CN108295092A - 石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 - Google Patents
石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 Download PDFInfo
- Publication number
- CN108295092A CN108295092A CN201810163407.4A CN201810163407A CN108295092A CN 108295092 A CN108295092 A CN 108295092A CN 201810163407 A CN201810163407 A CN 201810163407A CN 108295092 A CN108295092 A CN 108295092A
- Authority
- CN
- China
- Prior art keywords
- graphite alkene
- nano material
- bovine serum
- serum albumin
- alkene nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Graphite alkene Chemical class 0.000 title claims abstract description 142
- 229910002804 graphite Inorganic materials 0.000 title claims abstract description 137
- 239000010439 graphite Substances 0.000 title claims abstract description 137
- 239000002086 nanomaterial Substances 0.000 title claims abstract description 113
- 239000002516 radical scavenger Substances 0.000 title claims abstract description 25
- 229940123457 Free radical scavenger Drugs 0.000 title claims abstract description 20
- 229940124553 radioprotectant Drugs 0.000 title claims abstract description 14
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 81
- 229940098773 bovine serum albumin Drugs 0.000 claims description 81
- 239000007864 aqueous solution Substances 0.000 claims description 38
- 238000005119 centrifugation Methods 0.000 claims description 8
- 229910021642 ultra pure water Inorganic materials 0.000 claims description 7
- 239000012498 ultrapure water Substances 0.000 claims description 7
- 150000001345 alkine derivatives Chemical class 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000036571 hydration Effects 0.000 claims description 3
- 238000006703 hydration reaction Methods 0.000 claims description 3
- 239000004575 stone Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000005034 decoration Methods 0.000 claims description 2
- 150000003254 radicals Chemical class 0.000 abstract description 40
- 230000000694 effects Effects 0.000 abstract description 34
- 230000005855 radiation Effects 0.000 abstract description 18
- 230000002000 scavenging effect Effects 0.000 abstract description 12
- 230000006378 damage Effects 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 9
- 230000007760 free radical scavenging Effects 0.000 abstract description 6
- 238000001959 radiotherapy Methods 0.000 abstract description 4
- 230000006698 induction Effects 0.000 abstract description 3
- 230000009257 reactivity Effects 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 230000003078 antioxidant effect Effects 0.000 abstract description 2
- 235000006708 antioxidants Nutrition 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 description 23
- 239000000463 material Substances 0.000 description 21
- 210000002784 stomach Anatomy 0.000 description 16
- 238000003379 elimination reaction Methods 0.000 description 12
- 230000008030 elimination Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 210000004907 gland Anatomy 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 241000209094 Oryza Species 0.000 description 5
- 235000007164 Oryza sativa Nutrition 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 5
- 235000013339 cereals Nutrition 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 235000009566 rice Nutrition 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003575 carbonaceous material Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000002633 protecting effect Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 230000005779 cell damage Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- FSVCQIDHPKZJSO-UHFFFAOYSA-L nitro blue tetrazolium dichloride Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 FSVCQIDHPKZJSO-UHFFFAOYSA-L 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229910021393 carbon nanotube Inorganic materials 0.000 description 2
- 239000002041 carbon nanotube Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000021615 conjugation Effects 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 229910021389 graphene Inorganic materials 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000003608 radiolysis reaction Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000002525 ultrasonication Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 241000283725 Bos Species 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 241000892865 Heros Species 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 108010093894 Xanthine oxidase Proteins 0.000 description 1
- 102100033220 Xanthine oxidase Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 description 1
- 229960001097 amifostine Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 229910052976 metal sulfide Inorganic materials 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Carbon And Carbon Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810163407.4A CN108295092B (zh) | 2018-02-27 | 2018-02-27 | 石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810163407.4A CN108295092B (zh) | 2018-02-27 | 2018-02-27 | 石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108295092A true CN108295092A (zh) | 2018-07-20 |
CN108295092B CN108295092B (zh) | 2020-05-05 |
Family
ID=62848877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810163407.4A Active CN108295092B (zh) | 2018-02-27 | 2018-02-27 | 石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108295092B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111012800A (zh) * | 2019-12-30 | 2020-04-17 | 国家纳米科学中心 | 用于清除自由基的碳纳米颗粒及其制备方法和应用 |
CN111732091A (zh) * | 2020-05-20 | 2020-10-02 | 深圳大学 | 二维石墨炔纳米片的制备方法及工作电极和光电探测器 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105267238A (zh) * | 2015-10-15 | 2016-01-27 | 北京福纳康生物技术有限公司 | 一种预防和/或治疗骨髓抑制的微纳材料及其应用 |
CN105842314A (zh) * | 2016-05-23 | 2016-08-10 | 济南大学 | 一种基于石墨炔和银纳米笼的人麻疹免疫传感器的制备方法 |
CN105903020A (zh) * | 2016-01-21 | 2016-08-31 | 北京福纳康生物技术有限公司 | 预防和/或治疗骨髓抑制的富勒烯微纳材料及其应用 |
-
2018
- 2018-02-27 CN CN201810163407.4A patent/CN108295092B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105267238A (zh) * | 2015-10-15 | 2016-01-27 | 北京福纳康生物技术有限公司 | 一种预防和/或治疗骨髓抑制的微纳材料及其应用 |
CN105903020A (zh) * | 2016-01-21 | 2016-08-31 | 北京福纳康生物技术有限公司 | 预防和/或治疗骨髓抑制的富勒烯微纳材料及其应用 |
CN105842314A (zh) * | 2016-05-23 | 2016-08-10 | 济南大学 | 一种基于石墨炔和银纳米笼的人麻疹免疫传感器的制备方法 |
Non-Patent Citations (1)
Title |
---|
RAHMAN,AKHTER,AHMAD ET AL: "Emerging advances in cancer nanotheranostics with graphene nanocomposites: opportunities and challenges", 《NANOMEDICINE》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111012800A (zh) * | 2019-12-30 | 2020-04-17 | 国家纳米科学中心 | 用于清除自由基的碳纳米颗粒及其制备方法和应用 |
CN111732091A (zh) * | 2020-05-20 | 2020-10-02 | 深圳大学 | 二维石墨炔纳米片的制备方法及工作电极和光电探测器 |
Also Published As
Publication number | Publication date |
---|---|
CN108295092B (zh) | 2020-05-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112791099B (zh) | 硫铁矿纳米酶、抗肿瘤药物及应用 | |
He et al. | Advances in biodegradable nanomaterials for photothermal therapy of cancer | |
Dong et al. | Biofilm microenvironment response nanoplatform synergistically degrades biofilm structure and relieves hypoxia for efficient sonodynamic therapy | |
CN107411983A (zh) | 一种水溶性富勒烯外用组合物 | |
He et al. | Recent developments of inorganic nanosensitizers for sonodynamic therapy | |
CN110101858B (zh) | 一种铂@聚多巴胺-二氢卟吩纳米复合材料及其制备方法和应用 | |
CN108295092A (zh) | 石墨炔纳米材料作为自由基清除剂及辐射防护剂的新用途 | |
Yao et al. | Application of organic frame materials in cancer therapy through regulation of tumor microenvironment | |
CN110101860B (zh) | 铋掺杂的金属硫化物纳米花及其制备方法 | |
CN111888337B (zh) | 碳酸钙基复合物微粒及其制备和应用 | |
Zhao et al. | A metal ion-drug-induced self-assembly nanosystems for augmented chemodynamic and chemotherapy synergetic anticancer therapy | |
Li et al. | Applications and perspectives of cascade reactions in bacterial infection control | |
CN111012800B (zh) | 用于清除自由基的碳纳米颗粒及其制备方法和应用 | |
Chen et al. | A Cu 2+ doped mesoporous polydopamine Fenton nanoplatform for low-temperature photothermal therapy | |
Guo et al. | Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife | |
Peng et al. | Oxygen vacancy-enhanced photothermal performance and reactive oxygen species generation for synergistic tumour therapy | |
Ge et al. | Na2S2O4@ Co-metal organic framework (ZIF-67)@ glucose oxidase for biofilm-infecting wound healing with immune activation | |
Li et al. | Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms | |
CN113117077B (zh) | 一种用于肿瘤联合治疗的铂基单原子纳米酶及其制备方法 | |
Liu et al. | Nanoarchitectonics with Two‐Dimensional Black Phosphorus and MnO2 for Synergistic Photodynamic‐/Radiotherapy Against Cancer through Enhanced Reactive Oxygen Species Activity | |
WU et al. | Nanozyme: A new approach for anti-microbial infections | |
CN109078184A (zh) | 负载双药纳米颗粒及其制备方法与应用 | |
CN112972695A (zh) | 葡萄糖氧化酶纳米反应器及其制备方法和应用 | |
CN101972229A (zh) | 一种过氧化氢酶固体脂质纳米粒制剂的制备方法 | |
CN110201167B (zh) | 光照释放氧气的载酶硒化铋纳米粒子的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240530 Address after: 076250, Zone 218/A, 2nd Floor, Building B, Enterprise Incubation Building, No. 8 Shenkong Road, High tech Industrial Development Zone, Zhangjiakou City, Hebei Province Patentee after: Zhangjiakou Nagu Technology Co.,Ltd. Country or region after: China Address before: 100049 No. 19 (b) hospital, Shijingshan District, Yuquanlu Road, Beijing Patentee before: INSTITUTE OF HIGH ENERGY PHYSICS, CHINESE ACADEMY OF SCIENCES Country or region before: China |
|
TR01 | Transfer of patent right |