CN108309287A - A kind of physical detection methods that early screening cerebral function narrows - Google Patents
A kind of physical detection methods that early screening cerebral function narrows Download PDFInfo
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Abstract
The present invention provides a kind of physical detection methods that early screening cerebral function narrows comprising：Step S1：Stimulate layout；Using sound materials as stimulating, sound materials length is 230-300ms, and stimulus intervals are no less than 700ms；Step S2：Data acquire；By the multiple stimulations of loud speaker shuffle, volume 80dB, reproduction time amounts to 15 minutes；Using left and right ear-lobe as reference electrode, continuous EEG signals are recorded with eeg amplifier (Rainjet)；EEG signals amplify through amplifier, and are segmented extraction, are recorded after calibrated；Step S3：Data processing；By the EEG signals superposed average of record, the average value of left and right brain area is calculated separately out, obtains two curves；Step S4：Waveform recognition；The trough for finding and identifying curve automatically extracts its incubation period and wave amplitude.The present invention can be used for the early screening of aphasis and self-closing disease risk；By voice Induced by Stimulation event related potential, acquisition bears slow wave with aphasis relevant late period；The blank of domestic and international self-closing disease physical detection early screening is filled up.
Description
Technical field
The present invention relates to a kind of physical detection methods that early screening cerebral function narrows.
Background technology
Pavlov thinks that the most basic activity of cerebral cortex is activity, can inherently be distinguished conditional stimulus
For two major classes：One kind is the specific stimulation of reality, such as sound, light, electricity, taste stimulation, referred to as the first signal；Another kind of is abstract
Stimulation, i.e. spoken and written languages, referred to as second signal.To the cortex functional system that the first signal reacts, it is the first signal system,
It is that animal and people share.To the cortex functional system that second signal reacts, it is the second signal system, is that mankind institute is peculiar
's.The activity of the second signal system is the nervous activity maintained close ties with the language function of the mankind, is in baby's ontogeny
It gradually forms in journey, is set up on the basis of the first signal system or unconditioned reflex.
It is a kind of growth course that consciousness, which narrows, and in the process, brain moulds sensing capability using environment experience.This
Process can improve the sensing capability for the things that people are often subjected to itself, but make them to infrequently contacting the perception of things
Ability declines.This phenomenon is neural plasticity as a result, including conspicuous cloth study and cynapse trimming.By these mechanism, more pass through
The nerve pathway being often used is reinforced, and makes them more efficiently；And those rarely needed accesses become inefficient.This process exists
The tricky time of development is the most apparent.Human infant day, which is born with, can perceive various stimulations, with advancing age, they
By by one kind more meet it is socio-cultural in a manner of to various stimulations classify, start selectively narrow these recognize.This neck
Most of research in domain all concentrates in the face recognition and phoneme recognition of human infant.
Consciousness narrows also related with synesthesia.At birth, baby has extensive ability to go to find the similitude between language
And otherness.The phoneme of different language is different for the baby less than 6 months, but with the growth of baby and they
Brain development, they cannot be distinguished non-mother tongue phoneme and its mother tongue phoneme.This is probably due to baby and they is commonly used
Mother tongue, rather than more experiences are obtained in the case of non-mother tongue.Studies have shown that the phenomenon that narrows of this perception is happened at
The First Year of life.Compared with 8-10 months big babies, 6-8 month big babies have the non-local sound of differentiation of bigger
Ability.When 12 months big, baby starts that language is understood and manufactured with their mother tongue, in the First Year of baby due
Afterwards, baby can only show phoneme difference the low-level diagnostic ability similar with adult.
Autism children typically exhibits human communication disorders, is that perception narrows obstacle after all, show face recognition and
In terms of phoneme recognition；Therefore its risk of causing a disease is detected in advance, need to carry out face recognition or phoneme to it before 12 months
The detection of recognition capability；Since baby is unable to active control attention, visual stimulus is ineffective, therefore cannot carry out facial knowledge
Other ability detection, can only carry out another detection, i.e. phoneme recognition ability detects.
The thorns such as sound, light, the electricity that existing event related potential stimulating method generally use is designed according to the first signal system
Energizing mode or simple audiovisual stimulus modality do not contain sound materials, without specific aim yet.
Self-closing disease is difficult to treat once morbidity, and the later stage finds have no to help for treatment, therefore the early stage sieve of self-closing disease
It looks into necessary；It is early to find early intervention due to the neural plasticity highest of baby, specific aim voice training is carried out, hair can be reduced
Sick risk.
Therefore, how one kind is provided and contains sound materials, and becomes industry with targetedly physical detection methods to need
It solves the problems, such as.
Invention content
In view of the shortcomings of the prior art, the object of the present invention is to provide a kind of inspections of physics that early screening cerebral function narrows
Survey method containing sound materials, and has specific aim.
To achieve the goals above, the present invention provides a kind of physical detection methods that early screening cerebral function narrows,
Physical detection methods include：
Step S1：Stimulate layout；Using sound materials as stimulating, sound materials length is 230-300ms, between stimulation
Every no less than 700ms；
Step S2：Data acquire；By the multiple stimulations of loud speaker shuffle, volume 80dB, reproduction time amounts to 15 points
Clock；Using left and right ear-lobe as reference electrode, continuous EEG signals are recorded with eeg amplifier (Rainjet)；EEG signals are through amplification
Device amplifies, and is segmented extraction, is recorded after calibrated；
Step S3：Data processing；By the EEG signals superposed average of record, the average value of left and right brain area is calculated separately out,
Obtain two curves；
Step S4：Waveform recognition；The trough for finding and identifying curve automatically extracts its incubation period and wave amplitude.
In the present invention, experimental subjects is 12 months pervious babies.
In the present invention, in step S2, when playing stimulation, experimenter will be blown up a balloon in face of baby to attract its attention,
And increase tolerance of the baby to electrode sensor.
In the present invention, in step S3, there is no main effect and mutually influence in view of on each condition, for each brain hemisphere, lead to
It crosses the condition of upsetting and shows two curves；Each brain area has 4 leads.
The invention belongs to Electrophysiology fields, are related to event related potential (ERP) technology, can carry out professional recording or conjunction
At sound materials；In playing stimulating course, it is negative slow that aphasis relevant late period is collected by the electrode on brain scalp
Wave can be used for the early screening of aphasis and self-closing disease risk.
The difficult point of the present invention is to find out the effective normal form for being suitable for Chinese baby and its testing conditions, and according to the age and
Human-subject test designs detection scheme, selects applicable sound materials, and the time precision of voice stimulation is controlled in millisecond model
It encloses；Once selection of materials is improper and time control is bad, just it is difficult to induce event related potential late period negative slow wave, is not achieved
Expected Effect of screening.
The present invention is based on the law of development that the distinctive second signal system of the mankind and infant's phoneme consciousness narrow, screenings
With pairing infant it will be appreciated that sound materials, as event related potential stimulate material, to international strange ball normal form
(Oddball) it is improved, and carries out special layout and constitute passive double strange ball normal forms.
The present invention, once it is difficult to cure to fall ill, can only carry out early intervention and targetedly voice for current self-closing disease
Training, and there is no the present situation of self-closing disease early screening tool both at home and abroad, using the side of voice Induced by Stimulation event related potential
Method finds the onset risk of self-closing disease, the blank of domestic and international self-closing disease physical detection early screening has been filled up, to reach in advance
The early purpose for finding early treatment.
According to another specific implementation mode of the present invention, in step S1, stimulus intervals are to terminate from upper one stimulation to next
A time interval stimulated between starting.
According to another specific implementation mode of the present invention, in step S1, stimulation, which includes standard stimulus and deviation, to stimulate.
In the present solution, the sound materials that use of standard stimulus is Sichuan dialect/dia/, (diadia folds sound, is the meaning of grandfather
Think), account for the 80% of all stimulation total quantitys.
The sound materials that deviation stimulation uses is native languages and non-local language：
Local voice is mandarin/ta/ (pronunciation of such as tower), and all stimulations are accounted for always as the stimulation of sound materials using it
The 10% of quantity；
Non-native speech is Shaanxi dialect/da/ (dada folds sound, such as the meaning of big greatly uncle), using it as language
The stimulation of phoneme material accounts for the 10% of all stimulation total quantitys.
According to another specific implementation mode of the present invention, deviation stimulation at least will first play 2 standard stimulus before playing.
According to another specific implementation mode of the present invention, step S2 is carried out in the anechoic room of electronic shield.
According to another specific implementation mode of the present invention, in step S2, when EEG signals amplify through amplifier, band logical is
0.1-100Hz, digitizing rate 250Hz.
According to another specific implementation mode of the present invention, in step S2, the part that EEG signals are segmented extraction includes stimulation
Preceding 100ms and 700ms after stimulation.
According to another specific implementation mode of the present invention, in step S2, low-pass filtering of the EEG signals through 30Hz of extraction, with
The average value of 100ms carries out baseline correction as baseline before stimulation；After correction, it is divided to or so two regions in the electrode of front brain area
It is recorded, two regions in left and right are respectively left volume-central area and right volume-central area.
According to another specific implementation mode of the present invention, in step S3, only it is located at the standard stimulus before deviation stimulation and participates in
Superposition；3 kinds of stimulations are put together, and it is average to be overlapped.
According to another specific implementation mode of the present invention, in step S4, it is reference with bilateral mastoid process, knows in 250-550ms
Other slow n egative wave.
In the present solution, when carrying out average reference, average waveform is re-used as reference with the average value of all leads,
Identification in 300-700ms.
Compared with prior art, the present invention has following advantageous effect：
The present invention can be used for the early screening of aphasis and self-closing disease risk；It is mutually powered-down using voice Induced by Stimulation event
The method of position collects aphasis relevant late period negative slow wave by the electrode on brain scalp, finds self-closing disease in advance
Onset risk；The blank for having filled up domestic and international self-closing disease physical detection early screening, to achieve the purpose that early discovery early treatment.
The present invention is described in further detail below in conjunction with the accompanying drawings.
Description of the drawings
Fig. 1 is the electrode schematic view of the mounting position of the physical detection methods of embodiment 1；
Fig. 2 is the stimulus modality schematic diagram of the physical detection methods of embodiment 1.
Specific implementation mode
Embodiment 1
Present embodiments provide a kind of physical detection methods that early screening cerebral function narrows comprising：
Preparation：Registration is selected stimulation protocol by name, the monthly age of examining baby on software before detection；Enter a group condition：
In 12 months ages by inspection baby；Exclusion condition：Dysaudia baby.
Step S1：Stimulate layout；Using sound materials as stimulating, sound materials length is 230-300ms, between stimulation
Every 700ms.
Voice stimulation sum is 600；Stimulus intervals be since upper one stimulation terminate to it is next stimulation
Time interval.
Stimulation includes standard stimulus and deviation stimulation.
The sound materials that standard stimulus uses account for all for Sichuan dialect/dia/ (diadia folds sound, is the meaning of grandfather)
Stimulate the 80% of total quantity.
The sound materials that deviation stimulation uses is native languages and non-local language：
Local voice is mandarin/ta/ (pronunciation of such as tower), and all stimulations are accounted for always as the stimulation of sound materials using it
The 10% of quantity；
Non-native speech is Shaanxi dialect (unvoiced)/da/ (dada folds sound, such as the meaning of big greatly uncle), is adopted
It is used to account for the 10% of all stimulation total quantitys as the stimulation of sound materials.
Step S2：Data acquire；By the multiple stimulations of loud speaker shuffle, volume 80dB, reproduction time amounts to 15 points
Clock；Using left and right ear-lobe as reference electrode, continuous EEG signals are recorded with eeg amplifier (Rainjet)；EEG signals are through amplification
Device amplifies, and is segmented extraction, is recorded after calibrated.
Step S2 is carried out in the anechoic room of electronic shield；Deviation stimulation will first play 3 standard stimulus before playing.
When playing stimulation, experimenter will be blown up a balloon in face of baby to attract its attention, and is increased baby and passed to electrode
The tolerance of sensor；Electrode cap is worn to by inspection baby, the sponge electrode of brine was impregnated in installation；As shown in Figure 1, in front brain
The electrode position in area is divided to or so two regions to install electrode according to 10/10 system：Left volume-central area (FC1, FC5, C3, C5)
With right volume-central area ((FC2, FC6, C4, C6).
It installs, wears earphone to by inspection baby, electrode impedance is less than 5 kilo-ohms；As shown in Fig. 2, starting EEG sees waveform
It is whether steady, start ERP acquisitions after waveform is steady, and play stimulation simultaneously, it is desirable that be sitting on mother's leg or height by inspection baby
On foot chair, waits for that all stimulations finish, preserve initial data, i.e., continuous EEG signals.
When EEG signals amplify through amplifier, band logical 50Hz, digitizing rate 250Hz.
The part that EEG signals are segmented extraction includes 100ms and 700ms after stimulation before stimulation.
The average value of low-pass filtering of the EEG signals of extraction through 30Hz, the 100ms using before stimulation carries out baseline as baseline
Correction；After correction, two regions is divided to or so to be recorded in the electrode of front brain area, two regions in left and right are respectively in left volume-
Yang Qu and right volume-central area.
Step S3：Data processing；By the EEG signals superposed average of record, the average value of left and right brain area is calculated separately out,
Obtain two curves.
There is no main effect and mutually influence in view of on each condition, for each brain hemisphere, two are shown by upsetting condition
Curve；Each brain area has 4 leads.
Only it is located at the standard stimulus before deviation stimulation and participates in superposition；3 kinds of stimulations are put together, and it is average to be overlapped.
Step S4：Waveform recognition；The trough for finding and identifying curve automatically extracts its incubation period and wave amplitude.
It is to refer to bilateral mastoid process through 1-30 hertz of bandpass filtering, 250-550 milliseconds of models in waveform after the filtering
It encloses interior searching trough and is identified as negative slow wave, or automatic label bears slow wave, its incubation period, wave amplitude are automatically extracted out.
Embodiment 2
The present embodiment and the difference of embodiment 1 are：It is not reference with bilateral mastoid process in step S4, and carries out average ginseng
It examines；Average waveform is re-used as reference with the average value of all leads, is identified in 300-700ms.
Embodiment 3
The present embodiment and the difference of embodiment 1 are：The sound materials that standard stimulus uses is Sanskrit (voices)Account for the 80% of all stimulation total quantitys.
Local voice is that English combines (unvoiced sound)/ta/, and all stimulation sums are accounted for as the stimulation of sound materials using it
The 10% of amount；
Non-native speech is that Sanskrit combines (unvoiced sound)/da/, and all stimulations are accounted for always as the stimulation of sound materials using it
The 10% of quantity.
Although the present invention is disclosed above with preferred embodiment, it is not limited to the range that the present invention is implemented.Any
The those of ordinary skill in field improves in the invention scope for not departing from the present invention when can make a little, i.e., every according to this hair
Bright done same improvement, should be the scope of the present invention and is covered.
Claims (10)
1. a kind of physical detection methods that early screening cerebral function narrows, wherein the physical detection methods include：
Step S1：Stimulate layout；Using sound materials as stimulating, sound materials length is 230-300ms, and stimulus intervals are not
Less than 700ms；
Step S2：Data acquire；By the multiple stimulations of loud speaker shuffle, volume 80dB, reproduction time amounts to 15 minutes；With
Left and right ear-lobe is reference electrode, and continuous EEG signals are recorded with eeg amplifier (Rainjet)；EEG signals are put through amplifier
Greatly, and it is segmented extraction, is recorded after calibrated；
Step S3：Data processing；By the EEG signals superposed average of record, the average value of left and right brain area is calculated separately out, is obtained
Two curves；
Step S4：Waveform recognition；The trough for finding and identifying curve automatically extracts its incubation period and wave amplitude.
2. physical detection methods as described in claim 1, wherein in the step S1, stimulus intervals are to be stimulated from upper one
Terminate to next time interval stimulated between starting.
3. physical detection methods as described in claim 1, wherein in the step S1, stimulation includes standard stimulus and deviation
Stimulation.
4. physical detection methods as claimed in claim 3, wherein deviation stimulation at least will first play 2 standards before playing
Stimulation.
5. physical detection methods as described in claim 1, wherein the step S2 is carried out in the anechoic room of electronic shield.
6. physical detection methods as described in claim 1, wherein in the step S2, when EEG signals amplify through amplifier,
Band logical is 0.1-100Hz, digitizing rate 250Hz.
7. physical detection methods as described in claim 1, wherein in the step S2, EEG signals are segmented the portion of extraction
Divide 700ms after including the preceding 100ms of stimulation and stimulating.
8. physical detection methods as claimed in claim 7, wherein in the step S2, the EEG signals of extraction are through 30Hz's
The average value of low-pass filtering, the 100ms using before stimulation carries out baseline correction as baseline；After correction, it is divided to or so two regions preceding
The electrode of portion's brain area is recorded, and two regions in left and right are respectively left volume-central area and right volume-central area.
9. physical detection methods as claimed in claim 4, wherein in the step S3, be only located at the mark before deviation stimulates
Quasi- stimulation participates in superposition.
10. physical detection methods as described in claim 1, wherein it is reference with bilateral mastoid process in the step S4,
Slow n egative wave is identified in 250-550ms.
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