CN108428613B

CN108428613B - Open ion source and method

Info

Publication number: CN108428613B
Application number: CN201711494194.5A
Authority: CN
Inventors: 闻路红; 宁录胜; 赵鹏; 洪欢欢; 毕磊
Original assignee: China Innovation Instrument Co ltd; Ningbo University
Current assignee: China Innovation Instrument Co ltd; Ningbo University
Priority date: 2017-12-31
Filing date: 2017-12-31
Publication date: 2023-08-04
Anticipated expiration: 2037-12-31
Also published as: CN108428613A

Abstract

The invention provides an open type ion source and a method, wherein the ion source comprises a medium pipe, a high-voltage electrode and a grounding electrode; the first connector, the conductive connector, the second connector and the connecting piece are sequentially connected; the connecting piece is internally provided with a first channel and a second channel, and the included angle between the axis of the second channel and the axis of the first channel is an acute angle or a right angle; the medium pipe is arranged at the outlet of the connecting piece; the first pipeline is arranged in the first connector, and one end of the first pipeline extends into the conductive connector; the second pipeline is arranged in the second connector, one end of the second pipeline extends into the conductive connector, and the other end of the second pipeline extends into the first channel; the distance between the ends of the first and second pipes is greater than zero; the end of the second conduit within the first passage is downstream of the junction of the first passage and the second passage in the direction of flow of the fluid within the second conduit; the third joint is connected with the connecting piece; a third conduit is disposed within the third joint and extends into the second passage at one end. The invention has the advantages of wide application range and the like.

Description

Open ion source and method

Technical Field

The invention relates to drug detection and analysis, in particular to an open type ion source and a method.

Background

The open type mass spectrum ion source is a device capable of realizing sample ionization in an open type environment, and becomes a front-edge hot spot for the research of the existing mass spectrum technology by virtue of the advantages of small sample consumption, high analysis speed, support of real-time in-situ detection and the like. A variety of different open mass spectrometry ion sources have been developed, such as DESI, DART, DBDI, EESI.

The analysis technology mainly has the following defects: the broad spectrum has poor universality, different ion sources are needed for analyzing the unnecessary substances, for example DART is suitable for analyzing organic small molecular compounds, proton affinity energy small molecular compounds cannot be analyzed, DESI is suitable for analyzing polar large molecular compounds, and weak polar organic small molecular compounds cannot be analyzed.

Disclosure of Invention

In order to solve the defects in the prior art, the invention provides an open type ion source with wide application range.

The invention aims at realizing the following technical scheme:

an open ion source comprising a dielectric tube, a high voltage electrode, and a ground electrode; the open ion source further comprises:

a first joint;

a conductive contact;

a second joint;

the first connector, the conductive connector, the second connector and the connecting piece are connected in sequence; the connecting piece is internally provided with a first channel and a second channel, and the included angle between the axis of the second channel and the axis of the first channel is an acute angle or a right angle; the medium pipe is arranged at the outlet of the connecting piece;

a first conduit disposed within the first connector and having one end extending into the conductive connector;

a second conduit disposed within the second connector and having one end extending into the conductive connector and another end extending into the first channel; the distance between the ends of the first and second conduits within the contact block is greater than zero; the end of the second conduit within the first passage is downstream of the junction of the first and second passages in the direction of flow of the fluid within the second conduit;

the third joint is connected with the connecting piece;

and a third pipe disposed within the third joint and having one end extending into the second passage.

The invention also aims to provide a working method with wide application range according to the open type ion source, and the invention aims to be realized through the following technical scheme:

the working method of the open type ion source comprises the following steps:

applying a direct current voltage to the conductive contact to form an electric field between the conductive contact and a ground electrode; applying an alternating voltage to the high voltage electrode;

the liquid to be tested enters the second pipeline through the first pipeline and is sprayed out of the second pipeline, and spray is formed under the action of the electric field;

and the gas enters the second channel and the first channel from the third pipeline, and plasma is formed in a discharge area in the medium pipe, so that the sample in the atomized liquid to be measured in the medium pipe is ionized.

Compared with the prior art, the invention has the following beneficial effects:

the application range is wide, and the weak polar compound can be ionized by means of plasma, and the macromolecular compound can be ionized by means of electrospray.

Drawings

The present disclosure will become more readily understood with reference to the accompanying drawings. As will be readily appreciated by those skilled in the art: the drawings are only for illustrating the technical scheme of the present invention and are not intended to limit the scope of the present invention. In the figure:

fig. 1 is a schematic view of the structure of an open type ion source according to embodiment 1 of the present invention.

Detailed Description

Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. In order to teach the technical solution of the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or alternatives derived from these embodiments that fall within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the invention is not limited to the following alternative embodiments, but only by the claims and their equivalents.

Example 1:

fig. 1 schematically shows a schematic diagram of an open ion source according to an embodiment of the present invention, as shown in fig. 1, including:

a first joint 2 having an external thread;

a conductive joint 3, if made of metal, one end of the conductive joint is provided with an internal thread matched with the external thread of the first joint, and the other end of the conductive joint is provided with an internal thread matched with the external thread of one end of the second joint;

the second joint 5 is provided with external threads at two ends, and the external threads at the other end of the second joint are matched with the internal threads of the connecting piece;

the first connector, the conductive connector, the second connector and the connecting piece are connected in sequence; the connecting piece is internally provided with a first channel 12 and a second channel 13, and the included angle between the axis of the second channel and the axis of the first channel is an acute angle or a right angle;

a media tube 7 disposed at the outlet of the connector;

a first pipe 1 disposed within the first connector and having one end extending into the conductive connector;

a second conduit 4, such as a glass capillary or a stainless steel capillary, disposed within the second connector and having one end extending into the conductive connector and the other end extending into the first channel; the distance between the ends of the first and second conduits within the contact block is greater than zero; the end of the second conduit within the first passage is downstream of the junction of the first and second passages in the direction of flow of the fluid within the second conduit;

a third joint 10, said third joint connecting said connection member;

a third conduit 11 disposed within the third joint and having one end extending into the second passage;

a high voltage electrode 8 and a ground electrode 9, such as a high voltage electrode, are provided on the outside of the dielectric tube and a ground electrode is provided on the inside of the dielectric tube.

In order to facilitate the flow of the liquid to be measured, further, the axis of the first channel is a straight line.

In order to strengthen the ion source of the liquid to be measured, further, one end of the second pipeline passes through the first channel and extends into the medium pipe.

If the user of the ion source does not provide the direct current and alternating current which meet the requirements, the following power sources are provided:

and the power supply is used for providing direct-current voltage for the conductive connector and providing alternating-current voltage for the high-voltage electrode.

The working method of the open type ion source provided by the embodiment of the invention comprises the following steps:

applying a direct current voltage to the conductive connector, for example, the amplitude is 1KV-5KV, and forming an electric field between the conductive connector and the grounding electrode; applying alternating voltage to the high-voltage electrode, wherein the amplitude is 1KV-5KV and the frequency is 50Hz-1MHz;

Example 2:

application example of the open type ion source described in embodiment 1 of the present invention.

In this application example, the second pipe is a glass capillary or a metal capillary, the inner diameter is in the range of 25 μm to 200 μm, and the outer diameter is in the range of 150 μm to 400 μm; the medium tube comprises insulating medium tubes such as a quartz glass tube, a ceramic tube and the like, the inner diameter range is 1mm-5mm, and the outer diameter range is 2mm-6mm; the gas comprises helium, argon or nitrogen and other inert gases; the amplitude of the direct current voltage output by the power supply is 1KV-5KV, the amplitude of the alternating current voltage output by the power supply is 1KV-5KV, and the frequency is 50Hz-1MHz; the included angle between the central axis of the first channel and the central axis of the second channel is a right angle; the first channel is linear.

Claims

1. An open ion source comprising a dielectric tube, a high voltage electrode, and a ground electrode; the method is characterized in that: the open ion source further comprises:

a first joint;

a conductive contact;

a second joint;

the third joint is connected with the connecting piece;

2. The open ion source of claim 1 wherein: the axis of the first channel is a straight line.

3. The open ion source of claim 1 wherein: the second pipe is a quartz pipe or a stainless steel pipe.

4. The open ion source of claim 1 wherein: one end of the second pipe passes through the first passage and extends into the medium pipe.

5. The open ion source of claim 1 wherein: the open ion source further comprises:

6. The open ion source of claim 1 wherein: the first connector has external threads and the conductive connector has internal threads that mate with the external threads.

7. The open ion source of claim 1 wherein: the two ends of the second joint are provided with external threads, and the conductive joint and the connecting piece are respectively provided with internal threads matched with the external threads.

8. The open ion source of claim 5 wherein: the high-voltage electrode is arranged on the outer side of the medium pipe, and the grounding electrode is arranged on the inner side of the medium pipe.

9. The method of operating an open ion source according to any one of claims 1-8, the method of operating comprising:

10. The method of operation of claim 9, wherein: the amplitude of the direct current voltage is 1KV-5KV; the amplitude of the alternating voltage is 1KV-5KV, and the frequency is 50Hz-1MHz.