CN108310106A - A kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, the Chinese medicine composition of auxiliary improvement of memory and its application - Google Patents
A kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, the Chinese medicine composition of auxiliary improvement of memory and its application Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
A kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, the Chinese medicine composition of auxiliary improvement of memory and its application, are related to technical field of traditional Chinese medicine, solve the problems, such as it is existing using Western medicine alleviate existing for failure of memory it is palliative, toxic side effect is big.A kind of Chinese medicine composition with kidney tonifying, intelligence development, tranquilizing the mind and auxiliary improvement of memory of the present invention, is made of the following components in terms of parts by weight：2~8 parts by weight of Radix Polygalae；1~5 parts by weight of ginseng；1~6 parts by weight of Herba Cistanches；2~8 parts by weight of Schisandra chinensis.The present invention has kidney tonifying, intelligence development, tranquilizing the mind auxiliary improvement of memory power and other effects, safe, has no toxic side effect, and effect is definite, to brains inanition, phlegm stagnation in collateral, brain, which is become homeless, supports and occurs that progressive is forgetful, and hypophrenia is had a headache, dizziness is trembled, brain dementia, encephalatrophy etc..Preferably.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, and in particular to a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improve note
The Chinese medicine composition recalled and its application.
Background technology
Memory is memorize, holding, the ability for recognizing and reappearing content and experience that objective things are reflected again.Currently,
With modern life section gather it is continuous accelerate, socio-economic activity is continuously increased, modern increasingly experiences life and essence
God brings the immense pressure of oneself.Long-term life stress and operating pressure makes the sleeping time wretched insufficiency of people, causes
Every function of body is set to get muddled problem, simultaneous decrease of memory, neurolysis, anxiety haves the fidgets more
Seriously.If things go on like this, the immune function of body declines and then induces various diseases.
As China human mortality is gradually marched toward aging, the health problem of the elderly becomes increasingly conspicuous.In recent years, China person in middle and old age
The ratio of people dementia of middle-and old aged man patient is gradually increasing, and senile dementia refers to being happened at the various dull-witted synthesis in senescence phase
Sign, including Alzheimer disease (AD), vascular dementia (VD) and Mixed dementia etc., chief complaint shows as memory
It is decreased obviously, cognitive ability is decreased obviously, mental act is abnormal etc..Investigation is found, it is silly that severe old age is suffered from over-65s crowd
For slow-witted ratio up to 5% or more, and to after 80 years old, this ratio has just risen to 15-20%, investigation while the hair for showing senile dementia
Disease also presents rejuvenation trend, so, senile dementia has been our very important problems.Today's society,
Competition, in no matter working, learn or living, people have reached overload state for the use of brain.Cause
This, either the elderly or young man, all there is to supplement brain nutrition, mitigating brain fatigue and improvement for entire society
The health food demand of memory and other effects.
Invention content
In order to fill up people to Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory product demand, the present invention chooses remote
Will, ginseng, Herba Cistanches and Schisandra chinensis develop a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory as formula material
Chinese medicine composition, above-mentioned selected Chinese medicine is the traditional Chinese medicine in China, and application all has the history of more than one thousand years.
The present invention is that technical scheme applied to solve the technical problem is as follows：
The present invention a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory Chinese medicine composition, in terms of parts by weight by
Following component composition：
2~8 parts by weight of Radix Polygalae；
1~5 parts by weight of ginseng；
1~6 parts by weight of Herba Cistanches；
2~8 parts by weight of Schisandra chinensis.
As preferred embodiment, a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory Chinese medicine composition, with
Parts by weight meter is made of the following components：
5 parts by weight of Radix Polygalae；
2 parts by weight of ginseng；
4 parts by weight of Herba Cistanches；
5 parts by weight of Schisandra chinensis.
As preferred embodiment, a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory Chinese medicine composition, with
Parts by weight meter is made of the following components：
2 parts by weight of Radix Polygalae；
3 parts by weight of ginseng；
1 parts by weight of Herba Cistanches；
2 parts by weight of Schisandra chinensis.
As preferred embodiment, a kind of Chinese traditional medicine composition for being good for intelligence and auxiliary improvement of memory with cerebrum tonifying of the invention
Object is made of the following components in terms of parts by weight：
8 parts by weight of Radix Polygalae；
1 parts by weight of ginseng；
6 parts by weight of Herba Cistanches；
8 parts by weight of Schisandra chinensis.
Above-mentioned Chinese medicine composition can be used for preparing with Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improving memory function production
Product.
The product can be food, drug or health products.
The beneficial effects of the invention are as follows：
The present invention have a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory Chinese medicine composition, safe, nothing
Toxic side effect, effect is definite, is primarily adapted for use in following crowd：1, failure of memory person, this refers to old in failure of memory
Year people；2, the health food of brain worker, auxiliary improvement of memory power have brain-tonifying effect, to safeguarding the normal function of brain
There is positive meaning；3, numerous teenagers, learning pressure is big to have the demand for needing to be improved memory.
Specific implementation mode
The present invention a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory Chinese medicine composition, in terms of parts by weight by
Following component composition：
2~8 parts by weight of Radix Polygalae；
1~5 parts by weight of ginseng；
1~6 parts by weight of Herba Cistanches；
2~8 parts by weight of Schisandra chinensis.
Fang Xie：With age, the five internal organs virtual loss, malfunction, insufficiency of vital energy and blood, Qi dysfunction, qi-blood-body fluid operation is disorderly, causes
Phlegm-blood stasis is grown thickly, and phlegm-blood stasis alternate, mutualization, mutually knot are handed over resistance brain network and sent out as encephalopathy.Therefore, clinically qi deficiency to blood stasis, qi depression to blood stasis,
The deficiency of blood stagnation of the circulation of vital energy or phlegm is turbid and blood stasis as and see, the card of existing phlegm-blood stasis retardance brain network and there is the turbid time for blinding clear key of phlegm.Due to
Above-mentioned etiology and pathogenesis is different, total because causing brains hollow, phlegm stagnation in collateral, and brain is become homeless foster and forgetful, the hypophrenia that progressive occurs,
It has a headache, dizziness is trembled, brain dementia, encephalatrophy etc..Based on this etiology and pathology, machine is sought by dialectical, according to Chinese medicine pharmacology
By composition prescription.
Fang Zhong：
Radix Polygalae：
Meridian distribution of property and flavor：It is bitter, pungent, warm.Return：The heart, kidney, stomach.
Effect：Tranquilize the mind and promote the intelligence, restoring normal coordination between heart and kidney, eliminating the phlegm, detumescence.For insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear,
Wandering, expectoration is not well, sore swell and ache curative, mastosis.Can happy gas and antitoxic heart-soothing and sedative, and can lead to lung qi and will is not forgotten by force,
For restoring normal coordination between heart and kidney, stabilize mind, the good merchantable brand of the strong knowledge of intelligence development.
Pharmacological research shows：Radix Polygalae can enhance ability of learning and memory：Have going through for more than one thousand years as common memory drug
The improvement of history learning and memory is to study the behavioral indexes of nootropic drug nootropic effect.Zhang Yaochun etc. research shows that:Polygalin
Learning memory disorder model mice diving tower and water maze performance can be improved in the acquisition, consolidation, render stage of study, improve and learn
Practise memory capability.
Ginseng：
Meridian distribution of property and flavor：Sweet, slight bitter, tepor.Return：Spleen, lung, the heart, kidney channel
Effect：It reinforces vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.
For physically weak prevent prolapse, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, injury thirst, Heat Diabetes, deficiency of qi and blood, long
Sick empty win, insomnia of palpitating with fear, impotence, Gong Leng.Ginseng invigorating kidney qi, can improve that palpitaition disease is secondary, and shortness of breath uncomfortable in chest, the heart qi deficiencies such as feeble pulse decline
Symptom, and energy tranquilize the mind and promote the intelligence, treat insomnia and dreamful sleep, forgetful.
Treat neurasthenia
Ginseng has significant excitation to nervous system, can improve body activities ability, reduces fatigue；To different type
Neurastheniac have certain therapeutic effect, so that patient body weight is increased, eliminate or mitigate general weakness, headache, insomnia
Etc. symptoms.
Herba Cistanches：
Meridian distribution of property and flavor：It is sweet, salty, warm.Return：Kidney, large intestine channel
Effect：Kidney-replenishing, benefiting essence-blood, logical intestines are slided just.For the insufficiency of the kidney yang, menses virtual loss, impotence is infertile, soreness and weakness of waist and knees,
Muscles and bones is powerless, dry constipation of intestines.
Schisandra chinensis：
Meridian distribution of property and flavor：It is sour, sweet, warm.Return：Lung, the heart, kidney channel.
Effect：Restrain astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For chronic cough and dyspnea of deficiency type, emission, enuresis frequent micturition, chronic diarrhea is not
Only, spontaneous sweating, injury thirst.Heat Diabetes, insomnia of palpitating with fear.
《Essentials of Materia Medica》Call it " warm-natured, the five tastes have, and salty acid be more, thus it is special restrain lung qi and kidney nourishing water, nourishing generate fluid,
Qi-restoratives improving eyesight, strong cloudy puckery essence, arrest sweating of bringing down a fever, preventing or arresting vomiting live to rush down, relieving coughing Dingchuan, relieving thirst and restlessness ".
Zhu Pin is cooperateed with, and is had kidney tonifying gas, is filled Yuanyang, replenishing essence marrow, the work(of antitoxic heart-soothing and sedative.It is suitable for deficiency of kidney-QI, marrow virtual loss
Caused hypophrenia has a sleepless night, is forgetful.Memory can be improved in long term usage, improves the diseases such as forgetful, insomnia, can also prevent under memory
Drop.
Embodiment 1
Radix Polygalae 5g, ginseng 2g, Herba Cistanches 4g, Schisandra chinensis 5g are weighed, is crushed after being respectively washed, after mixing, according to normal
It is prepared by tablet, capsule or the granule technique of rule.
Embodiment 2
Radix Polygalae 2g, ginseng 3g, Herba Cistanches 1g, Schisandra chinensis 2g are weighed, is crushed after being respectively washed, after mixing, according to normal
It is prepared by tablet, capsule or the granule technique of rule.
Embodiment 3
Radix Polygalae 8g, ginseng 1g, Herba Cistanches 6g, Schisandra chinensis 8g are weighed, is crushed after being respectively washed, after mixing, according to normal
It is prepared by tablet, capsule or the granule technique of rule.
Influence of the Chinese medicine composition of 1 step dow n test of the test example test present invention to mouse memory
Experimental animal：Healthy qualified NIH mouse, half male and half female.
Laboratory apparatus：DT-200 diving towers auto testing instrument (Shanghai benefit joins science and education equipment Co., Ltd).Outside the device host
Shape size：280mm × 88mm × 195mm, reaction chamber appearance and size：320mm×225mm×330mm.
Test dose：150mg/kg·bw.
Experiment should be divided into blank control group, model control group, composition (2 or 3 dosage groups) medicine group and positive control
Group.Blank control group is physiological saline, gives intragastric administration on mice；Positive controls are natural taurine.
Experimental method：
1, experimental animal feeding and grouping：Healthy qualification NIH mouse are chosen, are grouped at random, every group of 20 mouse, male and female are each
Half, sub-cage rearing, the weight of animals was 18 ± 1g, by above-mentioned test dose continuous gavage 20 days.
2, Jumping test is trained
Diving tower device is when experiment, mouse to be placed on copper grid, when copper grid are powered, jump is on copper grid with long hair body
Mouse is shocked by electricity, and normal reaction is to hide electric shock to jump onto platform, and most of mouse is possible to again or repeatedly jump off platform
It is shocked by electricity, platform can be snapped back when being shocked by electricity again, be so trained.Frequency of training is every 1.5 days 1 time, the gavage phase
Between training 12 times, training before gavage 1 hour carry out.Specific training program is as follows：Voltage is controlled in 36V, and mouse is put into copper
On the net, first adapt to environment 3min, be then electrified to, after mouse is shocked by electricity, majority jump onto platform escape electric shock, if mouse jump off it is flat
Platform, it is to get an electric shock to contact copper mesh simultaneously with mouse biped, is considered as wrong reaction.Model control group is established, the 20th day, gives above-mentioned drug
After 1h, experiment each group gives that scopolamine hydrobromide 2mg/kg (outside blank control group) is injected intraperitoneally respectively, start after 30min into
Row Jumping test.When on-test, mouse is placed on diving tower, while start the watch, record mouse jumps off the time (i.e. for the 1st time
Get an electric shock incubation period), mouse wrong times in 5min are recorded, as memory index, its average value, specific data are taken to be shown in Table 1.
Table 1
| It gets an electric shock incubation period (second) | Errors number in 5min | |
| Blank control group | 181±5 | 3.6±0.1 |
| Embodiment 1 | 260±5 | 1.2±0.1 |
| Embodiment 2 | 261±5 | 1.3±0.1 |
| Embodiment 3 | 260±5 | 1.3±0.1 |
| Model control group | 25±5 | 20±0.1 |
| Positive controls | 30±5 | 20±0.1 |
3, interpretation of result：1 essential record of table is the errors number got an electric shock in incubation period and 5min, can be with by experimental data
Find out, compared with model control group, the present invention can make mouse electric shock prolongation of latency.In addition, compared with model control group,
The present invention can be such that errors number in mouse 5min substantially reduces.Thus demonstrate the present invention Chinese medicine composition have significantly change
The effect of kind memory.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (6)
1. the Chinese medicine composition of a kind of Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary improvement of memory, which is characterized in that in terms of parts by weight
It is made of the following components：
2~8 parts by weight of Radix Polygalae；
1~5 parts by weight of ginseng；
1~6 parts by weight of Herba Cistanches；
2~8 parts by weight of Schisandra chinensis.
2. Chinese medicine composition according to claim 1, which is characterized in that be made of the following components in terms of parts by weight：
5 parts by weight of Radix Polygalae；
2 parts by weight of ginseng；
4 parts by weight of Herba Cistanches；
5 parts by weight of Schisandra chinensis.
3. Chinese medicine composition according to claim 1, which is characterized in that be made of the following components in terms of parts by weight：
2 parts by weight of Radix Polygalae；
3 parts by weight of ginseng；
1 parts by weight of Herba Cistanches；
2 parts by weight of Schisandra chinensis.
4. Chinese medicine composition according to claim 1, which is characterized in that be made of the following components in terms of parts by weight：
8 parts by weight of Radix Polygalae；
1 parts by weight of ginseng；
6 parts by weight of Herba Cistanches；
8 parts by weight of Schisandra chinensis.
5. Chinese medicine composition as described in any one of Claims 1-4 is being prepared with Invigorate the kidney and fill the marrow, brain tonic and intelligence development, auxiliary
Help the application improved in memory function product.
6. application according to claim 5, which is characterized in that the product is food, drug or health products.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113599438A (en) * | 2021-09-07 | 2021-11-05 | 黑龙江省济仁药业有限公司 | Traditional Chinese medicine composition for treating children amnesia and preparation method and application thereof |
| CN115737762A (en) * | 2022-12-14 | 2023-03-07 | 华夏先葆(北京)中药研究院有限公司 | A preparation composition with memory improving, brain health protecting and cognitive functions |
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| CN101045087A (en) * | 2007-05-08 | 2007-10-03 | 暨南大学 | Traditional Chinese medicine for improving memory of learning and preventing memory failing |
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| KR20120054664A (en) * | 2006-05-22 | 2012-05-30 | 리 푸 | WATER SOLUTION OF 20(R)?GINSENOSIDE Rg3 PHARMACEUTICAL COMPOSITION AND PROCESS THEREOF |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113599438A (en) * | 2021-09-07 | 2021-11-05 | 黑龙江省济仁药业有限公司 | Traditional Chinese medicine composition for treating children amnesia and preparation method and application thereof |
| CN115737762A (en) * | 2022-12-14 | 2023-03-07 | 华夏先葆(北京)中药研究院有限公司 | A preparation composition with memory improving, brain health protecting and cognitive functions |
| CN115737762B (en) * | 2022-12-14 | 2024-02-02 | 华夏先葆(北京)中药研究院有限公司 | A pharmaceutical composition with memory improving and brain health and cognitive function protecting effects |
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