CN108309300A - A kind of gastroesophageal reflux waveform recognition system - Google Patents
A kind of gastroesophageal reflux waveform recognition system Download PDFInfo
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- CN108309300A CN108309300A CN201810209569.7A CN201810209569A CN108309300A CN 108309300 A CN108309300 A CN 108309300A CN 201810209569 A CN201810209569 A CN 201810209569A CN 108309300 A CN108309300 A CN 108309300A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
Abstract
The invention discloses a kind of gastroesophageal reflux waveform recognition systems, including：Acquisition module, the stomach esophagus impedance signal for obtaining goal-selling；Conversion module obtains corresponding wavelet coefficient for carrying out wavelet transformation to each impedance channel in stomach esophagus impedance signal by wavelet basis function；Detection module obtains corresponding singular point for carrying out inflection point detection to the corresponding wavelet coefficient of each impedance channel respectively；First mark module for corresponding to each singular point in original impedance signal, and carries out corresponding sign mutation point label；First identification module carries out reflux identification centered on each sign mutation point of label respectively for defining condition according to preset first impedance reflux.It realizes and gastroesophageal reflux waveform is accurately identified.And primary dcreening operation is carried out to impedance reflux catastrophe point by Wavelet Transform, it can be to avoid appearance the case where directly carrying out the missing inspection that reflux detection brings surely by unstability of base line by original impedance signal.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of gastroesophageal reflux waveform recognition system.
Background technology
As the improvement of people's living standards, gastroesophageal reflux disease (Gastroesophageal Reflux Disease,
Abbreviation GERD) incidence apparent ascendant trend is also presented, become a hot spot of digestive disease research field in recent years.
GERD refers to gastric content reflux to oesophagus, causes a kind of disease of corresponding esophageal symptoms and (or) complication.Clinically lead to
Gastroesophageal reflux is monitored frequently with impedance pH combination monitoring systems, with the gastric content and/or gas to reflux to stomach oesophagus
Situation is comprehensively and effectively monitored.
For the esophagus impedance pH combination monitoring systems of gastroesophageal reflux disease detection, check that duration is generally controlled for 24 hours,
The channels ph frequency acquisition is 1HZ at present, and impedance channel frequency acquisition is 50HZ, and the data volume of each impedance channel is about 24*
60*60*50=4320000 point if all being checked one by one to data by doctor, and carries out by hand impedance reflux situation
It if editor, needs to expend doctor's a large amount of time, extreme influence efficiency, and is reported in stomach esophagus impedance ph combination monitoring systems
It is applied alone the nearly all parameter diagnosed in reflux disease to be all based on impedance reflux result to obtain.
Therefore, how to realize and gastroesophageal reflux waveform is accurately identified, it is effective to be carried out to reflux disease
Detect and diagnose is a technical problem that technical personnel in the field need to solve at present.
Invention content
The object of the present invention is to provide a kind of gastroesophageal reflux method for waveform identification and systems, may be implemented anti-to stomach oesophagus
Stream waveform is accurately identified, to carry out effective detect and diagnose to reflux disease.
In order to solve the above technical problems, the present invention provides following technical solutions：
A kind of gastroesophageal reflux method for waveform identification is based on esophagus impedance pH combination monitoring systems, including：
Obtain the stomach esophagus impedance signal of goal-selling；
Wavelet transformation is carried out to each impedance channel in the stomach esophagus impedance signal by wavelet basis function, is corresponded to
Wavelet coefficient；
Inflection point detection is carried out to the corresponding wavelet coefficient of each impedance channel respectively, obtains corresponding singular point；
Each singular point is corresponded in original impedance signal, and carries out corresponding sign mutation point label；
Condition is defined according to preset first impedance reflux, is carried out centered on each sign mutation point of label respectively
Reflux identifies.
Preferably, described that small echo change is carried out to each impedance channel in the stomach esophagus impedance signal by wavelet basis function
It changes, obtains corresponding wavelet coefficient, including：
The most apparent impedance channel of the stomach esophagus impedance signal middle impedance reflux waveform is chosen as target impedance channel；
Wavelet transformation is carried out to the target impedance channel respectively by several wavelet basis functions, obtains each wavelet basis
The corresponding target wavelet coefficient of function；
The morther wavelet of the best target wavelet coefficient of regularity is chosen as target wavelet basic function；
Small echo is carried out respectively to each impedance channel in the stomach esophagus impedance signal by the target wavelet basic function
Transformation, obtains corresponding wavelet coefficient.
Preferably, described that inflection point detection is carried out to the corresponding wavelet coefficient of each impedance channel respectively, it obtains corresponding strange
Dissimilarity, including：
Calculate the modulus maximum of the corresponding wavelet coefficient of each impedance channel；
Detect that lipschitz indexes meet the point of preset condition as strange according to the modulus maximum of each wavelet coefficient
Dissimilarity.
Preferably, described that condition is defined according to preset first impedance reflux, respectively with each sign mutation of label
Reflux identification is carried out centered on point, including：
Sign mutation point is chosen according to preset sequence to be detected；
It is fixed with the presence or absence of the first impedance reflux is met in the preset range centered on current demand signal catastrophe point to judge
Doubtful impedance reflux in adopted condition starts the point of condition；
If so, it is doubtful impedance starting point to record the point；
If it is not, then deleting the current demand signal catastrophe point；
It is fixed with the presence or absence of the first impedance reflux is met in the preset range centered on current demand signal catastrophe point to judge
The point of doubtful impedance reflux termination condition in adopted condition；
If so, it is doubtful impedance end point to record the point；
If it is not, then deleting the current demand signal catastrophe point.
Preferably, the preset first impedance reflux defines condition, specially：
It is down or up to the 50% of baseline value that doubtful impedance reflux, which starts over position,.
Preferably, further include：
Condition is defined according to preset second impedance reflux, the goal-selling is occurred in the preset time period before symptom
Stomach esophagus impedance signal carry out reflux identification.
Preferably, described that condition is defined according to preset second impedance reflux, before symptom occurs to the goal-selling
Stomach esophagus impedance signal in preset time period carries out reflux identification, including：
Defining condition according to preset first impedance reflux, respectively centered on each sign mutation point of label into
Row reflux identification before, judge the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel time whether position
In preset time period before symptom occurs for the goal-selling；
If so, it is that preset second impedance reflux defines item that the switching preset first impedance reflux, which defines condition,
Part, and the stomach esophagus impedance signal goal-selling occurred in the preset time period before symptom carries out reflux identification.
Preferably, the preset second impedance reflux defines condition, specially：
Doubtful impedance reflux starts over position to be down or up to predetermined threshold value, and the predetermined threshold value is more than baseline value
50%.
Preferably, further include：
Judge whether the position of the doubtful impedance reflux starting point of each impedance channel is located at itself next impedance channel
Doubtful impedance reflux starting point and corresponding doubtful impedance reflux end point section in；
If so, by the position of the doubtful impedance reflux starting point and doubtful impedance reflux end point of each impedance channel
Labeled as final impedance reflux.
Preferably, further include：
When judging that it is described pre- that the time of the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel is located at
If when in the preset time period before target generation symptom, the doubtful impedance reflux for judging whether there is any impedance channel starts
The position of point is located at the doubtful impedance reflux starting point of the impedance channel of itself lower end and corresponding doubtful impedance reflux end point
Section in；
If so, by the position of the doubtful impedance reflux starting point and doubtful impedance reflux end point of the impedance channel
Labeled as final impedance reflux.
A kind of gastroesophageal reflux waveform recognition system is based on esophagus impedance pH combination monitoring systems, including：
Acquisition module, the stomach esophagus impedance signal for obtaining goal-selling；
Conversion module, for carrying out small echo to each impedance channel in the stomach esophagus impedance signal by wavelet basis function
Transformation, obtains corresponding wavelet coefficient；
Detection module obtains corresponding for carrying out inflection point detection to the corresponding wavelet coefficient of each impedance channel respectively
Singular point；
First mark module for corresponding to each singular point in original impedance signal, and carries out corresponding signal
Catastrophe point marks；
First identification module, for defining condition according to preset first impedance reflux, respectively with each letter of label
Reflux identification is carried out centered on number catastrophe point.
Preferably, the conversion module includes：
First selection unit, for choosing the most apparent impedance channel of the stomach esophagus impedance signal middle impedance reflux waveform
As target impedance channel；
First converter unit, for carrying out small echo change to the target impedance channel respectively by several wavelet basis functions
It changes, obtains the corresponding target wavelet coefficient of each wavelet basis function；
Second selection unit, for choosing the morther wavelet of the best target wavelet coefficient of regularity as target wavelet base letter
Number；
Second converter unit is used for through the target wavelet basic function to each impedance in the stomach esophagus impedance signal
Channel carries out wavelet transformation respectively, obtains corresponding wavelet coefficient.
Preferably, the detection module includes：
Computing unit, the modulus maximum for calculating the corresponding wavelet coefficient of each impedance channel；
Detection unit, it is default for detecting that lipschitz indexes meet according to the modulus maximum of each wavelet coefficient
The point of condition is as singular point.
Preferably, first identification module includes：
Third selection unit is detected for choosing sign mutation point according to preset sequence；
First judging unit meets institute for judging to whether there is in the preset range centered on current demand signal catastrophe point
It states the first impedance reflux and defines the point that the doubtful impedance reflux in condition starts condition；
First recording unit, for existing described in satisfaction in preset range centered on judgement is by current demand signal catastrophe point
When first impedance reflux defines the doubtful impedance reflux in condition and starts the point of condition, it is doubtful impedance starting point to record the point；
First deleting unit, for there is no to meet institute in preset range centered on judgement is by current demand signal catastrophe point
When stating the doubtful impedance reflux that the first impedance reflux defines in condition and starting the point of condition, the current demand signal catastrophe point is deleted；
Second judgment unit meets institute for judging to whether there is in the preset range centered on current demand signal catastrophe point
State the point for the doubtful impedance reflux termination condition that the first impedance reflux defines in condition；
Second recording unit, for existing described in satisfaction in preset range centered on judgement is by current demand signal catastrophe point
When first impedance reflux defines the point of the doubtful impedance reflux termination condition in condition, it is doubtful impedance end point to record the point；
Second deleting unit, for there is no to meet institute in preset range centered on judgement is by current demand signal catastrophe point
When stating the first impedance reflux and defining the point of doubtful impedance reflux termination condition in condition, the current demand signal catastrophe point is deleted.
Preferably, the preset first impedance reflux defines condition, specially：
It is down or up to the 50% of baseline value that doubtful impedance reflux, which starts over position,.
Preferably, further include：
For defining condition according to preset second impedance reflux to the goal-selling disease occurs for the second identification module
Stomach esophagus impedance signal in preset time period before shape carries out reflux identification.
Preferably, second identification module includes：
Third judging unit, for defining condition according to preset first impedance reflux, respectively with each described of label
Before carrying out reflux identification centered on sign mutation point, the corresponding stomach esophagus resistance of the corresponding singular point of each impedance channel is judged
Whether the time of antinoise signal is located in the preset time period before symptom occurs for the goal-selling；
Recognition unit, for defining condition according to preset first impedance reflux, respectively with each signal of label
Before carrying out reflux identification centered on catastrophe point, the corresponding stomach esophagus impedance letter of the corresponding singular point of each impedance channel is judged
Number time be located at the goal-selling occur symptom before preset time period in, then switch the preset first impedance reflux
Definition condition is that preset second impedance reflux defines condition, and the goal-selling occurs in the preset time period before symptom
Stomach esophagus impedance signal carry out reflux identification.
Preferably, the preset second impedance reflux defines condition, specially：
Doubtful impedance reflux starts over position to be down or up to predetermined threshold value, and the predetermined threshold value is more than baseline value
50%.
Preferably, further include：
First judgment module, for judging whether the position of the doubtful impedance reflux starting point of each impedance channel is located at
In the section of the doubtful impedance reflux starting point of itself next impedance channel and corresponding doubtful impedance reflux end point；
Second mark module, for being located at certainly in the position for judging the doubtful impedance reflux starting point of each impedance channel
When in the section of the doubtful impedance reflux starting point of the lower impedance channel of body and corresponding doubtful impedance reflux end point, Jiang Gesuo
The position mark of the doubtful impedance reflux starting point and doubtful impedance reflux end point of stating impedance channel is final impedance reflux.
Preferably, further include：
Second judgment module judges the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel for working as
Time be located at the goal-selling occur symptom before preset time period in when, judge whether there is any impedance channel
The position of doubtful impedance reflux starting point be located at the impedance channel of itself lower end doubtful impedance reflux starting point and it is corresponding doubt
In section like impedance reflux end point；
Third mark module, the doubtful impedance for being determined with any impedance channel in second judgment module are anti-
The position of stream starting point is located at the doubtful impedance reflux starting point of the impedance channel of itself lower end and corresponding doubtful impedance reflux
When in the section of end point, by the position of the doubtful impedance reflux starting point and doubtful impedance reflux end point of the impedance channel
Tagging is final impedance reflux.
Compared with prior art, above-mentioned technical proposal has the following advantages：
A kind of gastroesophageal reflux waveform recognition system that the embodiment of the present invention is provided is based on esophagus impedance pH combined monitorings
System, including：Acquisition module, the stomach esophagus impedance signal for obtaining goal-selling；Conversion module, for passing through wavelet basis letter
Each impedance channel in several esophagus impedance signals to stomach carries out wavelet transformation, obtains corresponding wavelet coefficient；Detection module is used for
Inflection point detection is carried out to the corresponding wavelet coefficient of each impedance channel respectively, obtains corresponding singular point；First mark module is used
It is corresponded in original impedance signal in by each singular point, and carries out corresponding sign mutation point label；First identification module, is used for
Condition is defined according to preset first impedance reflux, carries out reflux identification centered on each sign mutation point of label respectively.It is logical
It crosses after carrying out wavelet transformation to each impedance channel using wavelet basis function, the wavelet coefficient of each impedance channel is carried out unusual
Point detection, singular point is corresponded in original impedance signal, carrys out original resistance corresponding to singular point in conjunction with the definition of impedance reflux
Antinoise signal carries out reflux identification, is accurately identified to gastroesophageal reflux waveform with realizing, to have to reflux disease
The detect and diagnose of effect.And primary dcreening operation is carried out to impedance reflux catastrophe point by Wavelet Transform, it can be to avoid directly passing through original
Beginning impedance signal carries out the appearance of the case where missing inspection that reflux detection is brought surely by unstability of base line.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is the present invention
Some embodiments for those of ordinary skill in the art without creative efforts, can also basis
These attached drawings obtain other attached drawings.
Fig. 1 is a kind of gastroesophageal reflux method for waveform identification flow chart that specific implementation mode is provided of the present invention；
Fig. 2 answers for a kind of signal acquiring system for the stomach esophagus impedance reflux data that specific implementation mode is provided of the present invention
Use schematic diagram；
Fig. 3 is a kind of gastroesophageal reflux waveform recognition system structural schematic diagram that specific implementation mode is provided of the present invention.
Specific implementation mode
Core of the invention is to provide a kind of gastroesophageal reflux method for waveform identification and system, may be implemented anti-to stomach oesophagus
Stream waveform is accurately identified, to carry out effective detect and diagnose to reflux disease.
It is understandable in order to enable the above objects, features and advantages of the present invention to become apparent, below in conjunction with the accompanying drawings to this hair
Bright specific implementation mode is described in detail.
Detail is elaborated in the following description in order to fully understand the present invention.But the present invention can with it is a variety of not
Other manner described here is same as to implement, those skilled in the art can do class without violating the connotation of the present invention
Like popularization.Therefore the present invention is not limited by following public specific implementation mode.
It please refers to Fig.1 and Fig. 2, Fig. 1 is a kind of gastroesophageal reflux waveform recognition that specific implementation mode is provided of the present invention
Method flow diagram；Fig. 2 is a kind of signal acquisition system for the stomach esophagus impedance reflux data that specific implementation mode is provided of the present invention
System application schematic diagram.
A kind of specific implementation mode of the present invention provides a kind of gastroesophageal reflux method for waveform identification, is based on esophagus impedance
PH combination monitoring systems, including：
S11：Obtain the stomach esophagus impedance signal of goal-selling.
In the present embodiment, as shown in Fig. 2, providing a kind of signal acquiring system of stomach esophagus impedance reflux data,
That is esophagus impedance pH combination monitoring systems, it includes electrode catheter 21, data logger 22 and data analyzers 23.Electrode is led
Pipe is made of sensor, terminal box, conduit and pipe joint.Sensor includes impedance transducer and pH sensors and pH references
Electrode, encapsulation are integrated on conduit, wherein pH reference electrodes calibrate pH value using calibration solution.Contain in terminal box
Circuit board and data storage, wherein data storage can store electrode catheter information, and catheter information includes conduit
Access times, conduit sequence number, circuit board can be used for being powered each sensor, and will come from pH sensors and impedance biography
The data transmission of sensor is to data logger.Data logger include display, microprocessor, data-interface, push-button unit and
Data storage cell.Data storage cell stores the data from each sensor of electrode catheter.Display, data-interface, button
Unit and data storage cell are connected with microprocessor.Wherein, push-button unit be used to record patient symptom in monitoring process and
State.Data analyzer is used to carry out automatic calculate to the data from data logger storage unit to analyze.
The above-mentioned collected patient's stomach esophagus impedance signal of esophagus impedance pH combination monitoring systems, common is to be hindered by 6
Anti- channel, 1 ph or multiple channels ph composition.
It should be noted that present embodiment is only preferably pre- to obtain using above-mentioned esophagus impedance pH combination monitoring systems
If the stomach esophagus impedance signal of target, other esophagus impedance pH combination monitoring systems or other modes can also be used to obtain
The stomach esophagus impedance signal of goal-selling, present embodiment do not limit this.
S12：Wavelet transformation is carried out to each impedance channel in stomach esophagus impedance signal by wavelet basis function, is corresponded to
Wavelet coefficient.
In one embodiment of the invention, by wavelet basis function to each impedance channel in stomach esophagus impedance signal
Wavelet transformation is carried out, corresponding wavelet coefficient is obtained, including：It is most apparent to choose stomach esophagus impedance signal middle impedance reflux waveform
Impedance channel is as target impedance channel；Wavelet transformation is carried out to target impedance channel respectively by several wavelet basis functions, is obtained
To the corresponding target wavelet coefficient of each wavelet basis function；The morther wavelet of the best target wavelet coefficient of regularity is chosen as target
Wavelet basis function；Wavelet transformation is carried out respectively to each impedance channel in stomach esophagus impedance signal by target wavelet basic function,
Obtain corresponding wavelet coefficient.
In the present embodiment, suitable wavelet basis function is chosen, wavelet transformation is carried out to each impedance channel, to obtain
The corresponding wavelet coefficient in each channel.By being converted using different wavelet basis functions to a certain typical impedance channel, then
The characteristics of comparing the wavelet coefficient after transformation, the wavelet basis letter of impedance signal changing rule can more preferably be reflected by choosing wavelet coefficient
Number is used as suitable wavelet basis function, for carrying out wavelet transformation to all impedance channels.
Wherein, different wavelet basis functions is the wavelet basis function of different series, is chosen in the present embodiment common
Wavelet basis function, such as haar, db, coif, sym, gaus, morl, meyr, mexh etc. choose regularity by carrying out experiment
Better small echo.In order to preferably be compared, first to there are the apparent channels of impedance reflux to carry out small echo in impedance signal
The impedance reflux waveform of transformation, combined impedance reflux feature, usual distal channel is relatively the most apparent, i.e., most gos deep into patient's stomach food
Therefore the impedance channel in road chooses distalmost end impedance channel as target impedance channel, to be carried out using different wavelet basis functions
Transformation, obtains wavelet coefficient.Wavelet coefficient changing rule is corresponded in original impedance signal again, chooses and is easier to distinguish small
The morther wavelet of wave system number is as target wavelet basic function.In the present embodiment, there is the orthogonal wavelet haar small echos of compact schemes more
The changing rule of original impedance signal can be intuitively reflected, it is therefore preferable that the small echo is as the suitable wavelet basis function.
S13：Inflection point detection is carried out to the corresponding wavelet coefficient of each impedance channel respectively, obtains corresponding singular point.
Inflection point detection is carried out to the corresponding wavelet coefficient of each impedance channel respectively, obtains corresponding singular point, including：Meter
Calculate the modulus maximum of the corresponding wavelet coefficient of each impedance channel；Lipschitz is detected according to the modulus maximum of each wavelet coefficient
Index meets the point of preset condition as singular point.
When carrying out inflection point detection to the wavelet coefficient of each impedance channel after transformation, the power of singular point be by
Lipshitz indexes can be detected come what is portrayed by the modulus maximum in wavelet coefficient.
S14：Each singular point is corresponded in original impedance signal, and carries out corresponding sign mutation point label.
S15：Condition is defined according to preset first impedance reflux, is carried out centered on each sign mutation point of label respectively
Reflux identifies.
Condition is defined according to preset first impedance reflux, carries out reflux centered on each sign mutation point of label respectively
Identification, including：Sign mutation point is chosen according to preset sequence to be detected；Judge pre- centered on current demand signal catastrophe point
If defining the point that the doubtful impedance reflux in condition starts condition with the presence or absence of the first impedance reflux of satisfaction in range；If so,
It is doubtful impedance starting point to record the point；If it is not, then deleting the current demand signal catastrophe point；Judge in being with current demand signal catastrophe point
The point of the doubtful impedance reflux termination condition in condition is defined in the preset range of the heart with the presence or absence of the first impedance reflux of satisfaction；If
It is then to record the point as doubtful impedance end point；If it is not, then deleting the current demand signal catastrophe point.
Judge to whether there is around catastrophe point and meets the point that preset doubtful impedance reflux starts preset condition, if so,
The point is then recorded, the preset point for meeting impedance reflux and terminating preset condition is then found, is recorded as doubtful impedance end point, instead
It, then delete the catastrophe point, and location finding is started over until each channel of completion corresponds to doubtful impedance reflux.
In the present embodiment, preset first impedance reflux defines condition, specially：Doubtful impedance reflux starts over
Position is down or up to the 50% of baseline value.
After carrying out wavelet transformation to each impedance channel by using wavelet basis function, to the wavelet systems of each impedance channel
Number carries out inflection point detection, and singular point is corresponded in original impedance signal, comes to singular point pair in conjunction with the definition of impedance reflux
The original impedance signal answered carries out reflux identification, is accurately identified to gastroesophageal reflux waveform with realizing, so as to reflux
Disease carries out effective detect and diagnose.And primary dcreening operation is carried out to impedance reflux catastrophe point by Wavelet Transform, it can be to avoid
The appearance of the case where missing inspection directly brought surely by unstability of base line by the progress reflux detection of original impedance signal.
In one embodiment of the invention, gastroesophageal reflux method for waveform identification further includes：According to preset second
Impedance reflux defines condition, and stomach esophagus impedance signal goal-selling occurred in the preset time period before symptom carries out reflux knowledge
Not.
Wherein, condition is defined according to preset second impedance reflux, goal-selling occurs the preset time period before symptom
Interior stomach esophagus impedance signal carries out reflux identification, including：Condition is being defined according to preset first impedance reflux, respectively with mark
Before carrying out reflux identification centered on each sign mutation point of note, the corresponding stomach esophagus of the corresponding singular point of each impedance channel is judged
Whether the time of impedance signal is located in the preset time period before symptom occurs for goal-selling；If so, switching preset first
It is that preset second impedance reflux defines condition, and goal-selling occurs the preset time before symptom that impedance reflux, which defines condition,
Stomach esophagus impedance signal in section carries out reflux identification.Preset second impedance reflux defines condition, specially：Doubtful impedance is anti-
Stream starts over position to be down or up to predetermined threshold value, and predetermined threshold value is more than the 50% of baseline value.
In order to improve to patient symptom for the previous period in impedance reflux positive rate, particularly, present embodiment
For symptom for the previous period during impedance signal detection Rule of judgment reseted.Therefore, impedance letter is being corresponded to
When number carrying out the detection of doubtful impedance reflux starting position, it is located at symptom when the time that wavelet coefficient singular point corresponds to impedance signal
When interior for the previous period, then doubtful impedance reflux condition is reseted, that is, it is default to switch preset first impedance reflux to define condition
The second impedance reflux define condition, then carry out the detection that doubtful impedance reflux starts over position.On the contrary then use acquiescence item
Part is detected, i.e., defining condition using preset first impedance reflux is detected.
Further, in one embodiment of the invention, gastroesophageal reflux method for waveform identification further includes：Judge each
The doubtful impedance the reflux whether position of the doubtful impedance reflux starting point of impedance channel is located at itself next impedance channel starts
In the section of point and corresponding doubtful impedance reflux end point；If so, by the doubtful impedance reflux starting point of each impedance channel
Position mark with doubtful impedance reflux end point is final impedance reflux.
In the present embodiment, position is started over to each doubtful impedance reflux that above-mentioned each impedance channel searches out
It sets, judges whether to meet preset direction condition, direction condition here is under the impedance reflux starting position in a upper channel is located at
During one channel impedance reflux starts over, the impedance reflux in each channel for the condition that meets, which is started over position mark, is
Final impedance reflux.
Further, it is located in advance when the time of the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel of judgement
If when in the preset time period before target generation symptom, the doubtful impedance reflux for judging whether there is any impedance channel starts
The position of point is located at the doubtful impedance reflux starting point of the impedance channel of itself lower end and corresponding doubtful impedance reflux end point
Section in；If so, the position of the doubtful impedance reflux starting point of the impedance channel and doubtful impedance reflux end point is marked
It is denoted as final impedance reflux.
In the present embodiment, if doubtful impedance be located at patient symptom information for the previous period in, by above-mentioned direction
As long as condition is located between becoming having the doubtful impedance reversed flow region in channel above in the doubtful reflux section of lower end passage, then it is labeled as
Impedance reflux.
Referring to FIG. 3, Fig. 3 is a kind of gastroesophageal reflux waveform recognition system knot that specific implementation mode is provided of the present invention
Structure schematic diagram.
Correspondingly, one embodiment of the present invention provides a kind of gastroesophageal reflux waveform recognition system, is based on esophagus
Impedance pH combination monitoring systems, including：Acquisition module 31, the stomach esophagus impedance signal for obtaining goal-selling；Conversion module
32, for carrying out wavelet transformation to each impedance channel in stomach esophagus impedance signal by wavelet basis function, obtain corresponding small
Wave system number；Detection module 33 obtains corresponding for carrying out inflection point detection to the corresponding wavelet coefficient of each impedance channel respectively
Singular point；First mark module 34 for corresponding to each singular point in original impedance signal, and carries out corresponding sign mutation
Point label；First identification module 35, it is prominent with each signal of label respectively for defining condition according to preset first impedance reflux
Reflux identification is carried out centered on height.
In the present embodiment, as shown in Fig. 2, providing a kind of signal acquiring system of stomach esophagus impedance reflux data,
That is esophagus impedance pH combination monitoring systems, it includes electrode catheter 21, data logger 22 and data analyzers 23.Electrode is led
Pipe is made of sensor, terminal box, conduit and pipe joint.Sensor includes impedance transducer and pH sensors and pH references
Electrode, encapsulation are integrated on conduit, wherein pH reference electrodes calibrate pH value using calibration solution.Contain in terminal box
Circuit board and data storage, wherein data storage can store electrode catheter information, and catheter information includes conduit
Access times, conduit sequence number, circuit board can be used for being powered each sensor, and will come from pH sensors and impedance biography
The data transmission of sensor is to data logger.Data logger include display, microprocessor, data-interface, push-button unit and
Data storage cell.Data storage cell stores the data from each sensor of electrode catheter.Display, data-interface, button
Unit and data storage cell are connected with microprocessor.Wherein, push-button unit be used to record patient symptom in monitoring process and
State.Data analyzer is used to carry out automatic calculate to the data from data logger storage unit to analyze.
The above-mentioned collected patient's stomach esophagus impedance signal of esophagus impedance pH combination monitoring systems, common is to be hindered by 6
Anti- channel, 1 ph or multiple channels ph composition.
It should be noted that present embodiment is only preferably pre- to obtain using above-mentioned esophagus impedance pH combination monitoring systems
If the stomach esophagus impedance signal of target, other esophagus impedance pH combination monitoring systems or other modes can also be used to obtain
The stomach esophagus impedance signal of goal-selling, present embodiment do not limit this.
In one embodiment of the invention, conversion module includes：First selection unit, for choosing stomach esophagus impedance
The most apparent impedance channel of signal middle impedance reflux waveform is as target impedance channel；First converter unit, for by several
Wavelet basis function carries out wavelet transformation to target impedance channel respectively, obtains the corresponding target wavelet coefficient of each wavelet basis function；
Second selection unit, for choosing the morther wavelet of the best target wavelet coefficient of regularity as target wavelet basic function；Second
Converter unit, for carrying out small echo change respectively to each impedance channel in stomach esophagus impedance signal by target wavelet basic function
It changes, obtains corresponding wavelet coefficient.
In the present embodiment, suitable wavelet basis function is chosen, wavelet transformation is carried out to each impedance channel, to obtain
The corresponding wavelet coefficient in each channel.By being converted using different wavelet basis functions to a certain typical impedance channel, then
The characteristics of comparing the wavelet coefficient after transformation, the wavelet basis letter of impedance signal changing rule can more preferably be reflected by choosing wavelet coefficient
Number is used as suitable wavelet basis function, for carrying out wavelet transformation to all impedance channels.
Wherein, different wavelet basis functions is the wavelet basis function of different series, is chosen in the present embodiment common
Wavelet basis function, such as haar, db, coif, sym, gaus, morl, meyr, mexh etc. choose regularity by carrying out experiment
Better small echo.In order to preferably be compared, first to there are the apparent channels of impedance reflux to carry out small echo in impedance signal
The impedance reflux waveform of transformation, combined impedance reflux feature, usual distal channel is relatively the most apparent, i.e., most gos deep into patient's stomach food
Therefore the impedance channel in road chooses distalmost end impedance channel as target impedance channel, to be carried out using different wavelet basis functions
Transformation, obtains wavelet coefficient.Wavelet coefficient changing rule is corresponded in original impedance signal again, chooses and is easier to distinguish small
The morther wavelet of wave system number is as target wavelet basic function.In the present embodiment, there is the orthogonal wavelet haar small echos of compact schemes more
The changing rule of original impedance signal can be intuitively reflected, it is therefore preferable that the small echo is as the suitable wavelet basis function.
Detection module includes：Computing unit, the modulus maximum for calculating the corresponding wavelet coefficient of each impedance channel；Detection
Unit, for detecting that lipschitz indexes meet the point of preset condition as unusual according to the modulus maximum of each wavelet coefficient
Point.
When carrying out inflection point detection to the wavelet coefficient of each impedance channel after transformation, the power of singular point be by
Lipshitz indexes can be detected come what is portrayed by the modulus maximum in wavelet coefficient.
First identification module includes：Third selection unit is examined for choosing sign mutation point according to preset sequence
It surveys；First judging unit, for judging in the preset range centered on current demand signal catastrophe point with the presence or absence of the first resistance of satisfaction
Doubtful impedance reflux in anti-reflux definition condition starts the point of condition；First recording unit, for judging with current demand signal
The doubtful impedance reflux in condition is defined in the presence of the first impedance reflux of satisfaction start condition in preset range centered on catastrophe point
Point when, record the point be doubtful impedance starting point；First deleting unit, for centered on judgement is by current demand signal catastrophe point
Preset range in there is no when meeting the first impedance reflux and defining the doubtful impedance reflux in condition and start the point of condition, delete
The current demand signal catastrophe point；Second judgment unit, for judge in preset range centered on current demand signal catastrophe point whether
The point of the doubtful impedance reflux termination condition in condition is defined in the presence of the first impedance reflux of satisfaction；Second recording unit is used for
Judge that there is the first impedance reflux of satisfaction in the preset range centered on current demand signal catastrophe point defines the doubtful resistance in condition
When the point of anti-reflux termination condition, it is doubtful impedance end point to record the point；Second deleting unit, for judging currently to believe
There is no meet the first impedance reflux and define the doubtful impedance reflux in condition to terminate in preset range centered on number catastrophe point
When the point of condition, the current demand signal catastrophe point is deleted.
Judge to whether there is around catastrophe point and meets the point that preset doubtful impedance reflux starts preset condition, if so,
The point is then recorded, the preset point for meeting impedance reflux and terminating preset condition is then found, is recorded as doubtful impedance end point, instead
It, then delete the catastrophe point, and location finding is started over until each channel of completion corresponds to doubtful impedance reflux.
In the present embodiment, preset first impedance reflux defines condition, specially：Doubtful impedance reflux starts over
Position is down or up to the 50% of baseline value.
After carrying out wavelet transformation to each impedance channel by using wavelet basis function, to the wavelet systems of each impedance channel
Number carries out inflection point detection, and singular point is corresponded in original impedance signal, comes to singular point pair in conjunction with the definition of impedance reflux
The original impedance signal answered carries out reflux identification, is accurately identified to gastroesophageal reflux waveform with realizing, so as to reflux
Disease carries out effective detect and diagnose.And primary dcreening operation is carried out to impedance reflux catastrophe point by Wavelet Transform, it can be to avoid
The appearance of the case where missing inspection directly brought surely by unstability of base line by the progress reflux detection of original impedance signal.
In one embodiment of the invention, further include：Second identification module, for anti-according to preset second impedance
Definition condition is flowed, stomach esophagus impedance signal goal-selling occurred in the preset time period before symptom carries out reflux identification.
Second identification module includes：Third judging unit, for defining condition according to preset first impedance reflux, point
Before carrying out reflux identification not centered on each sign mutation point of label, judge that the corresponding singular point of each impedance channel is corresponding
Whether the time of stomach esophagus impedance signal is located in the preset time period before symptom occurs for goal-selling；Recognition unit is used for
Condition is defined according to preset first impedance reflux, reflux is carried out centered on each sign mutation point of label respectively identifies it
Before, before judging that the time of the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel is located at goal-selling generation symptom
Preset time period in, then switch preset first impedance reflux define condition be preset second impedance reflux define condition,
And stomach esophagus impedance signal goal-selling occurred in the preset time period before symptom carries out reflux identification.
Preset second impedance reflux defines condition, specially：Doubtful impedance reflux start over position be decline or on
Predetermined threshold value is risen to, predetermined threshold value is more than the 50% of baseline value.
In order to improve to patient symptom for the previous period in impedance reflux positive rate, particularly, present embodiment
For symptom for the previous period during impedance signal detection Rule of judgment reseted.Therefore, impedance letter is being corresponded to
When number carrying out the detection of doubtful impedance reflux starting position, it is located at symptom when the time that wavelet coefficient singular point corresponds to impedance signal
When interior for the previous period, then doubtful impedance reflux condition is reseted, that is, it is default to switch preset first impedance reflux to define condition
The second impedance reflux define condition, then carry out the detection that doubtful impedance reflux starts over position.On the contrary then use acquiescence item
Part is detected, i.e., defining condition using preset first impedance reflux is detected.
Further, in one embodiment of the invention, further include：First judgment module, for judging each impedance
The position of the doubtful impedance reflux starting point in channel whether be located at itself next impedance channel doubtful impedance reflux starting point and
In the section of corresponding doubtful impedance reflux end point；Second mark module, in the doubtful impedance for judging each impedance channel
The position of reflux starting point is located at the doubtful impedance reflux starting point of itself next impedance channel and corresponding doubtful impedance reflux
When in the section of end point, the position of the doubtful impedance reflux starting point of each impedance channel and doubtful impedance reflux end point is marked
It is denoted as final impedance reflux.
In the present embodiment, position is started over to each doubtful impedance reflux that above-mentioned each impedance channel searches out
It sets, judges whether to meet preset direction condition, direction condition here is under the impedance reflux starting position in a upper channel is located at
During one channel impedance reflux starts over, the impedance reflux in each channel for the condition that meets, which is started over position mark, is
Final impedance reflux.
In one embodiment of the invention, further include：Second judgment module, for being corresponded to when each impedance channel of judgement
The corresponding stomach esophagus impedance signal of singular point time be located at goal-selling occur symptom before preset time period in when, judge
Whether there is the position of the doubtful impedance reflux starting point of any impedance channel to be located at the doubtful of the impedance channel of itself lower end
In the section of impedance reflux starting point and corresponding doubtful impedance reflux end point；Third mark module, for judging second
The position that module is determined with the doubtful impedance reflux starting point of any impedance channel is located at the impedance channel of itself lower end
When in the section of doubtful impedance reflux starting point and corresponding doubtful impedance reflux end point, by the doubtful impedance of the impedance channel
The position mark of reflux starting point and doubtful impedance reflux end point is final impedance reflux.
In the present embodiment, if doubtful impedance be located at patient symptom information for the previous period in, by above-mentioned direction
As long as condition is located between becoming having the doubtful impedance reversed flow region in channel above in the doubtful reflux section of lower end passage, then it is labeled as
Impedance reflux.
In conclusion gastroesophageal reflux method for waveform identification provided by the invention and system, using suitable wavelet basis letter
After several progress wavelet transformations to each impedance channel, inflection point detection is carried out to the wavelet conversion coefficient of each impedance channel, it will
Singular point corresponds to original impedance signal, to carry out the corresponding original impedance signal of singular point in conjunction with the definition of impedance reflux anti-
Stream identification, especially in conjunction with clinical patient symptom information, to be reaffirmed to impedance reflux.It realizes anti-to stomach oesophagus
Stream waveform is accurately identified, to carry out effective detect and diagnose to reflux disease.And in this way, pass through wavelet transformation
Method to carry out primary dcreening operation to impedance reflux catastrophe point, can be to avoid directly by carrying out reflux detection in original impedance signal because of base
Line unstability brings missing inspection, and combines clinical patient symptom information, again to symptom for the previous period in impedance signal into
Row detects again, it is ensured that impedance reflux before symptom will not missing inspection, improve the positive rate of reflux identification.
A kind of gastroesophageal reflux method for waveform identification provided by the present invention and system are described in detail above.This
Specific case is applied in text, and principle and implementation of the present invention are described, the explanation of above example is only intended to
Help understands the present invention and its core concept.It should be pointed out that for those skilled in the art, not departing from
, can be with several improvements and modifications are made to the present invention under the premise of the principle of the invention, these improvement and modification also fall into this hair
In bright scope of the claims.
Claims (10)
1. a kind of gastroesophageal reflux waveform recognition system is based on esophagus impedance pH combination monitoring systems, which is characterized in that including：
Acquisition module, the stomach esophagus impedance signal for obtaining goal-selling；
Conversion module, for carrying out small echo change to each impedance channel in the stomach esophagus impedance signal by wavelet basis function
It changes, obtains corresponding wavelet coefficient；
Detection module obtains corresponding unusual for carrying out inflection point detection to the corresponding wavelet coefficient of each impedance channel respectively
Point；
First mark module for corresponding to each singular point in original impedance signal, and carries out corresponding sign mutation
Point label；
First identification module, it is prominent with each signal of label respectively for defining condition according to preset first impedance reflux
Reflux identification is carried out centered on height.
2. system according to claim 1, which is characterized in that the conversion module includes：
First selection unit, for choosing the most apparent impedance channel conduct of stomach esophagus impedance signal middle impedance reflux waveform
Target impedance channel；
First converter unit is obtained for carrying out wavelet transformation to the target impedance channel respectively by several wavelet basis functions
To the corresponding target wavelet coefficient of each wavelet basis function；
Second selection unit, for choosing the morther wavelet of the best target wavelet coefficient of regularity as target wavelet basic function；
Second converter unit is used for through the target wavelet basic function to each impedance channel in the stomach esophagus impedance signal
Wavelet transformation is carried out respectively, obtains corresponding wavelet coefficient.
3. system according to claim 2, which is characterized in that the detection module includes：
Computing unit, the modulus maximum for calculating the corresponding wavelet coefficient of each impedance channel；
Detection unit, for detecting that lipschitz indexes meet preset condition according to the modulus maximum of each wavelet coefficient
Point as singular point.
4. system according to claim 3, which is characterized in that first identification module includes：
Third selection unit is detected for choosing sign mutation point according to preset sequence；
First judging unit, for judging in the preset range centered on current demand signal catastrophe point with the presence or absence of meeting described the
One impedance reflux defines the point that the doubtful impedance reflux in condition starts condition；
First recording unit meets described first for existing in preset range centered on judgement is by current demand signal catastrophe point
When impedance reflux defines the doubtful impedance reflux in condition and starts the point of condition, it is doubtful impedance starting point to record the point；
First deleting unit, for there is no meet described the in preset range centered on judgement is by current demand signal catastrophe point
When one impedance reflux defines the doubtful impedance reflux in condition and starts the point of condition, the current demand signal catastrophe point is deleted；
Second judgment unit, for judging in the preset range centered on current demand signal catastrophe point with the presence or absence of meeting described the
One impedance reflux defines the point of the doubtful impedance reflux termination condition in condition；
Second recording unit meets described first for existing in preset range centered on judgement is by current demand signal catastrophe point
When impedance reflux defines the point of the doubtful impedance reflux termination condition in condition, it is doubtful impedance end point to record the point；
Second deleting unit, for there is no meet described the in preset range centered on judgement is by current demand signal catastrophe point
When one impedance reflux defines the point of the doubtful impedance reflux termination condition in condition, the current demand signal catastrophe point is deleted.
5. system according to claim 4, which is characterized in that the preset first impedance reflux defines condition, specifically
For：
It is down or up to the 50% of baseline value that doubtful impedance reflux, which starts over position,.
6. system according to any one of claims 1 to 5, which is characterized in that further include：
Second identification module, for defining condition according to preset second impedance reflux, before symptom occurs to the goal-selling
Preset time period in stomach esophagus impedance signal carry out reflux identification.
7. system according to claim 6, which is characterized in that second identification module includes：
Third judging unit, for defining condition according to preset first impedance reflux, respectively with each signal of label
Before carrying out reflux identification centered on catastrophe point, the corresponding stomach esophagus impedance letter of the corresponding singular point of each impedance channel is judged
Number time whether be located at the goal-selling occur symptom before preset time period in；
Recognition unit, for defining condition according to preset first impedance reflux, respectively with each sign mutation of label
Before carrying out reflux identification centered on point, the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel is judged
Time is located in the preset time period before symptom occurs for the goal-selling, then switches the preset first impedance reflux definition
Condition is that preset second impedance reflux defines condition, and the goal-selling occurs the stomach in the preset time period before symptom
Esophagus impedance signal carries out reflux identification.
8. system according to claim 7, which is characterized in that the preset second impedance reflux defines condition, specifically
For：
Doubtful impedance reflux starts over position to be down or up to predetermined threshold value, and the predetermined threshold value is more than baseline value
50%.
9. system according to claim 1, which is characterized in that further include：
First judgment module, for judging whether the position of the doubtful impedance reflux starting point of each impedance channel is located at itself
In the section of the doubtful impedance reflux starting point of next impedance channel and corresponding doubtful impedance reflux end point；
Second mark module, in the case where judging that the position of the doubtful impedance reflux starting point of each impedance channel is located at itself
When in the section of the doubtful impedance reflux starting point of one impedance channel and corresponding doubtful impedance reflux end point, by each resistance
The doubtful impedance reflux starting point in anti-channel and the position mark of doubtful impedance reflux end point are final impedance reflux.
10. system according to claim 7, which is characterized in that further include：
Second judgment module, for when judging the corresponding stomach esophagus impedance signal of the corresponding singular point of each impedance channel
Between be located at the goal-selling occur symptom before preset time period in when, judge whether there is the doubtful of any impedance channel
The position of impedance reflux starting point is located at the doubtful impedance reflux starting point of the impedance channel of itself lower end and corresponding doubtful resistance
In the section of anti-reflux end point；
Third mark module, the doubtful impedance reflux for being determined with any impedance channel in second judgment module are opened
The position of initial point is located at the doubtful impedance reflux starting point of the impedance channel of itself lower end and corresponding doubtful impedance reflux terminates
When in the section of point, the position of the doubtful impedance reflux starting point of the impedance channel and doubtful impedance reflux end point is marked
It is denoted as final impedance reflux.
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| US20050080832A1 (en) * | 2003-09-05 | 2005-04-14 | Stuebe Thomas D. | Esophageal waveform analysis for detection and quantification of reflux episodes |
| US20110313320A1 (en) * | 2008-08-18 | 2011-12-22 | Gewolb Ira H | Non-invasive device for diagnosing gastroesophageal reflux |
| CN104133999A (en) * | 2014-07-29 | 2014-11-05 | 上海交通大学 | Remote medical information service system for diseases of digestive tract |
| WO2016187456A1 (en) * | 2015-05-20 | 2016-11-24 | Gravitas Medical, Inc. | Methods and apparatus for guiding medical care based on sensor data from the gastrointestinal tract |
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2018
- 2018-03-14 CN CN201810209569.7A patent/CN108309300B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050080832A1 (en) * | 2003-09-05 | 2005-04-14 | Stuebe Thomas D. | Esophageal waveform analysis for detection and quantification of reflux episodes |
| US20110313320A1 (en) * | 2008-08-18 | 2011-12-22 | Gewolb Ira H | Non-invasive device for diagnosing gastroesophageal reflux |
| CN104133999A (en) * | 2014-07-29 | 2014-11-05 | 上海交通大学 | Remote medical information service system for diseases of digestive tract |
| WO2016187456A1 (en) * | 2015-05-20 | 2016-11-24 | Gravitas Medical, Inc. | Methods and apparatus for guiding medical care based on sensor data from the gastrointestinal tract |
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Effective date of registration: 20210916 Address after: 401120 1-1, 2-1, 3-1, building 5, No. 18, Cuiping Lane 2, Huixing street, Yubei District, Chongqing Patentee after: Chongqing Jinshan Medical Technology Research Institute Co.,Ltd. Address before: 401120 1 office buildings, Jinshan International Industrial City, 18 of Nei sang Road, Hui Xing street, Yubei District, Chongqing. Patentee before: CHONGQING JINSHAN MEDICAL APPLIANCE Co.,Ltd. |