CN108355090A - A kind of drug and preparation method thereof for treating pruitus - Google Patents

Abstract

The invention discloses a kind of drug and preparation method thereof for treating pruitus, drug of the present invention is mainly made of frutus cnidii, kuh-seng, alumen, the fruit of summer cypress, giant knotweed, the root bark of shaggy-fruited dittany, subprostrate sophora, another name for Sichuan Province green pepper, Golden Larch Bark, Cortex Phellodendri, purslane and smilax.There is the drug clearing heat and detoxicating, eliminating dampness wind-dispelling, antipruritic effect can be used for treating the diseases such as pruitus, and significant in efficacy, safety is without side-effects.

Description

A kind of drug and preparation method thereof for treating pruitus

Technical field

The present invention relates to a kind of drugs and preparation method thereof for treating pruitus, belong to the field of drug technology.

Technical background

Cutaneous pruritus is common clinical disease, be it is a kind of without apparent primary cutaneous damage and using itch as cardinal symptom Skin disease.Chinese medicine is referred to as " pruritus due to wind pathogen ", and successive dynasties TCM Document has different names according to different skin lesions and site of pathological change, such as " pruritus ", " pruritus vulvae " etc., now system is referred to as pruritus due to wind pathogen.Clinical manifestation is skin paroxysmal itch, and nothing of itching determines place or is confined to body The certain positions of body, it is relatively conventional with private parts, perianal, scalp, shank.Without primary skin lesion, visible scratch, blood are scratched repeatedly The secondary skin lesion such as scab, pigmentation and lichenification or even secondary infection cause epifolliculitis, furuncle, lymphnoditis etc..Easily send out repeatedly Make, has hair in winter autumn Mo, induced because cold is dry；Also there is hair in summer, because moist hidrosis induces.Systemic pruritus includes Pruritus senilis, pruritus aestivalis, pruritus aestivalis etc..Regional pruritus includes pruritus ani, pruritus scroti, cysthus Pruritus etc..This disease of Modern medical therapy mostly uses calm antiallergy therapy, really can in certain time, to a certain extent alleviate itch Sense, but be difficult to reach healing purpose.

Invention content：

The object of the present invention is to provide a kind of drug and preparation method thereof for treating pruitus, the drug has heat-clearing Removing toxic substances, eliminating dampness wind-dispelling, antipruritic effect can be used for treating the diseases such as pruitus, and significant in efficacy, safety is without side-effects.

The present invention is realized using following technical scheme：A kind of drug for treating pruitus, calculates by weight, mainly by 20-40 parts of frutus cnidii, 20-40 parts of kuh-seng, 20-40 parts of alumen, 20-40 parts of the fruit of summer cypress, 20-40 parts of giant knotweed, root bark of shaggy-fruited dittany 20-40 Part, 20-40 parts of subprostrate sophora, green pepper 5-15 parts of another name for Sichuan Province, 20-40 parts of Golden Larch Bark, 20-40 parts of Cortex Phellodendri, 50-70 parts of purslane and smilax 20-40 parts are made.

In the drug for the treatment of pruitus above-mentioned, calculate by weight, mainly by 25-35 parts of frutus cnidii, kuh-seng 25-35 Part, 25-35 parts of alumen, 25-35 parts of the fruit of summer cypress, 25-35 parts of giant knotweed, 25-35 parts of the root bark of shaggy-fruited dittany, 25-35 parts of subprostrate sophora, another name for Sichuan Province green pepper 8-12 25-35 parts of part, 25-35 parts of Golden Larch Bark, 25-35 parts of Cortex Phellodendri, 55-65 parts of purslane and smilax are made.

It in the drug for the treatment of pruitus above-mentioned, calculates by weight, mainly by 30 parts of frutus cnidii, 30 parts of kuh-seng, withered 30 parts of alum, 30 parts of the fruit of summer cypress, 30 parts of giant knotweed, 30 parts of the root bark of shaggy-fruited dittany, 30 parts of subprostrate sophora, 10 parts of another name for Sichuan Province green pepper, 30 parts of Golden Larch Bark, Cortex Phellodendri 30 30 parts of part, 60 parts of purslane and smilax are made.

A kind of production method of the drug for the treatment of pruitus above-mentioned, takes said medicine, can add auxiliary material, can not also Add auxiliary material, pharmaceutical preparation is made.

The production method of the drug for the treatment of pruitus above-mentioned, the pharmaceutical preparation are external preparation.

The production method of the drug for the treatment of pruitus above-mentioned, the external preparation are lotion, paste or patch.

The production method of the drug for the treatment of pruitus above-mentioned, the lotion make in this way：Said medicine is taken, adds 3000 Parts by volume water impregnates 20 minutes, after intense fire is fried open lasting 15 minutes, is cooked by slow fire 30 minutes, decocts to 1500 parts by volume of liquid；Again will Liquid adds water to 3000 parts by volume, and same method two is decocted to 1500 parts by volume of liquid, will twice liquid mix to get.

The production method of the drug for the treatment of pruitus above-mentioned, the paste make in this way：Said medicine is taken, 8-10 is added The water of amount impregnates 10-15 minutes again, and first big fire decocts 10-15min, is further continued for decocting 15-25min, decoction 3 times, mistake with small fire Filter, merging filtrate, when filtrate is condensed into 50-60 DEG C relative density be 1.20-1.25 medicinal extract to get.[A1] [A2]

Cutaneous pruritus TCM Document is referred to as " all to itch ", " disease of itching ", " pruritus " etc., illustrates the interpretation of the cause, onset and process of an illness of " itching " for the first time, when pushing away《Spirit Pivot》,《A Ling Shu Miraculous Pivot or Divine Axis Ci Jiezhen heresy pieces》Described in " ... it fights between skin, gas outgoing, opening of sweat pores, hair shakes, and gas is past Carry out row, then to itch.”《The Yellow Emperor's Canon of Internal Medicine》In have the record of " all sufferings sores, come under the heart ".《The General Treatise on the Cause and Symptoms of Diseases》Middle description：" wind The person of itching is physically weak wind-engaging, and wind enters space between skin and muscles, is mutually fought with vim and vigour, and all comes and goes and be between skin, and perverse trend is micro- cannot to impact for pain, Therefore but itch ".The Tang Dynasty SUN Si miao《Prescriptions worth thousand gold》The cause of disease, the symptom etc. of this disease are specifically described, such as " disease of itching is differed, Deficiency of blood skin itchy person, suitable Siwu Tang add it is windproof ... married woman's deficiency of blood, or the whole body are itched or head are itched, in worm row skin.Edge Month water is blown when coming by wind, not then is that the dynamic scenery of food causes it in puerperium.... there is spleen deficiency body to itch, this is without mange, the non-production of element Cotton-padded mattress, clean right the whole body, itching can not appoint, this is that spleen deficiency is stranded.Through cloud：All pains are all to itch as void to be real.Cloud the spleen controlling the muscles of whole body again, preferably Real spleen is first." cause of disease of this disease is classified as two class of the deficiency of blood and spleen deficiency, treatment is first with real spleen.《Surgery card controls pandect》In then It is named as " pruritus ", such as " itch all over, has no sore scabies, scratches more than." and propose that " the liver man deficiency of blood, dry hot air wind producing absurd can not be thrown The argument of expelling wind drug ".To sum up, Chinese medicine thinks, pruitus is mostly related with ailment said due to cold or exposure, wind or from diseases caused by external factors, or from interior life, Chang Yure, it is wet, The perverse trends such as dry, malicious are mingled with and are disease.So ancient Chinese medicine doctor is classified as blood-deficiency and wind-dry type, blood hot air wind producing type, wind (wet) hot dipping more Excessive type, blood stasis type, affection by exopathogenic cold-wind type, liver-kidney yin deficiency etc..This disease cause of disease is complicated, and there are many uncertain pathogenic factor, causes The treatment of this disease is very intractable, and the course of disease is long, touching refractory.

12 kinds of Chinese medicinal compositions of drug of the present invention, play clearing heat and detoxicating, eliminating dampness wind-dispelling, and antipruritic effective substance faces Bed uses significant in efficacy.To mitigating patient suffering, the quality of life for improving patient is significant, and safe, economic reality The advantages that favour, reduces the financial burden of patient.

【Pharmacological research and effect】Frutus cnidii is the ripening fruits of Umbelliferae annual herb plant cnidium monnieri.It is warm-natured, taste It is pungent, bitter, it is slightly poisonous.Return kidney channel.It is antipruritic with external application removing dampness and destroying parasites, take warming kidney and enhancing body orally, the effect of cold extermination eliminating dampness,《Prescriptions worth thousand gold》 This product levigation is applied alone, is applied except lard tune, treats mange itch,《Haigoushen》In also have " main strong wind body is itched, decoction bath difference.” Containing cnidimine, xanthotoxin in frutus cnidii, there is suppression to dermatophyte, drug-resistant S. aureus and pseudomonas aeruginosa It makes and uses, also there is stronger anti-inflammatory and analgesic activity.Kuh-seng is the root of pulse family semishrub plant kuh-seng, and cold in nature, bitter is returned Liver, courage, stomach, large intestine, bladder warp, the work(that this product local topical has heat-clearing, dehumidifying, desinsection antipruritic, with pruitus is controlled, often with solution Kill worm, dispelling wind and arresting itching medicine with using, with decoction washout, such as《Ulcer section gains in depth of comprehension collection》Kuh-seng soup, with it and frutus cnidii, the fruit of summer cypress, stone The medicines such as calamus are the same as use.Alumen, alum claim alumen after forging, and are crystallization made of the processed refinement of Sulfates mineral alum, and master contains Alum, cold in nature, sour, puckery, return lung, spleen, liver, large intestine channel are antipruritic to grow to hygroscopic outside, are particularly appropriate for eczema, wet sore Etc. the wet rotten itch person in sores face.Eczema itch, yellow water streamer person are controlled, it is end that this product, which can be applied alone, enters cold water and washes affected part.The fruit of summer cypress is The ripening fruits of Chenopodiaceae annual herb plant, cold in nature, bitter.Return kidney, bladder warp, work(is apt to clearing heat and promoting diuresis, dispelling wind and arresting itching,《Name Doctor does not record》Described in " remove hot gas in skin, dissipate malignant sore.”《The southern regions of the Yunnan Province book on Chinese herbal medicine》In also there is the record of " wind for washing skin ", this product to contain Retinoid substance has a variety of fungies different degrees of inhibiting effect.Another name for Sichuan Province green pepper also known as Chinese prickly ash, be Rutaceae machaka or The dry mature skin of dungarunga green pepper or Chinese prickly ash, property heat are pungent, slightly poisonous, returns spleen, stomach.External application energy removing dampness and destroying parasites is antipruritic, Eczema itch are controlled, can be applied alone or with kuh-seng, frutus cnidii, the fruit of summer cypress, Cortex Phellodendri etc., decoction has inhibiting effect, another name for Sichuan Province green pepper to various bacteria Volatile oil have certain inhibiting effect to a variety of dermatophytes and deep fungal, and can tag scabies, mite etc..Golden Larch Bark is The root skin or near root bark of Pinaceae magaphanerophytes golden larch, warm-natured, acrid flavour, return lung, the spleen channel, this product is toxic, is used externally only, have compared with Good desinsection treats tinea, removing dampness to stop itchin effect, to treat based on tinea,《A Supplement to the Compendium of Materia Medica》Described in its can " its skin controls all blood, Desinsection miasma tinea ", researches show that Golden Larch Bark organic acid, ethanol extract and benzene medicinal extract for doctor trained in Western medicine pharmacology, to common 10 kinds of pathogenic skin Fungi and candida albicans bacterium have certain antibacterial action.Smilax climbs up by holding on to liana smilacis glabra for Liliaceae is perennial Stem tuber, cold nature is sweet in flavor, light, Return liver, bladder, stomach, has clearing heat and detoxicating, the effect of dampness removing, can control eczema itch.In vain Fresh hide, be Rutaceae herbaceos perennial shaggy-fruited dittany and Dictamnus angustifolius root skin, cold in nature, bitter, micro-pungent, Return liver, courage, spleen, stomach, Lung, bladder warp, energy heat-clearing and damp-drying drug, removing toxic substances, wind-dispelling are kind to control pruitus, eczema, wet sore, heat toxin sore swells, the cards such as pruritus vulvae swelling of vulva. Cortex Phellodendri, two medicine of subprostrate sophora share clearing heat and detoxicating, eliminating dampness purging intense heat, and both there is the inhibition to a variety of skin pathomycetes to make With.Purslane, can clearing heat and detoxicating, cool blood.Giant knotweed has the benefits of clearing heat and detoxicating, promoting blood circulation.Pruitus can be by blood-head, blood Wind is given birth in stasis of blood dryness-transformation,《Required Readings for Medical Professionals》Medium cloud " controls wind and first controls blood, blood wind goes out certainly." purslane, one cool blood of giant knotweed, one promoting blood circulation, with Up to the purpose of dispelling wind and arresting itching.All medicines share, clearing heat and detoxicating, eliminating dampness wind-dispelling, antipruritic work(.

Treat example

Patient week certain, female, 77 years old, on December 2nd, 2016, head was examined.Because " trunk, the limbs skin itch 3+ months " is medical, patient tells 3+ Without apparent inducement there is trunk, limbs skin itch before month, have dry skin, see a small amount of scales of skin that peel off and scratch, had no at scratch exudation, Sepage has no apparent primary fash.It is wiped outside the various ointment of long-term external application（It is specifically unknown）, weight when symptom is light.Body is looked into：Trunk, Limbs skin is dried, and is had no apparent primary fash, is seen a small amount of scales of skin that peel off and scratch, and exudation, sepage, dermatograph examination are had no at scratch It tests（-）.Tongue is red, yellow and greasy fur, wiry and rolling pulse.Tcm diagnosis：Pruritus due to wind pathogen disease, dialectical category deficiency of qi and blood lose in outer solid, and ailment said due to cold or exposure is taken advantage of a weak point in opponent's defence outer It attacks, wind formation from blood deficiency, failure of skin and muscle to be nourished.With drug of the present invention（It is prepared by embodiment 1）Washout.Once a day, it visits to 2017 In 5 days 03 month year, pruitus has been fully recovered not to be recurred again.

Patient Shi, female, 69 years old, head was examined on 09 12nd, 2016, and because " whole skin itch January " is medical, patient tells January Preceding without apparent inducement sense double lower limb, abdomen itch, night is very dry skin, and the diseases such as no papule, macula, rotten to the corn exudation give mouth Medication object and external-applied ointment treatment（It is specifically unknown）, symptom is not alleviated, the gradual general hair whole body of itch.Body is looked into：Whole skin is dried, Have no apparent primary fash, it is seen that differ in size pigmentation spots, is dispersed in scratch, scab, sepage, dermatograph are had no at scratch Experiment（-）.Pale tongue, tongue is thin white, wiry and rolling pulse.Tcm diagnosis：Pruritus due to wind pathogen disease, dialectical category wind formation from blood deficiency, passages through which vital energy circulates retardance, skin are rare Warm therefore hair is this disease.Treatment uses drug of the present invention with antipyretic and itching-stopping, dispelling wind promoting blood circulation moisturizing（It is prepared by embodiment 1） Washout.Once a day, it visits on 01 2nd, 2017, pruitus has been fully recovered not to be recurred again.

Compared with prior art, there is the drug clearing heat and detoxicating, eliminating dampness wind-dispelling, antipruritic effect can be used for treating skin The diseases such as skin itch, significant in efficacy, safety is without side-effects.

Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.

Specific implementation mode：

Embodiment 1.

Formula：Frutus cnidii 30g, kuh-seng 30g, alumen 30g, fruit of summer cypress 30g, giant knotweed 30g, root bark of shaggy-fruited dittany 30g, subprostrate sophora 30g, another name for Sichuan Province green pepper 10g, Golden Larch Bark 30g, Cortex Phellodendri 30g, purslane 60g and smilax 30g.

Technique：The above Chinese medicine gives 3000 milliliters of water and impregnates 20 minutes, and head is decocted：Intense fire is fried open lasting 15 minutes, is cooked by slow fire 30 Minute, it decocts to 1500 milliliters of liquid；Liquid is added water to 3000 milliliters again, same method two is decocted to 1500 milliliters of liquid, will Liquid mixing twice is to get decoction.

Usage and dosage：Washout, 1500ml/ times, 2 times/day.

Embodiment 2.

Formula：Frutus cnidii 35g, kuh-seng 35g, alumen 35g, fruit of summer cypress 35g, giant knotweed 35g, root bark of shaggy-fruited dittany 35g, subprostrate sophora 35g, another name for Sichuan Province green pepper 12g, Golden Larch Bark 35g, Cortex Phellodendri 35g, purslane 65g and smilax 35g.

Technique：Said medicine is taken, the water of 10 times of amounts is added to impregnate 15 minutes, first big fire decocts 15min, is further continued for being decocted with small fire 25min is boiled, is decocted 3 times, filtering, merging filtrate, relative density is the medicinal extract of 1.20-1.25 when filtrate is condensed into 50-60 DEG C, i.e., Obtain paste.

Usage and dosage：External application, is applied to affected part, and each 4-6h replaces primary.

Embodiment 3.

Formula：Frutus cnidii 25g, kuh-seng 25g, alumen 25g, fruit of summer cypress 25g, giant knotweed 25g, root bark of shaggy-fruited dittany 25g, subprostrate sophora 25g, another name for Sichuan Province green pepper 8g, Golden Larch Bark 25g, Cortex Phellodendri 25g, purslane 55g and smilax 25g.

Technique：The above Chinese medicine gives 3000 milliliters of water and impregnates 20 minutes, and head is decocted：Intense fire is fried open lasting 15 minutes, is cooked by slow fire 30 Minute, it decocts to 1500 milliliters of liquid；Liquid is added water to 3000 milliliters again, same method two is decocted to 1500 milliliters of liquid, will Liquid mixing twice is to get decoction.

Usage and dosage：Washout, 1500ml/ times, 2 times/day.

Claims (8)

1. a kind of drug for treating pruitus, it is characterised in that：It calculates by weight, mainly by 20-40 parts of frutus cnidii, hardship Ginseng 20-40 parts, 20-40 parts of alumen, 20-40 parts of the fruit of summer cypress, 20-40 parts of giant knotweed, 20-40 parts of the root bark of shaggy-fruited dittany, 20-40 parts of subprostrate sophora, 20-40 parts of green pepper 5-15 parts of another name for Sichuan Province, 20-40 parts of Golden Larch Bark, 20-40 parts of Cortex Phellodendri, 50-70 parts of purslane and smilax are made.

2. the drug for the treatment of pruitus as described in claim 1, it is characterised in that：It calculates by weight, mainly by cnidium monnieri 25-35 parts sub-, 25-35 parts of kuh-seng, 25-35 parts of alumen, 25-35 parts of the fruit of summer cypress, 25-35 parts of giant knotweed, 25-35 parts of the root bark of shaggy-fruited dittany, mountain 25-35 parts of 25-35 parts of beans root, green pepper 8-12 parts of another name for Sichuan Province, 25-35 parts of Golden Larch Bark, 25-35 parts of Cortex Phellodendri, 55-65 parts of purslane and smilax It is made.

3. the drug for the treatment of pruitus as claimed in claim 2, it is characterised in that：It calculates by weight, mainly by cnidium monnieri Son 30 parts, 30 parts of kuh-seng, 30 parts of alumen, 30 parts of the fruit of summer cypress, 30 parts of giant knotweed, 30 parts of the root bark of shaggy-fruited dittany, 30 parts of subprostrate sophora, 10 parts of another name for Sichuan Province green pepper, 30 parts of 30 parts of Golden Larch Bark, 30 parts of Cortex Phellodendri, 60 parts of purslane and smilax are made.

4. a kind of production method of the drug for the treatment of pruitus as claimed in any one of claims 1-3, it is characterised in that： Said medicine is taken, auxiliary material can be added, auxiliary material can also be not added with, pharmaceutical preparation is made.

5. the production method of the drug for the treatment of pruitus as claimed in claim 4, it is characterised in that：The pharmaceutical preparation is External preparation.

6. the production method of the drug for the treatment of pruitus as claimed in claim 5, it is characterised in that：The external preparation is Lotion, paste or patch.

7. the production method of the drug for the treatment of pruitus as claimed in claim 6, it is characterised in that：The lotion is made in this way Make：Take said medicine, add 3000 parts by volume water impregnate 20 minutes, after intense fire is fried open lasting 15 minutes, be cooked by slow fire 30 minutes, decoct to 1500 parts by volume of liquid；Liquid is added water into 3000 parts by volume again, same method two is decocted to 1500 parts by volume of liquid, will medicine twice Liquid mixing to get.

8. the production method of the drug for the treatment of pruitus as claimed in claim 6, it is characterised in that：The paste is made in this way Make：Said medicine is taken, the 8-10 times of water measured is added to impregnate 10-15 minutes, first big fire decocts 10-15min, is further continued for being decocted with small fire 15-25min is decocted 3 times, filtering, merging filtrate, and relative density is the medicinal extract of 1.20-1.25 when filtrate is condensed into 50-60 DEG C, To obtain the final product.