CN108378440A - Chinese medicine antibacterial mask containing graphene oxide-copper silver nanoparticle compound - Google Patents
Chinese medicine antibacterial mask containing graphene oxide-copper silver nanoparticle compound Download PDFInfo
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- CN108378440A CN108378440A CN201810211454.1A CN201810211454A CN108378440A CN 108378440 A CN108378440 A CN 108378440A CN 201810211454 A CN201810211454 A CN 201810211454A CN 108378440 A CN108378440 A CN 108378440A
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
- A41D13/1192—Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D31/00—Materials specially adapted for outerwear
- A41D31/02—Layered materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The present invention proposes a kind of Chinese medicine antibacterial mask of the silver nanoparticle of copper containing graphene oxide compound, and mask middle layer is to have adsorbed the medical woven fabric of antiseptic anti-inflammatory, and the raw material for preparing of the liquid includes：Graphene oxide copper silver nanoparticle compound, radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, the achene of Siberian cocklebur, schizonepeta, the coptis.Mask outer layer is PM2.5 particle filter layers, and outer layer is connected by slide fastener on one side with internal layer, and middle layer is detachable.Air to entering lung has certain filter sterilization effect, and in respiratory infectious disease prevalence, in the environment of the pollutions such as dust when operation, in haze weather, wearing mask of the present invention has the function of protecting very much.
Description
Technical field
The present invention relates to a kind of masks, and in particular to a kind of Chinese medicine antibacterial mask.
Background technology
In recent years, haze becomes the matter of utmost importance of China's air pollution.It is right containing a large amount of poisonous and harmful particulate matters in haze
The generations such as human respiratory, cardiovascular system seriously damage, and the hair that asthma, bronchitis, myocardial infarction etc. laugh at disease is caused to write
Increase, very big influence is caused on people’s lives.Meanwhile the harmful bacteria in air is ubiquitous, including diplococcus, single ball
Bacterium, doctor sarcine, tetrads, staphylococcus etc., reproduction speed is fast, survival ability is strong, it is wide to involve range, passes in air
Sowing time causes many diseases, such as influenza, tuberculosis, measles, mumps, pertussis, diphtheria, they have
Stronger infectiousness and harmfulness.Therefore, there is an urgent need to a kind of effective means filtering dust particle and to prevent in air
Bacterium enter the method for human body.Currently, protective mask oneself block particulate matter and spread of germs approach, protection easily touching through becoming
Group, one of the important measures for carrying out effective body protection.Existing mask mainly by small-bore, high porosity come realize to
The grain object and obstruction carefully drawn, electrostatic attraction and effectively absorption.But existing mask material can't be realized efficient to particulate matter
It intercepts and by killing bacteria, all has certain protective action to particulate matter and bacterium under particular circumstances, but also deposit simultaneously
In shortcomings, as fibre diameter is thick, low to the filter efficiency of superfine particulate matter.
Metal nanoparticle is dispersed in the surface of graphene, not only increases the distance between graphene sheet layer, resistance
The aggregation of graphene film is stopped, and has served as the conductive channel between graphene film so that laminated film has high specific surface
Product and electric conductivity.Meanwhile graphene and its derivative are remarkably improved the stabilization of nano-particle as metallic nanoparticle subcarrier
Property.Therefore, with the graphene-based material of metal composite both can retained fraction itself performance, moreover it is possible to pass through synergistic effect, enhancing
The characteristic of basis material simultaneously assigns some new function, modern research shows that graphene oxide-copper argentum nano composite material pair
Various pathogen all show significant antibacterial activity.Therefore, by graphene oxide-copper silver nanoparticle compound and Traditional Chinese medicine bacteriostatic group
It closes object and is applied to the antibacterial activity for increasing mask in mask and antiphlogistic activity with good application prospect.
Invention content
In order to solve the above technical problems, the present invention provides a kind of containing in graphene oxide-copper silver nanoparticle compound
Medicine antibacterial mask, and a kind of Chinese medicine antibacterial anti-inflammatory liquid is provided, which is administered through mouth and nose mode, and counterpart, nasal inflammation have very
Good alleviation and therapeutic effect.
The present invention provides a kind of Chinese medicine antibacterial mask containing graphene oxide-copper silver nanoparticle compound, and mask middle layer is
The medical woven fabric of antiseptic anti-inflammatory is adsorbed, the liquid is prepared by the raw material including following parts by weight：Graphite oxide
Alkene -15-20 parts of copper silver nanoparticle compound, 15-20 parts of radix scutellariae, 15-20 parts of cloves, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of cordate houttuynia, the leaves of pulse plants
10-15 parts fragrant, 5-10 parts of folium artemisiae argyi, 5-10 parts of eupatorium, 5-10 parts of inular flower, 5-10 parts of Flos Magnoliae Liliflorae, 2-7 parts of gardenia, the achene of Siberian cocklebur
2-5 parts, 2-5 parts of schizonepeta, 2-5 parts of the coptis.
As further improvement of the invention, liquid is prepared by the raw material including following parts by weight：Graphene oxide-
20 parts of copper silver nanoparticle compound, 17 parts of cloves, 17 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of cordate houttuynia, 15 parts of wrinkled giant hyssop, 10 parts of folium artemisiae argyi, is worn at 20 parts of radix scutellariae
9 parts blue, 7 parts of inular flower, 5 parts of Flos Magnoliae Liliflorae, 4 parts of gardenia, 3 parts of the achene of Siberian cocklebur, 2 parts of schizonepeta, 2 parts of the coptis.
As further improvement of the invention, liquid also contains freshener n-ethyl-p-menthane-3 alcohol and fragrance.
As further improvement of the invention, the preparation method of graphene oxide-copper silver nanoparticle compound, steps are as follows：
(1) prepared by graphene oxide：Graphene oxide is prepared using improved Hummers methods；
(2) preparation of graphene oxide-copper silver nanoparticle compound：The graphene oxide of step (1) preparation is weighed, addition is gone
Ionized water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, be protected from light be added isometric silver nitrate solution,
Copper nitrate solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get oxidation
Graphene-copper silver nanoparticle compound.
As further improvement of the invention, the preparation method of antiseptic anti-inflammatory includes the following steps：
(1) radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, Siberian cocklebur are taken
Son, schizonepeta, the coptis mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, filtrate is spare；
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0-
1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in solvent, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug
Liquid.
As further improvement of the invention, antiseptic anti-inflammatory solvent can be ethyl alcohol, glycerine or its mixed solvent.
As further improvement of the invention, mask outer layer is PM2.5 particle filter layers, and internal layer is hospital gauze.
As further improvement of the invention, mask ectonexine is connected with slide fastener on one side, and middle layer is detachable.
The invention also includes antiseptic anti-inflammatories prepared by the above method and composition.
The present invention has the advantages that：
1, the present invention is prepared into antibacterial mask, can prevent PM2.5 particles and significantly it is antibacterial, can be used for ordinary people
Group, is also applied to medical mask, has a wide range of application；
2, antibacterial liquid medicine prepared by the present invention combines graphene oxide-copper silver nanoparticle compound and Traditional Chinese medicine bacteriostatic ingredient,
It prepares simply, can effectively inhibit various bacteriums, it is with obvious effects, have simultaneously for the mouths such as canker sore, rhinitis, disease of the nose good
Good Prevention effect；
3, it is connected by zipper between antibacterial mask ectonexine of the present invention, intermediate antibiotic layer, health can be replaced at any time
And it is economical and practical.
Description of the drawings
Fig. 1 is Chinese medicine antibacterial mask schematic diagram of the present invention.
Fig. 2 is Chinese medicine antibacterial mask sectional view of the present invention.
In figure, 1, slide fastener；2, PM2.5 particle filter layers；3, middle layer.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear, complete description,
Obviously, the embodiment described is the embodiment of the part of representative of the present invention, rather than whole embodiments, this field are general
Other all embodiments that logical technical staff is obtained without making creative work belong to the protection of the present invention
Range.
1 graphene oxide of embodiment-copper silver nanoparticle compound
(1) prepared by graphene oxide：Graphene oxide is prepared using improved Hummers methods；
(2) preparation of graphene oxide-copper silver nanoparticle compound：The graphene oxide of step (1) preparation is weighed, addition is gone
Ionized water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, be protected from light be added isometric silver nitrate solution,
Copper nitrate solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get oxidation
Graphene-copper silver nanoparticle compound.
The preparation of 2 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms：Graphene oxide -20 parts of copper silver nanoparticle compound, 20 parts of radix scutellariae, 20 parts of cloves, 15 parts of Rhizoma Atractylodis Macrocephalae, fish
15 parts of raw meat grass, 15 parts of wrinkled giant hyssop, 10 parts of folium artemisiae argyi, 10 parts of eupatorium, 10 parts of inular flower, 10 parts of Flos Magnoliae Liliflorae, 7 parts of gardenia, the achene of Siberian cocklebur 5
Part, 5 parts of schizonepeta, 5 parts of the coptis.
Preparation process：
(1) radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, Siberian cocklebur are taken
Son, schizonepeta, the coptis mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, filtrate is spare；
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0-
1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in ethanol-glycerol mixed solvent, and ultrasonic disperse is uniform,
Up to antiseptic anti-inflammatory.
The preparation of 3 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms：Graphene oxide -20 parts of copper silver nanoparticle compound, 20 parts of radix scutellariae, 17 parts of cloves, 17 parts of Rhizoma Atractylodis Macrocephalae, fish
15 parts of raw meat grass, 15 parts of wrinkled giant hyssop, 10 parts of folium artemisiae argyi, 9 parts of eupatorium, 7 parts of inular flower, 5 parts of Flos Magnoliae Liliflorae, 4 parts of gardenia, 3 parts of the achene of Siberian cocklebur, chaste tree
2 parts of mustard, 2 parts of the coptis.
Preparation process：
(1) radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, Siberian cocklebur are taken
Son, schizonepeta, the coptis mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, filtrate is spare；
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0-
1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in ethyl alcohol, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug
Liquid.
The preparation of 4 Chinese medicine antibacterial anti-inflammatory liquid of embodiment
Raw material forms：Graphene oxide -15 parts of copper silver nanoparticle compound, 15 parts of radix scutellariae, 15 parts of cloves, 10 parts of Rhizoma Atractylodis Macrocephalae, fish
10 parts of raw meat grass, 10 parts of wrinkled giant hyssop, 5 parts of folium artemisiae argyi, 5 parts of eupatorium, 5 parts of inular flower, 5 parts of Flos Magnoliae Liliflorae, 2 parts of gardenia, 2 parts of the achene of Siberian cocklebur, chaste tree
2 parts of mustard, 2 parts of the coptis.
Preparation process：
(1) radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, Siberian cocklebur are taken
Son, schizonepeta, the coptis mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, filtrate is spare；
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0-
1.5, graphene oxide-copper silver nanoparticle compound is added, by 1:2 are dissolved in glycerine, and ultrasonic disperse is uniformly to get antibiosis anti-inflammatory drug
Liquid.
The preparation of Chinese medicine antibacterial mask of the embodiment 5 containing graphene oxide-copper silver nanoparticle compound
Chinese medicine antibacterial mask includes outer layer, middle layer and internal layer successively；
Outer layer is PM2.5 particle filter layers far from face；
Middle layer is to have adsorbed the medical woven fabric of antiseptic anti-inflammatory, which prepares for embodiment 3, infiltration
Amount is 50g crude drug amounts/dm2；
Internal layer can allow the liquid energy mediate contact of middle layer to mouth, nose close to face, be internal layer be hospital gauze.
By above-mentioned outer layer (shape is rectangle, long 17cm, width 12cm), (shape is rectangle to middle layer, long 15cm, width
10cm), antibiotic layer (shape is rectangle, long 17cm, width 12cm) and internal layer (shape is rectangle, long 17cm, width 12cm), are pressed
Said sequence combines successively, and internal layer stays together with sewing with a needle and thread with three side of outer layer and sews on CONCEAL ZIPPER on one side, then in mask
(that is, two endpoints on broadside) sew on the hangers line of two 8cm long to get containing graphene oxide-copper respectively on the broadside of both sides
The Chinese medicine antibacterial mask of silver nanoparticle compound.
1 canker sore Healing Experiments of test example
1, group is tested.By graphene oxide-copper silver nanoparticle that 40 rats are randomly divided into control group, prepared by embodiment 1
Chinese medicine antibacterial anti-inflammatory liquid group (2 groups), compound silver chrysanthemum mixture group (3 prepared by ethanol solution group (1 group), the embodiment 3 of compound
Group), totally 4 groups, every group of l0 is only.Selected rat be Wistar rats, SPF grades, half male and half female, weight 180-220g, by Wuhan
University's Experimental Animal Center provides.
Modeling method：Each group rat is anesthetized with ether respectively, lies on the back and is fixed on mouse plate.Take the glass of an a diameter of 4rnm
Pipe；One cotton pellet is placed in one end, is allowed to concordant with nozzle；It is 900g/L that the cotton balls end of glass tube, which is immersed in mass fraction,
Phenol solution in, so that liquid is impregnated with cotton balls；Place it in calcination about 60s on the cheek mucous membrane of rat side.Remove glass tube
See that there is the white damage of diameter 4-6mm in the region；Next day naked eyes visible rat lip side is moist, slobbers, red and swollen at cheek mucous membrane,
That is modeling success.
2, experimental method.1 group：To 50 μ of ethanol solution of graphene oxide-copper silver nanoparticle compound prepared by embodiment 1
L/g weights, average mark 5 times instill at rat cheek mucosa ulcers, are spaced 2h；2 groups：The Chinese medicine antibacterial prepared to embodiment 3 disappears
50 μ L/g weights of scorching liquid, average mark 5 times instill at rat cheek mucosa ulcers, are spaced 2h；3 groups：To compound silver chrysanthemum mixture with
Water 1:The 50 μ L/g weights of liquid of 2 configurations, average mark 5 times instill at rat cheek mucosa ulcers, are spaced 2h；Control group is not given
Medicine.Fasting, taboo water 30min, successive administration 6d after each medication.
3, data acquire.Rat canker sore healing state is observed before being administered daily, oral ulcer surface after 6d is administered in record
The time and quantity of size (being indicated with mm) and rat the canker sore healing of diameter.Healing standard：Ulcer diameter<1mm is more
It closes, ulcer diameter >=1mm is not heal.
Experimental result is shown in Table 1.
1 each group rat oral ulcer surface diameter of table compares
| Group | Rat number/only | Ulcer surface diameter/mm |
| Control group | 10 | 2.12±0.59 |
| 1 group | 10 | 1.21±0.39 |
| 2 groups | 10 | 0.88±0.45 |
| 3 groups | 10 | 1.57±0.71 |
By above-mentioned experimental result it is found that Chinese medicine antibacterial prepared by graphene oxide-copper silver nanoparticle compound and the present invention disappears
Scorching liquid has the effect of apparent healing canker sore, effect to be superior to antiphlogistic compound silver chrysanthemum mixture.Wherein, Chinese medicine antibacterial
The anti-inflammatory effects of anti-inflammatory liquid are optimal, illustrate that the Chinese medicine antibacterial anti-inflammatory liquid of the present invention has good antiinflammation.
2 bacteriostatic experiment of test example
1, for trying strain：Escherichia coli, staphylococcus aureus, Escherichia coli, bacillus subtilis, Candida albicans
Bacterium；
2, for reagent product：The ethanol solution of graphene oxide-copper silver nanoparticle compound prepared by embodiment 1, embodiment 3 are made
Standby Chinese medicine antibacterial anti-inflammatory liquid；
3, the preparation of culture medium：
LB liquid medium：Peptone 10g, yeast powder 5g, NaCl10g add pure water to 1000ml, adjust pH value up to 7.0；
LB solid mediums：Beef extract 3g, peptone 10g, yeast powder 5g, NaC1 10g, 15~20g of agar, add pure
Water adjusts pH value up to 7.0 autoclave sterilizations, makes culture medium to 1000mL.
Culture dish and test tube are wrapped with newspaper, solid medium is prepared according to formula, high pressure is then put into together and goes out
It sterilizes in bacterium pot.Tablet is made in the solid medium culture dish of falling people, liquid aglucon pours into test tube.
4, the preparation of bacteria suspension：
Escherichia coli, staphylococcus aureus, Escherichia coli, bacillus subtilis, white are read with tablet setting-out method
Pearl bacterium is inoculated in respectively on LB solid mediums, is sealed with sealed membrane, is set for 37 DEG C and is cultivated reactivated bacteria for 24 hours in biochemical cultivation case,
After activation, with the bacterium of the same bacterium colony of oese picking, it is inoculated in the test tube equipped with LB liquid medium, is subsequently placed in gas bath
37 DEG C of culture 48h are used as experimental strain in constant-temperature table.
5, the experiment of drug fungistatic effect：
After experimental strain culture is good, start bacteriostatic experiment on superclean bench.Experimental strain is shaken up, liquid-transfering gun is used
50 μ L bacteria suspensions are pipetted on the tablet made, tiling smoothens, 5 kinds of experimental bacterias, each applies 30 tablets, then will be sterilized
Oxford cup is equidistantly placed on agar surface, quiet on super-clean bench to put 10min after all sequencing per 6, ware.It is sterilized with 1mL
Liquid-transfering gun draws 200 μ L of target liquid, injects in the Oxford cup set, and 5 Oxford cups note people's same drugs, Ling Yiniu in every ware
Tianjin cup injects the 200 μ L of bacterium ethyl alcohol that gone out and compares, and is then sealed with sealed membrane is careful.Each drug corresponds to each bacterium difference
Tablet is made, totally 25 tablets do ethanol solution (n=25) antibacterial of graphene oxide-copper silver nanoparticle compound, use sterile alcohol
For control group, same 25 tablets do Chinese medicine antibacterial anti-inflammatory liquid (n=25) antibacterial, are control group with sterile alcohol.Postposition
In cultivating the bacterial growth situation observed afterwards for 24 hours in culture dish in 37 DEG C of biochemical cultivation cases, it is used in combination micrometer to correspond to measurement each
The diameter and record of processing group and control group inhibition zone, effective to be denoted as "+", no effect is denoted as "-", presses down compared with the control group
Bacterium effect.
Experimental result is shown in Table 2.
The fungistatic effect of 2 two kinds of liquids of table
By the above experimental result it is found that graphene oxide-copper silver nanoparticle compound has apparent antibacterial and bacteriostasis, but
Only it is obvious to the inhibiting effect of Escherichia coli, bacillus subtilis and Candida albicans, by add it is some other in
Medicine component extract can enhance the fungistatic effect of graphene oxide-copper silver nanoparticle compound, reach have to five kinds of bacteriums it is bright
Aobvious inhibition.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention of claims determination, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (9)
1. a kind of Chinese medicine antibacterial mask containing graphene oxide-copper silver nanoparticle compound, which is characterized in that the mask middle layer
To have adsorbed the medical woven fabric of antiseptic anti-inflammatory, the liquid is prepared by the raw material including following parts by weight：Aoxidize stone
Black alkene -15-20 parts of copper silver nanoparticle compound, 15-20 parts of radix scutellariae, 15-20 parts of cloves, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of cordate houttuynia,
10-15 parts of wrinkled giant hyssop, 5-10 parts of folium artemisiae argyi, 5-10 parts of eupatorium, 5-10 parts of inular flower, 5-10 parts of Flos Magnoliae Liliflorae, 2-7 parts of gardenia, Siberian cocklebur
2-5 parts sub-, 2-5 parts of schizonepeta, 2-5 parts of the coptis.
2. the Chinese medicine antibacterial mask according to claim 1 containing graphene oxide-copper silver nanoparticle compound, which is characterized in that
The liquid is prepared by the raw material including following parts by weight：Graphene oxide -20 parts of copper silver nanoparticle compound, radix scutellariae 20
Part, 17 parts of cloves, 17 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of cordate houttuynia, 15 parts of wrinkled giant hyssop, 10 parts of folium artemisiae argyi, 9 parts of eupatorium, 7 parts of inular flower, Flos Magnoliae Liliflorae 5
Part, 4 parts of gardenia, 3 parts of the achene of Siberian cocklebur, 2 parts of schizonepeta, 2 parts of the coptis.
3. the Chinese medicine antibacterial mask according to claim 1 containing graphene oxide-copper silver nanoparticle compound, which is characterized in that
The liquid also contains freshener n-ethyl-p-menthane-3 alcohol and fragrance.
4. the Chinese medicine antibacterial mask according to claim 1 containing graphene oxide-copper silver nanoparticle compound, which is characterized in that
The preparation method of the graphene oxide-copper silver nanoparticle compound, steps are as follows：
(1) prepared by graphene oxide：Graphene oxide is prepared using improved Hummers methods；
(2) preparation of graphene oxide-copper silver nanoparticle compound：The graphene oxide of step (1) preparation is weighed, deionization is added
Water is ultrasonically treated 30min, obtains uniform graphene oxide-aqueous dispersions, is protected from light and isometric silver nitrate solution, nitric acid is added
Copper solution, glucose solution and ammonia spirit, are vigorously stirred reaction 2h, filtering, and deionized water is washed repeatedly to get graphite oxide
Alkene-copper silver nanoparticle compound.
5. the Chinese medicine antibacterial mask according to claim 1 containing graphene oxide-copper silver nanoparticle compound, which is characterized in that
The preparation method of the antiseptic anti-inflammatory includes the following steps：
(1) radix scutellariae, cloves, Rhizoma Atractylodis Macrocephalae, cordate houttuynia, wrinkled giant hyssop, folium artemisiae argyi, eupatorium, inular flower, Flos Magnoliae Liliflorae, gardenia, the achene of Siberian cocklebur, chaste tree are taken
Mustard, the coptis mix after crushing, and 10 times of volume of water are added, and impregnate 60min, decoct 2h, are filtered under diminished pressure, filtrate is spare；
(2) 7 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 100min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate adds to relative density 1.0-1.5
Enter graphene oxide-copper silver nanoparticle compound, by 1:2 are dissolved in solvent, and ultrasonic disperse is uniformly to get antiseptic anti-inflammatory.
6. according to the Chinese medicine antibacterial mouth containing graphene oxide-copper silver nanoparticle compound described in claim 1-5 any claims
Cover, which is characterized in that the antiseptic anti-inflammatory solvent can be ethyl alcohol, glycerine or its mixed solvent.
7. according to the Chinese medicine antibacterial mouth containing graphene oxide-copper silver nanoparticle compound described in claim 1-5 any claims
Cover, which is characterized in that the mask outer layer is PM2.5 particle filter layers, and internal layer is hospital gauze.
8. according to the Chinese medicine antibacterial mouth containing graphene oxide-copper silver nanoparticle compound described in claim 1-5 any claims
Cover, which is characterized in that the mask ectonexine is connected with slide fastener on one side, and middle layer is detachable.
9. a kind of antiseptic anti-inflammatory prepared according to composition described in claim 1-5 any claims.
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| CN110128731B (en) * | 2019-05-23 | 2021-11-02 | 福州大学 | Graphene/polyethylene composite antibacterial film |
| CN111466408A (en) * | 2020-04-14 | 2020-07-31 | 安徽万兴实业有限公司 | Preparation method of antibacterial material, manufacturing method of antibacterial nanofiber cloth and application |
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| CN111557498A (en) * | 2020-04-22 | 2020-08-21 | 康业(江苏)医疗科技有限公司 | Fragrant protective mask |
| GB2597933A (en) * | 2020-08-10 | 2022-02-16 | Stewan Kukard Gideon | Wet filter face mask |
| CN112391751A (en) * | 2020-09-10 | 2021-02-23 | 浙江采美新材料股份有限公司 | Production facility of compound anti-haze, antibacterial and bacteriostatic mask of receiving of straining based on graphene oxide |
| CN112522861A (en) * | 2020-10-12 | 2021-03-19 | 苏州冠洁纳米材料科技有限公司 | Application of composite nano particles of carbon and copper in melt-blown non-woven material |
| WO2022144679A1 (en) | 2020-12-30 | 2022-07-07 | Arcelormittal | Antiviral formulation, antiviral filtering material, methods of preparation thereof and antiviral face mask. |
| WO2022144573A1 (en) | 2020-12-30 | 2022-07-07 | Arcelormittal | Antiviral formulation, antiviral filtering material, methods of preparation thereof and antiviral face mask |
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