enlarged drawing at subordinate end,
Also calculate seat of the current viewfinder image visual field of digitlization filming apparatus on the full width low power enlarged drawing
Information is marked,
And the navigation path for being used for externally showing is formed between the target area and the current viewfinder image visual field
Line.
Further, coordinate information of the current viewfinder image visual field on the full width low power enlarged drawing is being calculated
When,
It is first matched in the image of multiple low powers amplification acquired before and has with the current viewfinder image visual field
There is the reference picture that can be as reference that subregion is overlapped,
Mode again based on the positioning of multiple Feature Points Matchings calculates the relatively described reference in the current viewfinder image visual field
The position of image,
Described in finally according to the reference picture, known coordinate information is extrapolated on the full width low power enlarged drawing
Coordinate information of the current viewfinder image visual field on the full width low power enlarged drawing.
The technical solution (two) that the present invention proposes to solve above-mentioned technical problem is：A kind of interactive virtual sliced sheet is remotely marked
Injection system,
Include the higher level's end unit and subordinate's end unit by network connection, subordinate's end unit can be to the higher level
End unit is sent about the complete full width low power enlarged drawing of slice；
Higher level's end unit includes image display and target area MIM message input module；
Described image display module is suitable for showing the image information sent by subordinate's end unit superior end unit；
The target area MIM message input module, which is suitable for generating, delimited by user on the full width low power enlarged drawing
The target area information that the further high power of needs of mark is shown；
Subordinate's end unit includes that image collection module, image mosaic module, target area show labeling module, current
Viewfinder image visual field locating module；
Described image acquisition module is suitable for obtaining about the office for being sliced low power or magnification at high multiple by digitizing filming apparatus
Portion's image；
Multiple slice low powers or magnification at high multiple that described image concatenation module is suitable for be obtained by described image acquisition module
Topography is spliced to generate the full width low power enlarged drawing；
The target area shows that labeling module is suitable for, and the target area information labeling is low to the local full width
On times enlarged drawing；
The current viewfinder image visual field locating module is suitable for regarding the current viewfinder image of the digitlization filming apparatus
Open country is positioned on full width low power enlarged drawing and generates instant current viewfinder image visual field coordinate information.
Further, the subordinate end further includes current viewfinder image visual field labeling module and navigation module；
The current viewfinder image visual field labeling module is suitable for according to the current viewfinder image visual field coordinate information at this
The coloring of the enterprising Mobile state of full width low power enlarged drawing on ground marks；
The navigation module is suitable for forming the navigation rail for display between the current viewfinder image visual field and target area
Trace.
The beneficial effects of the invention are as follows：
It, can be in network transfer speeds by the long-range mask method of interactive virtual sliced sheet and system in the application present invention
Under the premise of conditional, it can ensure the remote transmission of the magnification at high multiple image in pathological section remote medical consultation with specialists to key area.
It is specified to take pictures to several key areas progress high magnification after higher level's clinical expert inspects low range scan image in checking software
Or scanning.
The long-range mask method of interactive virtual sliced sheet in the present invention and system are scanned instead of to full slice high magnification,
And use low range scanning to be aided with local high magnification and take pictures or scan, obtain diagnostic key message avoid it is non-key
The acquisition of information.Therefore, the time loss of scanning process and data transmission later is reduced significantly, and can be better met
Instantaneity requires high application scenarios.
In addition, the long-range mask method of interactive virtual sliced sheet and system in the present invention be in scanning and movement, it can not
Dependent on machinery positioning, and software is used to calculate positioning, removes the demand to high-accuracy mechanical component, significantly reduce and set
Standby cost, is conducive to extensive use.
And microscopical visual field movement and focusing can be controlled by operator, than automation equipment fixation locus, fixed plan
It is slightly more flexible, ensure stability and success rate to the full extent.High application scenarios are required for instantaneity, it can be to avoid scanning
The huge loss of time that failure is then rescaned.
Description of the drawings
The long-range mask method of interactive virtual sliced sheet and system of the present invention are described further below in conjunction with the accompanying drawings.
Fig. 1 is the schematic diagram spliced in the present invention；
Fig. 2 is the typical flowchart of method and system in the present invention.
Specific implementation mode
Embodiment one
The present embodiment is related to a kind of long-range mask method of interactive virtual sliced sheet, and this method has different times dependent on tradition
The microscope of rate enlarging function.
Include the following steps：
It i, will be by the image mosaic of the low power amplification of multiple collected slice parts of digitlization filming apparatus continuous scanning
At one about the complete full width low power enlarged drawing of the slice.
It can be the electronic eyepiece being connected on microscope to digitize filming apparatus, can also be to be fixed by hanging frame device
The digital filming apparatus such as the mobile phone on microscope ocular.
As preferably：As shown in Figure 1, splicing refers to adjacent two images based on the opposite of multiple Feature Points Matchings
After the positioning of position, it includes in aforementioned two images in whole that the lap removal in two images is regenerated a width again
Hold the process of new images.This adjacent two images, which refers in two images, to partially overlap.Certainly in the case where calculation power is enough,
The primary splicing of multiple adjacent images may be implemented.
When adjacent two images are in the Relatively orientation based on multiple Feature Points Matchings, can be used as preferably：
First the characteristic point in the two images is matched and calculates its coordinate difference value vector.
Mode is taken in the coordinate difference value vector of all characteristic points pair again, to exclude a small number of matching errors.
Finally calculate this relative displacement and relative position relation between this two images.
The Selection Strategy of aforesaid plurality of characteristic point uses adaptive threshold, preferably：Using adaptive threshold strategy into
When row characteristic point is chosen, SURF or SIFT feature Processing Algorithm are used in each image, calculates the feature of each pixel
Point conspicuousness, the mathematical sense of the conspicuousness is the determinant of the Hessian eigenmatrixes of this pixel.In detection image
Characteristic point pixel coordinate, and it is described abstractly with description vectors.
SURF and SIFT feature Processing Algorithm are the prior art.
SURF characteristic points Processing Algorithm (Bay H, Ess A, Tuytelaars T, et al.Speeded-Up Robust
Features(SURF)[J].Computer Vision and Image Understanding,2008,110(3):346-
359.)。
SIFT feature Processing Algorithm (Lowe D G.Object recognition from local scale-
invariant features[C].international conference on computer vision,1999:1150-
1157.)。
Default feature is counted out upper limit value KmaxTo limit the calculated load upper limit and feature significance minimum threshold Tmin
To determine whether that there are any available feature minimum threshold Tmin。
Each image is segmented into several overlapped regions, each range test whether all pixels feature significance
Respectively less than Tmin, namely whether be white space；Remember that white space number in the ratio p of overall area number, and then calculates expected special
Levy the K that counts outexp=(1-p) Kmax。
The pixel coordinate that all feature significances in the full visual field of image are local maximum is arranged according to conspicuousness descending,
Take its preceding KexpA final set of characteristic points in the visual field thus, using feature point description vector record characteristic point adjacent pixels point when
Frequency domain characteristic.
By taking SURF algorithm as an example, the feature significance of each pixel can be by the determinant of its Hessian eigenmatrix
Quickly calculate, and feature vector of this point is its Haar wavelet transformation response vector, with packed record its surrounding pixel point when
Frequency domain characteristic.Other algorithms mostly use greatly similar mathematical theory basis, but have selected different operators and transform domain to calculate
Compromise is obtained between method complexity and robustness.
Ii, full width low power enlarged drawing is given to higher level end by network transmission.
After inspecting the full width low power enlarged drawing, selection needs the target area of magnification at high multiple with further by iii, expert
Medical analysis is supported, therefore after target area is selected, the mesh that need to acquire magnification at high multiple image is sent out from higher level end to subordinate end
Area information is marked, and coloring marks out target area on the full width low power enlarged drawing at subordinate end.Full width at subordinate end is low
After coloring marks out target area on times enlarged drawing.
It can be used as preferably promptly by visual field alignment target region for the ease of line lower end operator：Also
Coordinate information of the current viewfinder image visual field of digitlization filming apparatus on full width low power enlarged drawing is calculated, and in target
The navigation path line for externally showing is formed between region and the current viewfinder image visual field.Line lower end operator is according to navigation rail
Trace targetedly moves slice, to improve working efficiency.
When calculating the current viewfinder image visual field in the coordinate information on full width low power enlarged drawing, can be used as further
Preferably：It is first matched in the image of multiple low powers amplification acquired before and there is portion in the current viewfinder image visual field
The reference picture that can be as reference of subregion overlapping, then the mode based on the positioning of multiple Feature Points Matchings are calculated and are currently taken
Scape field of view is with respect to the position of reference picture, and finally according to reference picture, known coordinate is believed on full width low power enlarged drawing
Breath extrapolates coordinate information of the current viewfinder image visual field on full width low power enlarged drawing.
Particularly, if can count out with the feature of successful match very few in the two width visuals field, judge that visual field meta position moves past
Greatly, it need to remind operator that reverse movement is until Chong Die with the generation of the old visual field.
For operator under the continuous positioning of software and guide, the visual field is moved to specified region by operation microscope, and switching is aobvious
Objective inputs magnification information to high magnification and in software, is then taken pictures or partial sweep, is completed in a region
Afterwards, micro objective is switched back into low range and prompts software by operator.If there is other regions need high magnification to acquire, operation
Member repeats above step until being fully completed.
In operator's moving process, software is tracked using aforementioned locating scheme, is positioned and fed back to operator, because
And the grasp to present viewing field position can be kept；Operator switch object lens when, due to object lens multiplying power by operator input and
Its axis is constant, thus can calculate the front and back relative position relation of switching, and then is kept under different multiplying to working as forward sight
Wild positioning.
Iv, finally the magnification at high multiple image of scanning collection to target area is given to higher level end by network transmission.
Embodiment two
On the basis of the present embodiment is the method in embodiment one, a kind of interactive virtual sliced sheet of realization, which remotely marks, is
System.
System includes
By the higher level's end unit and subordinate's end unit of network connection, subordinate's end unit being capable of superior end unit transmission pass
In the complete full width low power enlarged drawing of slice.
Higher level's end unit includes image display and target area MIM message input module.
Image display is suitable for showing the image information sent by subordinate's end unit superior end unit.
Target area MIM message input module is suitable for generating the need by user's delimited mark on full width low power enlarged drawing
Want the target area information that further high power is shown.
Subordinate's end unit includes image collection module, image mosaic module, target area display labeling module, currently finds a view
Field of view locating module.
Image collection module is suitable for obtaining about the Local map for being sliced low power or magnification at high multiple by digitizing filming apparatus
Picture.
Image mosaic module is suitable for multiple the slice low powers obtained by image collection module or magnification at high multiple topography
Spliced to generate full width low power enlarged drawing.
Target area shows that labeling module is suitable for will be on target area information labeling to local full width low power enlarged drawing.
Current viewfinder image visual field locating module is suitable for digitize the current viewfinder image visual field of filming apparatus in full width
It is positioned on low power enlarged drawing and generates instant current viewfinder image visual field coordinate information.
It can be used as preferably：Subordinate end further includes current viewfinder image visual field labeling module and navigation module.
Current viewfinder image visual field labeling module is suitable for according to current viewfinder image visual field coordinate information in local full width
The coloring of the enterprising Mobile state of low power enlarged drawing marks.
Navigation module is suitable for forming the navigation path line for display between the current viewfinder image visual field and target area.
The present invention's is not limited to the above embodiment, and the technical solution of above-mentioned each embodiment of the invention can be handed over each other
Fork combination form new technical solution, in addition it is all using equivalent replacement formed technical solution, all fall within the present invention claims guarantor
It protects in range.
Claims (8)
1. a kind of long-range mask method of interactive virtual sliced sheet, including following characteristics step：
By the image mosaic amplified by the low power of multiple collected slice parts of digitlization filming apparatus continuous scanning at one
About the complete full width low power enlarged drawing of the slice；
The full width low power enlarged drawing is given to higher level end by network transmission；
The target area information of magnification at high multiple image need to be acquired by being sent out from higher level end to subordinate end, and in the full width at subordinate end
Coloring marks out the target area on low power enlarged drawing；
The magnification at high multiple image of scanning collection to target area is given to higher level end by network transmission.
2. the long-range mask method of interactive virtual sliced sheet according to claim 1, it is characterised in that：The splicing refers to adjacent
Two images remove the lap in two images again again after the Relatively orientation based on multiple Feature Points Matchings
Generate the process that a width includes full content new images in aforementioned two images；
The adjacent two images, which refer in two images, to partially overlap.
The Selection Strategy of the multiple characteristic point uses adaptive threshold.
3. the long-range mask method of interactive virtual sliced sheet according to claim 2, it is characterised in that：It adaptive is answered the door using described
When limit strategy carries out characteristic point selection,
SURF or SIFT feature Processing Algorithm are used in each image, calculate the characteristic point conspicuousness of each pixel, institute
The mathematical sense for stating conspicuousness is the determinant of the Hessian eigenmatrixes of this pixel；
Default feature is counted out upper limit value KmaxTo limit the calculated load upper limit and feature significance minimum threshold TminTo sentence
Surely it whether there is any available feature minimum threshold Tmin；
Each image is segmented into several overlapped regions, whether all pixels feature significance is small in each range test
In Tmin, namely whether be white space；Remember that white space number in the ratio p of overall area number, and then calculates expected characteristic point
Number Kexp=(1-p) Kmax；
The pixel coordinate that all feature significances in the full visual field of image are local maximum is arranged according to conspicuousness descending, takes it
Preceding KexpA final set of characteristic points in the visual field thus record the time-frequency domain of characteristic point adjacent pixels point using feature point description vector
Characteristic.
4. the long-range mask method of interactive virtual sliced sheet according to claim 2, it is characterised in that：Adjacent two images are in base
When the Relatively orientation of multiple Feature Points Matchings,
Characteristic point in the two images is first matched to and is calculated its coordinate difference value vector,
Mode is taken in the coordinate difference value vector of all characteristic points pair again, to exclude a small number of matching errors,
Finally calculate this relative displacement and relative position relation between this two images.
5. the long-range mask method of interactive virtual sliced sheet according to claim 1, it is characterised in that：In the described complete of subordinate end
After coloring marks out the target area on width low power enlarged drawing,
Also calculate coordinate letter of the current viewfinder image visual field of digitlization filming apparatus on the full width low power enlarged drawing
Breath,
And the navigation path line for being used for externally showing is formed between the target area and the current viewfinder image visual field.
6. the long-range mask method of interactive virtual sliced sheet according to claim 5, it is characterised in that：It described is currently taken calculating
Scape field of view in the coordinate information on the full width low power enlarged drawing,
It is first matched in the image of multiple low powers amplification acquired before and there is portion in the current viewfinder image visual field
The reference picture that can be as reference of subregion overlapping,
Mode again based on the positioning of multiple Feature Points Matchings calculates the relatively described reference picture in the current viewfinder image visual field
Position,
Finally according to the reference picture on the full width low power enlarged drawing known coordinate information extrapolate it is described current
Coordinate information of the viewfinder image visual field on the full width low power enlarged drawing.
7. a kind of long-range labeling system of interactive virtual sliced sheet, it is characterised in that：
Include the higher level's end unit and subordinate's end unit by network connection, subordinate's end unit can be to higher level end list
Member is sent about the complete full width low power enlarged drawing of slice；
Higher level's end unit includes image display and target area MIM message input module；
Described image display module is suitable for showing the image information sent by subordinate's end unit superior end unit；
The target area MIM message input module is suitable for generating delimit mark by user on the full width low power enlarged drawing
The target area information that shows of the further high power of needs；
Subordinate's end unit includes image collection module, image mosaic module, target area display labeling module, currently finds a view
Field of view locating module；
Described image acquisition module is suitable for obtaining about the Local map for being sliced low power or magnification at high multiple by digitizing filming apparatus
Picture；
Multiple slice low powers or magnification at high multiple part that described image concatenation module is suitable for be obtained by described image acquisition module
Image is spliced to generate the full width low power enlarged drawing；
The target area shows that labeling module is suitable for putting the target area information labeling to the local full width low power
On big image；
The current viewfinder image visual field locating module is suitable for existing in the current viewfinder image visual field of the digitlization filming apparatus
It is positioned on full width low power enlarged drawing and generates instant current viewfinder image visual field coordinate information.
8. the long-range labeling system of interactive virtual sliced sheet according to claim 7, it is characterised in that：The subordinate end further includes
Current viewfinder image visual field labeling module and navigation module；
The current viewfinder image visual field labeling module is suitable for according to the current viewfinder image visual field coordinate information in local
The coloring of the enterprising Mobile state of full width low power enlarged drawing marks；
The navigation module is suitable for forming the navigation path line for display between the current viewfinder image visual field and target area.
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| CN110672608A (en) * | 2019-10-15 | 2020-01-10 | 南京泰立瑞信息科技有限公司 | Dynamic planning method and system for full-slice scanning path |
| CN111191708A (en) * | 2019-12-25 | 2020-05-22 | 浙江省北大信息技术高等研究院 | Automatic sample key point marking method, device and system |
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