CN108404102A - A kind of graphene shoulder neck pain patch and preparation method thereof - Google Patents
A kind of graphene shoulder neck pain patch and preparation method thereof Download PDFInfo
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- CN108404102A CN108404102A CN201810576685.2A CN201810576685A CN108404102A CN 108404102 A CN108404102 A CN 108404102A CN 201810576685 A CN201810576685 A CN 201810576685A CN 108404102 A CN108404102 A CN 108404102A
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Abstract
The invention discloses a kind of graphene shoulder neck pain patches, including back sheet, graphene film layer, bulk pharmaceutical chemicals layer, adhering-resistant paper layer, bulk pharmaceutical chemicals are placed between adhering-resistant paper and back sheet, are bulk pharmaceutical chemicals in the centre position of bulk pharmaceutical chemicals layer, bulk pharmaceutical chemicals are by following material composition：Radix Angelicae Sinensis, Rhizoma Gastrodiae, pilose antler, it is windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, baked ginger, asarum, evodia rutaecarpa, safflower, teasel root and lopseed, sodium cellulose glycolate is also mixed in bulk pharmaceutical chemicals, sodium alginate and glycerine, so that bulk pharmaceutical chemicals coating is uniform, with good adhesiveness, larger mobility is not will produce, in the outside of bulk pharmaceutical chemicals, tiling has one layer of effectively activation damaged cell vigor, restore normal function graphene film layer, graphene shoulder neck pain patch is cheap, it is convenient to use, with channels sootheing and network vessel quickening, the effect of blood-activating and qi-promoting, the graphene film layer of bottom can effectively facilitate the transmission of drug, accelerate the absorption of bulk pharmaceutical chemicals, there is good healing effect to symptoms such as shoulder neck pain.
Description
Technical field
The present invention relates to a kind of drug paste, specially a kind of graphene shoulder neck pain patch and preparation method thereof.
Background technology
Human cervical spine is made of seven section centrums, and physiological bending is slightly preceding bent, and the head weight of people is about people
Body weight 1/10, cervical vertebra is comparatively relatively flexible, but due to bowing for a long time or good fortune is bent over one's desk working, causes cervical vertebrae physiological
The disappearance of bending results in the muscle being attached on bone, tendon due to the denaturation of bone, also neural, their position of blood vessel
It sets and shape is all changed, be then formed cervical spondylosis.When normal physiological bending disappears, it will cause the qi and bloods of part
It is stiff to recycle unsmooth, local muscle tendon, is exactly the accumulation of neck area extravasated blood, so as to cause shoulder neck pain.
Shoulder neck pain would generally cause insomnia, headache, disease of hand, memory loss, Hearing, under eye eyesight
Drop digests bad, mood agitation uncomfortable in chest etc., and cervical spondylosis can cause the problem of our necks are with upper bit, because of our necks
Rear side has artery to pass through, and when our cervical vertebras lose original physiological bending, we also can not normally circulate at arterial blood, because
How this, which alleviates shoulder neck pain, becomes the most concerned problem of shoulder neck pain patients, and currently used alleviation method mainly has movement to control
It treats, massage is alleviated, and drug therapy and sticks drug paste treatment, although exercise therapy is therapeutic modality the most healthy, by
In needing great self-disciplining and to adhere to just seeing effect for a long time, therefore it is greatly to choose for common patient
War, it is and more comfortable although massage therapy effect is good, often spend in the treatment it is higher, for general patient home
It is difficult to undertake a massage expense, therefore, selection drug paste becomes a kind of therapeutic modality of common shoulder neck pain, and drug paste makes
It is convenient with process, it is cheap, but since common drug paste is slower since drug effect plays, it is difficult to fast onset.
Therefore, how shoulder neck pain patch is improved, makes it overcome disadvantages mentioned above that can have the advantages that again certain, is this
A field technology personnel problem urgently to be resolved hurrily.
Invention content
It is convenient to use the main purpose of the present invention is to provide a kind of cheap, bulk pharmaceutical chemicals have channels sootheing and network vessel quickening,
The graphene film layer of the effect of blood-activating and qi-promoting, bottom effectively activate damaged cell vigor, restore normal function, meanwhile, graphene
Film layer can effectively facilitate the transmission of drug, and the graphene shoulder neck pain of the absorption of bulk pharmaceutical chemicals is accelerated to paste and preparation method thereof.
To achieve the above objectives, the technical solution adopted by the present invention is：A kind of graphene shoulder neck pain patch, including backing
Layer, graphene film layer, bulk pharmaceutical chemicals layer, adhering-resistant paper layer, the bulk pharmaceutical chemicals are placed between adhering-resistant paper and back sheet,
The centre position of bulk pharmaceutical chemicals layer is the bulk pharmaceutical chemicals of channels sootheing and network vessel quickening, blood-activating and qi-promoting, and the bulk pharmaceutical chemicals are by following material composition：Radix Angelicae Sinensis
15-20 parts by weight, Rhizoma Gastrodiae 15-20 parts by weight, pilose antler 1-3 parts by weight, windproof 5-10 parts by weight, Rhizoma Et Radix Notopterygii 5-10 parts by weight, Radix Angelicae Pubescentis
3-5 parts by weight, baked ginger 5-10 parts by weight, asarum 3-8 parts by weight, evodia rutaecarpa 3-8 parts by weight, safflower 5-10 parts by weight, teasel root 8-
12 parts by weight and lopseed 1-5 parts by weight are also mixed with sodium cellulose glycolate 0.5-2 parts by weight, sea in the bulk pharmaceutical chemicals
Mosanom 0.5-2 parts by weight and glycerine 0.5-2 parts by weight, in the outside of bulk pharmaceutical chemicals tiling have one layer of activation damaged cell vigor,
Restore the graphene film layer of normal function.
As an improvement, the bulk pharmaceutical chemicals are by following parts by weight material composition：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, deer
Fine and soft 2 parts by weight, windproof 8 parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, evodia rutaecarpa 6
Parts by weight, 3 parts by weight of 7 parts by weight of safflower, 10 parts by weight of teasel root and lopseed.
As an improvement, the thickness of the graphene film layer is 0.2-0.8 millimeters.
It is closed as an improvement, the bulk pharmaceutical chemicals of the graphene film layer and intermediate position are formed in the upper surface of bulk pharmaceutical chemicals layer
Plane.
As an improvement, the bulk pharmaceutical chemicals are circle in bulk pharmaceutical chemicals layer surface shape, it is 20-40 millimeters a diameter of.
The second object of the present invention is to provide a kind of preparation method of graphene shoulder neck pain patch, is included the following steps：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8
Parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 weight of safflower
Measure part, 3 parts by weight of 10 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then will be dense in S4
Contracting ointment is uniformly applied to the centre position of back sheet, after being stored at room temperature 30-60 minutes, by the tiling of adhering-resistant paper layer and original
Expect that the upper surface of medicine layer, encapsulation obtain graphene shoulder neck pain patch.
Preferably, whipping temp is 70 degrees Celsius in S2, and mixing time is 4 hours.
Preferably, it processes 2 hours, is soaked in 50 degrees Celsius of low temperature after 90 degrees Celsius of lower high temperature decoct 3 hours in S3
Take liquid.
Beneficial effects of the present invention are as follows：
Graphene shoulder neck pain patch provided by the invention, by using Radix Angelicae Sinensis, Rhizoma Gastrodiae, windproof and teasel root as main ingredient, property
Micro-sweet, temperature, pungent, Radix Angelicae Sinensis can enrich blood and can invigorate blood circulation, and Rhizoma Gastrodiae can be effectively improved extremity numbness, windproof effectively to expel pathogenic wind from the body surface, win
Wet analgesic, teasel root have filling liver kidney, strengthening the bones and muscles, continuous injured, stop the effect of uterine bleeding, and four traditional Chinese medicine material cooperates, and can effectively solve the problem that
The problem of rheumatism, shoulder neck aching and limp pain, the bulk pharmaceutical chemicals used is assisted to have：Pilose antler, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, baked ginger, asarum, Wu Zhu
On the one hand cornel, safflower and lopseed can rouse oneself and improve physical function, relieve pain, on the other hand, saturating in bulk pharmaceutical chemicals
Bone grass can effectively inhibit bacteria breed, ensure the cleaning on raw material drug paste surface, suitable for being pasted on the surface of body for a long time,
Sodium cellulose glycolate, sodium alginate and glycerine are also mixed in bulk pharmaceutical chemicals so that bulk pharmaceutical chemicals are equal in the coating of the surface of back sheet
It is even, when shoulder neck pain is pasted on skin surface, have good adhesiveness, not will produce larger mobility, using rise
Come more convenient, gelling agent in bulk pharmaceutical chemicals release drug is fast, the residence time is long and non-stimulated to human body, in back sheet and raw material
It is graphene film layer between medicine, the bulk pharmaceutical chemicals formation of graphene film layer and intermediate position is closed plane, the graphene film of bottom
Layer effectively activation damaged cell vigor, the normal function of recovery, meanwhile, graphene film layer can effectively facilitate the transmission of drug, add
The absorption of fast bulk pharmaceutical chemicals so that drug can quickly fully play drug effect, have good healing to act on shoulder neck pain.
Description of the drawings
Fig. 1 is graphene shoulder neck pain patch preparation method flow chart.
Specific implementation mode
It is described below for disclosing the present invention so that those skilled in the art can realize the present invention.It is excellent in being described below
Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.
Preparation method embodiment 1：
Formula：
18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8 parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 weight of Radix Angelicae Pubescentis
Measure part, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 parts by weight of safflower, 10 parts by weight of teasel root and lopseed
3 parts by weight.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8
Parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 weight of safflower
Measure part, 3 parts by weight of 10 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then will be dense in S4
Contracting ointment is uniformly applied to the centre position of back sheet, after being stored at room temperature 30-60 minutes, by the tiling of adhering-resistant paper layer and original
Expect that the upper surface of medicine layer, encapsulation obtain graphene shoulder neck pain patch.
Preparation method embodiment 2：
Formula：
15 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of Rhizoma Gastrodiae, 1 parts by weight of pilose antler, windproof 5 parts by weight, 5 parts by weight of Rhizoma Et Radix Notopterygii, 3 weight of Radix Angelicae Pubescentis
Measure part, 5 parts by weight of baked ginger, 3 parts by weight of asarum, 3 parts by weight of evodia rutaecarpa, 5 parts by weight of safflower, 5 parts by weight of teasel root and lopseed 1
Parts by weight.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：15 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of Rhizoma Gastrodiae, 1 parts by weight of pilose antler, windproof 5
Parts by weight, 5 parts by weight of Rhizoma Et Radix Notopterygii, 3 parts by weight of Radix Angelicae Pubescentis, 5 parts by weight of baked ginger, 3 parts by weight of asarum, 3 parts by weight of evodia rutaecarpa, 5 weight of safflower
Measure part, 1 parts by weight of 5 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then will be dense in S4
Contracting ointment is uniformly applied to the centre position of back sheet, after being stored at room temperature 30-60 minutes, by the tiling of adhering-resistant paper layer and original
Expect that the upper surface of medicine layer, encapsulation obtain graphene shoulder neck pain patch.
Preparation method embodiment 3：
Formula：
20 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of Rhizoma Gastrodiae, 3 parts by weight of pilose antler, windproof 10 parts by weight, 10 parts by weight of Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 5
Parts by weight, 10 parts by weight of baked ginger, 8 parts by weight of asarum, 8 parts by weight of evodia rutaecarpa, 10 parts by weight of safflower, 12 parts by weight of teasel root and thoroughly
Bone 5 parts by weight of grass.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：It is 20 parts by weight of Radix Angelicae Sinensis, 20 parts by weight of Rhizoma Gastrodiae, 3 parts by weight of pilose antler, windproof
10 parts by weight, 10 parts by weight of Rhizoma Et Radix Notopterygii, 5 parts by weight of Radix Angelicae Pubescentis, 10 parts by weight of baked ginger, 8 parts by weight of asarum, 8 parts by weight of evodia rutaecarpa, safflower
5 parts by weight of 10 parts by weight, 12 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then will be dense in S4
Contracting ointment is uniformly applied to the centre position of back sheet, after being stored at room temperature 30-60 minutes, by the tiling of adhering-resistant paper layer and original
Expect that the upper surface of medicine layer, encapsulation obtain graphene shoulder neck pain patch.
Preparation method embodiment 4：
Formula：
19 parts by weight of Radix Angelicae Sinensis, 19 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 9 parts by weight, 9 parts by weight of Rhizoma Et Radix Notopterygii, 5 weight of Radix Angelicae Pubescentis
Measure part, 8 parts by weight of baked ginger, 7 parts by weight of asarum, 7 parts by weight of evodia rutaecarpa, 8 parts by weight of safflower, 11 parts by weight of teasel root and lopseed
4 parts by weight.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：19 parts by weight of Radix Angelicae Sinensis, 19 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 9
Parts by weight, 9 parts by weight of Rhizoma Et Radix Notopterygii, 5 parts by weight of Radix Angelicae Pubescentis, 8 parts by weight of baked ginger, 7 parts by weight of asarum, 7 parts by weight of evodia rutaecarpa, 8 weight of safflower
Measure part, 4 parts by weight of 11 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then will be dense in S4
Contracting ointment is uniformly applied to the centre position of back sheet, after being stored at room temperature 30-60 minutes, by the tiling of adhering-resistant paper layer and original
Expect that the upper surface of medicine layer, encapsulation obtain graphene shoulder neck pain patch.
Preparation method embodiment 5：
The purpose of this preparation method embodiment is to prepare the common shoulder neck pain patch without containing graphene film layer, formula
Identical as preparation method embodiment 1, difference lies in the graphene film layers that the surface of back sheet in S5 does not contain ultrasonic disperse, specifically
It is as follows：
Formula：
18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8 parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 weight of Radix Angelicae Pubescentis
Measure part, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 parts by weight of safflower, 10 parts by weight of teasel root and lopseed
3 parts by weight.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8
Parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 weight of safflower
Measure part, 3 parts by weight of 10 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, is added
2 parts by weight of 1 parts by weight of sodium cellulose glycolate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 it is dense
Contracting ointment；
Concentration ointment in S4 is uniformly applied to the centre position of back sheet by S5, after being stored at room temperature 30-60 minutes,
By the upper surface of adhering-resistant paper layer tiling and bulk pharmaceutical chemicals layer, encapsulation obtains common shoulder neck pain patch.
Preparation method embodiment 6：
The purpose of this preparation method embodiment is to prepare the common shoulder neck without containing graphene film layer and gel-type vehicle
Pain is pasted, and formula is identical as preparation method embodiment 1, difference lies in being added without gel-type vehicle in S4, the surface of back sheet in S5
Graphene film layer without containing ultrasonic disperse, it is specific as follows：
Formula：
18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8 parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 weight of Radix Angelicae Pubescentis
Measure part, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 parts by weight of safflower, 10 parts by weight of teasel root and lopseed
3 parts by weight.
Preparation process：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8
Parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 weight of safflower
Measure part, 3 parts by weight of 10 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, vacuum is stirred by S2
It mixes, wherein whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3, by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours, in 40-60 degrees Celsius of low temperature
It processes 1-2 hours, obtains leaching liquid；
70 parts by weight of ethyl alcohol are added in gained leaching liquid by S4, and reflux concentration, reflux temperature is 80-100 degrees Celsius, is obtained
It is 1 to concentrate mass ratio:1.5 concentration ointment；
Concentration ointment in S4 is uniformly applied to the centre position of back sheet by S5, after being stored at room temperature 30-60 minutes,
By the upper surface of adhering-resistant paper layer tiling and bulk pharmaceutical chemicals layer, encapsulation obtains common shoulder neck pain patch.
Test example 1：
The graphene shoulder neck pain being prepared with the preparation method embodiment 1 of the present invention is pasted for test group, with the side of preparation
It is control group that common shoulder neck pain patch, which is prepared, in case embodiment 5, and application method is：It is attached to the shoulder neck painful area of patient,
Primary new graphene shoulder neck pain patch is replaced within every 24 hours, 2 weeks as a treatment course.
For the shoulder neck pain patch that table 1 shows, 86 patients are chosen, wherein female patient 43 uses table of random number
It is divided into 3 groups up to method, age distribution section is 18-70 Sui, and average course of disease is 12-14 a month, in therapeutic process, to two groups of patients'
The data such as age, sick time, gender compare, and no significant difference is comparable.
The standard of curative effect evaluation is with reference to national middle pipe office《Disease of tcm diagnostic criteria》.Clinical recovery：Shoulder neck pain, numbness,
The symptoms such as discomfort eliminate >=95% earlier above；It is effective：The symptoms such as shoulder neck pain, numbness, discomfort eliminate >=70% simultaneously earlier above<95%；
Effectively：The symptoms such as shoulder neck pain, numbness, discomfort eliminate >=30% simultaneously earlier above<70%；In vain：Shoulder neck pain, numbness, discomfort etc.
Symptom is eliminated earlier above<30%.
For statistical analysis with SPSS21.0, with mean ± standard deviation, (X ± s is examined measurement data using t, technical data
With Chi-square Test, with P<0.05 difference has statistical significance).
Graphene shoulder neck pain patch treatment group's curative effect of 3 courses for the treatment of of continuous treatment (6 weeks), embodiment 1 is general better than embodiment 5
The effect of logical shoulder neck pain patch, it is shown in Table 1：
Table 1：Two groups for the treatment of results：
During observation, two groups without serious adverse reaction.
Test example 2：
The graphene shoulder neck pain being prepared with the preparation method embodiment 1-6 of the present invention is pasted as test group, with open
Number be a kind of externally applied ointment base material disclosed in CN106333938A it is control group, application method is：It is attached to the shoulder neck pain of patient
Primary new graphene shoulder neck pain patch is replaced at pain position for every 24 hours, and 2 weeks as a treatment course.
For the shoulder neck pain patch that table 2 shows, 100 patients are chosen, wherein female patient 50 uses random digit
Representation is divided into 5 groups, and age distribution section is 18-70 Sui, and average course of disease is 12-14 months, in therapeutic process, to two groups of patients
The data such as age, sick time, gender compare, no significant difference is comparable.
After 3 courses for the treatment of of continuous treatment, the graphene shoulder neck pain patch of embodiment 1-4 and Publication No. CN106333938A institutes are public
A kind of the effect of externally applied ointment base material opened, it is shown in Table 2：
Table 2：
From table 2 it can be seen that the obtained graphene shoulder neck pain of preparation method embodiment 1-4 is attached to treatment shoulder neck pain
Pain aspect total effective rate is higher, and there is good curative effect, embodiment 5 not to include shoulder neck pain patch, the embodiment 6 of graphene
Healing not comprising the shoulder neck pain of gel-type vehicle and graphene film layer patch and control group relative to preparation method embodiment 1-4
It is efficient relatively low.
Such as：
So-and-so is revived, female, 46 years old, because of long-term work, shoulder pain was up to 3 years, it is difficult to be endured, which aches after two months
Pain gradually mitigates, and continues patch with until pain disappears.
Jiang so-and-so, man 32 years old, because being sitting in by computer for a long time, leads to cervical vertebra ache, when be about 1 year, after sticking one month,
Pain is substantially reduced or even disappears.
Test example 3
This test example is used to investigate the shadow with content hydroxymethylacrylate sodium and sodium alginate content to patch moulding process
It rings.Table 3：Test example
Hydroxymethylacrylate sodium and sodium alginate are introduced into gel-type vehicle as can be seen from Table 3, to raw material dispersion medicine,
The preferable mobility and viscosity for solving the problems, such as drug, promotes the transmission of drug, accelerates the absorption of drug.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection domain by appended claims and its
Equivalent defines.
Claims (8)
1. a kind of graphene shoulder neck pain patch, including back sheet, graphene film layer, bulk pharmaceutical chemicals layer, adhering-resistant paper layer, the original
Material medicine is placed between adhering-resistant paper and back sheet, is the original of channels sootheing and network vessel quickening, blood-activating and qi-promoting in the centre position of bulk pharmaceutical chemicals layer
Expect medicine, it is characterised in that：The bulk pharmaceutical chemicals are by following material composition：Radix Angelicae Sinensis 15-20 parts by weight, Rhizoma Gastrodiae 15-20 parts by weight, pilose antler
1-3 parts by weight, windproof 5-10 parts by weight, Rhizoma Et Radix Notopterygii 5-10 parts by weight, Radix Angelicae Pubescentis 3-5 parts by weight, baked ginger 5-10 parts by weight, asarum 3-8
Parts by weight, evodia rutaecarpa 3-8 parts by weight, safflower 5-10 parts by weight, teasel root 8-12 amounts part and lopseed 1-5 parts by weight, the original
Sodium cellulose glycolate 0.5-2 parts by weight, sodium alginate 0.5-2 parts by weight and glycerine 0.5-2 parts by weight are also mixed in material medicine,
The graphene film layer that tiling has one layer of activation damaged cell vigor, restores normal function in the outside of bulk pharmaceutical chemicals.
2. graphene shoulder neck pain patch according to claim 1, it is characterised in that：The bulk pharmaceutical chemicals are by following parts by weight object
Matter forms：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8 parts by weight, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 weight of Radix Angelicae Pubescentis
Measure part, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 parts by weight of safflower, 10 parts by weight of teasel root and lopseed
3 parts by weight.
3. graphene shoulder neck pain patch according to claim 2, it is characterised in that：The thickness of the graphene film layer is
0.2-0.8 millimeters.
4. graphene shoulder neck pain patch according to claim 3, it is characterised in that：The graphene film layer and wherein meta position
The bulk pharmaceutical chemicals set form in the upper surface of bulk pharmaceutical chemicals layer and are closed plane.
5. graphene shoulder neck pain patch according to claim 4, it is characterised in that：The bulk pharmaceutical chemicals are in bulk pharmaceutical chemicals layer surface
Shape is circle, 20-40 millimeters a diameter of.
6. a kind of preparation method of graphene shoulder neck pain patch, it is characterised in that：Include the following steps：
It is as follows to weigh bulk pharmaceutical chemicals by formula ratio by S1：18 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of Rhizoma Gastrodiae, 2 parts by weight of pilose antler, windproof 8 weight
Part, 8 parts by weight of Rhizoma Et Radix Notopterygii, 4 parts by weight of Radix Angelicae Pubescentis, 7 parts by weight of baked ginger, 6 parts by weight of asarum, 6 parts by weight of evodia rutaecarpa, 7 parts by weight of safflower,
3 parts by weight of 10 parts by weight of teasel root and lopseed；
Above-mentioned raw materials medicine was fully ground 80 mesh sieve, 100 parts by weight of pure water is added, fully dissolve, are stirred under vacuum by S2,
Middle whipping temp is 60-80 degrees Celsius, and mixing time is 3-4 hours, and filtering obtains raw material medicine solution；
S3 is processed by gained raw material medicine solution after 80-100 celsius temperatures decoct 2-4 hours in 40-60 degrees Celsius of low temperature
1-2 hours, obtain leaching liquid；
70 parts by weight of ethyl alcohol, reflux concentration are added in gained leaching liquid by S4, and reflux temperature is 80-100 degrees Celsius, and hydroxyl first is added
2 parts by weight of 1 parts by weight of base sodium cellulosate, 1 parts by weight of sodium alginate and glycerine, it is 1 to obtain concentration mass ratio:1.5 concentration medicine
Cream；
S5, by graphene film layer ultrasonic disperse, after being spun on the surface of back sheet, room temperature is dried, then by the concentration medicine in S4
Cream is uniformly applied to the centre position of back sheet, and after being stored at room temperature 30-60 minutes, adhering-resistant paper layer is tiled and bulk pharmaceutical chemicals
The upper surface of layer, encapsulation obtain graphene shoulder neck pain patch.
7. the production method of graphene shoulder neck pain patch according to claim 6, it is characterised in that：Whipping temp is in S2
70 degrees Celsius, mixing time is 4 hours.
8. the production method of graphene shoulder neck pain patch according to claim 7, it is characterised in that：In 90 degrees Celsius in S3
After lower high temperature decocts 3 hours, is processed 2 hours in 50 degrees Celsius of low temperature, obtain leaching liquid.
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