CN108383983A - A kind of preparation method of anti-oxidation drug bottle - Google Patents
A kind of preparation method of anti-oxidation drug bottle Download PDFInfo
- Publication number
- CN108383983A CN108383983A CN201810279651.7A CN201810279651A CN108383983A CN 108383983 A CN108383983 A CN 108383983A CN 201810279651 A CN201810279651 A CN 201810279651A CN 108383983 A CN108383983 A CN 108383983A
- Authority
- CN
- China
- Prior art keywords
- drug bottle
- preparation
- oxidation
- bottle
- oxidation drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
- C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings
- C08G63/181—Acids containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
- C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings
- C08G63/181—Acids containing aromatic rings
- C08G63/185—Acids containing aromatic rings containing two or more aromatic rings
- C08G63/187—Acids containing aromatic rings containing two or more aromatic rings containing condensed aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
- C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings
- C08G63/181—Acids containing aromatic rings
- C08G63/185—Acids containing aromatic rings containing two or more aromatic rings
- C08G63/187—Acids containing aromatic rings containing two or more aromatic rings containing condensed aromatic rings
- C08G63/189—Acids containing aromatic rings containing two or more aromatic rings containing condensed aromatic rings containing a naphthalene ring
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/13—Phenols; Phenolates
Abstract
Antioxidant effect in order to solve the problems, such as traditional PET medicine bottles is bad, and the present invention provides a kind of preparation methods of anti-oxidation drug bottle.After being modified to polyethylene terephthalate the invention firstly uses aromatic compound, ethylene glycol terephthalate is prepared into master batch in an extruder, modified PET plastic polymer masterbatch is finally prepared into medicine bottle using blow molding process.The anti-oxidation drug bottle antioxidant effect prepared through the present invention is good, and temperature tolerance is strong, can increase the storage shelf-life of drug.
Description
Technical field
The present invention relates to drug bottle production field, specially a kind of preparation method of anti-oxidation drug bottle.
Background technology
The unstable drug of drug, especially property, storage process kind due to storage time it is long, external condition such as
Temperature, humidity, daylight cause drug to hydrolyze under the influence of air etc., oxygenolysis or isomerization, and crystal transfer gathers
It closes, deliquesces, weathering and mouldy equal change.Drug not only becomes the appearance character of drug because of the impurity that above-mentioned variation generates
Change, and reduce the stability and quality of drug, or even drug is made to lose curative effect and generate murder by poisoning to human body.Medicine bottle, as
Drug storaging medium, to preventing medicine bottle is rotten from playing crucial effect.
Pet fiber（PET）It is commonly called as terylene, there is good mechanical performance, thermal property, it can
It is widely used in weaving, electronics and packaging industry.Traditional PET bottle kind at present, the gap of plastic foil to the permeability of oxygen compared with
Greatly, drug is still easily aoxidized in storage.Therefore, shelf-life of the oxygen permeability to extension drug for improving PET bottle, drug is improved
Quality play an important role.
Invention content
Bad for the PET antioxidant effects that solve the problems, such as traditional, the present invention provides a kind of systems of anti-oxidation drug bottle
Preparation Method.
In order to realize that above-mentioned target, the present invention adopt the following technical scheme that：
A kind of preparation method of anti-oxidation drug bottle, it is characterised in that include the following steps：
（1）After terephthalic acid (TPA), ethylene glycol, 1,2-PD, catalyst and aromatic compound are mixed, shift as 5L's
In one-pot flow polymeric kettle, at high temperature through melting, modified polyethylene terephthalate is made after fat polymerization；
（2）Polyethylene terephthalate, natural, which are put into squeeze out in plectonemic spiral bar, obtains master batch；
（3）Master batch is put into injection molding machine, after injection molding obtains type embryo, handles to obtain anti-oxidation drug bottle through blow moulding machine.
Further, step（1）Described in catalyst be KOH or NaOH.
Further,（1）Described in aromatic compound be 2,6-naphthalenedicarboxylic acid, 1,8- naphthalenedicarboxylic acids, 2,6- anthracene diformazans
One kind in acid, 2,7- pyrene dioctyl phthalate.
Further, step（1）Described in ethylene glycol with the molar ratio of terephthalic acid (TPA) be 1：0.9-1.1；It is described
1,2-PD addition is the 5-10% of terephthalic acid (TPA) molal weight, and the addition of the aromatic compound is terephthaldehyde
The 8-12% of sour molal weight.
Further, step（1）Described in height ask to be 220-250 DEG C, the fat polymerization time be 25-40min；
The average molecular weight of the polyethylene terephthalate is more than 29000；Its relative molecular mass distribution coefficient is in 1.9-
2.1。
Further, step（1）Described in natural be tea polyphenols, addition be poly terephthalic acid second
The 5-8% of diol ester.
Further, step（1）Described in type embryo be blow molded after placing 48h.
A kind of preparation method of anti-oxidation drug bottle of the present invention has the advantages that：The present invention is using fragrance
Compound modifies polyethylene terephthalate so that crosslinked polymer is even closer, is prepared into after drug bottle it
The porosity of plastics is lower, can effectively prevent passing through for free oxygen, and 1,2-PD is added in addition and is modified to polymer,
Strengthen the heat resistance of polymer.The anti-oxidation drug bottle antioxidant effect prepared through the present invention is good, and temperature tolerance is strong, can increase
The storage shelf-life of drug.
Specific implementation mode
A kind of preparation method of anti-oxidation drug bottle of the present invention is done further below with reference to specific embodiment
Elaboration, to help those skilled in the art to the inventive concept of the present invention, that technical solution has is more complete, accurate and deep
Understand.
Embodiment 1
By 1：1 molal weight than phthalic acid, after ethylene glycol mixing, be added 5% 1,2-PD, NaOH and 10%
After 2,6-naphthalenedicarboxylic acid mixing, transfer after being melted at 240 DEG C, is made as in the one-pot flow polymeric kettle of 5L after fat polymerization
It obtains molecular weight and is more than 29000 polyethylene terephthalates being modified；By polyethylene terephthalate, 6% tea polyphenols
It is put into plectonemic spiral bar and sends to obtain master batch；Master batch is put into injection molding machine, after injection molding obtains type embryo standing 48h, through blowing
Molding machine handles to obtain anti-oxidation drug bottle.
Embodiment 2
By 1：0.95 molal weight than phthalic acid, ethylene glycol mixing after, be added 6% 1,2-PD, KOH and 8%
The mixing of 1,8- naphthalenedicarboxylic acids after, transfer is as in the one-pot flow polymeric kettle of 5L, after being melted at 250 DEG C, after fat polymerization
Molecular weight is made and is more than 29000 polyethylene terephthalates being modified；The tea of polyethylene terephthalate, 7% is more
Phenol, which is put into plectonemic spiral bar, to be sent to obtain master batch；Master batch is put into injection molding machine, after injection molding obtains type embryo standing 48h, warp
Blow moulding machine handles to obtain anti-oxidation drug bottle.
Embodiment 3
By 1：1.05 molal weight than phthalic acid, ethylene glycol mixing after, be added 6% 1,2-PD, NaOH and 9%
The mixing of 2,6- anthracene dioctyl phthalate after, transfer is as in the one-pot flow polymeric kettle of 5L, after being melted at 250 DEG C, after fat polymerization
Molecular weight is made and is more than 29000 polyethylene terephthalates being modified；The tea of polyethylene terephthalate, 7% is more
Phenol, which is put into plectonemic spiral bar, to be sent to obtain master batch；Master batch is put into injection molding machine, after injection molding obtains type embryo standing 48h, warp
Blow moulding machine handles to obtain anti-oxidation drug bottle.
Embodiment 4
By 1：1 molal weight than phthalic acid, after ethylene glycol mixing, be added 5% 1,2-PD, NaOH and 10%
After the mixing of 2,7- pyrene dioctyl phthalate, transfer after being melted at 240 DEG C, is made as in the one-pot flow polymeric kettle of 5L after fat polymerization
It obtains molecular weight and is more than 29000 polyethylene terephthalates being modified；By polyethylene terephthalate, 7% tea polyphenols
It is put into plectonemic spiral bar and sends to obtain master batch；Master batch is put into injection molding machine, after injection molding obtains type embryo standing 48h, through blowing
Molding machine handles to obtain anti-oxidation drug bottle.
Comparative example
By 1：1 molal weight than phthalic acid, after ethylene glycol mixing, transfer as in the one-pot flow polymeric kettle of 5L,
Molecular weight is made after being melted at 240 DEG C, after fat polymerization and is more than 29000 polyethylene terephthalates being modified；It will be poly- pair
Ethylene terephthalate, 7% tea polyphenols be put into plectonemic spiral bar and send to obtain master batch；Master batch is put into injection molding machine,
After injection molding obtains type embryo standing 48h, handle to obtain anti-oxidation drug bottle through blow moulding machine.
Performance test
Embodiment 1,2, prepared PET bottle in the anti-oxidant bottle and comparative example prepared by 3, carry out oxygen diffusion rate test and
Decomposition temperature is tested, and measurement result is shown in Table 1.
The oxygen diffusion rate and decomposition temperature of the different PET bottles of table 1
Anti-oxidant bottle prepared by plasticizer prepared by the present invention is more preferable than traditional PET bottle oxygen barrier effect and heat resistance.
For the ordinary skill in the art, specific embodiment is only exemplarily described the present invention,
Obviously the present invention specific implementation is not subject to the restrictions described above, as long as use the inventive concept and technical scheme of the present invention into
The improvement of capable various unsubstantialities, or it is not improved by the present invention design and technical solution directly apply to other occasions
, the protection model in the present invention.
Claims (7)
1. a kind of preparation method of anti-oxidation drug bottle, it is characterised in that include the following steps：
（1）After terephthalic acid (TPA), ethylene glycol, 1,2-PD, catalyst and aromatic compound are mixed, it is transferred to the list of 5L
In kettle flow polymeric kettle, at high temperature through melting, modified polyethylene terephthalate is made after fat polymerization；
（2）Polyethylene terephthalate, natural are put into squeeze out in plectonemic spiral bar and obtain master batch；
（3）Master batch is put into injection molding machine, after injection molding obtains type embryo, handles to obtain anti-oxidation drug bottle through blow moulding machine.
2. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in urge
Agent is KOH or NaOH.
3. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in virtue
Aroma compounds are one kind in 2,6-naphthalenedicarboxylic acid, 1,8- naphthalenedicarboxylic acids, 2,6- anthracenes dioctyl phthalate, 2,7- pyrene dioctyl phthalate.
4. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in second
The molar ratio of glycol and terephthalic acid (TPA) is 1：0.9-1.1；The 1,2- propylene glycol addition is terephthalic acid (TPA) molal weight
5-10%, the addition of the aromatic compound is the 8-12% of terephthalic acid (TPA) molal weight.
5. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in height
Temperature is 220-250 DEG C, and the fat polymerization time is 25-40min；The average mark of the polyethylene terephthalate
Son amount is more than 29000；Its relative molecular mass distribution coefficient is in 1.9-2.1.
6. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in day
Right antioxidant is tea polyphenols, and addition is the 5-8% of polyethylene terephthalate.
7. a kind of preparation method of anti-oxidation drug bottle as described in claim 1, it is characterised in that step（1）Described in type
Embryo is blow molded after placing 48h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810279651.7A CN108383983A (en) | 2018-04-01 | 2018-04-01 | A kind of preparation method of anti-oxidation drug bottle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810279651.7A CN108383983A (en) | 2018-04-01 | 2018-04-01 | A kind of preparation method of anti-oxidation drug bottle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108383983A true CN108383983A (en) | 2018-08-10 |
Family
ID=63073159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810279651.7A Pending CN108383983A (en) | 2018-04-01 | 2018-04-01 | A kind of preparation method of anti-oxidation drug bottle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108383983A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110951062A (en) * | 2019-12-13 | 2020-04-03 | 江苏栖云新材料科技有限公司 | Bottle-grade polyester chip for medicine bottle and preparation method thereof |
| CN117417514A (en) * | 2023-12-18 | 2024-01-19 | 康辉新材料科技有限公司 | Anthracene-2, 6-dicarboxylic acid modified PBAT degradation material, preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1138059A (en) * | 1994-12-14 | 1996-12-18 | 国际壳牌研究有限公司 | Process for manufacturing polyester copolymers containing terephthalate and naphthalate units |
| CN1222111A (en) * | 1996-03-15 | 1999-07-07 | 纳幕尔杜邦公司 | Barrier polyester |
| CN1312303A (en) * | 2001-02-26 | 2001-09-12 | 南亚塑胶工业股份有限公司 | Prepn of copolyester containing glycol naphthalendicarboxylate |
| CN104263273A (en) * | 2014-09-28 | 2015-01-07 | 上海济仕新材料科技有限公司 | High-barrier polyester film as well as preparation method and applications thereof |
| JP2017110046A (en) * | 2015-12-14 | 2017-06-22 | Dic株式会社 | Laminate and packaging material |
-
2018
- 2018-04-01 CN CN201810279651.7A patent/CN108383983A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1138059A (en) * | 1994-12-14 | 1996-12-18 | 国际壳牌研究有限公司 | Process for manufacturing polyester copolymers containing terephthalate and naphthalate units |
| CN1222111A (en) * | 1996-03-15 | 1999-07-07 | 纳幕尔杜邦公司 | Barrier polyester |
| CN1312303A (en) * | 2001-02-26 | 2001-09-12 | 南亚塑胶工业股份有限公司 | Prepn of copolyester containing glycol naphthalendicarboxylate |
| CN104263273A (en) * | 2014-09-28 | 2015-01-07 | 上海济仕新材料科技有限公司 | High-barrier polyester film as well as preparation method and applications thereof |
| JP2017110046A (en) * | 2015-12-14 | 2017-06-22 | Dic株式会社 | Laminate and packaging material |
Non-Patent Citations (4)
| Title |
|---|
| 王箴: "《化工辞典第二版》", 31 December 1979, 化学工业出版社 * |
| 贾绍义，等: "《化工传质与分离过程第二版》", 31 July 2007, 化学工业出版社 * |
| 陆园: "抗氧剂的分类、作用机理及研究进展", 《塑料助剂》 * |
| 马城华，等: "引进1,2-丙二醇共聚单体制备新型共聚酯的研究", 《合成纤维》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110951062A (en) * | 2019-12-13 | 2020-04-03 | 江苏栖云新材料科技有限公司 | Bottle-grade polyester chip for medicine bottle and preparation method thereof |
| CN117417514A (en) * | 2023-12-18 | 2024-01-19 | 康辉新材料科技有限公司 | Anthracene-2, 6-dicarboxylic acid modified PBAT degradation material, preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104822742B (en) | The copolyesters plastified with polymeric plasticiser for shrink film applications | |
| US5266413A (en) | Copolyester/polyamide blend having improved flavor retaining property and clarity | |
| TWI482816B (en) | Oxygen scavenging plastic material | |
| JP5209485B2 (en) | Composition and container for enhancing gas barrier properties | |
| US20030032737A1 (en) | Polyester compositions of low residual aldehyde content | |
| CN103160084B (en) | Polylactic acid resin composition and resin molded article thereof | |
| EP1230301B1 (en) | Process for preparing polyester compositions of low residual aldehyde content | |
| US11220589B2 (en) | Method of decreasing aldehyde content in a polymeric material | |
| CN108383983A (en) | A kind of preparation method of anti-oxidation drug bottle | |
| JP5609039B2 (en) | Polyester container | |
| CN107922781A (en) | Blend polymer with the polyester based on furans | |
| CN103483784A (en) | Flame-retardant PET (polyethylene glycol terephthalate) heat shrink film and preparation method thereof | |
| JP6212008B2 (en) | Polyester resin composition and blow molded article comprising the same | |
| CN103160085B (en) | Polylactic acid resin composition and resin molded article thereof | |
| CA2376152C (en) | Polyester compositions of low residual aldehyde content | |
| CN104177788A (en) | Hydrolysis resistant aliphatic polyester resin composition and preparation method thereof | |
| JPH02302440A (en) | Hollow polyamide molded product | |
| KR102571439B1 (en) | Automated manufacturing method of polyester product and container by them | |
| JPH021756A (en) | Heat-resistant hollow container | |
| JP2017178996A (en) | Method for producing blow molded article | |
| TW201024370A (en) | Polyester composition having oxygen absorption capability | |
| JPH01319531A (en) | Gas-barrier packaging material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180810 |