CN108295382A - Application of the He-Ne Lasers in skin wound treatment - Google Patents
Application of the He-Ne Lasers in skin wound treatment Download PDFInfo
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- CN108295382A CN108295382A CN201810008687.1A CN201810008687A CN108295382A CN 108295382 A CN108295382 A CN 108295382A CN 201810008687 A CN201810008687 A CN 201810008687A CN 108295382 A CN108295382 A CN 108295382A
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- lasers
- skin
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- wound
- rabbit
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
Abstract
The application that the invention discloses He-Ne Lasers in skin wound treatment.The wavelength of the He-Ne Lasers is 620~650nm；Optical fiber output power is 20~30mW.The present invention handles the wound of rabbit by using the He-Ne Lasers of specific wavelength and dosage, as a result compared with the control group, the death rate by He-Ne Lasers processing group is decreased obviously, and wound can fast quick-recovery, resume speed is substantially better than jingwanhong soft plaster ointment medicament, and rabbit will not be caused to develop immunity to drugs；The method handled simultaneously using He-Ne Lasers is simple, at low cost, with good clinical application and promotion prospect.
Description
Technical field
The present invention relates to skin wound treatment fields, more particularly to application of the He-Ne Lasers in skin wound treatment.
Background technology
Skin is mainly made of epidermis, corium, subcutaneous tissue, is human body area maximum and the easy organ by wound.
In life, the case that skin injury occurs for animal is relatively conventional, if treatment is not in time or method not science, can cause superficial
Skin structure infections, warts wound, cellulitis and simple abscesses, it is serious to cause a variety of symptoms of whole body, or even danger
And life.
The treatment of existing skin injury commonly uses the medicines such as anti-inflammatory, analgesic and antibiotic to promote skin healing and infection control.
But antibiotic is a large amount of using the generation for being easy to cause drug resistance, the case that wound restores slowly after much damaging, wound occurs
Persistently have no that situations such as red and swollen, exudation, infection occur in healing or even some wounds.
The application of He-Ne Lasers clinically is extremely wide, has a variety of effects.It has been had not yet to see in skin machinery
Application in terms of trauma care.
Invention content
The present invention provides application of the He-Ne Lasers in skin wound treatment to overcome the above-mentioned deficiency of the prior art.
To achieve the goals above, the present invention is achieved by following scheme：
The wavelength of application of the He-Ne Lasers in skin wound treatment, the He-Ne Lasers is 620~650nm；Optical fiber output work(
Rate is 20~30mW.
He-Ne Lasers is a kind of laser of low-power, and biological effect is very complicated caused by irradiation of low intensity He Ne laser, main
If being realized by the biostimulation of laser.Its main function is：1. expansible blood vessel improves skin microcirculation；2. promotion group
Knit metabolism；3. increasing the phagocytosis of macrophage, inflammation is promoted to absorb；4. there is apparent antibacterial action；5. increasing leaching
Bar cell transformation rate increases immunoglobulin and complement in blood.The effect of based on He-Ne Lasers, by selecting specific wavelength and agent
The He-Ne Lasers of amount, handles skin trauma, it is found that the resume speed of the skin trauma by He-Ne Lasers processing is apparent
It is faster than general drug, such as jingwanhong soft plaster ointment.
Preferably, the wavelength of the He-Ne Lasers is 632.8nm；Optical fiber output power is 25mW.
Preferably, the optical fiber of the He-Ne Lasers is 10~25cm at a distance from skin wound；Processing time be 20~
30min。
It is highly preferred that the optical fiber of the He-Ne Lasers is 20cm at a distance from skin wound；Processing time is 30min, often
It is primary.
Preferably, the skin trauma is skin mechanical trauma.It is highly preferred that the skin trauma is holostrome cut wound, depth
To the skin mechanical trauma of fascia layer.
Preferably, before carrying out He-Ne Lasers processing, first clean skin wound with physiological saline, and remove slough and
Foreign matter.
Preferably, using the open treatment that do not wrap up after He-Ne Lasers processing.
Compared with prior art, the invention has the advantages that：
The present invention by using the He-Ne Lasers of specific wavelength and dosage handle skin mechanical trauma, as a result with control group phase
Than, the death rate by He-Ne Lasers processing group is decreased obviously, wound can fast quick-recovery, it is soft that resume speed is substantially better than jingwanhong soft plaster
Cream drug, and rabbit will not be caused to develop immunity to drugs；The method handled simultaneously using He-Ne Lasers is simple, at low cost, tool
There are good clinical application and promotion prospect.
Description of the drawings
Fig. 1 is that 3 groups of rabbit skin traumas test back wound healing situation.Wherein, 1 group is model control group, and 2 groups are capital
Ten thousand red groups, 3 groups are He-Ne Lasers group.
Fig. 2 is 3 groups of rabbit skin trauma skin organization healing situations.
Fig. 3 is different time points total white blood cells variance analysis after 3 groups of rabbit skin traumas.
Fig. 4 is different time points blood platelet variance analysis after 3 groups of rabbit skin traumas.
Fig. 5 is different time points NGF variance analyses after 3 groups of rabbit skin traumas.
Fig. 6 is rear different time points VEGF variance analyses after 3 groups of rabbit skin traumas.
Fig. 7 is different time points PDGF variance analyses after 3 groups of rabbit skin traumas.
Fig. 8 is different time points TGF-B1 variance analyses after 3 groups of rabbit skin traumas.
Specific implementation mode
With reference to the accompanying drawings of the specification and specific embodiment is made the present invention and is further elaborated, the embodiment
It is served only for explaining the present invention, be not intended to limit the scope of the present invention.Test method used in following embodiments is such as without spy
Different explanation, is conventional method；Used material, reagent etc., unless otherwise specified, for the reagent commercially obtained
And material.
Embodiment 1
The instrument used in following experimentation is：He-Ne Lasers instrument（Model ES-521, it is limited purchased from the prosperous medical instrument in Shanghai extensive region
Company）, microplate reader（Model MK3, purchased from the silent winged generation that science and technology of match（Shanghai）Co., Ltd）, Automatic Blood Cell Analyzer（Type
Number BX-2800Vet, from Mairui Biological Medical Electronic Co., Ltd., Shenzhen）.
Test therapeutic effect of the He-Ne Lasers to rabbit skin trauma：
1, test method
（1）Selection healthy adult rabbit 18, weight are（2000±500）G, half male and half female, female do not produce no pregnancy, purchased from south
Square medical university the experimental center, (Guangdong quality certification number SCXK）2016-0041.After adaptability is raised 1 week, it is randomly divided into 3 groups, every group
6（Half male and half female）.It weighs after first each group experimental rabbit is marked, the back rabbit hair is shaved off with razor, in rabbit back glabrous skin
The upper circle for drawing a diameter 5cm, rabbit is put into homemade closed small carton, stays a small hole to lead to anesthesia tube, will exhale
It inhales anesthesia tube and is put into hole, oxygen concentration controls between 1~1.5, and anesthetic concentration controls between 3~4, maintenance 2~
5min rabbits can enter depth fiber crops state.By rabbit prostrate, skin holostrome cut wound model is prepared with tissue shear, it is deep to arrive fascia
Layer, wound area are shown in Fig. 1.After hemostasis by compression, rabbit is put on into No. 6 Elizabethan's circles and puts back to cage.
（2）1st group model control group, the 2nd group is jingwanhong soft plaster group, and the 3rd group is He-Ne Lasers group.Jingwanhong soft plaster ointment is a kind of
The compound ointment formulation of the diseases such as burn, ulcer, wound can be treated, clinically common drug, therapeutic domain prolong from burn and scald
Various skin injuries illness, including skin wound treatment are reached, has effects that promoting blood circulation and detoxication, swelling and pain relieving, remove necrosis and promote granulation.
Start to treat within 1 day after modeling, GP TH processing is shown in Table 1.Wherein, it is cleaned daily with 0.9% physiological saline for the 1st group
Then the surface of a wound removes slough and foreign matter, puts on headgear and put back to cage；2nd group is cleaned the surface of a wound with 0.9% physiological saline daily,
Then slough and foreign matter are removed, jingwanhong soft plaster, which is uniformly applied to after the surface of a wound, to be put on headgear and put back to cage；3rd group daily with 0.9%
Physiological saline cleans the surface of a wound, then removes slough and foreign matter, is then treated with he-ne laser irradiation, optical maser wavelength：
632.8nm, optical fiber output：25mW, optical fiber is away from surface of a wound 20cm, timing 30min.
Treatment is primary daily for each group, is all made of and does not wrap up open treatment.Rabbit free water, feeding in experimental period.
The packet transaction of 13 groups of lab diagrams of table
（3）Diet, the state of mind, behavioral activity and other clinical symptoms of each group rabbit are observed and recorded daily.In rabbit
Post-traumatic 1st, 3,7,14,21,28 day of son, with No. 7 blood taking needles by rabbit ear edge vein exploitating blood 1mL, with containing for 2mL specifications
The negative pressure blood-taking tube of EDTAK2 collects blood sample 1mL blood, acquires 2mL blood with the common negative pressure blood-taking tube of 5mL specifications, contains
The blood of EDTAK2 uses blood routine Instrumental Analysis, the blood of general blood collection tube to be stored at room temperature 30min at once, waits for that blood sample is completely solidifying
Gu 3000 turns/min, centrifuging 5min.Serum is sub-packed in the sterile centrifugation tube of 1.5mL, and label is placed on -20 DEG C of preservations, whole
Sterile working.
Testing index is：1. physical signs：Including leucocyte（WBC), monocyte (MONO), neutrophil cell
(NEUT), blood platelet (PLT)；
2. biochemical indicator：TP (total protein), ALB (albumin) and AST (aspartate amino transferase)；
3. growth factor index：Including transforming growth factor（TGF-B1）, vascular endothelial growth factor（VEGF）, it is platelet derived
Growth factor（PDGF）, nerve growth factor（NGF）, it is the enzyme-linked bio tech ltd's production in Shanghai；
4. skin wound histology：Post-traumatic 7th, 14,21,28 day in rabbit, every group is put to death an experimental rabbit at random,
1cm is taken between wound tissue and health tissues2Skin histology is placed in 10% neutral formalin and fixes, paraffin embedding, HE dyes
Color, tissues observed healing state.
Data are all made of the significance of difference between 22.0 statistical analysis software one-way analysis of variance each groups of SPSS, pass through
Duncan ' s methods of inspection carry out the Multiple range test of mean between each group, and test data is indicated using " average value ± standard error ".
, experimental result
（1）Mortality statistics
During the experiment, the death rate of 3 groups of lab diagrams is counted daily.As a result it is：1st group of the death rate is 50%, respectively in reality
Each dead one of the 5th day, the 8th day and the 9th day tested, dissect result are confirmed death reason as wound infection death.2nd group dead
It is 16.67% to die rate, the 8th day dead one, dissect result is that wound infection is dead.3rd group of the death rate is 16.67%,
8th day dead one, dissect result is that wound infection is dead.It follows that jingwanhong soft plaster ointment group and He-Ne Lasers processing can be bright
The aobvious death rate for reducing experimental rabbit and being caused by infection.
（2）Clinical sign
The the 1st, 3,7,14,21, the 28 day healing state for recording its wound after rabbit modeling, concrete condition are shown in Fig. 1.Wherein, 1 group
For model control group, 2 groups are jingwanhong soft plaster group, and 3 groups are He-Ne Lasers group.
For the result from clinical sign it is found that the speed of he-ne laser irradiation wound recovery is obviously very fast, experiment proves helium
Ne laser irradiation treatment skin wound can promote rabbit surface of a wound skin histology to repair speed.
（3）Histologic analysis
Histologic analysis is carried out to rabbit wound the 7th, 14,21,28 day after modeling, obtains that the results are shown in Figure 2.
As shown in Figure 2, it models the 7th day, with the 1st group of comparison, the 2nd, 3 group of skin wound tissue repair cell number significantly increases
Add, comparison has conspicuousness；It models the 14th day, with the 1st, 2 group of comparison, the 3rd group of skin wound tissue repair cell quantity is apparent
Increase and substep is uniform；It models the 21st day, the 1st group of skin wound tissue repair cell largely invades profit, the 2nd group of skin wound tissue
Visible vessels generate, and the 3rd group of skin wound tissue repair cell differentiation forms skin histology；28th day, the 1st group of skin wound group
Visible vessels generation is knitted, the 2nd group of skin wound histocyte is differentiated to form skin histology, the 3rd group of visible base of skin wound tissue
Matter is formed and the tissue reconstruction phase.It can be seen that being substantially better than control group and capital using the wound resume speed that He-Ne Lasers is handled
Ten thousand red ointment groups.
（4）Physical signs testing result
The measurement result that the blood routine part index number of rabbit is tested each group using statistics software is analyzed, wherein monocyte
Sum and three groups of comparison result differences of neutrophil count are not notable（P>5）.Total white blood cells and total number of blood platelet analysis
As a result see Fig. 3 and Fig. 4.Wherein, letter is different on icon indicates significant difference（P<0.05）, letter is identical or is indicated without shoulder mark
Difference is not notable（P>0.05）；1 group is model control group, and 2 groups are jingwanhong soft plaster group, and 3 groups are He-Ne Lasers group.
From the figure 3, it may be seen that compared with the 2nd group, the 1st, 3 group of leukocyte count on day 3 is increased, and difference has conspicuousness
（P<0.05）；14th day, the 2nd group of leukocyte count was apparent higher than the 1st, 3 group；The 21st day and the 1st group of comparison, the 2nd group, 3 groups it is white
Cell number is decreased obviously, and difference has statistics（P<0.05）.Data above explanation can be dropped in the treatment of inflammatory reaction phase jingwanhong soft plaster
The effect of low leukocyte count, anti-inflammatory is strong, and short-term helium neon laser antiinflammation is weaker.
As shown in Figure 4, compared with the 1st, 2,3 groups were obviously increased in the 14th day platelet count, and comparison has conspicuousness（P<
0.01）；Other times with the 1st combine the 2nd group, and there was no significant difference；It can thus be appreciated that He-Ne Lasers processing can improve body
Coagulation function.
（5）Biochemical indicator testing result
The biochemical indicator testing result of 3 groups of experimental rabbits is as shown in table 2, table 3.
Different time points AST variance analyses after 23 groups of rabbit skin traumas of table
Note：With the female different expression significant differences of column data shoulder marking-up（P<0.05）, letter is identical or indicates difference not without shoulder mark
Significantly（P>0.05）.
As shown in Table 2, with the 1st group of comparison, the 2nd, 3 group on day 3 AST expressions slightly increase, but difference unobvious
（P>0.05）.At the 28th day, with the 1st, 2 group of comparison, the 3rd group of AST expression was decreased obviously, significant difference（P>0.05）.In serum
The raising of AST represents meronecrosis, liver and Myocardial damage, and the 3rd group of AST is decreased obviously after the 28th day, shows that He-Ne swashs
Meronecrosis and related internal disease can be effectively controlled after light processing skin trauma.
Different time points TP variance analyses after 33 groups of rabbit wounds of table
Note：With the female different expression significant differences of column data shoulder marking-up（P<0.05）, letter is identical or indicates difference not without shoulder mark
Significantly（P>0.05）.
As shown in Table 3, compared with the 1st group, the 2nd, 3 group on day 3, the 7th day and the 14th day TP expression reduce；
28th day, with the 1st group of comparison, the 2nd, 3 group of TP expression had increase, significant difference（P<0.01）.When TP is increased, reaction
A variety of causes dehydration leads to pachyemia and other immunity diseases.It can be seen that being reacted the phase in wound inflammation, at He-Ne Lasers
Reason skin wound can be relieved the haemoconcentration of animal body.
（6）Growth factor testing result
The growth factor testing result of 3 groups of experimental rabbits is as shown in Fig. 5~Fig. 8.
Wherein Fig. 5 is different time points NGF variance analyses after 3 groups of rabbit skin traumas.As seen from the figure, compared with the 1st group,
2nd, 3 group of NGF expressions decline on day 3, slightly increased, the 3rd group of NGF expression is than the 1st, 2 after 21 days by the 7th day
Group is high, but difference is not notable.As a result illustrate helium neon laser skin wound in the nearly tissue reconstruction after inflammatory reaction, it is right
The expression of NGF has an apparent facilitation, the generation of nerve fiber when promoting skin reconstruction.
Fig. 6 is different time points VEGF variance analyses after 3 groups of rabbit skin traumas.As seen from the figure, compared with the 1st, 2 group,
3rd group vegf expression is horizontal on day 3 significantly increases, and otherness is notable（P<0.01）.14th, 28 day, the 3rd group of vegf expression water
It is flat slightly to increase, but difference is not notable（P>0.05）.Vegf expression level slightly increases, and shows that he-ne laser irradiation treats skin
The surface of a wound can promote the expression of vascular endothelial growth factor, promote vascularization.
Fig. 7 is different time points PDGF variance analyses after 3 groups of rabbit skin traumas.As seen from the figure, compared with the 1st group, the
2,3 groups of PDGF expressions decline on day 3 was slightly increased at the 7th day, in the 28th day the 3rd group of PDGF expression than the 1st, 2
Group is high, but difference is not notable.During wound inflammation reacts, immune system is activated, and blood platelet blood coagulation latter stage discharges chemotactic factor (CF),
It can induce a large amount of leucocytes and migrate into wound from blood, be on the defensive and repair.This is the result shows that helium neon laser can be
The inflammatory reaction phase promotes the expression of PDGF, accelerates wound healing.
Fig. 8 is different time points TGF-B1 variance analyses after 3 groups of rabbit skin traumas.As seen from the figure, compared with the 1st group,
2nd, 3 group of TGF-B1 expressions reduction on day 3, significant difference；Slightly increase in the 7th day the 2nd, 3 group of TGF-B1 expression
It is high；It is higher than the 1st, 2 group in the 28th day the 3rd group of TGF-B1 expression, but difference is not notable.This statistics indicate that He-Ne Lasers in inflammation
The ability to express of TGF-B1 can be promoted weaker after the disease initial stage processing surface of a wound, after adhering to treatment, TGF-B1 expression water can be significantly improved
It is flat, promote the reparation of the surface of a wound.
The experimental results showed that, he-ne laser irradiation treats the significant effect of skin injury above, is created compared with jingwanhong soft plaster skin
Covering weave healing rate is fast, has apparent advantage, and not will produce drug resistance, is worth clinically being applied and promoting.
Claims (8)
1. application of the He-Ne Lasers in skin wound treatment, which is characterized in that the wavelength of the He-Ne Lasers be 620~
650nm；Optical fiber output power is 20~30mW.
2. applying according to claim 1, which is characterized in that the wavelength of the He-Ne Lasers is 632.8nm；Optical fiber output work(
Rate is 25mW.
3. applying according to claim 1, which is characterized in that the optical fiber of the He-Ne Lasers is 10 at a distance from skin wound
~25cm；Processing time is 20~30min.
4. applying according to claim 1, which is characterized in that the optical fiber of the He-Ne Lasers is at a distance from skin wound
20cm；Processing time is 30min, once a day.
5. applying according to claim 1, which is characterized in that the skin trauma is skin mechanical trauma.
6. applying according to claim 5, which is characterized in that the skin trauma is holostrome cut wound, the deep skin for arriving fascia layer
Skin mechanical trauma.
7. applying according to claim 1, which is characterized in that before carrying out He-Ne Lasers processing, first cleaned with physiological saline
Skin wound, and remove slough and foreign matter.
8. applying according to claim 1, which is characterized in that using the open treatment that do not wrap up after He-Ne Lasers processing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810008687.1A CN108295382A (en) | 2018-01-04 | 2018-01-04 | Application of the He-Ne Lasers in skin wound treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810008687.1A CN108295382A (en) | 2018-01-04 | 2018-01-04 | Application of the He-Ne Lasers in skin wound treatment |
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| CN108295382A true CN108295382A (en) | 2018-07-20 |
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ID=62868602
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| CN2912691Y (en) * | 2006-07-21 | 2007-06-20 | 王威 | Electronic beauty treatment device |
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| CN202355706U (en) * | 2011-11-29 | 2012-08-01 | 西安精英光电技术有限公司 | Wound auxiliary healing device of optical laser |
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| CN206152107U (en) * | 2016-05-20 | 2017-05-10 | 武汉三友创鑫科技有限公司 | Compound LED therapeutic instrument of helium neon laser |
| RU2619876C1 (en) * | 2016-02-18 | 2017-05-18 | Государственное бюджетное учреждение здравоохранения Центр организации специализированной медицинской помощи "Челябинский государственный институт лазерной хирургии" | Method for skin wounds treatment with radiation in infrared wavelength range |
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| CN1121435A (en) * | 1994-10-25 | 1996-05-01 | 北京科电微波电子公司 | Red light therapeutic apparatus for burn |
| CN1185980A (en) * | 1996-12-26 | 1998-07-01 | 詹鼎 | Microwave-laser therapeutical instrument |
| EP0904804A2 (en) * | 1997-09-25 | 1999-03-31 | Thomas Ruschke | Device of reinforcement of electromagnetical waves in order to influence a biological system |
| CN101247768A (en) * | 2003-07-31 | 2008-08-20 | 莱特生物科学有限公司 | System and method for the photodynamic treatment of burns, wounds, and related skin disorders |
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