CN108445240A - A kind of evaluation method of Iodine nutrition situation in hyperthyroidism - Google Patents
A kind of evaluation method of Iodine nutrition situation in hyperthyroidism Download PDFInfo
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Abstract
The present invention relates to a kind of evaluation method of Iodine nutrition situation in hyperthyroidism, it will be seen that urine iodine and the correlation between hyperthyroidism and subclinical hyperthyroidism, while provide scientific basis for the early prevention, keypoint control and early diagnosis of thyroid disease；Include the following steps：(1) research object is chosen；(2) serum thyroid function five indices measure；(3) Iodine assay is urinated；(4) it diagnoses；(5) statistical procedures.
Description
Technical field
The present invention relates to a kind of evaluation method of Iodine nutrition situation in hyperthyroidism.
Background technology
Iodine is one of raw material necessary to thyroid hormone synthesis, iodine intake number directly affect thyroid function.
Recently as the change of dietary structure, the increase of stress and the accelerating rhythm of life, the trouble of hyperthyroidism
Sick rate is in apparent ascendant trend.Subclinical hyperthyroidism is a kind of specific type of hyperthyroidism, quilt
It is considered that one of the risk factor of hyperthyroidism, such patient are not having apparent symptom, checking after the onset
It is easy to be ignored in the process.With medical detecting method and horizontal raising, subclinical hyperthyroidism is to human body
It is potentially hazardous have deeper into understanding, therefore obtained more concerns.Therefore understand urine iodine and hyperthyroidism
Correlation between subclinical hyperthyroidism is very necessary, while being early prevention, the emphasis of thyroid disease
Prevention and early diagnosis provide scientific basis.
Invention content
The present invention provides a kind of it will be seen that urine iodine and hyperthyroidism and subclinical hyperthyroidism
Between correlation, while for the early prevention, keypoint control and early diagnosis of thyroid disease provide scientific basis iodine battalion
Evaluation method of the situation of supporting in hyperthyroidism.
A kind of evaluation method of the Iodine nutrition situation of the present invention in hyperthyroidism, includes the following steps：
(1) research object is chosen：It chooses 200~300 patients with hyperthyroidism and 200~300 subclinical
Patients with hyperthyroidism chooses 100~200 healthy populations as a control group as experimental group；
(2) serum thyroid function five indices measure：Limosis vein blood sample 5ml is left and taken, using chemiluminescence immunoassay
Method measures thyroid function five indices：Thyrotropic hormone, free triiodothyronine, free thyroxine, Zong Jia
Shape parathyrine, total triiodothyronine；
(3) Iodine assay is urinated：Disposable urina sanguinis 10ml is acquired, is placed in cleaning vinyl tube, measures according to catalysis of iodine
The principle of arsenic cerium reaction selects urine iodine immue quantitative detection reagent box AR types；
(4) it diagnoses：
A, iodine status assessment standard is urinated：Medianofurinaryiodine<100 μ g/L are iodine deficiency, and Medianofurinaryiodine is in 100~199 μ g/
Appropriate for iodine between L, Medianofurinaryiodine is iodine excess between 200~299 μ g/L, and the Niao iodine Zhong Wei μ of Shuo≤300 g/L are iodine mistake
Amount；
B, the diagnosis of hyperthyroidism and subclinical hyperthyroidism：Hyperthyroidism；Have
The symptom or sign of hyperthyroidism, while free triiodothyronine>7.1pmol/L, free thyroxine>
22pmol/L, thyrotropic hormone<0.27mU/L person；Subclinical hyperthyroidism：Athyreosis hyperfunction disease
Symptom or sign, free triiodothyronine and free thyroxine are normal, thyrotropic hormone<0.27mU/L；
(5) statistical procedures：Using SPSS19.0 statistical softwares carry out statistical procedures, data withOr median
It indicates, measurement data compares with rank sum test and variance analysis, and the correlativity between each factor uses Liner correlation, P<
0.05 shows that difference has statistical significance.
Description of the drawings
Fig. 1 is the assessment of hyperthyroid group iodine-nutrition；
Fig. 2 is subclinical hyperthyroid group iodine-nutrition assessment；
Fig. 3 is the assessment of control group iodine-nutrition；
Specific implementation mode
With reference to the accompanying drawings and examples, the specific implementation mode of the present invention is described in further detail.Implement below
Example is not limited to the scope of the present invention for illustrating the present invention.
A kind of evaluation method of the Iodine nutrition situation of the present invention in hyperthyroidism, includes the following steps：
(1) research object is chosen：Experimental group：It chooses in Cangzhou hospitals of traditional Chinese and western medicine in March, 2015 in December, 2017
493 patients of secretion section are research object, wherein man 194, female 299.It is divided into two groups：Hyperthyroidism is (following
Abbreviation hyperthyroidism) group 251, wherein man 98, female 153 is 21~70 years old age, 42.2 ± 15.1 years old average；Subclinical first shape
Gland hyperfunction disease (hereinafter referred to as subclinical hyperthyroidism) organizes 242, wherein man 95, female 147 is 21~70 years old age, average
46.5 ± 17.4 years old.All cases are that first visit does not receive any treatment, clarify a diagnosis as hyperthyroidism through clinical and laboratory and
Subclinical hyperthyroidism excludes the systemic disease for merging non-thyroid disorders；Control group：It is total that the same period chooses medical center healthy population
130, wherein male 58, women 72,21~70 years old age, average age 45.3 ± 12.5 years old exclude internal system
And the systemic disease of Non-thyrogenous, liver, kidney, thyroid function, blood routine are normal；
(2) serum thyroid function five indices measure：Limosis vein blood sample 5ml is left and taken, using chemiluminescence immunoassay
Method measures thyroid function five indices：Thyrotropic hormone (thyroid stimulating hormone, TSH), free three
Iodine thyronine (serum free triiodothyronine, FT3), free thyroxine (serum free
Thyroxine, FT4), total thyroxin (total thyroxine, TT4), total triiodothyronine (total
Triiodothyronine, TT3), using German Roche Holding Ag Cobas e602 fully automatic electrics chemical illumination immunity analysis instruments and
Matched reagent detects；
(3) Iodine assay is urinated：Disposable urina sanguinis 10ml is acquired, is placed in cleaning vinyl tube, measures and selects urine iodine fixed
Measure detection kit AR types (being purchased from Wuhan all living creatures' biochemical technology Co., Ltd), original of the urine Iodine assay according to the reaction of catalysis of iodine arsenic cerium
Reason；
(4) it diagnoses：
A, iodine status assessment standard is urinated：Iodine deficiency is controlled by 2001 World Health Organization/United Nations Children's Fund/world
The standard that sick council proposes, Medianofurinaryiodine<100 μ g/L are iodine deficiency, and Medianofurinaryiodine is between 100~199 μ g/L
Appropriate iodine, Medianofurinaryiodine are iodine excess between 200~299 μ g/L, and the Niao iodine Zhong Wei μ of Shuo≤300 g/L are excessive iodine；
B, the diagnosis of hyperthyroidism and subclinical hyperthyroidism：1. hyperthyroidism：There is the symptom of hyperthyroidism
Or sign, while FT3>7.1pmol/L, FT4>22pmol/L, TSH<0.27mU/L person；2. subclinical hyperthyroidism：Symptom without hyperthyroidism
Or sign, FT3And FT4Normally, TSH<0.27mU/L.
(5) statistical procedures：Using SPSS19.0 statistical softwares carry out statistical procedures, data withOr median
It indicates, measurement data compares with rank sum test and variance analysis, and the correlativity between each factor uses Liner correlation, P<
0.05 shows that difference has statistical significance.
The result obtained according to the above method is as follows：
(1) experimental group urinates iodine results contrast with control group：(493) urine iodine ranging from 53.6~1173.2 μ g/ of experimental group
L, urine iodine MUI are 213.2 μ g/L；The urine iodine of control group (130) are 50.3~910.5 μ g/L, and urine iodine MUI is 174.3 μ g/L, two
Statistically significant (the P of difference between group<0.001) (table 1).
1 experimental group of table urinates iodine results contrast with control group
(2) hyperthyroid group, subclinical hyperthyroid group and control group urinate iodine results contrast：Hyperthyroid patient urine iodide level is less than subclinical
Hyperthyroid patient, urine iodide level no significant difference (P between two groups of patients<0.05), with control group urine iodide level comparing difference
Statistically significant (P<0.001).(251) urine iodine ranging from 64.9~1079.1 μ g/L of hyperthyroid patient, subclinical hyperthyroidism
(242) urine iodine ranging from 53.6~1173.2 μ g/L of patient, control group urinate iodine ranging from 50.3~910.5 μ g/L (table 2).
2 hyperthyroid group of table, subclinical hyperthyroid group and control group urinate iodine results contrast
(3) assessment of hyperthyroid group, subclinical hyperthyroid group and control group iodine-nutrition：Hyperthyroid group Iodine nutrition is configured to：Iodine
Appropriate group accounts for 47.4% (119), and iodine deficiency group accounts for 8.8% (22), and iodine excess group accounts for 21.9% (55), and excessive iodine group accounts for
21.9% (55), urine iodide level difference statistically significant (F=56.268, P between each group<0.001) (Fig. 1).Subclinical first
High group of Iodine nutrition is configured to：Appropriate group of iodine accounts for 45.4% (110), and iodine deficiency group accounts for 9.1% (22), and iodine excess group accounts for
18.2% (44), excessive iodine group account for 27.2% (66), the statistically significant (χ of urine iodide level comparing difference between each group2=
12.315 P<0.005) (Fig. 2).Control group Iodine nutrition is configured to：Iodine organizes 52.3% (68), iodine deficiency group 16.9% in right amount
(22), iodine excess group 13.1% (17), excessive iodine group 17.7% (23), urine iodide level difference has statistics meaning between each group
Justice (χ2=23.604, P<0.001) (Fig. 3).Hyperthyroid group is close with the iodine-nutrition composition ratio of subclinical hyperthyroid group, between two groups
No significant difference (P>0.05), hyperthyroid group and subclinical hyperthyroid group are constituted poor with Normal group iodine-nutrition
Different statistically significant (P<0.05).
(4) comparison of hyperthyroid group urine iodine number and thyroid function index：Difference urine iodine group hyperthyroid patient serum FT3、FT4、
TT3、TT4, comparing difference is not statistically significant (table 3) between TSH；It urinates iodine number and carries out correlation comparison, iodine with thyroid function index
The urine iodine number and serum FT of shortage group, iodine excess group and excessive iodine group patient3、FT4、TT3、TT4In significantly having correlation, institute
There is the urine iodine number of patient to serum TSH without related (table 4).
The different urine iodine group hyperthyroid patient thyroid function indicator difference analyses of table 3
4 hyperthyroid patient of table urinates iodine number and the index related comparison of thyroid function
(5) comparison of subclinical hyperthyroid group urine iodine number and thyroid function index：The difference urine subclinical hyperthyroid patient of iodine group
Serum FT3、FT4、TT3、TT4, comparing difference is not statistically significant (table 5) between TSH；The urine of excessive iodine group and iodine deficiency group patient
Iodine number and serum FT3、FT4There are relationship, only the urine iodine number of iodine deficiency group patient to have correlation (table 6) with serum TSH.
The subclinical hyperthyroid patient thyroid function indicator difference analysis of the different urine iodine groups of table 5
6 subclinical hyperthyroid patient of table urinates iodine number and the index related comparison of thyroid function
Iodine is the raw material of human body synthetic thyroid hormone, and the nutritional status of iodine decides thyroid functional status.Iodine master
If being drained by kidney and alimentary canal, excretion and intake are roughly equal, and the iodine of kidney excretion accounts for about the total discharge rate of iodine
90%, urine iodine detection is convenient, accurate, therefore is the objective indicator of reflection crowd's iodine nutrition level.
The present invention suffers from 251 hyperthyroid patients, 242 subclinical hyperthyroidisms to urinate iodine as the evaluation index of iodine-nutrition
Person and 130 healthy populations are researched and analysed.As a result it shows that control group healthy population urine iodine MUI is 174.3 μ g/L, is sought from iodine
It supports state composition ratio and sees that appropriate iodine, excessive iodine, iodine deficiency and iodine excess are followed successively by 52.3%, 17.7%, 16.9% and 13.1%,
Illustrate that carrying out whole people's Salt iodization policy has been achieved with certain achievement, healthy population totality urine iodide level is in optimum range, iodine
Nutritional status is good, but still has nearly half crowd to be in Iodine nutrition shortage and Iodine nutrition excess state, urine iodide level fluctuation
Range is larger, that is, urinates iodine range from 50.3~930.5 μ g/L, it should continue to carry out national Salt iodization, but more it should be noted that because of people
It enriches the iodine because ground carries out science.The study find that the urine iodide level of subclinical hyperthyroid patient is higher than hyperthyroid patient, the urine of two groups of patients
Iodine MUI is above 200 μ g/L, and is above control group, illustrates that two groups of patient's totality iodine nutrition levels are in Iodine nutrition excess shape
State；In iodine-nutrition composition ratio, hyperthyroidism and subclinical hyperthyroid patient iodine is appropriate, excessive iodine, iodine deficiency and iodine excess accounting
Close, two group differences are not statistically significant, but are compared with Normal group, find hyperthyroidism and subclinical hyperthyroid patient
Iodine-nutrition composition is different, and iodine deficiency ratio is low compared with control group, and the ratio of iodine excess and excessive iodine is higher than control group.
It is found after urine iodine number and the index related analysis of thyroid function to hyperthyroidism and subclinical hyperthyroid patient, hyperthyroid group
The urine iodide level and serum FT of excessive iodine, iodine excess and iodine deficiency patient3、FT4、TT3、TT4Index has apparent correlation, with
TSH non-correlations；And the appropriate patient's urine iodide level of iodine and serum FT3、FT4、TT3、TT4With TSH indexs without correlation；It is sub-
Clinical hyperthyroid group excessive iodine and the urine iodide level of iodine deficiency patient and serum FT3、FT4Index is in correlation, only iodine deficiency patient
Urine iodide level it is related to serum TSH index；And iodine is appropriate and iodine excess patient urine iodide level and serum FT3、FT4、TT3、
TT4To TSH indexs without related；Control group healthy population urine iodide level and serum FT3、FT4、TT3、TT4Do not have with TSH indexs
Correlation；Hyperthyroidism and subclinical hyperthyroid patient serum FT between difference urine iodine number group3、FT4、TT3、TT4Between TSH comparing difference without
Statistical significance.
This experimental result finds that hyperthyroidism and subclinical hyperthyroid patient urine iodide level are higher, but exist simultaneously high iodine and low iodine
And it deposits cash as iodine intake is excessive and iodine intake shortage is related with hyperthyroidism and the generation of subclinical hyperthyroidism disease, therefore should just confirm
Know effect of the iodine played in thyroid disease occurs, develops, can not blindly emphasize to enrich the iodine or limit to take the photograph iodine.
In conclusion after by carrying out Universal saltiodization, crowd's entirety iodine-nutrition has apparent improvement, but locates
Considerable proportion is still accounted in the number of iodine excess and excessive iodine, a certain proportion of iodine deficiency person is existed simultaneously, makes thyroid disease
Morbidity spectrum changed.Iodine-nutrition and the generation of hyperthyroidism and subclinical hyperthyroidism are closely related, and therefore, urine iodine detection can
It is healthy individuals so that as a routine clinical inspection, the monitoring of urine iodide level is carried out to Healthy People and Patients With Various Thyroid Disorders
Diet provides the suggestion of science, in due course, instructs patient's Iodine nutrition diet in right amount, should take the initiative and arrange to urine iodine patients with abnormal
It applies Iodine nutrition control in appropriate level, by the treatment curative effect and early prevention important in inhibiting to improving disease.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications, these improvements and modifications can also be made
Also it should be regarded as protection scope of the present invention.
Claims (1)
1. a kind of evaluation method of Iodine nutrition situation in hyperthyroidism, which is characterized in that include the following steps：
(1) research object is chosen：Choose 200~300 patients with hyperthyroidism and 200~300 subclinical first shapes
Gland hyperfunction disease patient chooses 100~200 healthy populations as a control group as experimental group；
(2) serum thyroid function five indices measure：Limosis vein blood sample 5ml is left and taken, using Electrochemiluminescence immunoassay
Measure thyroid function five indices：Thyrotropic hormone, free triiodothyronine, free thyroxine, total first shape
Parathyrine, total triiodothyronine；
(3) Iodine assay is urinated：Disposable urina sanguinis 10ml is acquired, is placed in cleaning vinyl tube, measures according to catalysis of iodine arsenic cerium
The principle of reaction selects urine iodine immue quantitative detection reagent box AR types；
(4) it diagnoses：
A, iodine status assessment standard is urinated：Medianofurinaryiodine<100 μ g/L be iodine deficiency, Medianofurinaryiodine 100~199 μ g/L it
Between for iodine it is appropriate, Medianofurinaryiodine between 200~299 μ g/L be iodine excess, the Niao iodine Zhong Wei μ of Shuo≤300 g/L be excessive iodine；
B, the diagnosis of hyperthyroidism and subclinical hyperthyroidism：Hyperthyroidism：There is first shape
The symptom or sign of gland hyperfunction disease, while free triiodothyronine>7.1pmol/L, free thyroxine>
22pmol/L, thyrotropic hormone<0.27mU/L person；Subclinical hyperthyroidism：Athyreosis hyperfunction disease
Symptom or sign, free triiodothyronine and free thyroxine are normal, thyrotropic hormone<0.27mU/L；
(5) statistical procedures：Statistical procedures are carried out using SPSS19.0 statistical softwares, data are indicated with x ± S or median,
Measurement data compares with rank sum test and variance analysis, and the correlativity between each factor uses Liner correlation, P<0.05 table
Bright difference has statistical significance.
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Citations (2)
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204600832U (en) * | 2015-04-29 | 2015-09-02 | 刘阳 | A kind of shoulder joint elastic force anti-drop fixing band |
| CN106645701A (en) * | 2017-01-13 | 2017-05-10 | 沧州医学高等专科学校 | Thyroid autoantibody screening and analyzing method for people in iodine excess water region and application |
Non-Patent Citations (3)
| Title |
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| 宋向欣 等: "新疆住院维族和汉族患者甲状腺功能与碘营养状态分析", 《海南医学》 * |
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