CN108324748A - 一种用于治疗支气管哮喘的中药 - Google Patents
一种用于治疗支气管哮喘的中药 Download PDFInfo
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Abstract
本发明涉及一种用于治疗支气管哮喘的中药，它是由以下重量配比的原料药材制备而成：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、鹅管石15份、僵蚕10份。临床实验证明，本发明能够安全有效治疗支气管哮喘。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗支气管哮喘的中药。
背景技术
支气管哮喘是临床上的常见病和多发病。西医治疗以抗过敏，解除气道痉挛，控制炎症为主，并配合全身或局部的糖皮质激素的应用，在哮喘急性发作期，尤其是哮喘持续状态，其作用较为明显，单哮喘是反复发作性疾病，长期应用西药支气管解痉剂有一定的副作用，中医药治疗支气管哮喘在巩固疗效，减少复发，部分甚至完全撤除激素等方面具有较为明显的优势。支气管哮喘最为常见的症状是：呼气时很困难，并有咳嗽、咯痰等症状，检查肺部时可听到吹口哨似的声音，叫“哮鸣音”。等主要临床症状。
本发明所涉及药材研究现状如下：
黄芪 【别名】绵芪、绵黄芪。【 来源 】本品为豆科植物蒙古黄芪或膜荚黄芪的干燥根。春、秋二季采挖，除去须根及根头，晒干。【性味】甘，温。【归经】归肺、脾经。【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。【用法用量】内服：煎汤，9～30g。【摘录】《中华本草》。
蛤蚧【别名】对蛤蚧、蛤蚧于、仙蟾、蚧蛇、德多、握儿、石牙。【来源】本品为壁虎科动物蛤蚧的干燥体。全年均可捕捉，除去内脏，拭净，用竹片撑开，使全体扁平顺直，低温干燥。【性味】咸，平。【归经】归肺、肾经。【功能主治】补肺益肾，纳气定喘，助阳益精。用于虚喘气促，劳嗽咳血，阳萎遗精。【用法用量】内服：煎汤，3～6g。【注意】外感风寒喘嗽忌服。【摘录】《中华本草》。
党参【别名】东党、台党、潞党、口党。【来源】本品为桔梗科植物党参、素花党参（西党参）或川党参的干燥根。秋季采挖，洗净，晒干。【性味】甘，平。【归经】归脾、肺经。【功能主治】补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。【用法用量】内服：煎汤，9-30g。【注意】不宜与藜芦同用。【摘录】《中华本草》。
防风【别名】铜芸、茴芸、茴草、百枝、闾根、百蜚、屏风、风肉。【来源】本品为伞形科植物防风的干燥根。春、秋二季采挖未抽花茎植株的根，除去须根及泥沙，晒干。【性味】辛、甘，温。【归经】归膀胱、肝、脾经。【功能主治】解表祛风，胜湿，止痉。用于感冒头痛，风湿痹痛，风疹瘙痒，破伤风。【用法用量】内服：煎汤，4.5～9g。【注意】 血虚痉急或头痛不因风邪者忌服。【摘录】《中华本草》。
白术【别名】于术、冬术、浙术、种术。【来源】本品为菊科植物白术的干燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】 健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】内服：煎汤，6～12g。【注意】 阴虚燥渴，气滞胀闷者忌服。【摘录】《中华本草》。
僵蚕【别名】白僵蚕、僵虫、天虫。【来源】本品为蚕蛾科昆虫家蚕4～5龄的幼虫感染（或人工接种）白僵菌而致死的幼虫干燥体。多于春、秋季生产，将感染白僵菌病死的蚕干燥。【性味】咸、辛，平。【归经】归肝、肺、胃经。【功能主治】祛风定惊，化痰散结。用于惊风抽搐，咽喉肿痛，皮肤瘙痒，颌下淋巴结炎，面神经麻痹。【用法用量】内服：煎汤，5～9g。【摘录】《中华本草》。
鹅管石【别名】 玉金、白丝郁金。【来源】为海产腔肠动物树珊瑚科的栎珊瑚以石灰质骨骼入药。全年可采集，敲去杂石部分取条状物即成。【性味】甘，温。【归经】归肾、肺经。【功能主治】补肺，壮阳，通乳。用于肺痨咳嗽气喘，吐血，阳痿，腰膝无力，乳汁不下等症。【用法用量】内服：煎汤，1～5g。【摘录】《全国中草药汇编》。
发明内容
本发明旨在提供一种用于治疗支气管哮喘的中药，通过选择合适的药材及其配比，达到安全有效治愈支气管哮喘的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、鹅管石15份、僵蚕10份的中药，其特征在于，它是由以下重量配比的原料药材制备而成：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、鹅管石15份、僵蚕10份
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月~2013年10月间共收集门诊及住院支气管哮喘患者70例，随机分为治疗组35例与对照组35例，治疗组男17例，女18例，病程1~11年，年龄21～55岁，平均年龄42岁；对照组男19例，病程1~12年，女16例，年龄20～55岁，平均年龄45岁。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国支气管哮喘临床专业会议的诊断标准：（1）、呼吸困难：紧随先兆症状后，出现胸闷，胸部紧迫甚至窒息感，感觉古巴胸部仿佛为重石所压迫，约10-15分钟后发生呼吸困难，并带有尖音调的哮鸣音。
（2）、咳嗽、咯痰：先兆期常因支气管粘膜过敏而引起咳嗽，先为干咳无痰，程度不等。至发作期时咳嗽往往减轻，转以喘息为主。（3）、胸痛：若哮喘发作较重、时间持续较久者可有胸痛，可能与呼吸肌过度疲劳有关。当合并气胸时，可突然出现严重的胸痛。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例1制得的胶囊剂，每日2次。疗程1个月。
对照组口吸舒利迭（沙美特罗、氟替卡松），每次1吸，每天2次口吸，疗程1个月。
3、疗效标准与治疗结果
3.1 疗效标准
以积分法评定疗效，计分方法按支气管哮喘的症状分级量化标准，按轻、中、重度分别计3、6、9分。按中医证候疗效评定标准。
临床控制：临床症状体征消失或基本消失，证候积分减少95%以上；
显效：临床症状体征明显改善，证候积分减少70%以上而低于95%；
有效：临床症状有好转，证候积分减少30%以上而低于70%；
无效：临床症状体征无明显改善，证候积分减少低于30%。
3.2 治疗结果见表1。
表1 两组疗效比较
| 组别 | n | 临床控制 | 显效 | 有效 | 无效 | 总有效率(%) | 严重不良反应例 |
| 治疗组 | 35 | 13 | 12 | 8 | 2 | 94.28% | 0 |
| 对照组 | 35 | 8 | 8 | 10 | 9 | 74.28% | 0 |
可见，本发明制得的药物能够安全有效治疗支气管哮喘，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：黄芪20克、党参10克、白术10克、防风6克、蛤蚧6克、鹅管石15克、僵蚕10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗支气管哮喘。口服，每日分早晚两次服用。
具体实施例2
称取：黄芪20克、党参10克、白术10克、防风6克、蛤蚧6克、鹅管石15克、僵蚕10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗支气管哮喘。口服，每日分早晚两次服用。
具体实施例3
称取：黄芪20克、党参10克、白术10克、防风6克、蛤蚧6克、鹅管石15克、僵蚕10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗支气管哮喘。口服，每日分早晚两次服用。
Claims (4)
1.一种用于治疗支气管哮喘的中药，其特征在于，它是由以下重量配比的原料药材制备而成：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、僵蚕10份。
2.如权利要求1所述的用于支气管哮喘的中药，其特征在于，其制备方法为：称取：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、僵蚕10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的用于治疗支气管哮喘的中药，其特征在于，其制备方法为：称取：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、僵蚕10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的用于治疗支气管哮喘的中药，其特征在于，其制备方法为：称取：黄芪20份、党参10份、白术10份、防风6份、蛤蚧6份、僵蚕10份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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