CN108426984A - One kind being used for Natural Medicine Analysis sampler and its Pharmaceutical Analysis method - Google Patents
One kind being used for Natural Medicine Analysis sampler and its Pharmaceutical Analysis method Download PDFInfo
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- CN108426984A CN108426984A CN201810642397.2A CN201810642397A CN108426984A CN 108426984 A CN108426984 A CN 108426984A CN 201810642397 A CN201810642397 A CN 201810642397A CN 108426984 A CN108426984 A CN 108426984A
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- 239000003814 drug Substances 0.000 title claims abstract description 78
- 229940079593 drug Drugs 0.000 title claims abstract description 73
- 238000004458 analytical method Methods 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000005220 pharmaceutical analysis Methods 0.000 title claims abstract description 17
- 238000001514 detection method Methods 0.000 claims abstract description 66
- 239000000523 sample Substances 0.000 claims abstract description 28
- 238000005070 sampling Methods 0.000 claims abstract description 25
- 230000000452 restraining effect Effects 0.000 claims abstract description 4
- 230000005540 biological transmission Effects 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 5
- KJDGFQJCHFJTRH-YONAWACDSA-N 16-Ketoestradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](C(=O)C4)O)[C@@H]4[C@@H]3CCC2=C1 KJDGFQJCHFJTRH-YONAWACDSA-N 0.000 claims description 3
- 125000000205 L-threonino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])[C@](C([H])([H])[H])([H])O[H] 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000009825 accumulation Methods 0.000 claims description 3
- 238000000149 argon plasma sintering Methods 0.000 claims description 3
- 230000027455 binding Effects 0.000 claims description 3
- 238000009739 binding Methods 0.000 claims description 3
- 239000003640 drug residue Substances 0.000 claims description 3
- 230000008030 elimination Effects 0.000 claims description 3
- 238000003379 elimination reaction Methods 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 238000009434 installation Methods 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000151 deposition Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention belongs to medical detection technique fields, disclose one kind and being used for Natural Medicine Analysis sampler and its Pharmaceutical Analysis method, are provided with fuselage；Fuselage top screw is fixed with controller and display screen；Fuselage bottom is fixed with sampling box；The ear formula handle that may be collapsible into body is arranged in fuselage, is convenient for carrying, is also not take up volume；Fuselage is adjusted bar and passes through, and adjustment rod set has the fixed ring of annular；Restraining position ring block is respectively set up and down in adjustment bar, and there are one disk, disk is uniformly distributed 5 detection probes for bottom end installation, also can up and down adjustment this 5 probes sample or sample simultaneously respectively；Disk is rotatable, avoids damaging because of individual probe, does not influence instrument detection and uses.Present invention analytical sampling efficiency easy to operation and improving drug；Detection probe is mounted on by adjusting bar on fuselage, and detection probe is quickly replaced by fixed mechanism, improves the efficiency of detection and easy to operate；Controller can directly display detection information on a display screen.
Description
Technical field
The invention belongs to medical detection technique fields, more particularly to one kind being used for Natural Medicine Analysis sampler and its medicine
Object analysis method.
Background technology
Currently, Pharmaceutical Analysis sampler is a kind of widely used Pharmaceutical Analysis detection device, it is chiefly used in the inspection of hospital
It tests in section, when for different Pharmaceutical Analysis samplings, needs to replace the detection probe in equipment.It is in the prior art
The shortcomings that Pharmaceutical Analysis sampler, is：One is being unable to quick-replaceable detection probe, the complexity and shadow of operation are increased
The efficiency of detection is rung；The second is when needing to move down detection probe, completed generally by liftable rack is arranged
The action equally also increases the complexity of operation.Therefore, it is necessary to design a kind of new structural Natural Medicine Analysis sampling
Device.
In conclusion problem of the existing technology is：
(1) traditional detection device is unable to quick-replaceable detection probe, increases the complexity of operation and affects detection
Efficiency；The second is when needing to move down detection probe, the action is completed generally by liftable rack is arranged, together
Sample also increases the complexity of operation.
(2) existing drug parameters detection method is time-consuming and laborious there are detection device complexity.
Invention content
In view of the problems of the existing technology, the present invention provides one kind being used for Natural Medicine Analysis sampler and its medicine
Object analysis method.
The invention is realized in this way a kind of Pharmaceutical Analysis method for Natural Medicine Analysis sampler, the use
Include in the Pharmaceutical Analysis method of Natural Medicine Analysis sampler：
(1) required detection drug is positioned in sampling box, the position of detection probe is adjusted by adjusting bar and fixed ring,
Place it in suitable position；
(2) it turns on the switch, under the control of the controller, the drug in sampling box is detected, after detection, by depositing
Reservoir stores detection information, and shows testing result by display screen；
The medicine kinetics equation group of drug：
m1(0)=m0
m2(0)=0；
m2(t)=c2(t)v；
And byObtain drug time to peak：
Peak drug concentration：
m0Original is drug quality；m1For sampling box drug residue；m2For drug quality in detection probe；m3For detection
Drug quality afterwards；V is apparent volume；v2For the volume of single discharge；v3For the accumulation rate of drug；c2For drug concentration；c3For
Sampling box concentration；kaFor the absorption rate constant of drug；k2For with drug ratio that tissue can be effectively reached after all kinds of protein bindings
Example；kelFor elimination rate constant of the drug through tissue；keTo drain first order rate constant；t1For detection time；t4For this period
Once and t1Interval time；t6For upper period last time detection time and t1Time interval；t7For the second time for this period
Detection and t1Interval time；ToFor detection cycle.
Further, the storage data rate of the detection information：
The Signal Interference and Noise Ratio of MUE is defined as：
The Signal Interference and Noise Ratio of FUE is defined as：
Had according to Shannon's theorems：
K-th of MUE transmitted data rates is in time slot j：Rmkj=log2(1+γmkj)；
It is with some FUE transmitted data rates in the relevant IFC of k-th of MUE in time slot j：Rffj=log2(1+γffj)；
Transmission rate is unrelated with time slot j, obtain in any one time slot with all FUE in the relevant IFC of k-th of MUE into
Capable data rate is
Further, the imaging model of the display screen is：
Wherein, I ° (x) indicates that original image, J ° (x) indicate clear image, and A ° indicates ambient light,Indicate light transmission
Rate,Indicate that light scattering rate, c indicate three Color Channels of red, green, blue in image.
Further, the colour cast level calculating method of the display screen is：
Wherein, mean_a, mean_b indicate that a in Lab color spaces, the mean value of b components, M_a, M_b distinguish table respectively
Show a, the mean square deviation of b components, σ2For the variance of L * component, Thres is preset threshold value.
Another object of the present invention is to provide the drugs point that Natural Medicine Analysis sampler is used for described in a kind of application
Analysis method be used for Natural Medicine Analysis sampler, it is described that Natural Medicine Analysis sampler is provided with fuselage；
Fuselage top screw is fixed with controller and display screen；
The fuselage bottom is fixed with sampling box.
Further, the fuselage setting may be collapsible into the ear formula handle of body；The fuselage is adjusted bar and passes through, the tune
Whole rod set has the fixed ring of annular；Restraining position ring block is respectively set up and down in the adjustment bar, and bottom end is equipped with that there are one disk, disks
It is uniformly distributed 5 detection probes.
Further, it is provided with microprocessor and memory in the controller, is provided with switch on the outside of controller and USB connects
Mouthful.And microprocessor, memory, display screen and detection probe are electrically connected.
Advantages of the present invention and good effect are：The present invention for Natural Medicine Analysis sampler it is small, it is light-weight,
It is simple in structure；Analytical sampling efficiency that is easy to operation and improving drug；Detection probe is mounted on by adjusting bar on fuselage,
On the one hand detection probe can be quickly replaced by fixed mechanism, on the other hand improve the efficiency of detection and easy to operate；And
And controller can directly display detection information on a display screen.Theoretical model of the present invention in the application to equipment requirement not
Height can utilize chemical sensor to measure drug concentration, eliminate spectroscopic methodology, immunization, HPLC methods etc. when obtaining drug parameters
Required complex detection equipment, therefore it has the characteristics that simplicity is flexible, has popularization.
Description of the drawings
Fig. 1 is provided in an embodiment of the present invention for Natural Medicine Analysis sampler structural schematic diagram；
Fig. 2 is fixed ring structural schematic diagram provided in an embodiment of the present invention；
Fig. 3 is control structure schematic diagram provided in an embodiment of the present invention；
In figure：1, fuselage；2, controller；3, display screen；4, sampling box；5, bar is adjusted；6, fixed ring；7, spacing ring；8、
Detection probe；9, microprocessor；10, memory；11, it switchs；12, ear formula handle；13, USB interface；14, disk.
Specific implementation mode
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and coordinate attached drawing
Detailed description are as follows.
The structure of the present invention is explained in detail below in conjunction with the accompanying drawings.
As shown in Figure 1-Figure 3, provided in an embodiment of the present invention that Natural Medicine Analysis sampler is provided with fuselage 1；
1 top screw of the fuselage is fixed with controller 2 and display screen 3；
As the preferred embodiment of the present invention, the fuselage bottom is fixed with sampling box 4；
As the preferred embodiment of the present invention, the fuselage is adjusted bar 5 and passes through, and the adjustment bar 5 is cased with consolidating for annular
Determine ring 6；Restraining position ring block 7 is respectively set in about the 5 adjustment bar, and bottom end is equipped with disk 14, has detection to visit on the disk 14
Needle 8；
As the preferred embodiment of the present invention, microprocessor 9 and memory 10, controller 2 are provided in the controller 2
Outside is provided with switch 11 and usb 13.And microprocessor 9, memory 10, display screen 3 and detection probe 8 are electrically connected.
The operation principle of the present invention：In use, Natural Medicine Analysis sampler and its Pharmaceutical Analysis method are used for, by institute
Drug need to be detected to be positioned in sampling box 4, the position of detection probe 8 is adjusted by adjusting bar 5 and fixed ring 6, places it in conjunction
It sets right position.11 are turned on the switch, under the control 2 of controller, the drug in sampling box 4 is detected, it, can be with after detection
Detection information is stored by memory 10, and testing result is shown by display screen 3.
The application principle of the present invention is further described with reference to specific embodiment.
Pharmaceutical Analysis method provided in an embodiment of the present invention for Natural Medicine Analysis sampler includes：
(1) required detection drug is positioned in sampling box, the position of detection probe is adjusted by adjusting bar and fixed ring,
Place it in suitable position；
(2) it turns on the switch, under the control of the controller, the drug in sampling box is detected, after detection, by depositing
Reservoir stores detection information, and shows testing result by display screen；
The medicine kinetics equation group of drug：
m1(0)=m0
m2(0)=0；
m2(t)=c2(t)v；
And byObtain drug time to peak：
Peak drug concentration：
m0Original is drug quality；m1For sampling box drug residue；m2For drug quality in detection probe；m3For detection
Drug quality afterwards；V is apparent volume；v2For the volume of single discharge；v3For the accumulation rate of drug；c2For drug concentration；c3For
Sampling box concentration；kaFor the absorption rate constant of drug；k2For with drug ratio that tissue can be effectively reached after all kinds of protein bindings
Example；kelFor elimination rate constant of the drug through tissue；keTo drain first order rate constant；t1For detection time；t4For this period
Once and t1Interval time；t6For upper period last time detection time and t1Time interval；t7For the second time for this period
Detection and t1Interval time；ToFor detection cycle.
Further, the storage data rate of the detection information：
The Signal Interference and Noise Ratio of MUE is defined as：
The Signal Interference and Noise Ratio of FUE is defined as：
Had according to Shannon's theorems：
K-th of MUE transmitted data rates is in time slot j：Rmkj=log2(1+γmkj)；
It is with some FUE transmitted data rates in the relevant IFC of k-th of MUE in time slot j：Rffj=log2(1+γffj)；
Transmission rate is unrelated with time slot j, obtain in any one time slot with all FUE in the relevant IFC of k-th of MUE into
Capable data rate is
Further, the imaging model of the display screen is：
Wherein, I ° (x) indicates that original image, j ° (x) indicate clear image, and A ° indicates ambient light,Indicate light transmission
Rate,Indicate that light scattering rate, c indicate three Color Channels of red, green, blue in image.
Further, the colour cast level calculating method of the display screen is：
Wherein, mean_a, mean_b indicate that a in Lab color spaces, the mean value of b components, M_a, M_b distinguish table respectively
Show a, the mean square deviation of b components, σ2For the variance of L * component, Thres is preset threshold value.
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Every any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (7)
1. a kind of Pharmaceutical Analysis method for Natural Medicine Analysis sampler, which is characterized in that described to be used for natural drug
The Pharmaceutical Analysis method of analytical sampling device includes：
(1) required detection drug is positioned in sampling box, the position of detection probe is adjusted by adjusting bar and fixed ring, makes it
It is placed in suitable position；
(2) it turns on the switch, under the control of the controller, the drug in sampling box is detected, after detection, by memory
Detection information is stored, and testing result is shown by display screen；
The medicine kinetics equation group of drug：
m1(0)=m0
m2(0)=0；
m2(t)=c2(t)v；
And byObtain drug time to peak：
Peak drug concentration：
m0Original is drug quality；m1For sampling box drug residue；m2For drug quality in detection probe；m3For drug after detection
Quality；V is apparent volume；v2For the volume of single discharge；v3For the accumulation rate of drug；c2For drug concentration；c3For sampling box
Concentration；kaFor the absorption rate constant of drug；k2For with drug ratios that tissue can be effectively reached after all kinds of protein bindings；kelFor
Elimination rate constant of the drug through tissue；keTo drain first order rate constant；t1For detection time；t4For this period for the first time with
t1Interval time；t6For upper period last time detection time and t1Time interval；t7For this period second detect with
t1Interval time；ToFor detection cycle.
2. being used for the Pharmaceutical Analysis method of Natural Medicine Analysis sampler as described in claim 1, which is characterized in that described
The storage data rate of detection information：
The Signal Interference and Noise Ratio of MUE is defined as：
The Signal Interference and Noise Ratio of FUE is defined as：
Had according to Shannon's theorems：
K-th of MUE transmitted data rates is in time slot j：Rmkj=log2(1+γmkj)；
It is with some FUE transmitted data rates in the relevant IFC of k-th of MUE in time slot j：Rffj=log2(1+γffj)；
Transmission rate is unrelated with time slot j, obtains carrying out with all FUE in the relevant IFC of k-th of MUE in any one time slot
Data rate is
3. being used for the Pharmaceutical Analysis method of Natural Medicine Analysis sampler as described in claim 1, which is characterized in that described
The imaging model of display screen is：
Wherein, I ° (x) indicates that original image, J ° (x) indicate clear image, and A ° indicates ambient light,Indicate light transmission,Indicate that light scattering rate, c indicate three Color Channels of red, green, blue in image.
4. being used for the Pharmaceutical Analysis method of Natural Medicine Analysis sampler as described in claim 1, which is characterized in that described
The colour cast level calculating method of display screen is：
Wherein, mean_ α, mean_b indicate that a in Lab color spaces, the mean value of b components, M_a, M_b indicate a, b respectively respectively
The mean square deviation of component, σ2For the variance of L * component, Thres is preset threshold value.
5. a kind of being used for crude drug using the Pharmaceutical Analysis method for being used for Natural Medicine Analysis sampler described in claim 1
Object analytical sampling device, which is characterized in that described that Natural Medicine Analysis sampler is provided with fuselage；
Fuselage top screw is fixed with controller and display screen；
The fuselage bottom is fixed with sampling box.
6. being used for Natural Medicine Analysis sampler as claimed in claim 5, which is characterized in that the fuselage setting is collapsible
Into the ear formula handle of body；The fuselage is adjusted bar and passes through, and the adjustment rod set has the fixed ring of annular；On the adjustment bar
Under be respectively set restraining position ring block, bottom end is equipped with there are one disk, and disk is uniformly distributed 5 detection probes.
7. being used for Natural Medicine Analysis sampler as claimed in claim 5, which is characterized in that be provided in the controller
Microprocessor and memory, controller outside are provided with switch and USB interface；And microprocessor, memory, display screen and detection
Probe is electrically connected.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810642397.2A CN108426984A (en) | 2018-06-21 | 2018-06-21 | One kind being used for Natural Medicine Analysis sampler and its Pharmaceutical Analysis method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112973178A (en) * | 2021-02-26 | 2021-06-18 | 重庆文理学院 | Traditional chinese medicine pharmacy is with squeezing extraction device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105096783A (en) * | 2015-08-03 | 2015-11-25 | 武汉华星光电技术有限公司 | Detection equipment and probe component thereof |
| CN205483994U (en) * | 2016-02-24 | 2016-08-17 | 沈红霞 | Crude drug analyzing sampled device |
| CN206975012U (en) * | 2017-08-03 | 2018-02-06 | 佛山市云米电器科技有限公司 | A kind of plate of water route water quality detection sensor |
-
2018
- 2018-06-21 CN CN201810642397.2A patent/CN108426984A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105096783A (en) * | 2015-08-03 | 2015-11-25 | 武汉华星光电技术有限公司 | Detection equipment and probe component thereof |
| CN205483994U (en) * | 2016-02-24 | 2016-08-17 | 沈红霞 | Crude drug analyzing sampled device |
| CN206975012U (en) * | 2017-08-03 | 2018-02-06 | 佛山市云米电器科技有限公司 | A kind of plate of water route water quality detection sensor |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112973178A (en) * | 2021-02-26 | 2021-06-18 | 重庆文理学院 | Traditional chinese medicine pharmacy is with squeezing extraction device |
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Application publication date: 20180821 |
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