CN110201004A - A kind of woman's probiotic composition, preparation method, its application and feminine care products - Google Patents
A kind of woman's probiotic composition, preparation method, its application and feminine care products Download PDFInfo
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- CN110201004A CN110201004A CN201910572749.6A CN201910572749A CN110201004A CN 110201004 A CN110201004 A CN 110201004A CN 201910572749 A CN201910572749 A CN 201910572749A CN 110201004 A CN110201004 A CN 110201004A
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- lactobacillus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Abstract
The invention discloses a kind of woman probiotic composition, preparation method, its application and feminine care products, it is related to pharmaceutical technology field, specifically, the woman is able to solve the prior art there are the effective survival rates of strain low, definite value ability difference technical problem with probiotic composition, the malaise symptoms of women privates are effectively improved, vaginal pH is adjusted, restore vaginal flora balance, meanwhile having the advantages that be effectively improved the symptoms such as female gynecological inflammation such as vaginitis, pelvic inflammatory disease, cervicitis.
Description
Technical field
The present invention relates to pharmaceutical technology field, in particular to a kind of woman probiotic composition, preparation method,
It is applied and feminine care products.
Background technique
It likes hot and spicy food, stay up late, sexual life, abuse of antibiotics can all cause privates beneficial bacterium to reduce.The reduction of privates self-cleaning function,
The unbalance and bacterial invasion of flora, can all lead to gynaecological imflammation.Currently, by probiotic supplemented, adjustable vagina
The biotin of colony balance, probiotics secretion can directly inhibit the growth of harmful bacteria, adjust privates environmental pH.
Probiotics is the microorganism beneficial to human health, and the flora of human body intestinal canal, oral cavity, skin and vagina can be maintained strong
Kangping weighing apparatus, probiotic products in the market are many kinds of, very different, mainly include solid beverage, compressed tablets, capsule etc.,
However strain is less in existing product on the market, number of viable is lower, and strain colonization ability is poor, causes effect not significant.
Summary of the invention
The first object of the present invention is the provision of a kind of woman's probiotic composition, is able to solve prior art presence
Strain between generate antagonism, by the restriction of the content between specific strain and each strain, solve strain and effectively deposit
Motility rate is low, definite value ability difference technical problem, can be effectively improved the malaise symptoms of women privates, adjusts vaginal pH, restores
Vaginal flora balance.
It not only can effectively safeguard the microecology in vaginas stable state of women's Population Health, (such as antibiotic makes confrontation daily state
With) caused by transience microecology in vaginas disorder, more can be to many vaginal diseases caused by pathologic Tiny ecosystem disorder (such as
Nonspecific vaginitis disease) related symptoms have good improvement.
" woman's antibacterial powder of probiotics " is by Lactobacillus crispatus (LC12), lactobacillus plantarum (LP05), Lactobacillus rhamnosus
(LR07), four kinds of probiotics prescriptions of lactobacillus reuteri (LR19) form.The prebiotic Pseudomonas of prescription (level) selection, it is more based on team
Year accumulation the hypervariable region Chinese women microecology in vaginas 16S DNA netic module large database concept analysis, China's approved " can
Strain list for food ", and the implementation experience of international similar product, it calls the roll of the contestants in athletic events meticulously.
Wherein Lactobacillus crispatus is not only the highest lactobacillus of China's vagina abundance, and most of kind of the category
Strain can produce the metabolin of many inhibition pathogens including hydrogen peroxide, also therefore be commonly used for inhibiting women urinary tract
Inflammation and infection；Lactobacillus plantarum is the middle abundance mark Pseudomonas for being present in China's vagina, the hair widely loved by its people
Largely exist in ferment food, peculiar bacterial strain not only is used to inhibit the embodiment of vaginal pathogenic by multiple patents, to human body
The immune activation effect of itself is more applied to the clinical protocol of oncotherapy；Lactobacillus reuteri category and Lactobacillus rhamnosus
Belong to, also can human activin itself immunocompetence and inhibit colpitis, especially use progress by international multiple similar products
The production of single formulation or prescription use.
Women's Population Health can effectively be safeguarded by " woman's antibacterial powder of probiotics " that four kinds of lactobacillus prescriptions are developed
Microecology in vaginas stable state fights transience microecology in vaginas disorder caused by daily state, can be quickly extensive after antibiotic usage
The bacterium work of the multiple endogenous lactobacillus of vagina and abundance.In particular, the nonspecific vaginitis disease female caused by pathologic Tiny ecosystem disorder
Property patient intervention in use, the prescription product can effectively restore vaginal pH is horizontal, endogenous lactobacillus bacterium it is living with
Abundance simultaneously can improve related symptoms such as pruritus of vagina and secretion abnormal leucorrhea.
The second object of the present invention is the provision of a kind of preparation method of woman's probiotic composition, the preparation method energy
Enough preparing effective prepare being capable of the high woman's probiotic composition of viable bacteria amount.
The third object of the present invention is to provide a kind of woman's probiotic composition prepared using above-mentioned preparation method.
The fourth object of the present invention is to provide a kind of above-mentioned woman's probiotic composition or the preparation of above-mentioned preparation method
Application of the woman with probiotic composition in the drug for improving vaginal disease provides a kind of new way to solve women privates
Diameter.
The fifth object of the present invention is to provide a kind of feminine care products comprising has woman's probiotic composition, has
There is the advantages of capable of being effectively improved women privates malaise symptoms.
The present invention is implemented as follows:
A kind of woman's probiotic composition, according to parts by weight comprising following raw material: 25~35 parts of lactobacillus plantarums,
25~35 parts of Lactobacillus crispatus, 15~25 parts of lactobacillus reuteris and 15~25 parts of Lactobacillus rhamnosus.
In some preferred embodiments, in woman's probiotic composition, the viable count of above-mentioned lactobacillus plantarum is more than or equal to
0.6×108CFU/g；The viable count of Lactobacillus crispatus is more than or equal to 0.6 × 108CFU/g；The viable count of lactobacillus reuteri is greater than
Equal to 0.4 × 108CFU/g；The viable count of Lactobacillus rhamnosus is more than or equal to 0.4 × 108CFU/g。
Further, in some preferred embodiments, the viable count of above-mentioned lactobacillus plantarum be (0.6~0.8) ×
108CFU/g；The viable count of Lactobacillus crispatus is (0.6~0.8) × 108CFU/g；The viable count of lactobacillus reuteri be (0.4~
0.5)×108CFU/g；The viable count of Lactobacillus rhamnosus is (0.4~0.5) × 108CFU/g。
The present invention also provides a kind of preparation methods of woman's probiotic composition comprising: by 25~35 parts of plant creams
Bacillus, 25~35 parts of Lactobacillus crispatus, 15~25 parts of lactobacillus reuteris and 15~25 parts of Lactobacillus rhamnosus mixing.
In some preferred embodiments, before mixing, preparation method includes the preparation of probiotics: by probiotics strain 35
~38 DEG C are cultivated 10~14 hours, and it is spare that thalline were collected by centrifugation, and probiotics strain is Lactobacillus rhamnosus, lactobacillus plantarum, volume
Bent lactobacillus and lactobacillus reuteri；
Preferably, the preparation of probiotics includes -40 DEG C~-20 DEG C frozen drying disintegrating process of use, after mixing
Probiotic powder be broken to 80~120 mesh, obtain uniformly mixed Freeze-dry Powder of Probioctics；
Preferably, selected probiotics is the good probiotics of acid resistance, alkali resistance, bile tolerance and adhesiveness；
Preferably, the culture medium for cultivating probiotics strain is MRS culture medium.
The embodiment of the present application also provides a kind of using woman's probiotic composition made from above-mentioned preparation method.
The embodiment of the present application also provides a kind of such as above-mentioned woman probiotic composition or such as above-mentioned woman's probiotic group
The woman for closing the preparation of object preparation method is preparing the application in the drug for improving vaginal disease with probiotic composition.
It in some preferred embodiments, is for inhibiting staphylococcus aureus, Escherichia coli for improving vaginal disease
And/or the breeding of Candida albicans.
It in some preferred embodiments, is so that pH value is maintained 3.5 for improving vaginal pH for improving vaginal disease
~5.5.
The embodiment of the present application also provides a kind of feminine care products comprising above-mentioned woman's probiotic composition or on
State woman's probiotic composition of preparation method preparation.
The invention has the following advantages:
The embodiment of the invention provides a kind of woman's probiotic composition, which is able to solve existing with probiotic composition
The technical problem that there are the effective survival rates of strain is low for technology, colonization ability is poor, is effectively improved the malaise symptoms of women privates, adjusts
Vaginal pH restores vaginal flora balance, meanwhile, it is effectively improved female gynecological inflammation such as vaginitis, pelvic inflammatory disease, cervicitis
Etc. symptoms the advantages of.
The embodiment of the invention provides a kind of preparation method of woman's probiotic composition, which can simply have
Effect is prepared, the high woman's probiotic composition for being used to improve vaginal environment of viable bacteria amount.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of woman's probiotic compositions, according to parts by weight comprising following raw material:
27 parts of lactobacillus plantarums, 30 parts of Lactobacillus crispatus, 23 parts of lactobacillus reuteris and 20 parts of Lactobacillus rhamnosus.
Embodiment 2
The present embodiment provides a kind of woman's probiotic compositions, according to parts by weight comprising following raw material:
25 parts of lactobacillus plantarums, 25 parts of Lactobacillus crispatus, 15 parts of lactobacillus reuteris and 15 parts of Lactobacillus rhamnosus.
Embodiment 3
The present embodiment provides a kind of woman's probiotic compositions, according to parts by weight comprising following raw material:
30 parts of lactobacillus plantarums, 30 parts of Lactobacillus crispatus, 18 parts of lactobacillus reuteris and 18 parts of Lactobacillus rhamnosus.
Embodiment 4
The present embodiment provides a kind of preparation methods of woman's probiotic composition comprising:
Probiotics strain is cultivated 12 hours with 37 DEG C of MRS culture medium, it is spare that thalline were collected by centrifugation, and selected prebiotic strain is
Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri.
Using -20 DEG C of frozen drying disintegrating process, the mixed probiotic powder of prebiotic strain is broken to 100 mesh, is obtained
To uniformly mixed Freeze-dry Powder of Probioctics.
Selected probiotics is the good probiotics of acid resistance, alkali resistance, bile tolerance and adhesiveness.
Smashed Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri freeze-dried powder are weighed,
It is uniformly mixed, is filled in the Perle of microencapsulation probiotics, the micro- glue of every probiotics according to the important number of embodiment 2
Capsule is 0.4g.
Embodiment 5
The present embodiment provides a kind of preparation methods of woman's probiotic composition comprising:
Probiotics strain is cultivated 12 hours with 37 DEG C of MRS culture medium, it is spare that thalline were collected by centrifugation, and selected prebiotic strain is
Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri.
Using -30 DEG C of frozen drying disintegrating process, the mixed probiotic powder of prebiotic strain is broken to 120 mesh, is obtained
To uniformly mixed Freeze-dry Powder of Probioctics.
Selected probiotics is the good probiotics of acid resistance, alkali resistance, bile tolerance and adhesiveness.
Smashed Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri freeze-dried powder are weighed,
It is uniformly mixed, is filled in the Perle of microencapsulation probiotics, the micro- glue of every probiotics according to the important number of embodiment 1
Capsule is 0.4g.
Embodiment 6
The present embodiment provides a kind of preparation methods of woman's probiotic composition comprising:
Probiotics strain is cultivated 12 hours with 37 DEG C of MRS culture medium, it is spare that thalline were collected by centrifugation, and selected prebiotic strain is
Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri.
Using -40 DEG C of frozen drying disintegrating process, the mixed probiotic powder of prebiotic strain is broken to 80 mesh, is obtained
Uniformly mixed Freeze-dry Powder of Probioctics.
Selected probiotics is the good probiotics of acid resistance, alkali resistance, bile tolerance and adhesiveness.
Smashed Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri freeze-dried powder are weighed,
It is uniformly mixed, is filled in the Perle of microencapsulation probiotics, the micro- glue of every probiotics according to the important number of embodiment 3
Capsule is 0.4g.
Comparative example 1
Select 100 women with gynaecological imflammation, specific symptom is vagina privates itch, and abnormal leucorrhea is randomly divided into 2
Group.
Outer 1 woman of use-case are distinguished with the antibacterial powder of probiotics (embodiment 1, daily 0.40g) and outer use-case to 2 groups of test personnel
2 woman are with including the capsulae vacuus of placebo, daily 0.40g, example 1 and after 2 equal external application of example 1 month, carry out itch to the every person of participating in the experiment
And the investigation of abnormal leucorrhea number, investigation statistics result is referring to table 1.
1 every group of itch of table and abnormal leucorrhea personnel status
As shown in Table 1, the application uses the women of 1 woman of the embodiment antibacterial powder of probiotics, can preferably improve privates
Malaise symptoms such as itch is hard to bear, abnormal leucorrhea symptom, while woman can clean scale removal with the antibacterial powder of probiotics with sterilizing and itch-relieving, adjust
Women privates pH value is saved, vaginal flora balance is restored.
Comparative example 2
120 people of patient for suffering from bacterial vaginitis is chosen, the age is 26-55 years old, is randomly divided into 4 groups, every group of 30 people.Often
Group drinks Isodose and halves antibiosis anti-inflammatory drug tinidazole tablets (daily to take orally 0.5, once a day, 1 0.5g).
First group of 1 woman of external application embodiment antibacterial powder of probiotics, and compare 3 groups of reference examples of setting.
Probiotic composition in reference examples 1 are as follows: 27 parts of lactobacillus plantarums, 30 parts of Lactobacillus crispatus, 23 parts of bulgarian milks
Bacillus and 20 parts of lactobacillus reuteris；
2 probiotic composition of reference examples are as follows: 27 parts of lactobacillus plantarums, 30 parts of Lactobacillus crispatus, 23 parts of bulgarian milk bars
Bacterium and 20 parts of lactobacillus acidophilus；
3 probiotic composition of reference examples are as follows: 27 parts of lactobacillus plantarums, 30 parts of Lactobacillus salivarius, 23 parts of bulgarian milk bars
Bacterium and 20 parts of lactobacillus acidophilus.
It is prepared by the preparation method that embodiment 1 and 3 group reference examples are all made of embodiment 5.
Application method: woman daily one with the antibacterial powder of probiotics, vaginal plugging continues external application 3 weeks, to every subject into
Row feedback survey.
Judgment criteria
(1) effective: itch, scorching hot and secretion disappear；
(2) effectively: itch, scorching hot remission, secretion are reduced；
(3) invalid: each symptom is slightly alleviated or unchanged.
According to judgment criteria, subject is judged, evaluation result is as shown in table 2:
2 evaluation result of table
| Group | Effective (people) | Effectively (people) | (people) in vain |
| First group | 18 | 10 | 2 |
| Reference examples 1 | 15 | 12 | 3 |
| Reference examples 2 | 10 | 15 | 5 |
| Reference examples 3 | 1 | 6 | 23 |
As shown in Table 2, the patient's itch and scorching hot degree of first group of probiotics of external application of the present invention are alleviated, and secretion obviously subtracts
Few, vaginitis is effectively improved, and the patient symptom of external application reference examples 3 is not relieved, and illustrates woman of the present invention with the antibacterial powder of probiotics
Formula can be effectively improved the malaise symptoms of bacterial vaginitis, have significant curative effect to bacterial vaginitis, efficient
Up to 93.3%.
Comparative example 3
The non-pregnancy women of child-bearing age that 100 absence of vagina of experimental selection take a disease, are randomly divided into two groups, 100 volunteers
Perorally administrable antimicrobial anti-inflammatory drug tinidazole tablets 1, first group of daily external application woman antibacterial powder of probiotics (embodiment 5), and second group is every
Day external application woman antibacterial powder of probiotics (with the reference examples 1 in comparative example 2) Therapy lasted week age.
Application method: woman is daily one (0.4g) with the antibacterial powder of probiotics, vaginal plugging；Antibiosis anti-inflammatory drug is using oral stomach
Enteral administration is only taken before experiment starts once, Therapy lasted one week, and carry out feedback survey to every subject.
Judgment criteria: every volunteer's vagina microorganism composition and abundance level are measured before experiment starts, is opened in experiment
Every volunteer's vagina microorganism composition and abundance level were detected in the 1st, 3,5,7 day after beginning, counts cream in two groups of groups
Bacillus separation rate (isolate the number of lactobacillus/group in total number of persons) and average viable count in organizing.
According to judgment criteria, testing result such as the following table 3:
3 testing result of table
As shown in Table 3, the separation rate of 1 group of lactobacillus after taking antibiotic of probiotic group and reference examples all occurs bright
Aobvious to glide, viable count largely reduces, this also illustrates that antibiotic can seriously affect the normal Tiny ecosystem stable state of vagina；Subsequent
In testing result, after having used woman's antibacterial powder of probiotics, microecology in vaginas is substantially returned in third day using antibiotic
Level before, viable count be restored to before level, the separation rate of lactobacillus is also improved, under relatively, control
Due to changing the probiotics type of external addition in 1 group of example, Lactobacillus rhamnosus has changed lactobacillus bulgaricus into, the 7th
It when, organize in lactobacillus and average viable count be also relatively difficult to recover level when starting.Therefore, it is not difficult to find that woman is with prebiotic
Transience microecology in vaginas caused by foeign element (especially antibiotic) is unbalance to have good improvement to imitate to the antibacterial powder of bacterium restoring
Fruit.
Comparative example 4
Experimental selection 100 suffer from the patients of nonspecific vaginitis, this 100 volunteer is randomly divided into two groups, the
One group of daily external application, one woman antibacterial powder of probiotics (embodiment 5), second group of daily external application, one woman antibacterial powder of probiotics
(with the reference examples 2 in comparative example 2) continued for two weeks, and started four basic indexs of before and after look volunteer in experiment
(vaginal pH, secretion, lactobacillus number and itch situation), inspection result is as shown in table 4:
4 testing result of table
With table 4 it is found that before and after the use of 5 woman of the embodiment antibacterial powder of probiotics, vaginal pH is decreased obviously, is more advantageous to
The field planting of intravaginal lactic acid bacteria, while the common disease of nonspecific vaginitis, if leukorrhea is more, itch etc., which has, to be significantly improved,
In two weeks after use, Lactobacillus vaginalis number is significantly improved, and the health status of microecology in vaginas is substantially achieved improvement.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of woman's probiotic composition, which is characterized in that according to parts by weight comprising following raw material:
25~35 parts of lactobacillus plantarums, 25~35 parts of Lactobacillus crispatus, 15~25 parts of lactobacillus reuteris and 15~25 portions of mouse
Lee's sugar lactobacillus.
2. woman's probiotic composition according to claim 1, which is characterized in that in woman's probiotic composition
In, the viable count of the lactobacillus plantarum is more than or equal to 0.6 × 108CFU/g；The viable count of the Lactobacillus crispatus is more than or equal to
0.6×108CFU/g；The viable count of the lactobacillus reuteri is more than or equal to 0.4 × 108CFU/g；The Lactobacillus rhamnosus
Viable count is more than or equal to 0.4 × 108CFU/g。
3. a kind of preparation method of woman's probiotic composition, characterized in that it comprises: by 25~35 parts of lactobacillus plantarums,
25~35 parts of Lactobacillus crispatus, 15~25 parts of lactobacillus reuteris and 15~25 parts of Lactobacillus rhamnosus mixing.
4. preparation method according to claim 3, which is characterized in that before the mixing, the preparation method includes benefit
The preparation of raw bacterium: probiotics strain is cultivated 10~14 hours at 35~38 DEG C, it is spare that thalline were collected by centrifugation, selected probiotics bacterial
Kind is Lactobacillus rhamnosus, lactobacillus plantarum, Lactobacillus crispatus and lactobacillus reuteri.
5. the preparation method according to claim 4, which is characterized in that the preparation of the probiotics include -40 DEG C of use~-
Mixed probiotic powder is broken to 80~120 mesh, obtains uniformly mixed probiotics by 20 DEG C of frozen drying disintegrating process
Freeze-dried powder；
Preferably, selected probiotics is the good probiotics of acid resistance, alkali resistance, bile tolerance and adhesiveness；
Preferably, the culture medium for cultivating the probiotics strain is MRS culture medium.
6. using woman's probiotic composition as made from claim 3~5 described in any item preparation methods.
7. woman as claimed in claim 1 or 2 probiotic composition or woman's probiotic composition as claimed in claim 6
Preparing the application in the drug for improving vaginal disease.
8. application according to claim 7, which is characterized in that the improvement vaginal disease is by inhibiting golden yellow grape
The breeding of coccus, Escherichia coli and/or Candida albicans.
9. application according to claim 7, which is characterized in that the improvement vaginal disease be by improve vaginal pH,
PH value is set to maintain 3.5~5.5.
10. a kind of feminine care products, which is characterized in that it includes woman's probiotic composition as claimed in claim 1 or 2
Or woman's probiotic composition as claimed in claim 5.
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| CN111647525A (en) * | 2020-05-18 | 2020-09-11 | 深圳市华大农业应用研究院 | Composite probiotics, microbial inoculum and application of composite probiotics and microbial inoculum in preparation of microbial inoculum for preventing and treating candida albicans vaginitis |
| CN113274414A (en) * | 2021-04-08 | 2021-08-20 | 北京亿康倍尔生物科技有限公司 | Probiotics preparation for repairing and maintaining vaginal microecological balance |
| CN113384601A (en) * | 2021-07-19 | 2021-09-14 | 山东沐曦生物科技有限公司 | Composition for improving vaginal microecological balance |
| CN113384601B (en) * | 2021-07-19 | 2024-03-22 | 山东沐曦生物科技有限公司 | Composition for improving vaginal microecological balance |
| CN114053244A (en) * | 2021-11-15 | 2022-02-18 | 四川滋兴生物科技有限公司 | Preparation method of freeze-dried active factor antibacterial capsule |
| CN114921389A (en) * | 2022-07-20 | 2022-08-19 | 广东益可维生物技术有限公司 | Probiotic composition with female intestinal private part nursing and mammary gland anti-inflammatory effects and application thereof |
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