CN108311062A - A kind of efficient wet mixing granulation system of particulate species drug - Google Patents
A kind of efficient wet mixing granulation system of particulate species drug Download PDFInfo
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- CN108311062A CN108311062A CN201810343481.4A CN201810343481A CN108311062A CN 108311062 A CN108311062 A CN 108311062A CN 201810343481 A CN201810343481 A CN 201810343481A CN 108311062 A CN108311062 A CN 108311062A
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- 239000003814 drug Substances 0.000 title claims abstract description 91
- 238000002156 mixing Methods 0.000 title claims abstract description 51
- 229940079593 drug Drugs 0.000 title claims abstract description 36
- 238000005469 granulation Methods 0.000 title claims abstract description 17
- 230000003179 granulation Effects 0.000 title claims abstract description 17
- 206010001497 Agitation Diseases 0.000 claims abstract description 24
- 238000013019 agitation Methods 0.000 claims abstract description 24
- 238000001035 drying Methods 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 14
- 238000010438 heat treatment Methods 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims description 84
- 239000000843 powder Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 238000005192 partition Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 239000010453 quartz Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 4
- 235000013599 spices Nutrition 0.000 abstract description 2
- 241000894007 species Species 0.000 description 6
- 238000010079 rubber tapping Methods 0.000 description 4
- 229940126589 solid medicine Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 244000228957 Ferula foetida Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 238000004663 powder metallurgy Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
- B01F33/831—Devices with consecutive working receptacles, e.g. with two intermeshing tools in one of the receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/834—Mixing in several steps, e.g. successive steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
- B01F33/83612—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by crushing or breaking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8364—Mixing plants; Combinations of mixers combining mixing with other treatments with drying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/02—Crushing or disintegrating by roller mills with two or more rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/28—Details
- B02C4/30—Shape or construction of rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention discloses a kind of efficient wet mixing granulation systems of particulate species drug, including transport platform, transport platform is provided at both ends with drive shaft, the bottom of transport platform is fixed with support leg, the bottom end of support leg is fixed with support base, drying box and grain forming case are provided at the top of transport platform, drying box is internally provided with heating board, grain forming case is internally provided with grain forming plate, the bottom of grain forming plate is provided with grain forming hole, the side of grain forming plate is provided with stripper plate, the side of stripper plate is fixed with telescopic rod, gluey discharge nozzle is provided at the top of grain forming case, grain forming case is connected with secondary agitation case by gluey discharge nozzle, spice is mixed again, so the ingredient between drug can be sufficiently mixed, and then improve the quality for producing rear medicine particle.
Description
Technical field
The present invention relates to pharmaceutical equipment technical field, the efficient wet mixing granulation system of specially a kind of particulate species drug
System.
Background technology
Efficient wet mixing granulation function is fast and effeciently stirred dry medicinal powder, then produces the wet-milling grain of homogeneous,
Efficiently, quickly, homogeneous, so that mixing and one step of granulation is completed, can be improved compared with original stirring plus swing granulation mode
As many as four times of work efficiency, thus more traditional granulating process equipment has significant superiority is to meet the ideal granulations of GMP standards to set
It is standby, it is suitable for the industries such as pharmacy, chemical industry, food, powder metallurgy, cosmetics, dyestuff, detergent.
But existing medicine granulating machine is mostly that can only be processed the drug of crushed into powder state, can not be incited somebody to action
The solid drugs not crushed are processed, it is therefore desirable to be spent additional time and be crushed solid-state drug, and existing device
Solid-state drug, which can only be processed, cannot process liquid medicine, also be exactly existing device to reduce the working efficiency of pharmacy
Only once stirred in whipping process, therefore it is uneven to lead to make the drug ingedient come, so as to cause medicine particle at
Quality is bad.
So how to design a kind of efficient wet mixing granulation system of particulate species drug, becoming us will currently solve
The problem of.
Invention content
The purpose of the present invention is to provide a kind of efficient wet mixing granulation systems of particulate species drug, to solve the above-mentioned back of the body
The low problem low with drug quality of working efficiency is proposed in scape technology.
To achieve the above object, the present invention provides the following technical solutions：The efficient wet mixing system of a kind of particulate species drug
Grain system, including transport platform, the transport platform are provided at both ends with drive shaft, and the bottom of the transport platform is fixed with support leg,
The bottom end of the support leg is fixed with support base, and drying box and grain forming case are provided at the top of the transport platform, described
Drying box is internally provided with heating board, and the grain forming case is internally provided with grain forming plate, the grain forming plate
Bottom be provided with grain forming hole, the side of the grain forming plate is provided with stripper plate, and the side of the stripper plate is fixed
There is telescopic rod, gluey discharge nozzle is provided at the top of the grain forming case, the grain forming case is connected by gluey discharge nozzle
It is connected to secondary agitation case, detent box is installed at the top of the secondary agitation case, the secondary agitation case is internally provided with system
Turn axis, the detent box are connected with swingle by braking shaft, and the outer surface of the swingle is fixed with stirring blade, institute
The side for stating secondary agitation case is connected with solid-liquid mixing case by once stirring discharge port, and case is mixed in the solid-liquid
Top is provided with mixer cone, and the side of the mixer cone is fixed with powder conveying plate and liquid discharge nozzle, and the liquid goes out
One end of expects pipe is connected with liquid medicine blending bin, and liquid funnel, the liquid are provided at the top of the liquid medicine blending bin
State drug blending bin is internally provided with engine shaft, and one end of the engine shaft is equipped with mixing shaft, described mixed
Hybrid blade is fixed on the outside of hing straps, the center position of the engine shaft is provided with engine, the engine
Side is provided with solid-state medicament disintegrating case, and the other end of the engine shaft is connected with connection shaft and crushing rotary drum, described
The side of solid-state medicament disintegrating case is provided with powder discharge port, and solid-state funnel is provided at the top of the solid-state medicament disintegrating case,
The bottom that case is mixed in the liquid medicine blending bin, solid-state medicament disintegrating case and solid-liquid is both provided with partition board.
Further, the support base is provided with multiple, and the support base is closely welded with support leg.
Further, the heating board is process by quartz material, and the heating board is fitted closely in drying box
On inner wall.
Further, the telescopic rod is composed of two sections of supporting rods, and is flexibly connected between the supporting rod of both ends.
Further, the liquid discharge port is horizontal by 45 degree of angles, and the liquid discharge nozzle is through setting
In the side of liquid medicine blending bin.
Further, the crushing rotary drum is in " cylinder ", and the outer surface of the crushing rotary drum is provided with multiple sawtooth
Particle.
Compared with prior art, the beneficial effects of the invention are as follows：The efficient wet mixer-granulator of this kind of granule medicament,
It is improved and increases on the basis of original granulator, this kind of device is provided with solid-state medicament disintegrating machine and liquid medicine mixing
Case, when work, staff only needs blocky drug being put into solid-state medicament disintegrating case by solid-state funnel, works at the same time people
Member pours into pure water or liquid medicine in liquid medicine blending bin by liquid funnel, and engine band passes through engine at this time
Shaft drives connection shaft rotation, and being then connected to shaft can drive crushing rotary drum to run at high speed, when solid medicine touches crushing
When sawtooth particle on roller, since the sawtooth particle on outer surface of cylinder can squeeze solid medicine moment, excessive compression
As a result it is exactly that solid fragmentation is become powdered, then entering solid-liquid by powder discharge port and powder conveying plate is mixed
In case, at the same engine shaft drive mixing shaft run at high speed, then mix shaft drive hybrid blade run at high speed, just into
Enter between each ingredient of liquid medicine of liquid medicine blending bin and highly mix, carries out basis for next process, then mix
The liquid medicine crossed enters solid-liquid by liquid discharge nozzle and is mixed in case, in addition such work process not only saves
Time and manpower is spent to go to crush the time of solid-state drug, additionally it is possible to which solid-liquid drug is processed together, therefore improves device
Working efficiency, this kind of device be provided with solid-liquid and case and secondary agitation case, powder pharmaceutical after crushing and mixing be mixed
When the liquid medicine crossed enters solid-liquid mixing case by mixer cone, case is mixed in solid-liquid can be tentatively by solid-liquid drug
It is tentatively mixed, but is only once stirred it is possible that solid-liquid mixes non-uniform phenomenon, therefore this kind of device setting
There is secondary agitation case, is entered in secondary agitation case when case is mixed from solid-liquid in stirring material by once stirring tapping channel
When, brake can drive swingle high speed rotation, subsequent swingle that stirring blade can be driven to carry out high speed rotation by braking shaft
Turn to be stirred, will go into material in secondary agitation case and carry out secondary agitation, spice is mixed again, thus drug it
Between ingredient can be sufficiently mixed, and then improve the quality for producing rear medicine particle.
Description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the drying box and grain forming case cross-sectional view of the present invention；
Fig. 3 is the secondary agitation case cross-sectional view of the present invention；
Fig. 4 is the liquid medicine blending bin cross-sectional view of the present invention；
Fig. 5 is the solid-state medicament disintegrating case cross-sectional view of the present invention.
In figure：1, support base, 2, support leg, 3, transport platform, 4, drive shaft, 5, finished product discharge port, 6, drying box, 601,
Heating board, 7, grain forming case, 701, grain forming plate, 702, grain forming hole, 703, telescopic rod, 704, stripper plate, 8, glue
Shape discharge nozzle, 9, secondary agitation case, 901, braking shaft, 902, swingle, 903, stirring blade, 10, detent box, 11, primary
Stir tapping channel, 12, solid-liquid be mixed case, 13, mixer cone, 14, powder conveying plate, 15, liquid discharge nozzle, 16, hair
Motivation, 17, liquid funnel, 18, liquid medicine blending bin, 1801, mixing shaft, 1802, hybrid blade, 19, solid-state funnel,
20, solid-state medicament disintegrating case, 2001, connection shaft, 2002, engine shaft, 2003, crushing rotary drum, 2004, powder discharging
Mouthful, 21, partition board.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
- 5 are please referred to Fig.1, the present invention provides a kind of technical solution：A kind of efficient wet mixing granulation system of particulate species drug
System, including support base 1, support leg 2, transport platform 3, drive shaft 4, finished product discharge port 5, drying box 6, heating board 601, particle at
Molding box 7, grain forming plate 701, grain forming hole 702, telescopic rod 703, stripper plate 704, gluey discharge nozzle 8, secondary agitation case
9, shaft 901, swingle 902, stirring blade 903, detent box 10, primary stirring tapping channel 11, solid-liquid is braked to be mixed
Case 12, mixer cone 13, powder conveying plate 14, liquid discharge nozzle 15, engine 16, liquid funnel 17, liquid medicine blending bin
18, shaft 1801, hybrid blade 1802, solid-state funnel 19, solid-state medicament disintegrating case 20, connection shaft 2001, engine are mixed
Shaft 2002, crushing rotary drum 2003, powder discharge port 2004 and partition board 21, transport platform 3 are provided at both ends with drive shaft 4, conveying
The bottom of platform 3 is fixed with support leg 2, and the bottom end of support leg 2 is fixed with support base 1, and support base 1 is provided with multiple, and props up
It supports pedestal 1 closely to weld with support leg 2, and then a stable environment is provided and is worked to device, the top of transport platform 3 is provided with
Drying box 6 and grain forming case 7, drying box 6 are internally provided with heating board 601, heating board 601 processed by quartz material and
At, and heating board 601 is fitted closely on the inner wall of drying box 6, and then medicine particle after molding is subjected to drying plastotype,
Grain shaping box 7 is internally provided with grain forming plate 701, and the bottom of grain forming plate 701 is provided with grain forming hole 702,
The side of grain profiled sheeting 701 is provided with stripper plate 704, and the side of stripper plate 704 is fixed with telescopic rod 703, and telescopic rod 703 is by two
Section supporting rod is composed, and is flexibly connected between the supporting rod of both ends, and then stripper plate 704 is pushed to carry out extruding colloidal drug,
The top of grain forming case 7 is provided with gluey discharge nozzle 8, and grain forming case 7 is connected with secondary agitation case by gluey discharge nozzle 8
9, the top of secondary agitation case 9 is equipped with detent box 10, and secondary agitation case 9 is internally provided with braking shaft 901, detent box 10
It is connected with swingle 902 by braking shaft 901, the outer surface of swingle 902 is fixed with stirring blade 903, secondary agitation case 9
Side by once stir discharge port 11 be connected with solid-liquid be mixed case 12, solid-liquid be mixed case 12 top be provided with
The side of mixer cone 13, mixer cone 13 is fixed with powder conveying plate 14 and liquid discharge nozzle 15, liquid discharge port 15 and water
Plane is in 45 degree of angles, and liquid discharge nozzle 15 is disposed through the side of liquid medicine blending bin 18, and then utilizes gravity
Liquid medicine is flowed into solid-liquid and is mixed in case 12 by potential energy, and one end of liquid discharge nozzle 15 is connected with liquid medicine blending bin
18, the top of liquid medicine blending bin 18 is provided with liquid funnel 17, and liquid medicine blending bin 18 is internally provided with engine
One end of shaft 2002, engine shaft 2002 is equipped with mixing shaft 1801, and the outside of hybrid blade 1801 is fixed with mixing
The center position of blade 1802, engine shaft 2002 is provided with engine 16, and the side of engine 16 is provided with solid-state drug
The other end of crush box 20, engine shaft 2002 is connected with connection shaft 2001 and crushing rotary drum 2003, crushing rotary drum 2003
The outer surface of " cylinder ", and crushing rotary drum 2003 is provided with multiple sawtooth particles, and then by solid-state medicament disintegrating at powder
Shape is conducive to next process, and the side of solid-state medicament disintegrating case 20 is provided with powder discharge port 2004, solid-state medicament disintegrating case 20
Top be provided with solid-state funnel 19, case 12 is mixed in liquid medicine blending bin 18, solid-state medicament disintegrating case 20 and solid-liquid
Bottom is both provided with partition board 21.
Operation principle：First, whether each component capabilities of staff's check device are normal, if finding some component capabilities not
When normal, it should repair in time or with changing, after each component capabilities of device to be checked are normal, device is placed in specified work
Make place and open power switch, subsequent staff only needs blocky drug being put into solid-state drug powder by solid-state funnel 19
In broken case 20, works at the same time personnel and pure water or liquid medicine are poured into liquid medicine blending bin 18 by liquid funnel 17
Interior, 16 band of engine drives connection shaft 2001 to rotate by engine shaft 2002 at this time, and being then connected to shaft 2001 can band
Dynamic crushing rotary drum 2003 runs at high speed, when solid medicine touches the sawtooth particle on crushing rotary drum 2003, due to roller outside
Sawtooth particle on surface can squeeze solid medicine moment, and the result of excessive compression is exactly that solid fragmentation is become powdered,
Then enter solid-liquid by powder discharge port 2004 and powder conveying plate 14 to be mixed in case 12, while engine shaft 2002
It drives mixing shaft 1801 to run at high speed, then mixes shaft 1801 and hybrid blade 1802 is driven to run at high speed, will go into liquid
It is highly mixed between each ingredient of liquid medicine of state drug blending bin 18, carries out basis for next process, then mixed
Liquid medicine enters solid-liquid by liquid discharge nozzle 15 and is mixed in case 12, powder pharmaceutical after crushing and mixes
When liquid medicine enters solid-liquid mixing case 12 by mixer cone 13, case 12 is mixed in solid-liquid can be tentatively by solid-liquid medicine
Product are tentatively mixed, but are only once stirred it is possible that solid-liquid mixes non-uniform phenomenon, therefore this kind of device is set
It is equipped with secondary agitation case 9, secondary stir is entered by once stirring tapping channel 11 when case 12 is mixed from solid-liquid in stirring material
When mixing in case 9, brake 10 can drive 902 high speed rotation of swingle, subsequent swingle 902 that can drive by braking shaft 901
Stirring blade 903 carries out high speed rotation and is stirred, and the material that will go into secondary agitation case carries out secondary agitation, finally, glue
Shape drug is entered by gluey discharge nozzle 8 in grain forming case 7, and the telescopic rod 703 in grain forming case 7 pushes stripper plate 704
Gluey drug is squeezed, gluey drug can become particle from the grain forming hole 702 of 701 bottom of grain forming plate and go out at this time
Come, side drying box 6 is then entered by transport platform 3, heating board 601 can give off heat is dried modeling by medicine particle
Shape, last staff collect finished product from finished product discharge port 5.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of efficient wet mixing granulation system of particulate species drug, including transport platform（3）, it is characterised in that：The conveying
Platform（3）Be provided at both ends with drive shaft（4）, the transport platform（3）Bottom be fixed with support leg（2）, the support leg（2）'s
Bottom end is fixed with support base（1）, the transport platform（3）Top be provided with drying box（6）With grain forming case（7）, described
Drying box（6）Be internally provided with heating board（601）, the grain forming case（7）Be internally provided with grain forming plate
（701）, the grain forming plate（701）Bottom be provided with grain forming hole（702）, the grain forming plate（701）One
Side is provided with stripper plate（704）, the stripper plate（704）Side be fixed with telescopic rod（703）, the grain forming case（7）
Top be provided with gluey discharge nozzle（8）, the grain forming case（7）Pass through gluey discharge nozzle（8）It is connected with secondary agitation case
（9）, the secondary agitation case（9）Top detent box is installed（10）, the secondary agitation case（9）Be internally provided with braking
Shaft（901）, the detent box（10）By braking shaft（901）It is connected with swingle（902）, the swingle（902）'s
Outer surface is fixed with stirring blade（903）, the secondary agitation case（9）Side by once stirring discharge port（11）It is connected with
Case is mixed in solid-liquid（12）, the solid-liquid mixing case（12）Top be provided with mixer cone（13）, the stirring leakage
Bucket（13）Side be fixed with powder conveying plate（14）With liquid discharge nozzle（15）, the liquid discharge nozzle（15）One end connection
There is liquid medicine blending bin（18）, the liquid medicine blending bin（18）Top be provided with liquid funnel（17）, the liquid
Drug blending bin（18）Be internally provided with engine shaft（2002）, the engine shaft（2002）One end be equipped with it is mixed
Close shaft（1801）, the hybrid blade（1801）Outside be fixed with hybrid blade（1802）, the engine shaft
（2002）Center position be provided with engine（16）, the engine（16）Side be provided with solid-state medicament disintegrating case
（20）, the engine shaft（2002）The other end be connected with connection shaft（2001）And crushing rotary drum（2003）, described solid
State medicament disintegrating case（20）Side be provided with powder discharge port（2004）, the solid-state medicament disintegrating case（20）Top setting
There is solid-state funnel（19）, the liquid medicine blending bin（18）, solid-state medicament disintegrating case（20）Case is mixed with solid-liquid（12）
Bottom be both provided with partition board（21）.
2. a kind of efficient wet mixing granulation system of particulate species drug according to claim 1, it is characterised in that：It is described
Support base（1）It is provided with multiple, and the support base（1）With support leg（2）Close welding.
3. a kind of efficient wet mixing granulation system of particulate species drug according to claim 1, it is characterised in that：It is described
Heating board（601）It is process by quartz material, and the heating board（601）It fits closely in drying box（6）Inner wall on.
4. a kind of efficient wet mixing granulation system of particulate species drug according to claim 1, it is characterised in that：It is described
Telescopic rod（703）It is composed of two sections of supporting rods, and is flexibly connected between the supporting rod of both ends.
5. a kind of efficient wet mixing granulation system of particulate species drug according to claim 1, it is characterised in that：It is described
Liquid discharge port（15）Horizontal by 45 degree of angles, and the liquid discharge nozzle（15）It is disposed through liquid medicine mixing
Case（18）Side.
6. a kind of efficient wet mixing granulation system of particulate species drug according to claim 1, it is characterised in that：It is described
Crushing rotary drum（2003）In " cylinder ", and the crushing rotary drum（2003）Outer surface be provided with multiple sawtooth particles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810343481.4A CN108311062A (en) | 2018-04-17 | 2018-04-17 | A kind of efficient wet mixing granulation system of particulate species drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810343481.4A CN108311062A (en) | 2018-04-17 | 2018-04-17 | A kind of efficient wet mixing granulation system of particulate species drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108311062A true CN108311062A (en) | 2018-07-24 |
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| CN201810343481.4A Pending CN108311062A (en) | 2018-04-17 | 2018-04-17 | A kind of efficient wet mixing granulation system of particulate species drug |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109663534A (en) * | 2019-02-19 | 2019-04-23 | 长风药业股份有限公司 | It is a kind of for prepare sucking preparation second batch tank |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205163661U (en) * | 2015-11-10 | 2016-04-20 | 北京长峰金鼎科技有限公司 | Medicine granule production line |
| CN208482400U (en) * | 2018-04-17 | 2019-02-12 | 江西铜鼓仁和制药有限公司 | A kind of efficient wet mixer-granulator of particulate species drug |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205163661U (en) * | 2015-11-10 | 2016-04-20 | 北京长峰金鼎科技有限公司 | Medicine granule production line |
| CN208482400U (en) * | 2018-04-17 | 2019-02-12 | 江西铜鼓仁和制药有限公司 | A kind of efficient wet mixer-granulator of particulate species drug |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109663534A (en) * | 2019-02-19 | 2019-04-23 | 长风药业股份有限公司 | It is a kind of for prepare sucking preparation second batch tank |
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Application publication date: 20180724 |