CN108309919A - 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 - Google Patents
羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 Download PDFInfo
- Publication number
- CN108309919A CN108309919A CN201810431796.4A CN201810431796A CN108309919A CN 108309919 A CN108309919 A CN 108309919A CN 201810431796 A CN201810431796 A CN 201810431796A CN 108309919 A CN108309919 A CN 108309919A
- Authority
- CN
- China
- Prior art keywords
- peptide
- goat placenta
- composition
- skin
- placenta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000283707 Capra Species 0.000 title claims abstract description 46
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 39
- 102000008186 Collagen Human genes 0.000 title claims abstract description 38
- 108010035532 Collagen Proteins 0.000 title claims abstract description 38
- 229920001436 collagen Polymers 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 230000001815 facial effect Effects 0.000 title claims abstract description 17
- 239000007788 liquid Substances 0.000 title claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 18
- 229920001184 polypeptide Polymers 0.000 claims abstract description 17
- 210000002826 placenta Anatomy 0.000 claims abstract description 15
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 14
- 235000009508 confectionery Nutrition 0.000 claims abstract description 12
- 235000011187 glycerol Nutrition 0.000 claims abstract description 12
- 241001494479 Pecora Species 0.000 claims abstract description 9
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 9
- 244000144927 Aloe barbadensis Species 0.000 claims abstract description 8
- 235000002961 Aloe barbadensis Nutrition 0.000 claims abstract description 8
- 244000042664 Matricaria chamomilla Species 0.000 claims abstract description 8
- 244000178231 Rosmarinus officinalis Species 0.000 claims abstract description 8
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 8
- 230000007062 hydrolysis Effects 0.000 claims abstract description 8
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 8
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 claims abstract description 7
- 102000015636 Oligopeptides Human genes 0.000 claims abstract description 7
- 108010038807 Oligopeptides Proteins 0.000 claims abstract description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 7
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 6
- 239000004475 Arginine Substances 0.000 claims abstract description 6
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 6
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 6
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 6
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 6
- 239000011570 nicotinamide Substances 0.000 claims abstract description 6
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 6
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 6
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 5
- 230000003301 hydrolyzing effect Effects 0.000 claims abstract description 4
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 3
- 235000019834 papain Nutrition 0.000 claims abstract description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims description 6
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims description 2
- 238000005538 encapsulation Methods 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 230000037394 skin elasticity Effects 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 abstract description 9
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical group CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 abstract description 5
- 229920002125 Sokalan® Polymers 0.000 abstract description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract description 4
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract description 4
- 229960001631 carbomer Drugs 0.000 abstract description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract description 4
- 229940101267 panthenol Drugs 0.000 abstract description 4
- 239000011619 pantothenol Substances 0.000 abstract description 4
- 239000004365 Protease Substances 0.000 abstract description 3
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 abstract description 2
- 108090000526 Papain Proteins 0.000 abstract description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 abstract description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 229940055729 papain Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 19
- 230000000694 effects Effects 0.000 description 7
- 239000002253 acid Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- HYBIBLNGGIWWAY-UHFFFAOYSA-N [K].[K].OC(=O)C(O)=O Chemical compound [K].[K].OC(=O)C(O)=O HYBIBLNGGIWWAY-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000003158 alcohol group Chemical group 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- -1 phosphatide Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 235000019419 proteases Nutrition 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- QQGISFDJEJMKIL-JAIQZWGSSA-N (5z)-5-[[3-(hydroxymethyl)thiophen-2-yl]methylidene]-10-methoxy-2,2,4-trimethyl-1h-chromeno[3,4-f]quinolin-9-ol Chemical compound C1=CC=2NC(C)(C)C=C(C)C=2C2=C1C=1C(OC)=C(O)C=CC=1O\C2=C/C=1SC=CC=1CO QQGISFDJEJMKIL-JAIQZWGSSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 244000189799 Asimina triloba Species 0.000 description 1
- 235000006264 Asimina triloba Nutrition 0.000 description 1
- 235000009467 Carica papaya Nutrition 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- DUFKCOQISQKSAV-UHFFFAOYSA-N Polypropylene glycol (m w 1,200-3,000) Chemical class CC(O)COC(C)CO DUFKCOQISQKSAV-UHFFFAOYSA-N 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 238000005360 mashing Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical class COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 210000005059 placental tissue Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了羊胎盘肽‑骨胶原蛋白多肽组合物,其特征在于,含有以下质量百分数的各组分:1‑3%双丙甘醇、3‑8%甘油、0.5‑1%甘油聚丙烯酸酯、1‑3%黄原胶、0.5‑1%泛醇、1‑3%卡波姆、0.5‑1%烟酰胺、0.5‑1%甘草酸二钾、0.05‑1.5%水解胎盘(羊)提取物、0.3‑0.5%羊胎盘肽、0.2‑0.3%骨胶原蛋白多肽、0.05‑1.5%水解胶原、1‑3%库拉索芦荟叶汁、3‑6%母菊花提取物、0.5‑1%的β‑葡聚糖、0.5‑1%精氨酸、0.05‑1.5%透明质酸、0.5‑1%寡肽‑1、0.5‑1%棕榈酰五肽‑4、0.5‑1%棕榈酰三肽‑5、1‑3%糖类同分异构体、1‑3%木瓜蛋白酶、0.5‑1%十三烷醇聚醚‑9、2‑5%香蜂花花/叶/茎水、1‑3%迷迭香叶水、0.05‑0.5%羟苯甲酯、0.05‑0.5%EDTA二纳、0.01%香精,余量为水。上述羊胎盘肽‑骨胶原蛋白多肽组合物制成面膜液,能增强肌肤弹性,有效保湿,收紧及软化肌肤细小皱纹,使肌肤更显光泽。
Description
技术领域
本发明涉及化妆品技术领域,更具体地,涉及羊胎盘肽组合物、含有该羊胎盘肽组合物的面膜液。
背景技术
羊胎盘是母羊孕育胎儿时候负责母体和胎儿血液和养分交换的组织,能够产生非常多活性物质,而羊胎盘是自然界中最为接近人类胎盘的组织,所以能够很好的被吸收。
羊胎盘的主要功效在于:富含孕育生命所必需的所有原始生命物质,其中含有丰富的蛋白质、17种氨基酸、14种微量元素、磷脂、脂多糖、维生素,还有与免疫功能和基体正常运转相关的多种活性多肽,其营养成分天然搭配的比例最接近人体的需求。
胶原蛋白多肽是通过对胶原蛋白链酶法水解,然后进行提取,变成可溶解性的水解胶原蛋白,是片段的,但保存了具立体活性的三螺旋多肽结构。
羊胎盘肽、胶原蛋白多肽是一种高效、天然的化妆品成分,然而现有技术还没有将羊胎盘肽、骨胶原蛋白多肽制成的化妆品组合物。
发明内容
本发明的目的是为了提供一种全新的羊胎盘肽-骨胶原蛋白多肽组合物,以解决上述技术问题。
根据本发明的一个方面,本发明首先提供一种羊胎盘肽-骨胶原蛋白多肽组合物,其特征在于,含有以下质量百分数的各组分:1-3%双丙甘醇、3-8%甘油、0.5-1%甘油聚丙烯酸酯、1-3%黄原胶、0.5-1%泛醇、1-3%卡波姆、0.5-1%烟酰胺、0.5-1%甘草酸二钾、0.05-1.5%水解胎盘(羊)提取物、0.3-0.5%羊胎盘肽、0.2-0.3%骨胶原蛋白多肽、0.05-1.5%水解胶原、1-3%库拉索芦荟叶汁、3-6%母菊花提取物、0.5-1%的β-葡聚糖、0.5-1%精氨酸、0.05-1.5%透明质酸、0.5-1%寡肽-1、0.5-1%棕榈酰五肽-4、0.5-1%棕榈酰三肽-5、1-3%糖类同分异构体、1-3%木瓜蛋白酶、0.5-1%十三烷醇聚醚-9、2-5%香蜂花花/叶/茎水、1-3%迷迭香叶水、0.05-0.5%羟苯甲酯、0.05-0.5%EDTA二纳、0.01%香精,余量为水。
本发明上述羊胎盘肽-骨胶原蛋白多肽组合物,采用了多种具有补水、保湿、祛皱功能的组分,尤其是采用了具有水解胎盘(羊)提取物、羊胎盘肽(分子量≤500道尔顿)和骨胶原蛋白多肽(分子量≤500道尔顿),使其能够携带其他有效成分直接渗透到皮肤深层并被皮肤细胞吸收。羊胎盘肽和骨胶原蛋白多肽相互配合,充分发挥了除皱和丰泽肌肤的功效,有效的给肌肤补充营养,起到滋阴、养血、安神的作用。本发明的组合物,具有增强肌肤弹性,有效保湿,收紧皮肤,减少细小皱纹,温和,清洁,使肌肤更显光泽的效果。
其中,羊胎盘肽是采用羊胎盘组织,经过低温处理、组织捣碎、灭菌、生物酶解、提纯、浓缩、高温瞬时干燥而制成的高纯度小分子肽粉剂;羊胎盘肽的分子量分布在500道尔顿以下,是分子极小的功能肽,活性超强,极易被人体或肌肤吸收,能够快捷参与细胞生理活动,具有超强的美容养颜、延缓衰老的攻效。
除此之外,羊胎盘肽还具有以下功效:
1、羊胎盘肽中的免疫球蛋白、细胞生长因子、多种酶等有效成分有抗细胞脂质过氧化作用、促进皮肤新陈代谢作用、细胞分裂促进作用、抗炎作用、抗过敏作用以及保湿作用。
2、除斑点、皱纹功效:紫外线的照射可产生活性氧,活性氧产生过多就会溢出细胞外而成为有害物质,使皮肤生成黑色素,羊胎盘肽具有去除活性氧(细胞外)的作用,所以可用于去除斑点、皱纹,使得皮肤增白。
3、抗衰老作用:活性氧和由不饱和脂肪酸产生的过氧化脂质可使皮肤老化,羊胎盘肽对此有高效的去除作用。
4、活化增白功效:羊胎盘肽含有各种氨基酸、矿物质及维生素等成分,尤其含有与皮肤有关的各种生长因子,如上皮细胞生长因子(EGF)、内皮细胞生长因子(ECGF)、成纤维细胞生长因子(FGF)等,因此羊胎盘肽对皮肤具有活化增白功效。
组合物中,香蜂花(MELISSA OFFICINALIS)花/叶/茎水、迷迭香(ROSMARINUSOFFICINALIS)叶水这两者是用于给皮肤杀菌和收敛毛孔的,能促进血液循环,减少毛孔堵塞和痘痘生长。
库拉索芦荟叶汁(ALOE BARBADENSIS)、母菊花提取物(CHAMOMILLA RECUTITA)这两者是用于给皮肤深层补水的,有效防止肌肤衰老,减少皱纹和色斑。
寡肽-1、棕榈酰五肽-4、棕榈酰三肽-5,这三者能够促进产生胶原蛋白,同时保护胶原蛋白不被基质金属蛋白酶分解,三者协同作用,有效祛皱纹,改善肤质。
根据本发明的另外一方面,还提供了一种皮肤外用制剂,由上述羊胎盘肽-骨胶原蛋白多肽组合物的各组分,加上化妆品领域中的辅助性成分制备而成。该外用制剂可以为凝胶剂、软膏、乳液、护肤水、精华素或面膜。
此外,本发明还提供上述羊胎盘肽-骨胶原蛋白多肽组合物在增加皮肤弹性、保湿和淡化皱纹方面的应用。
本发明上述羊胎盘肽-骨胶原蛋白多肽组合物可以单独作为精华液使用,也可以与其他护肤品成分混合使用。
本发明还提供上述羊胎盘肽-骨胶原蛋白多肽组合物在制备护肤品中的应用。
本发明还提供上述羊胎盘肽组合物在制备面膜中的应用。
在一些实施方式中,上述制备面膜的方法为:将面膜基材浸泡在由羊胎盘肽-骨胶原蛋白多肽组合物制成的面膜液中0.5-2小时,取出即为面膜。
在另外一些实施方式中,上述制备面膜的方法为:将面膜基材浸泡在含羊胎盘组合物制成的面膜液的包装袋中,封装即可。
具体实施方式
下面结合实施例对本发明作进一步详细的说明。
实施例1
羊胎盘肽-骨胶原蛋白多肽组合物,其含有以下质量百分数的各组分:3%双丙甘醇、3%甘油、0.5%甘油聚丙烯酸酯、2%黄原胶、1%泛醇、1%卡波姆、1%烟酰胺、0.5%甘草酸二钾、1.5%水解胎盘(羊)提取物、0.3%羊胎盘肽、0.3%骨胶原蛋白多肽、0.05%水解胶原、2%库拉索芦荟叶汁、3%母菊花提取物、0.5%的β-葡聚糖、0.5%精氨酸、1.5%透明质酸、0.5%寡肽-1、1%棕榈酰五肽-4、0.8%棕榈酰三肽-5、3%糖类同分异构体、2%木瓜蛋白酶、0.6%十三烷醇聚醚-9、2%香蜂花花/叶/茎水、3%迷迭香叶水、0.05%羟苯甲酯、0.1%EDTA二纳、0.01%香精,余量为水。
实施例2
羊胎盘肽-骨胶原蛋白多肽组合物,其含有以下质量百分数的各组分:1%双丙甘醇、8%甘油、0.5%甘油聚丙烯酸酯、3%黄原胶、0.5%泛醇、2%卡波姆、0.5%烟酰胺、0.5%甘草酸二钾、1%水解胎盘(羊)提取物、0.4%羊胎盘肽、0.3%骨胶原蛋白多肽、1.5%水解胶原、3%库拉索芦荟叶汁、4%母菊花提取物、1%的β-葡聚糖、0.7%精氨酸、1%透明质酸、0.8%寡肽-1、0.7%棕榈酰五肽-4、0.5%棕榈酰三肽-5、2%糖类同分异构体、1%木瓜蛋白酶、1%十三烷醇聚醚-9、4%香蜂花花/叶/茎水、2%迷迭香叶水、0.3%羟苯甲酯、0.5%EDTA二纳、0.01%香精,余量为水。
实施例3
羊胎盘肽-骨胶原蛋白多肽组合物,其含有以下质量百分数的各组分:2%双丙甘醇、6%甘油、1%甘油聚丙烯酸酯、1%黄原胶、0.5%泛醇、3%卡波姆、0.5%烟酰胺、1%甘草酸二钾、0.05%水解胎盘(羊)提取物、0.5%羊胎盘肽、0.2%骨胶原蛋白多肽、1%水解胶原、1%库拉索芦荟叶汁、6%母菊花提取物、0.5%的β-葡聚糖、1%精氨酸、0.05%透明质酸、1%寡肽-1、0.5%棕榈酰五肽-4、1%棕榈酰三肽-5、1%糖类同分异构体、3%木瓜蛋白酶、0.5%十三烷醇聚醚-9、5%香蜂花花/叶/茎水、1%迷迭香叶水、0.5%羟苯甲酯、0.05%EDTA二纳、0.01%香精,余量为水。
选择脸部皮肤有皱纹或斑点、手背皮肤干燥的受试者40人,男女比例近半,将实施例1到实施例3制备得到的羊胎盘肽-骨胶原蛋白多肽组合物用于皮肤测试,分别涂抹于脸部(重点关注:眼睛周围和嘴角的笑纹处、法令纹、脸上的斑点)和手背(重点关注:补水情况,干纹减少情况),早晚各一次,使用前先将皮肤擦洗干净,记录连续使用15天和30天的情况,结果如下表1;并于30天试用结束后对受试者进行事后调查,结果如下表2;并将部分受试者情况记录于表3。
表1
整体疗效评价 | 人数 | 百分比(%) |
显效(效果明显) | 30 | 75.0 |
有效(还可以) | 10 | 25.0 |
无效 | 0 | 0 |
不良反应 | 0 | 0 |
总计 | 40 | 100 |
表2
表3
以上所述的仅是本发明的一些实施方式。对于本领域的普通技术人员来说,在不脱离本发明创造构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。
Claims (8)
1.羊胎盘肽-骨胶原蛋白多肽组合物,其特征在于,含有以下质量百分数的各组分:1-3%双丙甘醇、3-8%甘油、0.5-1%甘油聚丙烯酸酯、1-3%黄原胶、0.5-1%泛醇、1-3%卡波姆、0.5-1%烟酰胺、0.5-1%甘草酸二钾、0.05-1.5%水解胎盘(羊)提取物、0.3-0.5%羊胎盘肽、0.2-0.3%骨胶原蛋白多肽、0.05-1.5%水解胶原、1-3%库拉索芦荟叶汁、3-6%母菊花提取物、0.5-1%的β-葡聚糖、0.5-1%精氨酸、0.05-1.5%透明质酸、0.5-1%寡肽-1、0.5-1%棕榈酰五肽-4、0.5-1%棕榈酰三肽-5、1-3%糖类同分异构体、1-3%木瓜蛋白酶、0.5-1%十三烷醇聚醚-9、2-5%香蜂花花/叶/茎水、1-3%迷迭香叶水、0.05-0.5%羟苯甲酯、0.05-0.5%EDTA二纳、0.01%香精,余量为水。
2.一种皮肤外用制剂,其特征在于,所述的皮肤外用制剂由权利要求1所述的各组分,加上化妆品领域中的辅助性成分制备而成。
3.根据权利要求2所述的皮肤外用制剂,其特征在于,所述外用制剂为凝胶剂、软膏、乳液、护肤水、精华素或面膜。
4.权利要求1所述的羊胎盘肽-骨胶原蛋白多肽组合物在增加皮肤弹性、保湿和祛皱方面的应用。
5.权利要求1所述的羊胎盘肽-骨胶原蛋白多肽组合物在制备护肤品中的应用。
6.权利要求1所述的羊胎盘肽-骨胶原蛋白多肽组合物在制备面膜中的应用。
7.根据权利要求6所述的应用,其特征在于,是将面膜基材浸泡在由羊胎盘肽-骨胶原蛋白多肽组合物制成的面膜液中0.5-2小时,取出即为面膜。
8.根据权利要求6所述的应用,其特征在于,是将面膜基材浸泡在含羊胎盘组合物制成的面膜液的包装袋中,封装即可。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810431796.4A CN108309919A (zh) | 2018-05-08 | 2018-05-08 | 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810431796.4A CN108309919A (zh) | 2018-05-08 | 2018-05-08 | 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108309919A true CN108309919A (zh) | 2018-07-24 |
Family
ID=62895890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810431796.4A Pending CN108309919A (zh) | 2018-05-08 | 2018-05-08 | 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108309919A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114376958A (zh) * | 2022-02-18 | 2022-04-22 | 奥珀莱健康产业科技(广州)有限公司 | 一种抗衰老胎盘素原液及其制备方法 |
US11571378B2 (en) | 2021-01-22 | 2023-02-07 | The Procter & Gamble Company | Skin care composition and method of using the same |
US11771637B2 (en) | 2021-01-22 | 2023-10-03 | The Procter & Gamble Company | Skin care composition and method of using the same |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101524320A (zh) * | 2009-04-17 | 2009-09-09 | 武汉名实生物医药科技有限责任公司 | 一种能祛斑美白、保湿抗皱的复方制剂及其制备方法 |
WO2010041972A1 (ru) * | 2008-10-06 | 2010-04-15 | Shurdov Mikhail Arkadievich | Пептидный экстракт плаценты и способ его изготовления |
CN105687081A (zh) * | 2016-02-03 | 2016-06-22 | 程雪娇 | 一种抗衰老保湿凝胶及制备方法 |
CN105748360A (zh) * | 2016-03-25 | 2016-07-13 | 无锡简玺生物科技有限公司 | 一种锁水保湿组合物面膜及其制备方法 |
CN106176427A (zh) * | 2016-08-24 | 2016-12-07 | 米聚(上海)国际贸易有限公司 | 一种能改善肌肤的骨胶原活性肽产品及其烘干工艺 |
CN106619177A (zh) * | 2016-11-25 | 2017-05-10 | 兰州大学 | 一种白牦牛骨胶原蛋白肽美白保湿化妆品及其制备方法 |
CN107823095A (zh) * | 2017-12-07 | 2018-03-23 | 安徽生物肽产业研究院有限公司 | 一种活性肽面膜 |
CN107970181A (zh) * | 2017-12-18 | 2018-05-01 | 沈晓杰 | 一种保湿美肤精华液 |
-
2018
- 2018-05-08 CN CN201810431796.4A patent/CN108309919A/zh active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010041972A1 (ru) * | 2008-10-06 | 2010-04-15 | Shurdov Mikhail Arkadievich | Пептидный экстракт плаценты и способ его изготовления |
CN101524320A (zh) * | 2009-04-17 | 2009-09-09 | 武汉名实生物医药科技有限责任公司 | 一种能祛斑美白、保湿抗皱的复方制剂及其制备方法 |
CN105687081A (zh) * | 2016-02-03 | 2016-06-22 | 程雪娇 | 一种抗衰老保湿凝胶及制备方法 |
CN105748360A (zh) * | 2016-03-25 | 2016-07-13 | 无锡简玺生物科技有限公司 | 一种锁水保湿组合物面膜及其制备方法 |
CN106176427A (zh) * | 2016-08-24 | 2016-12-07 | 米聚(上海)国际贸易有限公司 | 一种能改善肌肤的骨胶原活性肽产品及其烘干工艺 |
CN106619177A (zh) * | 2016-11-25 | 2017-05-10 | 兰州大学 | 一种白牦牛骨胶原蛋白肽美白保湿化妆品及其制备方法 |
CN107823095A (zh) * | 2017-12-07 | 2018-03-23 | 安徽生物肽产业研究院有限公司 | 一种活性肽面膜 |
CN107970181A (zh) * | 2017-12-18 | 2018-05-01 | 沈晓杰 | 一种保湿美肤精华液 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11571378B2 (en) | 2021-01-22 | 2023-02-07 | The Procter & Gamble Company | Skin care composition and method of using the same |
US11771637B2 (en) | 2021-01-22 | 2023-10-03 | The Procter & Gamble Company | Skin care composition and method of using the same |
US11850299B2 (en) | 2021-01-22 | 2023-12-26 | The Procter & Gamble Company | Skin care composition and method of using the same |
CN114376958A (zh) * | 2022-02-18 | 2022-04-22 | 奥珀莱健康产业科技(广州)有限公司 | 一种抗衰老胎盘素原液及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105106098B (zh) | 一种用于制备骆驼奶面膜的组合物及其制备方法 | |
CN103565728B (zh) | 一种黑果枸杞美白保湿柔肤水及其制备方法 | |
CN103565699B (zh) | 一种黑果枸杞祛斑美白抗衰老精华液及其制备方法 | |
CN106344427A (zh) | 用于面部护理的多肽复合物及其制备方法 | |
KR101244149B1 (ko) | 줄기세포 증식 촉진 기능을 갖는 피부 미백용 펩타이드 조성물 | |
CN102188332A (zh) | 一种含有海洋贝类活性肽的化妆品及其制备方法和应用 | |
CN110997694A (zh) | 可用于治疗和/或护理皮肤、毛发、指甲和/或粘膜的化合物 | |
CN108309919A (zh) | 羊胎盘肽-骨胶原蛋白多肽组合物、含有该组合物的面膜液 | |
CN107854326A (zh) | 一种水蛭素润颜保湿修护精华液 | |
CN109330954B (zh) | 美白亮肤水及其制备方法和酪氨酸酶抑制剂 | |
CN101172095A (zh) | 含有蜂王浆的蛋白水解物的化妆材料 | |
CN108066215A (zh) | 一种美白、抗衰老的组合物、包含其的护肤品及制备方法 | |
CN108379215A (zh) | 一种具有美白肌肤功效的冻干粉组合物和包含该冻干粉组合物的化妆品组合物 | |
CN110496067A (zh) | 一种祛皱组合物及其制备方法和应用 | |
CN107365355B (zh) | 抗皱纹的肽以及包含其的化妆品 | |
CN102836093A (zh) | 一种含有i型胶原蛋白的面霜 | |
CN110478256A (zh) | 一种龟甲肽蚕丝面膜配方 | |
CN110151621A (zh) | 舒缓修护面贴膜及其制备方法 | |
CN103432059A (zh) | 一种松寄生膏蛋清面膜 | |
CN108272651A (zh) | 大鲵皮胶原蛋白的应用及含大鲵皮胶原蛋白的面膜及其制备方法 | |
CN103269707A (zh) | 皮肤胶原产生促进剂 | |
CN108096113B (zh) | 羊胎盘肽组合物、含有该羊胎盘肽组合物的面膜液 | |
CN104323966A (zh) | 黄金水疗组合物及其使用方法 | |
US20170035687A1 (en) | Skin treatment formulations | |
CN108186438A (zh) | 一种含有细胞生长因子的晒后修复凝胶及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190508 Address after: 528200 Room 215, 7 Royal Fort International Business Center, 15 Shilong North Road, Guicheng Street, Nanhai District, Foshan City, Guangdong Province Applicant after: Guangdong Peptide Shijia Biotechnology Co., Ltd. Address before: 510000 room 1216, 3 peace Middle Street, Guangzhou Avenue South, Guangzhou, Guangdong, Haizhuqu District Applicant before: Wang Qingxiu |
|
TA01 | Transfer of patent application right | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180724 |
|
RJ01 | Rejection of invention patent application after publication |