CN108403640B - Film-forming quick drying device for polyene paclitaxel liposome - Google Patents
Film-forming quick drying device for polyene paclitaxel liposome Download PDFInfo
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- CN108403640B CN108403640B CN201810395912.1A CN201810395912A CN108403640B CN 108403640 B CN108403640 B CN 108403640B CN 201810395912 A CN201810395912 A CN 201810395912A CN 108403640 B CN108403640 B CN 108403640B
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- 238000001035 drying Methods 0.000 title claims abstract description 25
- 239000002502 liposome Substances 0.000 title claims abstract description 16
- 229930012538 Paclitaxel Natural products 0.000 title claims description 17
- 229960001592 paclitaxel Drugs 0.000 title claims description 17
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims description 17
- 150000004291 polyenes Chemical class 0.000 title claims description 9
- 239000000463 material Substances 0.000 claims abstract description 41
- 239000012528 membrane Substances 0.000 claims abstract description 27
- 238000007790 scraping Methods 0.000 claims abstract description 12
- 230000000007 visual effect Effects 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract description 8
- 229960003668 docetaxel Drugs 0.000 abstract description 8
- 238000010030 laminating Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 210000000038 chest Anatomy 0.000 description 12
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 102000029749 Microtubule Human genes 0.000 description 2
- 108091022875 Microtubule Proteins 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 210000004688 microtubule Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 description 1
- 206010055113 Breast cancer metastatic Diseases 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000025090 microtubule depolymerization Effects 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Drying Of Solid Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to a rapid drying device for a formed film of docetaxel liposome, which comprises a frame and a supporting table, wherein a storage box is fixedly connected to the frame, a driving shaft is arranged below the storage box, a fixed frame is sleeved outside a gap of the driving shaft, a plurality of sliding chutes are arranged in the fixed frame, each sliding chute comprises a high end and a bottom end, a driving groove is arranged on the driving shaft, two sliding rods are connected in the driving groove in a sliding manner, one opposite ends of the two sliding rods are connected with a tension spring, and the other ends of the two sliding rods are abutted against the inner; a material bag is fixedly connected in the driving groove, a driving gear is coaxially and fixedly connected with the driving shaft, the driving gear is meshed with a screw rod, the screw rod is in threaded connection with a nut, the nut is connected to the rack in a sliding manner, a scraping plate is arranged on the nut, a membrane plate is arranged on the supporting platform, material storage grooves are formed in two ends of the membrane plate, a material guide pipe is communicated between the material bag and the material storage grooves, and membrane holes are formed in the membrane plate; still include the conveyer belt, be equipped with the low temperature layer on the conveyer belt, low temperature layer intermittent type and membrane hole laminating. The present apparatus balances the relationship between drying rate and temperature.
Description
Technical Field
The invention relates to the field of drying instruments, in particular to a film forming and rapid drying device for docetaxel liposome.
Background
The docetaxel is a semi-synthetic taxol antitumor drug, has an action target on cytoplasmic microtubules, enhances the rate of tubulin assembled into microtubules, prolongs tubulin polymerization and inhibits microtubule depolymerization to form stable non-functional vascular bundles, thereby destroying mitosis and cell proliferation, and is the most effective single-dose chemotherapeutic drug for treating metastatic breast cancer and non-small cell lung cancer in the existing drugs. Generally, the curative effect of chemotherapy is enhanced with the increase of dosage, but the corresponding toxic and side effects are also increased, and the patients cannot tolerate the chemotherapy.
The targeted drug delivery system is a novel drug delivery system which can selectively position and deliver drugs to pathological cells by utilizing a carrier, thereby improving the curative effect and reducing the toxic and side effects. The liposome is a hot research point of a targeted drug delivery system in recent years, and has good biocompatibility, lowest toxicity, a cell membrane-like structure and controllable drug release. After extraction, the polydilute paclitaxel is usually subjected to rotary evaporation to prepare a polydilute paclitaxel concentrated solution, then a film forming process is carried out, and after film forming, the polydilute paclitaxel liposome is low in drying speed and easy to generate adhesion phenomenon, so that a film forming and drying device is produced at will, but the traditional drying device usually achieves the purpose of drying through heating, the membrane structure is damaged by high temperature, and the drying speed is low due to insufficient temperature.
Disclosure of Invention
The invention aims to provide a rapid film-forming drying device for docetaxel liposome, which aims to solve the problems that the traditional drying device can damage the film structure at high temperature and the drying speed is low due to insufficient temperature.
In order to achieve the purpose, the technical scheme of the invention is as follows: a film-forming rapid drying device for docetaxel liposome comprises a frame and a supporting table, wherein the supporting table is provided with a through groove, the frame is positioned above the supporting table, the frame is fixedly connected with a first storage box and a second storage box, the bottom of the first storage box is provided with a first discharge hole, the first discharge hole is communicated with a first guide pipe, the bottom of the second storage box is provided with a second discharge hole, the second discharge hole is communicated with a second guide pipe, the free end of the first guide pipe and the free end of the second guide pipe are both communicated with a discharging pipe, an intermittent discharging mechanism is arranged below the discharging pipe, the intermittent discharging mechanism comprises a driving shaft which is rotatably connected with the frame, the driving shaft is connected with a driving motor, a fixed frame which is fixedly connected with the frame is sleeved outside the driving shaft in a clearance manner, the inner wall of the fixed frame is provided with a plurality of chutes, each chute comprises a high end and, a driving groove is formed in the end face of the driving shaft, two sliding rods are connected in the driving groove in a sliding mode, one ends, opposite to each other, of the two sliding rods are connected with tension springs, and the ends, far away from each other, of the two sliding rods are abutted to the inner wall of the sliding groove; a material bag is fixedly connected in the driving groove, the free end of the blanking pipe is communicated with the material bag, and the tension spring is sleeved outside the material bag; the driving shaft is coaxially and fixedly connected with a driving gear, the driving gear is meshed with a screw rod, the screw rod is in threaded connection with a nut, the nut is connected to the rack in a sliding mode, a scraping plate is vertically and slidably connected to the nut, a transverse plate is fixedly connected to the nut at the top of the scraping plate, and a telescopic spring is connected between the top of the scraping plate and the transverse plate; the supporting table is provided with a film forming mechanism, the film forming mechanism comprises a film plate fixedly connected to the supporting table, storage tanks are arranged at two ends of the film plate, a material guide pipe is communicated between the material bag and the storage tanks, and a plurality of film holes are formed in the film plate; the through groove is internally provided with a conveyor belt, the conveyor belt is connected with a stepping motor, the surface of the conveyor belt is provided with a low-temperature layer, and the low-temperature layer is intermittently attached to the film holes.
By adopting the technical scheme, in practical application, the rack plays a role in supporting and stabilizing equipment connection, the first storage box and the second storage box are respectively used for storing docetaxel concentrated solution and ethanol solution, the docetaxel concentrated solution and the ethanol solution respectively flow into the material bag of the intermittent blanking mechanism along the first guide pipe and the second guide pipe through the blanking pipe, the docetaxel concentrated solution and the ethanol solution are mixed to form colloidal suspension, the driving shaft rotates under the driving of the driving motor, the driving shaft rotates to drive the sliding rods in the driving groove to rotate, the two sliding rods simultaneously slide along the sliding grooves of the fixing frame in the rotating process, as the high ends and the low ends in the sliding grooves are sequentially arranged, when the ends, far away from each other, of the two sliding rods are moved to the high ends of the sliding grooves, the opposite ends of the two sliding rods are close to each other and extrude the material bag, at the moment, the tension spring contracts, and the material bag is extruded by the two sliding rods, the colloidal suspension in the material bag flows into a material storage tank at one end of the membrane plate along the material guide pipe.
The drive shaft rotates the drive gear that drives coaxial fixed connection with it and rotates, and then the lead screw that drives gear engagement with it rotates, because nut and lead screw threaded connection, and nut sliding connection is in the frame, make the nut can only lead screw relatively remove and can not rotate, the scraper blade on the nut removes the drive nut removes, the scraper blade removes the in-process, even the membrane hole of scraping to the lamina membranacea of colloidal suspension in the stock chest, the conveyer belt plays the effect of support this moment, and simultaneously, the conveyer belt makes colloidal suspension by the stand into the film in the membrane hole with the cooperation of lamina membranacea, because be equipped with the low temperature layer on the conveyer belt, colloidal suspension is freeze-dried rapidly at low temperature, form the film.
The beneficial effects of this technical scheme lie in:
1. this device sets up the low temperature layer through the surface at the conveyer belt, and when the scraper blade scraped colloidal suspension to the membrane pore, the conveyer belt played the effect of support on the one hand, and the low temperature layer on the other hand conveyer belt can make rapid quilt freeze-drying of colloidal suspension, forms the film, avoids the high temperature drying to the destruction problem of membrane structure.
2. This device passes through the drive shaft and rotates, drives drive gear and rotates, and then drives the lead screw and rotate, and the lead screw rotates and drives the nut and remove along the lead screw, and then drives the scraper blade and remove along the template surface, realizes scraping the colloidal suspension in the stock chest even to the membranopore of lamina membranacea in, and unnecessary taxol liposome colloidal suspension is then scraped to the stock chest of the lamina membranacea other end in, avoids the waste of raw materials.
3. This device passes through the cooperation of drive shaft and locating frame for the slide bar slides along the spout of locating frame when following the drive shaft pivoted, and then makes the material bag in the middle of the one end intermittent type nature's that two slide bars are close to each other the extrusion, and the material bag is receiving the extrusion back, realizes the process of intermittent type nature unloading, avoids the waste that the continuity unloading caused and the problem that the raw materials was hoarded in the stock chest.
Furthermore, the driving shaft is fixedly connected with a driving rod horizontally arranged, a pull ring is arranged at the free end of the driving rod, a swing plate is rotatably connected to the rack, the bottom of the swing plate is opposite to the position of the membrane hole, a clamping groove is formed in the swing plate, and a pull rope is fixedly connected between the pull ring and the clamping groove. The drive shaft rotates and drives the actuating lever fixedly connected with the drive shaft to rotate, and then drives the pull rope to move through the pull ring, because the free end of the pull rope is connected with the swing plate, and the swing plate rotates and is connected on the frame, the pull rope moves and drives the swing plate to swing in a reciprocating manner, and the air generated by the swing of the swing plate can assist the low-temperature layer to dry the film in the film hole, so that the drying speed is further accelerated.
Furthermore, both ends of the screw rod are fixedly connected with baffle plates. The baffle at the two ends of the screw rod plays a role in limiting the moving distance of the nut, the nut is prevented from moving excessively and being disengaged from the screw rod, and stable operation of equipment is guaranteed.
Furthermore, all be equipped with visual window on first storage case and the second storage case, be equipped with the scale mark on the visual window. Solution surplus in first storage case and the second storage case is observed to operating personnel accessible visual window, and the scale mark can assist operating personnel to carry out accurate the accuse to solution surplus.
Further, the junction of stock chest and diaphragm is all slick and sly set up. The equal rounding off in junction of stock chest and diaphragm plate sets up and to avoid being blocked when the scraper blade moves to the diaphragm plate top by the stock chest, guarantees the smoothness nature that the scraper blade removed.
Further, the both ends of diaphragm plate all are equipped with the striker plate, and the striker plate all is located the outside of stock chest. The striker plate has the effect of holding back colloidal suspension, avoids when the scraper blade slides to the stock chest from the lamina membranacea in, colloidal suspension receives the impact force of scraper blade and the phenomenon of splashing outward.
Furthermore, a first support plate is arranged at the bottom of the conveyor belt, a connecting rod is connected between the first support plate and the scraper, a support spring is fixedly connected to the bottom of the first support plate, and a second support plate is fixedly connected to the free end of the support spring. When the scraper plate moves onto the membrane plate from the storage tank, the scraper plate moves upwards at a vertical position, the first support plate is driven to move upwards through the connecting rod, the support spring is in an extension state at the moment, and the first support plate moves upwards to enable the belt surface of the conveyor belt to move upwards so that the conveyor belt is attached to the membrane hole; when the scraper slides downwards into the material storage tank from the membrane plate, the vertical position of the scraper moves downwards to enable the first support plate to move downwards, the support spring is in a compressed state at the moment, the conveyor belt moves downwards to enable the low-temperature layer on the conveyor belt to be separated from the membrane holes, and the dried membrane on the conveyor belt is conveyed along with the movement of the conveyor belt.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention.
Fig. 2 is a top view of an intermittent blanking mechanism in an embodiment of the invention.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: frame 1, a supporting bench 2, first storage case 3, second storage case 4, unloading pipe 5, drive shaft 6, fixed frame 7, spout 8, high-end 9, low-end 10, driving groove 11, slide bar 12, extension spring 13, material bag 14, drive gear 15, lead screw 16, nut 17, scraper 18, expanding spring 19, diaphragm 20, storage groove 21, diaphragm orifice 22, conveyer belt 23, actuating lever 24, pull ring 25, swing plate 26, draw-in groove 27, stay cord 28, baffle 29, striker plate 30.
The embodiment is basically as shown in the attached figure 1: film-forming rapid drying device of polyene paclitaxel liposome, including frame 1 and brace table 2, be equipped with logical groove on brace table 2, frame 1 is located the top of brace table 2, frame 1 is gone up the first storage case of fixedly connected with 3 and second storage case 4, all be equipped with visual window on first storage case 3 and the second storage case 4, be equipped with the scale mark on the visual window, the bottom of first storage case 3 is equipped with first discharge gate, first discharge gate intercommunication has first pipe, the bottom of second storage case 4 is equipped with the second discharge gate, second discharge gate intercommunication has the second pipe, the free end of first pipe all communicates with the free end of second pipe and has unloading pipe 5.
An intermittent blanking mechanism is arranged below the blanking pipe 5, the intermittent blanking mechanism comprises a driving shaft 6 which is rotatably connected to the rack 1, the driving shaft 6 is connected with a driving motor, a fixed frame 7 which is fixedly connected to the rack 1 is sleeved outside the driving shaft 6 in a clearance manner, as shown in a combined figure 2, four sliding grooves 8 are formed in the inner wall of the fixed frame 7, a high end 9 and a low end 10 are respectively arranged in each sliding groove 8, the high end 9 and the low end 10 of the four sliding grooves 8 are sequentially arranged, a driving groove 11 is formed in the end face of the driving shaft 6, two sliding rods 12 are slidably connected in the driving groove 11, one ends, opposite to the two sliding rods 12, are connected with a tension spring 13, and one; a material bag 14 is fixedly connected in the driving groove 11, the free end of the blanking pipe 5 is communicated with the material bag 14, and the tension spring 13 is sleeved outside the material bag 14.
The driving shaft 6 is fixedly connected with a driving rod 24 horizontally arranged, the right end of the driving rod 24 is provided with a pull ring 25, the rack 1 is rotatably connected with a swinging plate 26, the swinging plate 26 is provided with a clamping groove 27, and a pull rope 28 is fixedly connected between the pull ring 25 and the clamping groove 27. The driving shaft 6 is coaxially and fixedly connected with a driving gear 15, the driving gear 15 is meshed with a screw rod 16, the screw rod 16 is in threaded connection with a nut 17, two ends of the screw rod 16 are fixedly connected with baffle plates 29, the nut 17 is connected to the rack 1 in a sliding mode, a scraping plate 18 is vertically and slidably connected to the nut 17, a transverse plate is fixedly connected to the nut 17 at the top of the scraping plate 18, and a telescopic spring 19 is connected between the top of the scraping plate 18 and the transverse plate; be equipped with film forming mechanism on brace table 2, film forming mechanism includes fixed connection the lamina membranacea 20 on brace table 2, and the both ends of lamina membranacea 20 all are equipped with stock chest 21, and the equal rounding off in junction of stock chest 21 and lamina membranacea 20 sets up, and the both ends of lamina membranacea 20 all are equipped with striker plate 30, and striker plate 30 all is located the outside of stock chest 21.
A material guide pipe is communicated between the material bag 14 and the material storage tank 21, a plurality of film holes 22 are formed in the film plate 20, and the bottom of the swing plate 26 is opposite to the film holes 22; the conveying belt 23 is arranged in the through groove, the conveying belt 23 is connected with a stepping motor, a low-temperature layer is arranged on the surface of the conveying belt 23 and is a low-temperature plate connected with a refrigerator, the low-temperature layer is intermittently attached to the film hole 22, a first supporting plate is arranged at the bottom of the conveying belt 23, a connecting rod is connected between the first supporting plate and the scraper 18, a supporting spring is fixedly connected to the bottom of the first supporting plate, and a second supporting plate is fixedly connected to the free end of the supporting spring.
The specific implementation process is as follows: firstly, injecting a dilute paclitaxel concentrated solution and an ethanol solution into the first storage tank 3 and the second storage tank 4 respectively, monitoring the injection amount of the dilute paclitaxel concentrated solution and the ethanol solution through a visible window and a scale mark on the first storage tank 3 and the second storage tank 4, and respectively flowing the dilute paclitaxel concentrated solution and the ethanol solution into the material bag 14 through the blanking pipe 5 along the first guide pipe and the second guide pipe and mixing in the material bag 14. Turning on a driving motor, wherein the driving motor rotates clockwise to drive the driving shaft 6 to rotate clockwise, as shown in fig. 2, the driving shaft 6 rotates clockwise to drive the sliding rods 12 in the driving grooves 11 to rotate clockwise, so that the ends, away from each other, of the two sliding rods 12 slide along the inner walls of the sliding grooves 8 of the fixed frame 7 respectively, when the ends, away from each other, of the two sliding rods 12 slide along the inner walls of the sliding grooves 8 from the high end 9 of the sliding groove 8 to the low end of the sliding groove 8, the two sliding rods 12 are away from each other, and at this time, the tension spring 13 is; when one end of each of the two sliding rods 12, which is far away from each other, slides from the lower end 10 of the chute 8 to the upper end 9 of the chute 8 along the inner wall of the chute 8, the two sliding rods 12 approach each other, so that the two sliding rods 12 extrude the material bag 14, at this time, the tension spring 13 is in a compressed state, and after the material bag 14 is extruded, the mixed liquid in the material bag 14 flows into the material storage tank 21 at the left end of the membrane plate 20 along the material guide pipe and forms colloidal suspension.
As shown in fig. 1, the driving shaft 6 rotates forward to drive the driving gear 15 coaxially and fixedly connected therewith to rotate forward, the driving gear 15 rotates forward to drive the screw rod 16 engaged therewith to rotate forward, the screw rod 16 is in threaded connection with the nut 17, and the nut 17 is slidably connected to the frame 1, so that the nut 17 can only move relative to the screw rod 16 and cannot rotate, the nut 17 moves to drive the scraper 18 on the nut 17 to move, when the scraper 18 is located in the storage tank 21 at the left end of the diaphragm plate 20, the scraper 18 makes the bottom end of the scraper 18 abut against the storage tank 21 under the supporting force of the expansion spring 19, at this time, the belt surface of the conveyor belt 23 is not attached to the diaphragm hole 22, the nut 17 moves from left to right along the screw rod 16 along with the rotation of the screw rod 16 to drive the scraper 18 on the nut 17 to move from left to right, during the movement of the scraper 18, when the scraper 18 slides from the storage, the scraper 18 moves upwards, drives the first support plate to move upwards through the connecting rod, further drives the conveyor belt 23 to move upwards, so that the low-temperature layer of the conveyor belt 23 is attached to the membrane holes 22, meanwhile, the bottom end of the scraper 18 scrapes out the colloidal suspension in the storage tank 21 at the left end, and the colloidal suspension is uniformly spread in each membrane hole 22 in the moving process. The low temperature layer on the surface of the conveyor belt 23 rapidly freeze-dries the colloidal suspension in the membrane pores 22.
When the scraper 18 moves into the storage tank 21 at the right end of the membrane plate 20, the scraper 18 stores the redundant colloidal suspension into the storage tank 21 at the right end, at the moment, the conveyor belt 23 moves downwards, the low-temperature layer of the conveyor belt 23 is not attached to the membrane hole 22 any more, the stepping motor is started, and the dried membrane is conveyed. Then the driving shaft 6 is reversed, so that the screw rod 16 is reversed, the nut 17 moves along the screw rod 16 from right to left, and the scraper 18 continuously spreads the colloidal suspension in the storage tank 21 at the left end in the film hole 22, thereby realizing the continuous operation of the device.
The driving shaft 6 rotates to drive the driving rod 24 fixedly connected with the driving shaft to rotate, and then the pull ring 25 drives the pull rope 28 to move, because the free end of the pull rope 28 is connected in the clamping groove 27 of the swinging plate 26, the swinging plate 26 is rotatably connected on the rack 1, the pull rope 28 moves to drive the swinging plate 26 to swing in a reciprocating manner, and the wind generated by the swinging of the swinging plate 26 can assist the low-temperature layer to dry the film in the film hole 22, so that the drying speed is further accelerated.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (6)
1. The fast film-forming drying device for the polyene paclitaxel liposome is characterized in that: the device comprises a rack and a supporting table, wherein a through groove is formed in the supporting table, the rack is positioned above the supporting table, a first storage box and a second storage box are fixedly connected to the rack, a first discharge hole is formed in the bottom of the first storage box and communicated with a first guide pipe, a second discharge hole is formed in the bottom of the second storage box and communicated with a second guide pipe, a discharge pipe is communicated with the free end of the first guide pipe and the free end of the second guide pipe, an intermittent discharging mechanism is arranged below the discharge pipe and comprises a driving shaft which is rotatably connected to the rack, the driving shaft is connected with a driving motor, a fixing frame fixedly connected to the rack is sleeved outside the driving shaft in a clearance mode, a plurality of chutes are formed in the inner wall of the fixing frame, a high end and a low end are included in each chute, the high end and the low end of each chute are sequentially arranged, and a driving groove is formed in the, two sliding rods are connected in the driving groove in a sliding manner, one ends, opposite to the two sliding rods, of the two sliding rods are connected with tension springs, and the ends, far away from each other, of the two sliding rods are abutted against the inner wall of the sliding groove; a material bag is fixedly connected in the driving groove, the free end of the blanking pipe is communicated with the material bag, and the tension spring is sleeved outside the material bag; the driving shaft is coaxially and fixedly connected with a driving gear, the driving gear is meshed with a screw rod, the screw rod is in threaded connection with a nut, the nut is connected to the rack in a sliding mode, a scraping plate is vertically and slidably connected to the nut, a transverse plate is fixedly connected to the nut at the top of the scraping plate, and a telescopic spring is connected between the top of the scraping plate and the transverse plate; the supporting table is provided with a film forming mechanism, the film forming mechanism comprises a film plate fixedly connected to the supporting table, storage troughs are arranged at two ends of the film plate, a material guide pipe is communicated between the material bag and the storage troughs, and a plurality of film holes are formed in the film plate; the conveying belt is arranged in the through groove, the conveying belt is connected with the stepping motor, the surface of the conveying belt is provided with the low-temperature layer, the low-temperature layer is intermittently attached to the membrane hole, the driving shaft is fixedly connected with the driving rod horizontally arranged, the free end of the driving rod is provided with a pull ring, the rack is rotatably connected with a swinging plate, the bottom of the swinging plate is right opposite to the membrane hole, the swinging plate is provided with a clamping groove, and a pull rope is fixedly connected between the pull ring and the.
2. The apparatus for rapid drying of polyene paclitaxel liposome according to claim 1, wherein: both ends of the screw rod are fixedly connected with baffle plates.
3. The apparatus for rapid drying of polyene paclitaxel liposome according to claim 2, wherein: visual windows are arranged on the first storage box and the second storage box, and scale marks are arranged on the visual windows.
4. The apparatus for rapid drying of polyene paclitaxel liposome according to claim 3, wherein: the junction of the storage tank and the membrane plate is smoothly arranged.
5. The apparatus for rapid drying of polyene paclitaxel liposome according to claim 4, wherein: both ends of the diaphragm plate are provided with material blocking plates, and the material blocking plates are located outside the material storage tank.
6. The apparatus for rapid drying of polyene paclitaxel liposome according to claim 5, wherein: the bottom of the conveyor belt is provided with a first support plate, a connecting rod is connected between the first support plate and the scraper, the bottom of the first support plate is fixedly connected with a support spring, and the free end of the support spring is fixedly connected with a second support plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810395912.1A CN108403640B (en) | 2018-04-27 | 2018-04-27 | Film-forming quick drying device for polyene paclitaxel liposome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810395912.1A CN108403640B (en) | 2018-04-27 | 2018-04-27 | Film-forming quick drying device for polyene paclitaxel liposome |
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| Publication Number | Publication Date |
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| CN108403640A CN108403640A (en) | 2018-08-17 |
| CN108403640B true CN108403640B (en) | 2020-04-10 |
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| CN201810395912.1A Expired - Fee Related CN108403640B (en) | 2018-04-27 | 2018-04-27 | Film-forming quick drying device for polyene paclitaxel liposome |
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| CN (1) | CN108403640B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112617812B (en) * | 2020-12-04 | 2022-10-28 | 重庆医药高等专科学校 | Application evaluation device of paclitaxel liposome |
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| CN108403640A (en) | 2018-08-17 |
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