CN108310474A - A kind of medical body cavity imports lubricating fluid and preparation method thereof - Google Patents
A kind of medical body cavity imports lubricating fluid and preparation method thereof Download PDFInfo
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- CN108310474A CN108310474A CN201810165625.1A CN201810165625A CN108310474A CN 108310474 A CN108310474 A CN 108310474A CN 201810165625 A CN201810165625 A CN 201810165625A CN 108310474 A CN108310474 A CN 108310474A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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Abstract
The present invention provides a kind of medical body cavities to import lubricating fluid and preparation method thereof.Preparation method is as follows：（1）Brazil wax, lauryl sodium sulfate, pentaerythritol stearate are added in the water of 5 times of parts by weight, heating stirring to solution is uniformly mixed；（2）Polyethylene glycol oxide, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and are stirred evenly；（3）Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate be added to step under agitation（2）Solution in, high-speed stirred emulsification is uniform；（4）The pH to 4.0 7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.The medical body cavity of the present invention imports lubricating fluid and imports conveniently, reduces the damage of mucosal tissue, mitigates the pain of patient.
Description
Technical field
The present invention relates to field of medical materials, and in particular to a kind of medical body cavity imports lubricating fluid and preparation method thereof.
Background technology
It is that one kind provides lubrication assistant in clinic diagnosis or surgical procedure for all kinds of instruments that medical body cavity, which imports lubricating fluid,
Water gelling agent, mucilage and mineral oil, be mainly used for human body natural's cavity intubation or endoscope lubrication, operation suture thread
Lubrication, the lubrication etc. of the lubrication of gynecologial examination instrument and stapler.Raising with medical consultations technology and " people-oriented "
Modern Nursing theory is popularized, and the performance that doctor and patient imports medical body cavity lubricating fluid made higher requirement.
But clinically the lubricant properties of cavity endoscope-use are single in practical application at present, mostly use silicone oil, glycerine, atoleine
Deng, and these drugs can only play lubricating action, not have local anaesthesia and good lubricity, patient is difficult to receive.In clinic
It has also been found that the dispersion of lubricant is uneven in use, preparation is sticky, poorly water-soluble, uneven, and transparency is inadequate, is easily formed after use
The cement of block solid fraction is attached on the tube walls such as alimentary canal, blocks lesions position instead, influences the accuracy checked or missing inspection.Make
With in engineering, conduit and surgical instrument and it is mucocutaneous between friction, be allowed to import difficult, the damage of mucosal tissue, to disease
People brings unnecessary pain.
Invention content
Technical problems to be solved：The object of the present invention is to provide a kind of medical body cavities to import lubricating fluid, and it is convenient to import, and subtracts
The damage of small mucosal tissue mitigates the pain of patient.
Technical solution：A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：Polyethylene glycol oxide
0.5-1.5 parts, 1-4 parts of diisobutyl carbinol (DIBC), 1.6-3.2 parts of Brazil wax, 1.2-2.5 parts of lauryl sodium sulfate, season penta
3-6 parts of tetrol stearate, 1.5-3.5 parts of Avocado Oil, 1.2-3.2 parts of Chinese tallow, 1-4 parts of sodium hydroxybutyrate, methyl hydroxybenzoate 0.5-
1.2 parts, 5-10 parts of allantoin, 1-5 parts of mannitol, 0.2-1 parts of magnesium sulfate, 2-3 parts of castor oil poly- hydrocarbon oxygen ester, 76-92 parts of water.
It is further preferred that a kind of medical body cavity imports lubricating fluid, it is prepared by weight by following component：
0.8-1.2 parts of polyethylene glycol oxide, 2-3 parts of diisobutyl carbinol (DIBC), 2-2.8 parts of Brazil wax, lauryl sodium sulfate 1.5-2.1
Part, 4-5 parts of pentaerythritol stearate, 2.1-2.8 parts of Avocado Oil, 1.5-2.6 parts of Chinese tallow, 2-3 parts of sodium hydroxybutyrate, oxybenzene first
0.7-1 parts of ester, 6-8 parts of allantoin, 2-4 parts of mannitol, 0.4-0.8 parts of magnesium sulfate, 2-3 parts of castor oil poly- hydrocarbon oxygen ester, water 80-88
Part.
Above-mentioned medical body cavity imports the preparation method of lubricating fluid, includes the following steps：
（1）Brazil wax, lauryl sodium sulfate, pentaerythritol stearate are added in the water of 5 times of parts by weight, are heated to
85-95 DEG C, stirring to solution is uniformly mixed；
（2）Polyethylene glycol oxide, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and are stirred evenly,
Whipping temp is 60-70 DEG C；
（3）Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate stirring
Step is added under the conditions of mixing（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 1500-2500r/min, emulsification
Time is 40min；
（4）The pH to 4.0-7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Further, a kind of medical body cavity imports the preparation method of lubricating fluid, the step（1）Middle heating temperature
It is 90 DEG C.
Further, a kind of medical body cavity imports the preparation method of lubricating fluid, the step（2）Middle temperature is
63-67℃。
Further, a kind of medical body cavity imports the preparation method of lubricating fluid, the step（3）Middle mixing speed
For 1800-2400r/min.
Further, a kind of medical body cavity imports the preparation method of lubricating fluid, the step（4）Middle pH is 6.5-
7.5。
Advantageous effect：The medical body cavity importing lubricating fluid coefficient of kinetic friction of the present invention is low, and dynamic viscosity is low, lubricant effect
It is good, the multiple use of clinical application can be met, be suitable for the lubrication assistant of partes corporis humani position, lubricating fluid neck is imported in medical body cavity
Domain has boundless application prospect.
Specific implementation mode
Embodiment 1
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：0.5 part of polyethylene glycol oxide, two isobutyls
1 part of base methanol, 3.2 parts of Brazil wax, 2.5 parts of lauryl sodium sulfate, 3 parts of pentaerythritol stearate, Avocado Oil 1.5
Part, 3.2 parts of Chinese tallow, 1 part of sodium hydroxybutyrate, 0.5 part of methyl hydroxybenzoate, 5 parts of allantoin, 5 parts of mannitol, 1 part of magnesium sulfate, castor oil
Poly- 2 parts of hydrocarbon oxygen ester, 76 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 85 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 70 DEG C；（3）
Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate is in stirring condition
Under be added to step（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 1500r/min, emulsification times 40min；
（4）The pH to 4.0 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Embodiment 2
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：1.5 parts of polyethylene glycol oxide, two isobutyls
4 parts of base methanol, 1.6 parts of Brazil wax, 1.2 parts of lauryl sodium sulfate, 6 parts of pentaerythritol stearate, Avocado Oil 3.5
Part, 1.2 parts of Chinese tallow, 4 parts of sodium hydroxybutyrate, 1.2 parts of methyl hydroxybenzoate, 10 parts of allantoin, 1 part of mannitol, 0.2 part of magnesium sulfate, castor
3 parts of the poly- hydrocarbon oxygen ester of sesame oil, 92 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 95 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 60 DEG C；（3）
Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate is in stirring condition
Under be added to step（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 2500r/min, emulsification times 40min；
（4）The pH to 7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Embodiment 3
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：0.8 part of polyethylene glycol oxide, two isobutyls
2 parts of base methanol, 2 parts of Brazil wax, 1.5 parts of lauryl sodium sulfate, 5 parts of pentaerythritol stearate, 2.8 parts of Avocado Oil,
1.5 parts of Chinese tallow, 2 parts of sodium hydroxybutyrate, 0.7 part of methyl hydroxybenzoate, 8 parts of allantoin, 2 parts of mannitol, 0.4 part of magnesium sulfate, castor oil
Poly- 2 parts of hydrocarbon oxygen ester, 80 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 90 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 63 DEG C；（3）
Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate is in stirring condition
Under be added to step（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 1800r/min, emulsification times 40min；
（4）The pH to 6.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Embodiment 4
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：1.2 parts of polyethylene glycol oxide, two isobutyls
3 parts of base methanol, 2.8 parts of Brazil wax, 2.1 parts of lauryl sodium sulfate, 4 parts of pentaerythritol stearate, Avocado Oil 2.1
Part, 2.6 parts of Chinese tallow, 3 parts of sodium hydroxybutyrate, 1 part of methyl hydroxybenzoate, 6 parts of allantoin, 4 parts of mannitol, 0.8 part of magnesium sulfate, castor oil
Poly- 3 parts of hydrocarbon oxygen ester, 88 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 90 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 67 DEG C；（3）
Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate is in stirring condition
Under be added to step（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 2400r/min, emulsification times 40min；
（4）The pH to 7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Embodiment 5
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：1 part of polyethylene glycol oxide, diisobutyl
2.5 parts of methanol, 2.4 parts of Brazil wax, 1.8 parts of lauryl sodium sulfate, 4.5 parts of pentaerythritol stearate, Avocado Oil 2.4
Part, 2.2 parts of Chinese tallow, 2.5 parts of sodium hydroxybutyrate, 0.8 part of methyl hydroxybenzoate, 7 parts of allantoin, 3 parts of mannitol, 0.6 part of magnesium sulfate, castor
2.5 parts of the poly- hydrocarbon oxygen ester of sesame oil, 85 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 90 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 67 DEG C；（3）
Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate is in stirring condition
Under be added to step（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 2200r/min, emulsification times 40min；
（4）The pH to 7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
Comparative example 1
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：0.5 part of polyethylene glycol oxide, two isobutyls
1 part of base methanol, 1.5 parts of Avocado Oil, 3.2 parts of Chinese tallow, 1 part of sodium hydroxybutyrate, 0.5 part of methyl hydroxybenzoate, 5 parts of allantoin, mannitol 5
Part, 1 part of magnesium sulfate, 2 parts of the poly- hydrocarbon oxygen ester of castor oil, 76 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）Polyethylene glycol oxide, diisobutyl carbinol (DIBC), allantoin,
Mannitol, magnesium sulfate, which are added to the water, to stir evenly, and whipping temp is 70 DEG C；（2）Avocado Oil, Chinese tallow, castor oil are gathered successively
Hydrocarbon oxygen ester, sodium hydroxybutyrate, methyl hydroxybenzoate are added to step under agitation（1）Solution in, high-speed stirred emulsification is uniform, stirs
It is 1500r/min, emulsification times 40min to mix speed；（4）The pH to 4.0 of emulsion is adjusted to get profit with 0.5M sodium hydroxides
Synovia.
Comparative example 2
A kind of medical body cavity importing lubricating fluid, is prepared by weight by following component：1.5 parts of polyethylene glycol oxide, two isobutyls
4 parts of base methanol, 1.6 parts of Brazil wax, 1.2 parts of lauryl sodium sulfate, 6 parts of pentaerythritol stearate, sodium hydroxybutyrate 4
Part, 1.2 parts of methyl hydroxybenzoate, 10 parts of allantoin, 1 part of mannitol, 0.2 part of magnesium sulfate, 3 parts of the poly- hydrocarbon oxygen ester of castor oil, 92 parts of water.
The preparation method that above-mentioned medical body cavity imports lubricating fluid is：（1）By Brazil wax, lauryl sodium sulfate, season
Penta tetrol stearate is added in the water of 5 times of parts by weight, is heated to 95 DEG C, stirring to solution is uniformly mixed；（2）By polyoxyethylene
Alkene, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and stir evenly, and whipping temp is 60 DEG C；（3）
Successively by step（1）The poly- hydrocarbon oxygen ester of solution castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate be added to step under agitation（2）
Solution in, high-speed stirred emulsification is uniform, mixing speed 2500r/min, emulsification times 40min；（4）With 0.5M hydroxides
Sodium adjusts the pH to 7.5 of emulsion to get lubricating fluid.
Lubricity is measured to be measured with being lubricated property of MXD-01 friction coefficient instruments.Sliding block and force value sensor are connected when measurement
It connects and is put on horizontal plane, force value sensor stops after pulling slide block movement a distance with constant speed, you can measures cunning
PE films are fixed on sliding block bottom surface by the friction coefficient between block and horizontal plane, and tunica fibrosa is fixed with the specimen holder on horizontal plane,
Embodiment 1-5 and comparative example 1,2 sample liquids are applied between PE films and tunica fibrosa, the coefficient of kinetic friction is measured, rotational viscometer is used in combination
The dynamic viscosity of determination sample liquid.
The property indices of material of the present invention see the table below, it may be seen that this medical body cavity imports lubricating fluid dynamic friction
Coefficient is low, and dynamic viscosity is low, high lubricating effect, can meet the multiple use of clinical application, is suitable for the auxiliary of partes corporis humani position
Lubrication, importing lubricating fluid field in medical body cavity has boundless application prospect.
1 medical body cavity of table imports the property indices of lubricating fluid
| Name of product | The coefficient of kinetic friction（µ） | Dynamic viscosity（mPa·s)） |
| Embodiment 1 | 0.052 | 58 |
| Embodiment 2 | 0.049 | 59 |
| Embodiment 3 | 0.041 | 62 |
| Embodiment 4 | 0039 | 65 |
| Embodiment 5 | 0.024 | 52 |
| Comparative example 1 | 0.177 | 225 |
| Comparative example 2 | 0.168 | 194 |
Claims (7)
1. a kind of medical body cavity imports lubricating fluid, which is characterized in that be prepared by weight by following component：Polyethylene glycol oxide
0.5-1.5 parts, 1-4 parts of diisobutyl carbinol (DIBC), 1.6-3.2 parts of Brazil wax, 1.2-2.5 parts of lauryl sodium sulfate, season penta
3-6 parts of tetrol stearate, 1.5-3.5 parts of Avocado Oil, 1.2-3.2 parts of Chinese tallow, 1-4 parts of sodium hydroxybutyrate, methyl hydroxybenzoate 0.5-
1.2 parts, 5-10 parts of allantoin, 1-5 parts of mannitol, 0.2-1 parts of magnesium sulfate, 2-3 parts of castor oil poly- hydrocarbon oxygen ester, 76-92 parts of water.
2. a kind of medical body cavity according to claim 1 imports lubricating fluid, which is characterized in that by weight by following component
It is prepared：0.8-1.2 parts of polyethylene glycol oxide, 2-3 parts of diisobutyl carbinol (DIBC), 2-2.8 parts of Brazil wax, dodecyl sulphate
1.5-2.1 parts of sodium, 4-5 parts of pentaerythritol stearate, 2.1-2.8 parts of Avocado Oil, 1.5-2.6 parts of Chinese tallow, sodium hydroxybutyrate 2-3
Part, 0.7-1 parts of methyl hydroxybenzoate, 6-8 parts of allantoin, 2-4 parts of mannitol, 0.4-0.8 parts of magnesium sulfate, the poly- hydrocarbon oxygen ester 2-3 of castor oil
Part, 80-88 parts of water.
3. a kind of medical body cavity imports the preparation method of lubricating fluid, which is characterized in that include the following steps：
（1）Brazil wax, lauryl sodium sulfate, pentaerythritol stearate are added in the water of 5 times of parts by weight, are heated to
85-95 DEG C, stirring to solution is uniformly mixed；
（2）Polyethylene glycol oxide, diisobutyl carbinol (DIBC), allantoin, mannitol, magnesium sulfate are added in the water of surplus and are stirred evenly,
Whipping temp is 60-70 DEG C；
（3）Successively by step（1）Solution, Avocado Oil, Chinese tallow, the poly- hydrocarbon oxygen ester of castor oil, sodium hydroxybutyrate, methyl hydroxybenzoate stirring
Step is added under the conditions of mixing（2）Solution in, high-speed stirred emulsification is uniform, mixing speed 1500-2500r/min, emulsification
Time is 40min；
（4）The pH to 4.0-7.5 of emulsion is adjusted to get lubricating fluid with 0.5M sodium hydroxides.
4. a kind of medical body cavity according to claim 3 imports the preparation method of lubricating fluid, it is characterised in that：The step
（1）Middle heating temperature is 90 DEG C.
5. a kind of medical body cavity according to claim 3 imports the preparation method of lubricating fluid, it is characterised in that：The step
（2）Middle temperature is 63-67 DEG C.
6. a kind of medical body cavity according to claim 3 imports the preparation method of lubricating fluid, it is characterised in that：The step
（3）Middle mixing speed is 1800-2400r/min.
7. a kind of medical body cavity according to claim 3 imports the preparation method of lubricating fluid, it is characterised in that：The step
（4）Middle pH is 6.5-7.5.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810165625.1A CN108310474A (en) | 2018-02-28 | 2018-02-28 | A kind of medical body cavity imports lubricating fluid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810165625.1A CN108310474A (en) | 2018-02-28 | 2018-02-28 | A kind of medical body cavity imports lubricating fluid and preparation method thereof |
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| CN108310474A true CN108310474A (en) | 2018-07-24 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051669A1 (en) * | 1998-10-07 | 2001-12-13 | Mcghee Diane | Lubricious coating |
| CN101035573A (en) * | 2004-10-07 | 2007-09-12 | 科洛普拉斯特公司 | A medical device having a wetted hydrophilic coating |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN104387678A (en) * | 2014-11-17 | 2015-03-04 | 杭州麦迪凯医疗科技有限公司 | Medical thermoplastic elastomer composition and preparation method of medical tube thereof |
-
2018
- 2018-02-28 CN CN201810165625.1A patent/CN108310474A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051669A1 (en) * | 1998-10-07 | 2001-12-13 | Mcghee Diane | Lubricious coating |
| CN101035573A (en) * | 2004-10-07 | 2007-09-12 | 科洛普拉斯特公司 | A medical device having a wetted hydrophilic coating |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN104387678A (en) * | 2014-11-17 | 2015-03-04 | 杭州麦迪凯医疗科技有限公司 | Medical thermoplastic elastomer composition and preparation method of medical tube thereof |
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