CN108338993A - A kind of symphysis unit composition of conditioning female reproductive health and its preparation and application - Google Patents
A kind of symphysis unit composition of conditioning female reproductive health and its preparation and application Download PDFInfo
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- CN108338993A CN108338993A CN201810104899.XA CN201810104899A CN108338993A CN 108338993 A CN108338993 A CN 108338993A CN 201810104899 A CN201810104899 A CN 201810104899A CN 108338993 A CN108338993 A CN 108338993A
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- female reproductive
- unit composition
- reproductive health
- symphysis unit
- conditioning
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- 239000000203 mixture Substances 0.000 title claims abstract description 94
- 230000009933 reproductive health Effects 0.000 title claims abstract description 72
- 230000003750 conditioning effect Effects 0.000 title claims abstract description 61
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 40
- 239000006041 probiotic Substances 0.000 claims abstract description 39
- 235000018291 probiotics Nutrition 0.000 claims abstract description 39
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 4
- 229940079593 drug Drugs 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 235000013402 health food Nutrition 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 208000017443 reproductive system disease Diseases 0.000 claims abstract description 4
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 17
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 17
- 241000193749 Bacillus coagulans Species 0.000 claims description 16
- 244000063299 Bacillus subtilis Species 0.000 claims description 16
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 16
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 16
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 16
- 241000186673 Lactobacillus delbrueckii Species 0.000 claims description 16
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 16
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 16
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 16
- 241000194108 Bacillus licheniformis Species 0.000 claims description 15
- 229940054340 bacillus coagulans Drugs 0.000 claims description 15
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 14
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 13
- 241000756042 Polygonatum Species 0.000 claims description 13
- 235000008737 Polygonatum biflorum Nutrition 0.000 claims description 13
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 13
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 13
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 13
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 13
- 235000013824 polyphenols Nutrition 0.000 claims description 13
- 229920001282 polysaccharide Polymers 0.000 claims description 13
- 239000005017 polysaccharide Substances 0.000 claims description 13
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 11
- 241000894006 Bacteria Species 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 244000269722 Thea sinensis Species 0.000 claims 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 230000009545 invasion Effects 0.000 abstract description 2
- 244000052769 pathogen Species 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 abstract description 2
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 description 19
- 241001122767 Theaceae Species 0.000 description 11
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 230000027939 micturition Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010061926 Purulence Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 125000000647 trehalose group Chemical group 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- -1 Granula Substances 0.000 description 1
- 208000016599 Uterine disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 241000385540 bacterium 10 Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000015124 ovarian disease Diseases 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000013464 vaginal disease Diseases 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a kind of symphysis unit composition of conditioning female reproductive health, the symphysis unit composition of the conditioning female reproductive health includes prebiotics, probiotics, and weight ratio is 1~10:1~10.The preparation of the symphysis unit composition of the conditioning female reproductive health is also disclosed, pharmaceutically acceptable auxiliary material, which is added, in the symphysis unit composition of the conditioning female reproductive health is made powder, tablet, granule and capsule.And disclose application of the symphysis unit composition of the conditioning female reproductive health in the drug or health food for preparing preventing/treating female genital disorders.The symphysis unit composition of the present invention is by a variety of probiotics, prebiotics proportioning combination, help to inhibit harmful levels of pathogens breeding, balance vaginal pH, colony balance is adjusted, to safeguard the human body Tiny ecosystem ecological balance, effectively conditioning female reproductive health resists pathogenic bacteria invasion.
Description
Technical field
The invention belongs to microbe additive technical fields, and in particular to a kind of symphysis tuple of conditioning female reproductive health
Close object and its preparation and application.
Background technology
With the development of the society, modern society people live, learn that rhythm is fast, pressure is big mostly, it is raw for women
It grows systemic disease and often annoyings many people, and obstinate, great inconvenience is brought to normal life, work, due to being permitted
More people lack due understanding to gynecological disease, lack health care of body, various bad life habits are the important originals of illness in addition
Cause, it is repeatedly sick that physiological health is caused to go from bad to worse.Disease in the female sexual system is women common disease, frequently-occurring disease, such as vulva disease
Disease, vaginal disease, uterine disease, diseases of fallopian tubes, disease of ovary etc..In traditional therapeutic scheme, for female reproductive health
Problem is mainly treated by taking antibiotic etc, not only kills the dead pathogenic bacteria of meeting in this way, while also will be in human body
Very useful probiotics kills in leucocyte, immunocyte and human body, and especially prolonged and repeated morbidity causes physical function every
Condition more under, complexion is obscure, withered and yellow.For this purpose, a kind of product that can solve above-mentioned health problem of research and development is very important.
Invention content
The first object of the present invention is to provide a kind of symphysis unit composition of conditioning female reproductive health；Second purpose exists
In a kind of preparation of the symphysis unit composition of conditioning female reproductive health of offer；Third is designed to provide a kind of conditioning women life
Grow the application of the symphysis unit composition of health.
The first object of the present invention is achieved in that the symphysis unit composition for including the conditioning female reproductive health
Including prebiotics, probiotics, weight ratio is 1~10：1~10.
The second object of the present invention is achieved in that the preparation of the symphysis unit composition of conditioning female reproductive health, institute
Be added in the symphysis unit composition for the conditioning female reproductive health stated pharmaceutically acceptable auxiliary material be made powder, tablet,
Granula, liquid preparation and capsule.
The third object of the present invention is achieved in that the application of the symphysis unit composition of conditioning female reproductive health, institute
The symphysis unit composition for the conditioning female reproductive health stated is in the drug or health food for preparing preventing/treating female genital disorders
In application.
Compared with prior art, the present invention has the following technical effects：
1, symphysis unit composition of the invention is to contribute to a variety of probiotics, prebiotics proportioning combination to inhibit harmful levels of pathogens numerous
It grows, balance vaginal pH, adjust colony balance and effectively improve female reproductive health to safeguard the human body Tiny ecosystem ecological balance,
Resist pathogenic bacteria invasion；
2, symphysis unit composition of the invention can both play the physiological bacterial activity of probiotics, and cooperation prebiotics are again alternative
Ground quickly increases the quantity of probiotics, makes that probiotic action speed is fast and effect is lasting, to play probiotics and prebiotic simultaneously
The physiological function of member；The present invention also has the advantages that significant effect, quick, safe；
3, the present invention obtains the material composition proportioning of science through a large number of experiments, targetedly selects benefit according to application crowd
The optimum composition method of raw bacterium and prebiotics, by scientific and effective proportioning so that the symphysis unit composition plays maximum work(
Effect so that the present invention can not only effectively realize its effect, and selected prebiotics can effective stimulus arranged in pairs or groups it is prebiotic
Bacterium is proliferated, reasonable composition；
4, instructions of taking dosage of the invention is reasonable, and it is indefinite to effectively prevent existing probiotics preparation dosage for obvious effect
It is caused take after to no effect or take the ill effect excessively brought.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated, but is not limited in any way to the present invention,
Based on present invention teach that made by it is any transform or replace, all belong to the scope of protection of the present invention.
The symphysis unit composition of conditioning female reproductive health of the present invention includes prebiotics, probiotics, weight ratio 1
~10：1~10.
The symphysis unit composition of the conditioning female reproductive health includes prebiotics, probiotics, and weight ratio is 3~10：
1。
The symphysis unit composition of the conditioning female reproductive health includes prebiotics, probiotics, weight ratio 1：1~7.
The prebiotics include weight percent composition：It is trehalose 35~45%, xylo-oligosaccharide 5~15%, oligomeric different
Maltose 15~25%, chitosan oligosaccharide 5~15%, Siberian solomonseal rhizome polysaccharide 5~15%, tea polyphenols 5~15%.
The prebiotics include weight percent composition：It is trehalose 38~42%, xylo-oligosaccharide 8~12%, oligomeric different
Maltose 18~22%, chitosan oligosaccharide 8~12%, Siberian solomonseal rhizome polysaccharide 8~12%, tea polyphenols 8~12%.
The probiotics includes weight percent composition：The probiotics includes weight percent composition：Acidophilus breast
Bacillus 23~55%, Lactobacillus rhamnosus 5~10%, Lactobacillus delbrueckii 11~15%, lactobacillus plantarum 5~10%, Luo Yishi
Lactobacillus 5~10%, bacillus subtilis 0~14%, bacillus licheniformis 0~20%, bacillus coagulans 0~14%.
The probiotics includes weight percent composition：Lactobacillus acidophilus 23~26%, Lactobacillus rhamnosus 5~8%,
Lactobacillus delbrueckii 11~14%, lactobacillus plantarum 5~8%, lactobacillus reuteri 5~8%, bacillus subtilis 11~14%,
Bacillus licheniformis 17~20%, bacillus coagulans 11~14%.
The probiotics includes weight percent composition：Lactobacillus acidophilus 24~25%, Lactobacillus rhamnosus 6~7%,
Lactobacillus delbrueckii 12~13%, lactobacillus plantarum 6~7%, lactobacillus reuteri 6~7%, bacillus subtilis 12~13%,
Bacillus licheniformis 18~19%, bacillus coagulans 12~13%.
Be added in the symphysis unit composition of the conditioning female reproductive health pharmaceutically acceptable auxiliary material be made it is scattered
Agent, tablet, granule, liquid preparation and capsule.
The symphysis unit composition of the conditioning female reproductive health is in the drug for preparing preventing/treating female genital disorders
Or the application in health food.
The symphysis unit composition instructions of taking of the conditioning female reproductive health is 1~2 time on the one, every time 10~20g.
The entitled Lactobacillus acidophilus of Latin of the lactobacillus acidophilus.
The entitled L.rhamnosus of Latin of the Lactobacillus rhamnosus.
The entitled L.debrueckii of Latin of the Lactobacillus delbrueckii.
The entitled L.plantarum of Latin of the lactobacillus plantarum.
The entitled L.reuteri of Latin of the lactobacillus reuteri.
The entitled Bacillus subtilis of Latin of the bacillus subtilis.
The entitled B.lincheniformis of Latin of the bacillus licheniformis.
The entitled B.coagulans of Latin of the bacillus coagulans.
Embodiment 1
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 1:10.
Embodiment 2
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 10:1.
Embodiment 3
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 9:2.
Embodiment 4
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 2:9.
Embodiment 5
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 7.5:3.
Embodiment 6
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 3:7.5.
Embodiment 7
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 5:4.
Embodiment 8
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 3:1.
Embodiment 9
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 1:7.
Embodiment 10
The symphysis unit composition for improving female reproductive health includes prebiotics, probiotics, weight ratio 1:1.
Embodiment 11
The symphysis unit composition of conditioning female reproductive health as described in Example 1, the prebiotics include weight percent
Ingredient：Trehalose 35%, xylo-oligosaccharide 5%, oligoisomaltose 15%, chitosan oligosaccharide 15%, Siberian solomonseal rhizome polysaccharide 15%, tea polyphenols
15%.
Embodiment 12
The symphysis unit composition of conditioning female reproductive health as described in Example 2, the prebiotics include weight percent
Ingredient：Trehalose 45%, xylo-oligosaccharide 15%, oligoisomaltose 25%, chitosan oligosaccharide 5%, Siberian solomonseal rhizome polysaccharide 5%, tea polyphenols
5%.
Embodiment 13
The symphysis unit composition of conditioning female reproductive health as described in Example 3, the prebiotics include weight percent
Ingredient：Trehalose 38%, xylo-oligosaccharide 8%, oligoisomaltose 18%, chitosan oligosaccharide 12%, Siberian solomonseal rhizome polysaccharide 12%, tea polyphenols
12%.
Embodiment 14
The symphysis unit composition of conditioning female reproductive health as described in Example 4, the prebiotics include weight percent
Ingredient：Trehalose 42%, xylo-oligosaccharide 12%, oligoisomaltose 22%, chitosan oligosaccharide 8%, Siberian solomonseal rhizome polysaccharide 8%, tea polyphenols
8%.
Embodiment 15
The symphysis unit composition of conditioning female reproductive health as described in Example 5, the prebiotics include weight percent
Ingredient：Trehalose 45%, xylo-oligosaccharide 15%, oligoisomaltose 25%, chitosan oligosaccharide 5%, Siberian solomonseal rhizome polysaccharide 5%, tea polyphenols
5%.
Embodiment 16
The symphysis unit composition of conditioning female reproductive health as described in Example 6, the prebiotics include weight percent
Ingredient：Trehalose 35%, xylo-oligosaccharide 5%, oligoisomaltose 15%, chitosan oligosaccharide 15%, Siberian solomonseal rhizome polysaccharide 15%, tea polyphenols
15%.
Embodiment 17
The symphysis unit composition of conditioning female reproductive health as described in Example 7, the prebiotics include weight percent
Ingredient：Trehalose 42%, xylo-oligosaccharide 12%, oligoisomaltose 22%, chitosan oligosaccharide 8%, Siberian solomonseal rhizome polysaccharide 8%, tea polyphenols
8%.
Embodiment 18
The symphysis unit composition of conditioning female reproductive health as described in Example 8, the prebiotics include weight percent
Ingredient：Trehalose 38%, xylo-oligosaccharide 8%, oligoisomaltose 18%, chitosan oligosaccharide 12%, Siberian solomonseal rhizome polysaccharide 12%, tea polyphenols
12%.
Embodiment 19
The symphysis unit composition of conditioning female reproductive health as described in Example 9, the prebiotics include weight percent
Ingredient：Trehalose 40%, xylo-oligosaccharide 10%, oligoisomaltose 20%, chitosan oligosaccharide 10%, Siberian solomonseal rhizome polysaccharide 10%, tea polyphenols
10%.
Embodiment 20
The symphysis unit composition of conditioning female reproductive health as described in Example 10, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 23%, Lactobacillus rhamnosus 5%, Lactobacillus delbrueckii 11%, lactobacillus plantarum 5%, lactobacillus reuteri
8%, bacillus subtilis 14%, bacillus licheniformis 20%, bacillus coagulans 14%.
Embodiment 21
The symphysis unit composition of conditioning female reproductive health as described in Example 1, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 26%, Lactobacillus rhamnosus 8%, Lactobacillus delbrueckii 14%, lactobacillus plantarum 8%, lactobacillus reuteri
5%, bacillus subtilis 11%, bacillus licheniformis 17%, bacillus coagulans 11%.
Embodiment 22
The symphysis unit composition of conditioning female reproductive health as described in Example 2, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 24%, Lactobacillus rhamnosus 6%, Lactobacillus delbrueckii 12%, lactobacillus plantarum 6%, lactobacillus reuteri
7%, bacillus subtilis 13%, bacillus licheniformis 19%, bacillus coagulans 13%.
Embodiment 23
The symphysis unit composition of conditioning female reproductive health as described in Example 3, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 25%, Lactobacillus rhamnosus 7%, Lactobacillus delbrueckii 13%, lactobacillus plantarum 7%, lactobacillus reuteri
6%, bacillus subtilis 12%, bacillus licheniformis 18%, bacillus coagulans 12%.
Embodiment 24
The symphysis unit composition of conditioning female reproductive health as described in Example 4, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 26%, Lactobacillus rhamnosus 8%, Lactobacillus delbrueckii 14%, lactobacillus plantarum 8%, lactobacillus reuteri
5%, bacillus subtilis 11%, bacillus licheniformis 17%, bacillus coagulans 11%.
Embodiment 25
The symphysis unit composition of conditioning female reproductive health as described in Example 5, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 23%, Lactobacillus rhamnosus 5%, Lactobacillus delbrueckii 11%, lactobacillus plantarum 5%, lactobacillus reuteri
8%, bacillus subtilis 14%, bacillus licheniformis 20%, bacillus coagulans 14%.
Embodiment 26
The symphysis unit composition of conditioning female reproductive health as described in Example 6, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 25%, Lactobacillus rhamnosus 7%, Lactobacillus delbrueckii 13%, lactobacillus plantarum 7%, lactobacillus reuteri
6%, bacillus subtilis 12%, bacillus licheniformis 18%, bacillus coagulans 12%.
Embodiment 27
The symphysis unit composition of conditioning female reproductive health as described in Example 7, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 24%, Lactobacillus rhamnosus 6%, Lactobacillus delbrueckii 12%, lactobacillus plantarum 6%, lactobacillus reuteri
7%, bacillus subtilis 13%, bacillus licheniformis 19%, bacillus coagulans 13%.
Embodiment 28
The symphysis unit composition of conditioning female reproductive health as described in Example 8, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 24.5%, Lactobacillus rhamnosus 6.5%, Lactobacillus delbrueckii 12.5%, lactobacillus plantarum 6.5%, Roy
Family name's lactobacillus 6.5%, bacillus subtilis 12.5%, bacillus licheniformis 18.5%, bacillus coagulans 12.5%.
Embodiment 29
The symphysis unit composition of conditioning female reproductive health as described in Example 9, the probiotics includes weight percent
Ingredient：Lactobacillus acidophilus 55%, Lactobacillus rhamnosus 10%, Lactobacillus delbrueckii 15%, lactobacillus plantarum 10%, Luo Yishi breast bars
Bacterium 10%.
Embodiment 30
A kind of preparation of the symphysis unit composition of conditioning female reproductive health, the preparation is in symphysis described in embodiment 1
Pharmaceutically acceptable auxiliary material is added in first composition, powder is made.
Embodiment 31
A kind of preparation of the symphysis unit composition of conditioning female reproductive health, the preparation is in symphysis described in embodiment 3
Pharmaceutically acceptable auxiliary material is added in first composition, tablet is made.
Embodiment 32
A kind of preparation of the symphysis unit composition of conditioning female reproductive health, the preparation is the symphysis described in embodiment 5
Pharmaceutically acceptable auxiliary material is added in first composition, granule is made.
Embodiment 33
A kind of preparation of the symphysis unit composition of conditioning female reproductive health, the preparation is the symphysis described in embodiment 7
Pharmaceutically acceptable auxiliary material is added in first composition, liquid preparation is made.
Embodiment 34
A kind of preparation of the symphysis unit composition of conditioning female reproductive health, the preparation is the symphysis described in embodiment 9
Pharmaceutically acceptable auxiliary material is added in first composition, capsule is made.
Case 1
Perhaps certain, female, Yuanmou of Yunnan Province people, 32 years old, symptom was that frequent micturition, urgent urination, odynuria, complexion are obscure, withered and yellow, uses symphysis of the present invention
First composition capsule preparation, once a day, each 20g, after being used continuously 21 days, symptom obviously takes a turn for the better, and has rosy cheeks glossy,
It is further continued for using after 14 days, frequent micturition, urgent urination, odynuria symptom have disappeared.
Case 2
Lin, female, Honghe, Yunnan people, 27 years old, symptom was leucorrhea increasing, there is taste, and with slight pruritus vulvue, complexion is dark
Heavy, withered and yellow, using symphysis unit composition capsule preparation of the present invention, two times a day, each 10g, after being used continuously 14 days, symptom is bright
It is aobvious to take a turn for the better, it has rosy cheeks glossy, is further continued for using after 14 days, abnormal leucorrhea has taste, pruritus vulvue symptom to disappear.
Case 3
Zhao so-and-so, female, In Xishuangbanna of Yunnan people, 48 years old, symptom increased for vaginal fluid, was in mucus purulence, complexion is obscure, withered
Huang, using symphysis unit composition capsule preparation of the present invention, once a day, each 20g, after being used continuously 28 days, symptom obviously turns
It is good, it has rosy cheeks glossy, is further continued for using after 7 days, mucus purulence symptom has disappeared.
Claims (9)
1. a kind of symphysis unit composition of conditioning female reproductive health, it is characterised in that the conjunction of the conditioning female reproductive health
Raw member composition includes prebiotics, probiotics, and weight ratio is 1~10：1~10.
2. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that the conditioning
The symphysis unit composition of female reproductive health includes prebiotics, probiotics, and weight ratio is 3~10：1.
3. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that the conditioning
The symphysis unit composition of female reproductive health includes prebiotics, probiotics, weight ratio 1：1~7.
4. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that described is prebiotic
Member includes weight percent composition：Trehalose 35~45%, xylo-oligosaccharide 5~15%, oligoisomaltose 15~25%, shell are few
Sugar 5~15%, Siberian solomonseal rhizome polysaccharide 5~15%, tea polyphenols 5~15%.
5. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that described is prebiotic
Member includes weight percent composition：Trehalose 38~42%, xylo-oligosaccharide 8~12%, oligoisomaltose 18~22%, shell are few
Sugar 8~12%, Siberian solomonseal rhizome polysaccharide 8~12%, tea polyphenols 8~12%.
6. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that described is prebiotic
Bacterium bag includes weight percent composition：Lactobacillus acidophilus 23~55%, Lactobacillus rhamnosus 5~10%, Lactobacillus delbrueckii 11~
15%, lactobacillus plantarum 5~10%, lactobacillus reuteri 5~10%, bacillus subtilis 0~14%, bacillus licheniformis 0
~20%, bacillus coagulans 0~14%.
7. the symphysis unit composition of conditioning female reproductive health according to claim 1, it is characterised in that described is prebiotic
Bacterium bag includes weight percent composition：Lactobacillus acidophilus 24~25%, Lactobacillus rhamnosus 6~7%, Lactobacillus delbrueckii 12~
13%, lactobacillus plantarum 6~7%, lactobacillus reuteri 6~7%, bacillus subtilis 12~13%, bacillus licheniformis 18
~19%, bacillus coagulans 12~13%.
8. a kind of preparation of the symphysis unit composition of conditioning female reproductive health as described in claim 1~7 is any, feature
It is that pharmaceutically acceptable auxiliary material, which is added, in the symphysis unit composition of the conditioning female reproductive health is made powder, piece
Agent, granule, liquid preparation and capsule.
9. a kind of application of the symphysis unit composition of conditioning female reproductive health as described in claim 1~7 is any, feature
It is the symphysis unit composition of the conditioning female reproductive health in drug or the guarantor for preparing preventing/treating female genital disorders
Application in health food.
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| CN112206241A (en) * | 2020-10-26 | 2021-01-12 | 河南健悦生物科技有限公司 | Bacillus coagulans composition for conditioning female reproductive health and application thereof |
| US11504406B2 (en) * | 2019-09-04 | 2022-11-22 | Delta Electronics, Inc. | Probiotic and probiotic combination for inhibition of vancomycin-resistant enterococci and use thereof |
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