CN108424832A - Organize device fine crushing and the equipment with tissue device fine crushing - Google Patents
Organize device fine crushing and the equipment with tissue device fine crushing Download PDFInfo
- Publication number
- CN108424832A CN108424832A CN201710080916.6A CN201710080916A CN108424832A CN 108424832 A CN108424832 A CN 108424832A CN 201710080916 A CN201710080916 A CN 201710080916A CN 108424832 A CN108424832 A CN 108424832A
- Authority
- CN
- China
- Prior art keywords
- fine crushing
- device fine
- assembly
- strainer
- filling component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 9
- 230000006698 induction Effects 0.000 claims description 3
- 230000008520 organization Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
Abstract
The present invention provides a kind of tissue device fine crushing and the equipment with tissue device fine crushing, and it includes a motor sub-assembly, a filling component, a strainer, a conduit, a cutter assembly and a conducting element to organize device fine crushing.Filling component, which includes a hollow cylinder and one, can movably be arranged in the piston rod of hollow cylinder, and one end of piston rod is resisted against motor sub-assembly, filling component is made to be connected with motor sub-assembly.Strainer is set to the one end of hollow cylinder far from motor sub-assembly.Conduit is set to motor sub-assembly and fills the side of component, and wherein conduit is set to the nozzle of tube at one end comprising one, and is adjacent to the one end of strainer far from filling component.Cutter assembly is adjacent to strainer.Conducting element is set to one end of hollow cylinder adjacent screen.The present invention separately provides a kind of equipment with tissue device fine crushing, and manpower and time and the effect of organization of unity granularity are saved to reach.
Description
Technical field
The present invention relates to a kind of devices fine crushing, are especially used for the device fine crushing of tissue.The present invention is separately related to a kind of automatic
Equipment, the especially equipment with tissue device fine crushing.
Background technology
In recent years, the technology of extraction primary cell culture developed it is quite ripe, and primary cell is continued to cultivate
A variety of different fields are had been applied in, so that extraction primary cell is just being badly in need of largely being manufactured at present and unified operation
Specification.
In the prior art, since the extraction of primary cell involves multiple steps, wherein will organize step fine crushing is the most
An important step is also wanted to avoid being polluted by the external world other than it must be completed in a short time separation.Therefore, when
It is preceding that step fine crushing will be organized to be only capable of being dependent under artificial operational circumstances, the qualification of operating personnel and careful degree and
The size of minced tissue will influence subsequently to extract success or not and the efficiency of primary cell.Once needing a large amount of extraction primary thin
Born of the same parents, if only being operated by the same operating personnel, other than it will increase the tissue operating time fine crushing, once intermediate occur
Contamination can just be found when often arriving the stage finally cultivated, and can not retrieve.
In view of this, how to develop saving manpower, while the device fine crushing of pollution is reduced, the prior art is to be improved in fact
Necessity.
Invention content
The shortcomings that in order to overcome the prior art, the purpose of the present invention is to provide a kind of tissue device fine crushing and has tissue
The equipment of device fine crushing saves the effect of manpower is with time and organization of unity granularity to reach.
For the goal of the invention for reaching above-mentioned, the present invention provides a kind of tissue device fine crushing, and it includes a motor sub-assembly, one to fill
Fill out component, a strainer, a conduit, a cutter assembly and a conducting element.The filling component includes that a hollow cylinder and one live
Stopper rod；The piston rod can movably be arranged in the hollow cylinder, and one end of the piston rod is resisted against the motor sub-assembly, makes the filling
Component is connected with the motor sub-assembly.The strainer is set to the one end of hollow cylinder far from the motor sub-assembly of the filling component.It should
Conduit is set to the side of the motor sub-assembly and the filling component, and the wherein conduit includes a nozzle, which is set to the conduit
One end, and it is adjacent to the one end of the strainer far from the filling component.The cutter assembly is adjacent to the strainer.The conducting element is set to should
Fill the one end of hollow cylinder with respect to the strainer of component.
Preferably, the motor sub-assembly is stepper motor, servo motor or induction motor.
Preferably, the strainer have multiple holes, the strainer adjacent to the filling component one end and in each described
Tapered protrusion between hole.
Preferably, the cutter assembly have a blade that can be moved back and forth and one be connected with the blade first
Motor, and the blade can the neighbouring one end of the strainer far from the filling component.
Preferably, the cutter assembly is a ultrasonic knife group (ultrasonic for being used for histotomy
instruments for tissue biopsy slicer)。
Preferably, the cutter assembly is a laser knife group.
The present invention separately provides a kind of equipment with tissue device fine crushing, and it includes one to organize device fine crushing as previously described
An and frame body.The frame body includes a pedestal, two plate bodys and a swivel plate.Such plate body is L-shaped, wherein one end of each plate body
It is connected respectively with the both sides of the pedestal.The swivel plate can be rotatably arranged between each plate body and one end far from the pedestal；It should
Swivel plate has second motor for being set to the swivel plate side；Tissue device fine crushing is set on the swivel plate.
Preferably, the swivel plate has an elastic force locked instrument, one end of the elastic force locked instrument is fixedly arranged on rotation
The one side of plate, the other end can actively be resisted against the hollow cylinder of the filling component of tissue device fine crushing with elastic force.
More preferably, the conduit is set to one side of the swivel plate far from the filling component.
More preferably, the cutter assembly is set to one side of the swivel plate far from the filling component.
The advantages of tissue device fine crushing of the present invention, is, is resisted against the motor sub-assembly by one end of the piston rod, makes
It squeezes and detaches via each hole positioned at the tissue of the hollow cylinder；By the strainer adjacent to one end of the filling component and in each
Tapered protrusion between hole exposes outside the one end of strainer far from the filling component so that tissue separation is squeezed into each hole
Tissue, then exposed tissue is shredded via cutter assembly.By containing buffer solution in conduit after nozzle sprays, make tissue
It is easily isolated.By the conducting element, making the tissue through cutting off, sequentially water conservancy diversion is collected with profit along the conducting element.In addition, of the invention
The equipment with tissue device fine crushing, by the elastic force locked instrument and the filling component against one end movably pull
It is dynamic, so that the filling component is easy to from tissue device dismounting fine crushing and is loaded.By the swivel plate there is electro-motor auxiliary to turn over
Turn, and tissue device fine crushing can carry out tissue separation fine crushing automatically, to reach saving manpower, simultaneously organization of unity is fine crushing with the time
The effect of degree.
Description of the drawings
The following drawings are only intended to schematically illustrate and explain the present invention, not delimit the scope of the invention.Wherein：
Fig. 1 is the stereo appearance figure of the tissue device fine crushing of the present invention.
Fig. 2 is the optical cable of the tissue device fine crushing of the present invention.
Fig. 3 is the stereo appearance figure of the strainer of the tissue device fine crushing of the present invention.
Fig. 4 is the sectional view of the strainer of another preferred embodiment of the tissue device fine crushing of the present invention.
Fig. 5 is the stereo appearance figure of the equipment with tissue device fine crushing of the present invention.
Fig. 6 is the exploded view of the equipment with tissue device fine crushing of the present invention.
Specific implementation mode
Coordinate schema and presently preferred embodiments of the present invention, the skill that the present invention is further explained is taken by reached purpose below
Art means.
As shown in Figs.1 and 2, a kind of tissue device fine crushing of the invention, it includes a motor sub-assembly 10, one fillings
Component 20, a strainer 30, a conduit 40, a cutter assembly 50 and a conducting element 60.
The motor sub-assembly 10 is stepper motor, servo motor or induction motor.
The filling component 20 is connected with the motor sub-assembly 10, which lives comprising a hollow cylinder 21 and one
Stopper rod 22；The piston rod 22 is movably arranged in the hollow cylinder 21, and one end of the piston rod 22 is resisted against the motor sub-assembly
10。
Shown in please see Fig. 2 to Fig. 4, which is set to the hollow cylinder 21 of the filling component 20 far from the motor sub-assembly
10 one end.The strainer 30 have multiple holes 31, the strainer 30 adjacent to the filling component 20 one end and in each hole 31
Between tapered protrusion.
The conduit 40 is set to the side of the motor sub-assembly 10 and the filling component 20, and the wherein conduit 40 includes a nozzle
41, which is set to one end of the conduit 40, and is adjacent to the one end of the strainer 30 far from the filling component 20.Preferably one
Embodiment in, the one end of the conduit 40 far from the nozzle 41 be equipped with a bottle house buffer solution.
The cutter assembly 50 is adjacent to the strainer 30.The cutter assembly 50 has a blade 51 and one that can be moved back and forth
The first motor 52 being connected with the blade 51, the blade 51 can the neighbouring one end of the strainer 30 far from the filling component 20.
In one preferred embodiment, which is a ultrasonic knife group (ultrasonic for being used for histotomy
instruments for tissue biopsy slicer).In another preferred embodiment, which is a laser
Knife group.
The conducting element 60 is set to the one end of the hollow cylinder 21 of the filling component 20 relative to the strainer 30.
Shown in please see Fig. 2 to Fig. 4, tissue of the invention is fine crushing to be installed in use, a tissue is placed in the hollow
In body 21, then the piston rod 22 is placed in the hollow cylinder 21；It is resisted against the motor sub-assembly by one end of the piston rod 22
10, once the motor sub-assembly 10 is driven just to push the piston rod 22, it is located at the tissue of the hollow cylinder 21 just via the strainer 30
Each hole 31 squeeze separation；Meanwhile by the strainer 30 adjacent to one end of the filling component 20 and between each hole 31
Tapered protrusion, so that tissue separation is squeezed into each hole 31.By the exposed tissue of each hole 31 then by the cutting
Component 50 is cut off, and simultaneously with the buffer solution in conduit 40 after the ejection of nozzle 41, can obtain tissue fine crushing.
In addition, by the conducting element 60, making the tissue through cutting off, sequentially water conservancy diversion is collected with profit along the conducting element 60.
Please refer to shown in Fig. 5 and Fig. 6, the present invention separately provides a kind of equipment with tissue device fine crushing, it includes just like
Preceding the tissue device fine crushing and a frame body 70.
The frame body 70 includes a pedestal 71, two plate bodys 72 and a swivel plate 73.Such plate body 72 is L-shaped, each plate body 72
Wherein one end be connected respectively with the both sides of the pedestal 71；The swivel plate 73 is rotatably arranged between each plate body 72 and separate
One end of the pedestal 71；There is the swivel plate 73 an elastic force locked instrument 731 and one to be set to the second of 73 side of swivel plate
Motor 732, one end of the elastic force locked instrument 731 are fixedly arranged on the one side of swivel plate 73, the other end movably with elastic force against
In the hollow cylinder 21 of the filling component 20 of tissue device fine crushing；The conduit 40 is set to the swivel plate 73 with the cutter assembly 50
One side far from the filling component 20.
The equipment with tissue device fine crushing of the present invention is in use, pass through the elastic force locked instrument 731 and the filling
Component 20 against one end movably pull, so that the filling component 20 is disassembled from tissue device fine crushing.When being replaced as
It is another when filling organized filling component 20 and being loaded into tissue device fine crushing, the hollow cylinder 21 upward, and the piston rod
22, which are located at 21 lower section of hollow cylinder, avoids tissue from flowing out.When being then ready for tissue separation fine crushing, which just turns over
Turn that the hollow cylinder 21 is made to carry out with profit downward.The action fine crushing such as occupation mode of preceding tissue device fine crushing, has detached when fine crushing
Bi Shi, which overturns again makes the hollow cylinder 21 upward.Since the swivel plate 73 is assisted with second motor 73
Overturning, and tissue device fine crushing can carry out tissue separation fine crushing automatically, therefore manpower and time can be saved, and organization of unity is thin
Broken degree, i.e. the volume size of organization of unity.
The foregoing is merely the schematical specific implementation modes of the present invention, are not limited to the scope of the present invention.It is any
Those skilled in the art, made equivalent variations and modification under the premise of not departing from design and the principle of the present invention,
The scope of protection of the invention should be belonged to.And it should be noted that each component part of the present invention is not limited in above-mentioned entirety
Using one can be selected individually to use according to actual needs for each technical characteristic described in specification of the invention or selection is more
Item combines use, and therefore, the present invention covers in the nature of things related with this case inventive point other to be combined and specifically answer
With.
Claims (10)
1. a kind of tissue device fine crushing, which is characterized in that the tissue device fine crushing includes：
One motor sub-assembly；
One filling component, it includes：
One hollow cylinder；And
One piston rod, can movably be arranged in the hollow cylinder, and one end of the piston rod is resisted against the motor sub-assembly, this is made to fill
Component is filled out with the motor sub-assembly to be connected；
One strainer is set to the one end of hollow cylinder far from the motor sub-assembly of the filling component；
One conduit, is set to the side of the motor sub-assembly and the filling component, and the wherein conduit includes：
One nozzle, is set to one end of the conduit, and is adjacent to the one end of the strainer far from the filling component；
One cutter assembly, adjacent to the strainer；And
One conducting element is set to the one end of hollow cylinder with respect to the strainer of the filling component.
2. organizing device fine crushing as described in claim 1, which is characterized in that the motor sub-assembly is stepper motor, servo motor
Or induction motor.
3. organizing device fine crushing as described in claim 1, which is characterized in that the strainer has multiple holes, the strainer adjacent
In one end of the filling component and the tapered protrusion between each described hole.
4. organizing device fine crushing as claimed any one in claims 1 to 3, which is characterized in that the cutter assembly has an energy
The blade of reciprocating movement and first motor that is connected with the blade, and the blade can the neighbouring strainer far from the filling group
One end of part.
5. organizing device fine crushing as claimed any one in claims 1 to 3, which is characterized in that the cutter assembly is used for for one
The ultrasonic knife group of histotomy.
6. organizing device fine crushing as claimed any one in claims 1 to 3, which is characterized in that the cutter assembly is a laser
Knife group.
7. a kind of equipment with tissue device fine crushing, which is characterized in that the equipment with tissue device fine crushing includes：
Just like tissue device fine crushing according to any one of claims 1 to 6；And
One frame body, it includes：
One pedestal；
Two plate bodys, L-shaped, wherein one end of each plate body is connected with the both sides of the pedestal respectively；And
One swivel plate, can be rotatably arranged between each plate body and one end far from the pedestal；The swivel plate is set to one should
Second motor of swivel plate side；Tissue device fine crushing is set on the swivel plate.
8. the equipment with tissue device fine crushing as claimed in claim 7, which is characterized in that the swivel plate has a snap lock
It is fixedly mounted with and sets, one end of the elastic force locked instrument is fixedly arranged on the one side of swivel plate, and the other end actively can be resisted against this with elastic force
Organize the hollow cylinder of the filling component of device fine crushing.
9. the equipment with tissue device fine crushing as claimed in claim 8, which is characterized in that it is remote that the conduit is set to the swivel plate
One side from the filling component.
10. the equipment with tissue device fine crushing as claimed in claim 8, which is characterized in that the cutter assembly is set to the rotation
One side of the flap far from the filling component.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710080916.6A CN108424832B (en) | 2017-02-15 | 2017-02-15 | Device with tissue fine-crushing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710080916.6A CN108424832B (en) | 2017-02-15 | 2017-02-15 | Device with tissue fine-crushing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108424832A true CN108424832A (en) | 2018-08-21 |
| CN108424832B CN108424832B (en) | 2021-10-08 |
Family
ID=63155245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710080916.6A Active CN108424832B (en) | 2017-02-15 | 2017-02-15 | Device with tissue fine-crushing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108424832B (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040082952A1 (en) * | 2001-04-06 | 2004-04-29 | Dycus Sean T. | Vessel sealer and divider |
| US20060086221A1 (en) * | 2004-10-21 | 2006-04-27 | Kong George Y | Sliding blade microtome |
| CN201505937U (en) * | 2009-09-07 | 2010-06-16 | 邓少斌 | Food cutting machine |
| CN101796181A (en) * | 2007-05-04 | 2010-08-04 | 埃里克·松德斯特伦 | Slicing device |
| CN103038333A (en) * | 2010-05-20 | 2013-04-10 | 里波热姆斯国际公司 | Device and method for preparing tissue, particularly adipose tissue |
| CN203458835U (en) * | 2013-08-19 | 2014-03-05 | 无锡加莱克色谱科技有限公司 | Homogenate pipe support for filling preparative liquid chromatogram column |
| CN103997974A (en) * | 2011-11-08 | 2014-08-20 | 奥康细胞实验室公司 | Systems and methods for processing cells |
| CN104048861A (en) * | 2013-03-15 | 2014-09-17 | 徕卡生物系统努斯洛克有限公司 | Apparatus for working on histological samples |
| CN204180837U (en) * | 2014-10-28 | 2015-03-04 | 吉林曙光农牧有限公司 | A kind of spiral is cooked meat machine |
| CN204848894U (en) * | 2015-07-29 | 2015-12-09 | 国玺干细胞应用技术股份有限公司 | Stem cell preparation device |
| CN205252995U (en) * | 2015-11-14 | 2016-05-25 | 湖北隶德生物工程有限公司 | Special high -efficient mixing arrangement of animal remedy |
| CN205659755U (en) * | 2016-06-01 | 2016-10-26 | 新都区马家镇新越机械厂 | Meat supplied materials cuts up processingequipment |
-
2017
- 2017-02-15 CN CN201710080916.6A patent/CN108424832B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040082952A1 (en) * | 2001-04-06 | 2004-04-29 | Dycus Sean T. | Vessel sealer and divider |
| US20060086221A1 (en) * | 2004-10-21 | 2006-04-27 | Kong George Y | Sliding blade microtome |
| CN101796181A (en) * | 2007-05-04 | 2010-08-04 | 埃里克·松德斯特伦 | Slicing device |
| CN201505937U (en) * | 2009-09-07 | 2010-06-16 | 邓少斌 | Food cutting machine |
| CN103038333A (en) * | 2010-05-20 | 2013-04-10 | 里波热姆斯国际公司 | Device and method for preparing tissue, particularly adipose tissue |
| CN103997974A (en) * | 2011-11-08 | 2014-08-20 | 奥康细胞实验室公司 | Systems and methods for processing cells |
| CN104048861A (en) * | 2013-03-15 | 2014-09-17 | 徕卡生物系统努斯洛克有限公司 | Apparatus for working on histological samples |
| CN203458835U (en) * | 2013-08-19 | 2014-03-05 | 无锡加莱克色谱科技有限公司 | Homogenate pipe support for filling preparative liquid chromatogram column |
| CN204180837U (en) * | 2014-10-28 | 2015-03-04 | 吉林曙光农牧有限公司 | A kind of spiral is cooked meat machine |
| CN204848894U (en) * | 2015-07-29 | 2015-12-09 | 国玺干细胞应用技术股份有限公司 | Stem cell preparation device |
| CN205252995U (en) * | 2015-11-14 | 2016-05-25 | 湖北隶德生物工程有限公司 | Special high -efficient mixing arrangement of animal remedy |
| CN205659755U (en) * | 2016-06-01 | 2016-10-26 | 新都区马家镇新越机械厂 | Meat supplied materials cuts up processingequipment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108424832B (en) | 2021-10-08 |
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Effective date of registration: 20221123 Address after: 6th Floor, No. 250, Section 1, Neihu Road, Neihu District, Taipei, Taiwan, China, China Patentee after: DRSIGNAL BIOTECHNOLOGY Co.,Ltd. Address before: Samoa City, Apia Patentee before: SCL BIOTECH Ltd. |
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