CN108289973A - Urinate smelly inhibitor - Google Patents
Urinate smelly inhibitor Download PDFInfo
- Publication number
- CN108289973A CN108289973A CN201680068619.3A CN201680068619A CN108289973A CN 108289973 A CN108289973 A CN 108289973A CN 201680068619 A CN201680068619 A CN 201680068619A CN 108289973 A CN108289973 A CN 108289973A
- Authority
- CN
- China
- Prior art keywords
- smelly
- alcohol
- paracresol
- urine
- or9q2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000002700 urine Anatomy 0.000 claims abstract description 140
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Landscapes
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Fats And Perfumes (AREA)
Abstract
The present invention provides the substance that a kind of inhibition paracresol is smelly or urine is smelly.The present invention is a kind of smelly inhibitor of paracresol or the smelly inhibitor of urine of the antagonist using olfactory receptor OR9Q2 as active ingredient.
Description
Technical field
The present invention relates to a kind of smelly inhibitor of urine.
Background technology
In recent years, the improvement built with sewer, have because in lavatory excrement with urine Long Term Contact due to generate it is strong
Ammonia odor the problem of reduction tendency.On the other hand, in recent years, although the intensity of stink is weaker, the urine to splash from lavatory
Or the urine that the relevant absorbent commodity of absorption of used diaper etc. and urine is sent out is smelly as problem.
As the relevant absorbent commodity of absorption with urine, it is not only infant or by care-giver's diaper, light incontinence
It is also contained in it with the product of the absorbable urine of the results such as the light incontinences such as diaper or urine absorbent pad articles for use and then physiological articles for women
In.Especially in recent years, infant is not only or by care-giver's diaper, for nursing in the elderly, multipara, disease or after being ill
The demand of the light incontinences articles for use such as the light incontinence diaper of the light incontinence of person etc. or cushion constantly increases.These light incontinences
Articles for use are to use in daily life, so after being not only use, urinate smelly prevent also as important project in dress.
It records in patent document 1 to splashing and the smelly tribute of urine that the urine of drying or the diaper placed from after use are sent out
It is paracresol to offer highest ingredient.In addition, recording in patent document 1 can be by paracresol and the carbon atom number other than it
6~10 phenolic compounds, for example, phenol, xylenol, metoxyphenol, methoxy-ethylene base phenol, dihydroxy benzenes group
Close object and to reproduce the urine smelly.Additionally, it is known that if GRD beta-glucuronidase caused by bacterium acts on urine, phenol, paracresol, 4-
Vinyl -2- methoxy-phenols, 4-Vinyl phenol, 2- methoxyl group -1,3- Benzenediols, 1,4- Benzenediols, 1,3- Benzenediols,
The ingredients such as indoles increase in urine, and the smelly intensity of urine is made to dramatically increase (patent document 2).Think these ingredients be pair in lavatory
The urine smelly tribute different from the ammonia odor that the relevant absorbent commodity of absorption of urine is sent out such as the urine of middle splashing or used diaper
Offer higher ingredient.
Previously, as fragrance material, it is known to acetyl cedrene (Acetyl cedrene), isolongitolanone (Iso-
Longifolanone), nerolidol (Nerolidol), Asiatic sweet leaf alcohol (Bacdanol) and Amber Core (registered trademark).Into
And report that it is the short of money of the olfactory receptor of identification scatol to have acetyl cedrene, nerolidol and Amber Core (registered trademark)
Anti-agent, and the substance (patent document 3) to inhibit scatol smelly.Acetyl cedrene, flores aurantii uncle are disclosed in patent document 4
The combination that alcohol and Amber Core (registered trademark) are smelly as the base for covering cosmetic hair, amine is smelly, ammonia odor, sulphur are smelly etc.
A kind of ingredient of object.In turn, disclose acetyl cedrene as the alkaline stench deodorant such as Trimethylamine a kind of ingredient,
And a kind of ingredient (patent document of the spice composition of stench caused by the amine in reproduction path is urinated by being present in as inhibition
5、6).Usable Amber Core (registered trademark) are disclosed in patent document 7 as the fragrance group inhibited by urinating generation ammonia
Close a kind of ingredient of object.It discloses on the one hand also to have as fragrance material in patent document 8 and inhibits the movable of olfactory cell
The substance of effect.Disclose in patent document 9 isolongitolanone as be added in hair dye and inhibit hair dyeing when it is produced
Ammonia odor gas one of ingredient.Nerolidol is disclosed in patent document 10 to neutralize as the foul smell that can be matched with containing esters
One example of the fragrance ingredient in agent.However, have no at this stage these fragrance materials to paracresol and due to its urine it is smelly
Report with inhibition.
Recently, be provided with it is a kind of by specifically hinder olfactory receptor to be used as target stench activity to inhibit
The method (for example, patent document 3) of the stench.Suppression based on the smell that the receptor active using such antagonist agent hinders
System or the mechanism of modified tone are referred to as olfactory receptor antagonism.Utilize the inhibition or change of the smell that olfactory receptor antagonism generates
Tune is different from by additional other deodorizing methods of stronger smell such as perfume or aromatic, can become the knowledge of the stench of target
It does not disappear specifically, in addition, the case where generating discomfort because of the stronger smell of aromatic is also not present, therefore is excellent
The deodorization means of choosing.
(patent document 1) Japanese Unexamined Patent Publication 2009-132770 bulletins
(patent document 2) International Publication bulletin the 2009/037861st
(patent document 3) Japanese Unexamined Patent Publication 2012-250958 bulletins
(patent document 4) Japanese Unexamined Patent Publication 2003-137758 bulletins
No. 5695288 bulletins of (patent document 5) Japanese Patent Publication No.
(patent document 6) International Publication bulletin the 2004/098666th
(patent document 7) US publication bulletin the 2015/0079017th
(patent document 8) International Publication bulletin the 2009/125604th
(patent document 9) Japanese Unexamined Patent Publication 2004-067598 bulletins
(patent document 10) Japanese Patent Publication No. 4520682
Invention content
Therefore, the present invention provides a kind of smelly using at least one kind of paracresol as active ingredient in following compounds
Inhibitor.In addition, the present invention provides a kind of smelly inhibition of at least one kind of urine as active ingredient using in following compounds
Agent.
Vertofix coeur；
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone；
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls；
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol；And
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
Description of the drawings
Fig. 1 is response of the olfactory receptor expression cell to the paracresol of various concentration.N=3~4, error bar=± SE.
Fig. 2 is the inhibition of the paracresol response of the olfactory receptor OR9Q2 expression cells generated by substances.Horizontal axis
Indicate the concentration of substances, when the longitudinal axis indicates the response intensity individually stimulated for paracresol (100 μM) being set as 100%
The response (%) of paracresol and receptor-expressing cells when substances is used in combination.N=3, error bar=± SE.
Fig. 3 A：The sense evaluation (n=9) of the smelly inhibition of paracresol of substances.Fig. 3 B：The smelly suppression of urine of substances
The sense evaluation (n=10) of effect processed.The distribution of data is indicated using box traction substation.It is indicated respectively most from the line of case stretched out up and down
Big value and minimum value.Three articles of horizontal lines of case indicate the 1st, 3 quartile points and median.
Specific implementation mode
In the present specification, so-called " by the inhibition for the stink that olfactory receptor antagonism generates ", is by applying together
Target malodor molecules and other molecules, to hinder the receptor active for target malodor molecules using other molecules, as a result
Inhibit the means of the stink gone out by individual identification.Even if the inhibition of the stink generated by olfactory receptor antagonism is similarly to make
With the means of other molecules, also with the hand that passes through the fragrance of fragrance as the deodorization carried out using aromatic and cover target stink
Section distinguishes.One example of the inhibition of the stink generated by olfactory receptor antagonism be using antagonist etc. hinder smell by
The example of the active substance of body.If the receptor application of the malodor molecules to bringing specific odor hinders its active substance,
This receptor is to the activity inhibiteds of the malodor molecules, so final can inhibit the stink being aware of by individual.
In the present specification, so-called " the relevant absorbent commodity of absorption with urine " (or referred to as " absorbent commodity "),
Refer to infant or by the light incontinences articles for use such as care-giver's diaper, light incontinence diaper, urine absorbent pad, physiological articles for women
Etc. the product for being worn in human or animal and the absorbable urine of result.
In the present invention, so-called " stink caused by paracresol (or cresols is smelly) " can be caused by paracresol
Stink.About " stink caused by paracresol " in the present invention, for representative, can behave as pissing or adopt after urine by
It in the dresses such as the stink that dry urine is sent out or the diaper placed from after use or is used from urine or splashing after a period of time
It is attached with the stink for the urine that the absorbent commodity of urine is sent out afterwards.Comprising because of ferment possessed by bacterium included in it in these urine
The effect of β glycuronidases and the paracresol generated.β glycuronidases are by various alcohols, phenols, amine etc. and grape
The ferment for compound (glucuronic acid) hydrolysis that uronic acid is combined into, containing in the bacterium included in urine.
In the present specification, so-called " urine smelly " is preferably sent out after urine from pissing or adopting through urine after a period of time
Stink.For example, the stink for the urine that " urine is smelly " in this specification can be dried for splashing or the diaper etc. placed from after use
The stink for the urine that the absorbent commodity of urine is sent out is attached in dress or after.In addition, " urine is smelly " in this specification is preferably
The stink of the urine or its extracts that acted on by β glycuronidases (so-called corruption urine is smelly)." β grapes in this specification
The urine that uronic acid enzyme is acted on " also includes energetically to add β glycuronidases to pissing or adopting in the urine of urine and be allowed to act on
Urine on the other hand since β glycuronidases are included in piss or adopt in the urine of urine and act on the urine, so piss or
It is also contained in the urine that β glycuronidases are acted on through urine after a period of time after adopting urine.β glycuronidases are acted on
Urine in include the paracresol that is generated because it is acted on.Therefore, " urine is smelly " in this specification can be more preferably β grape alditols
The stink for the urine comprising paracresol that sour enzyme is acted on is smelly due to the urine of paracresol.
In the present specification, so-called " olfactory receptor polypeptide ", refer to olfactory receptor or with its polypeptide with same function,
The so-called polypeptide with olfactory receptor with same function refers to the polypeptide with following function in the same manner as olfactory receptor：It can be
Expressed on cell membrane, by scent molecule in conjunction with by activate, and make adenosine when be activated the intracellular G α s conjugation of Shi Huiyu
Cyclase of acid activates, thus make the increase of intracellular cAMP amounts (Nat.Neurosci., 2004,5：263-278).
In the present specification, the homogeneity of nucleotide sequence and amino acid sequence is by Lippmann-Pearson's method
(Lipman-Pearson methods；Science, 1985,227：1435-41) calculate.Specifically, at by using hereditary information
Manage software Genetyx-Win (Ver.5.1.1；Software development) homology analysis (Search homology) program, by Unit
Size to compare (ktup) are set as 2 and are analyzed and calculated.
In the present specification, so-called relevant " at least 80% homogeneity " with nucleotide sequence and amino acid sequence, be
Refer to 80% or more, be preferably 85% or more, more preferably 90% or more and then preferably 95% or more and then is more preferred
For 98% or more, further preferably 99% or more homogeneity.
The present invention relates to provide the inhibitor for urinating stink that is smelly or being generated by its reason substance.
Present inventors found that olfactory receptor OR9Q2 expression cells can be to making as the paracresol for urinating smelly reason substance
Go out response；And inhibit the substance of the response of OR9Q2 expression cells that can inhibit by paracresol institute via olfactory receptor antagonism
The stink of generation and due to its urine it is smelly.
The inhibitor that paracresol provided by the present invention is smelly or urine is smelly can inhibit paracresol by olfactory receptor antagonism
Smelly and due to it urine is smelly.Therefore, it according to the inhibitor, not will produce in the existing deodorization using deodorant or aromatic
The problem of the discomfort of the overpowering odor based on aromatic generated in method etc., and can remove produced by paracresol or urine
Stink.According to the present invention, can inhibit such as by splash in lavatory urinate, the hairs such as absorbent commodity used diaper
The stink of the urine different from ammonia odor gone out.
Olfactory receptor OR9Q2 is the olfactory receptor expressed in mankind olfactory cell, as GI：284413710 are registered in
GenBank.OR9Q2 is the gene code of the nucleotide sequence represented by with sequence number 1 comprising represented by sequence number 2
The protein of amino acid sequence.Present inventor et al. has found that olfactory receptor OR9Q2 is to as the paracresol for urinating smelly reason substance
Show the receptor for paracresol of the activation (Fig. 1) of concentration dependence.
It therefore, can be by the OR9Q2 antagonists for the response for inhibiting olfactory receptor OR9Q2 expression cells for inhibiting paracresol smelly
Or urine is smelly.OR9Q2 antagonists inhibit OR9Q2 to be directed to the activity of paracresol by olfactory receptor antagonism, thus make individual
Paracresol is smelly or the smelly identification of urine generates variation, as a result can inhibit that paracresol is smelly or urine is smelly.
Therefore, in one embodiment, the present invention provides a kind of paracresol using OR9Q2 antagonists as active ingredient
Inhibitor smelly or that urine is smelly.As the OR9Q2 antagonists used in the present invention, can enumerate following：
Vertofix coeur ([1- [(1S, 2R, 5R, 7S) -2,6,6,8- tetramethyl tricyclics [5.3.1.01,5] 11 carbon -8-
Alkene -9- bases] ethyl ketone；Acetyl cedrene)；
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone (2,2,7,7-tetramethyltricyclo
[6.2.1.01,6]undecan-5-one；Isolongitolanone)；
12 carbon -1,6,10- triolefin -3- alcohol (3,7,11-trimethyldodeca-1,6,10- of 3,7,11- trimethyls
trien-3-ol；Nerolidol)；
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol ((E) -2-ethyl-4-
(2,2,3-trimethyl-1-cyclopent-3-enyl)but-2-en-1-ol；Asiatic sweet leaf alcohol)；And
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol (1- (2-tert-butylcyclohexyl) oxybutan-2-
ol；Amber core (registered trademark)).
More specifically, above compound is to be directed to OR9Q2 or short of money with its olfactory receptor polypeptide with same function
Anti-agent.In the present specification, so-called " with OR9Q2 have same function olfactory receptor polypeptide ", refer to by with 2 tables of sequence number
Amino acid sequence of the amino acid sequence shown at least 80% homogeneity is constituted and paracresol is smelly or urine is smelly with being directed to
The olfactory receptor polypeptide of responsiveness.As the example of the olfactory receptor polypeptide with OR9Q2 with same function, can enumerate by sequence
The olfactory receptor Olfr1497 for the mouse that amino acid sequence represented by numbers 3 is constituted and the amino acid sequence represented by sequence number 4
Arrange the olfactory receptor Olfr377 of the rat constituted and polypeptide identical with these 95% or more sequences.Olfr1497 be with
The olfactory receptor of the identical mouse of OR9Q2, and the amino acid sequence represented by with sequence number 2 is with 86% homogeneity
Amino acid sequence is constituted, and with for the smelly responsiveness of paracresol.Olfr377 be rat identical with OR9Q2 smell by
Body, and amino acid sequence of the amino acid sequence represented by with sequence number 2 with 84% homogeneity is constituted, and there is needle
The responsiveness smelly to paracresol.
Above-mentioned cited OR9Q2 agonist compounds previously as fragrance material are known to masses, but and are unaware of
It is with the antagonist action for being directed to OR9Q2 or has the function of selectively inhibiting paracresol smelly or urinate smelly.In addition, these
OR9Q2 agonist compounds have the function of inhibiting paracresol smelly or urinate smelly, another aspect, can show this as fragrance material
The fragrance of body, therefore while as the inhibitor that paracresol is smelly or urine is smelly, it is also possible to make fragrance.
Above-mentioned cited OR9Q2 agonist compounds it is commercially available enter commercially available product (reference《Synthetic perfume chemistry is known with commodity
Know》Supplement revised edition, print rattan member one write, chemical industry day newspaper office, in March, 2005 distribution).For example, above-mentioned OR9Q2 antagonists
Close object can from Firmenich S.A., Givaudan S.A., International Flavors＆Fragrances Inc.,
The acquisitions such as SIGMA-ALDRICH Corporation, Takasago spices Industry Co, Kao Corp.Alternatively, can also lead to
It crosses chemical synthesis and manufactures substance identical with the commercially available product or the composition comprising it.
The inhibitor that the paracresol of the present invention is smelly or urine is smelly contains in above-mentioned cited OR9Q2 antagonists at least
1 kind of compound is as active ingredient.For example, the present invention paracresol it is smelly or urinate smelly inhibitor active ingredient can be selected from upper
State at least one kind of, for example individually any or arbitrary two or more combination in cited OR9Q2 antagonists.Alternatively, this hair
The inhibitor that bright paracresol is smelly or urine is smelly substantially can be by least one kind of structure in above-mentioned cited OR9Q2 antagonists
At.
In another embodiment of the present invention, above-mentioned cited OR9Q2 antagonists can be used as inhibiting paracresol
Active ingredient smelly or that urine is smelly.
In one embodiment, above-mentioned cited OR9Q2 antagonists can be used as inhibiting paracresol smelly or urinating smelly
Active ingredient and containing in for inhibiting paracresol smelly or the smelly compound or composition of urine.Alternatively, cited by above-mentioned
OR9Q2 antagonists can be used for manufacturing the inhibitor that paracresol is smelly or urine is smelly or for manufacturing for inhibiting paracresol smelly or urinating smelly
Compound or composition.As for inhibiting paracresol smelly or urinating the example of smelly compound or composition, lavatory use can be enumerated
Deodorant or aromatic, lavatory remover, the lotion of underpants or diaper or softening agent etc..
In one embodiment, above-mentioned cited OR9Q2 antagonists, which can be directed to, expects to inhibit paracresol smelly or urinates smelly
All compound or compositions or can be used as in the case where expecting to inhibit paracresol smelly or the smelly all environment of urine for inhibiting pair
The active ingredient that cresols is smelly or urine is smelly.Alternatively, the OR9Q2 antagonists can be used as inhibit paracresol smelly or urine it is smelly it is effective at
Divide and is used to manufacture the compound or composition for expecting to inhibit that paracresol is smelly or urine is smelly.Inhibit paracresol smelly as expectation or urinates smelly
Compound or composition example, absorbent commodity can be enumerated (for example, infant or by care-giver's diaper, light incontinence
With the light incontinences such as diaper or urine absorbent pad articles for use, physiological articles for women), bedding, mattress, sheet, woollen blanket, underpants, closestool, horse
Bucket seat cushion, lavatory cushion, the wall of lavatory or flooring board etc..
The inhibitor that above-mentioned paracresol is smelly or urine is smelly and the compound or composition for inhibiting paracresol smelly or urine is smelly are removed
Other than above-mentioned cited OR9Q2 antagonists, also it can suitably contain other ingredients with deodorizing effect according to its purpose.As
Other ingredients with deodorizing effect can enumerate the ingredient for the ferment β glycuronidases for hindering to generate paracresol in urine
That is 8- ring hexadecenes -1- ketone (Globanone (registered trademark)) etc..In turn, above-mentioned inhibitor and for inhibiting paracresol smelly or
It urinates smelly compound or composition and also may include any ingredient usually added in deodorant or deodorant.
As another way, the present invention provides the suppressing method that a kind of paracresol is smelly or urine is smelly comprising keeps paracresol smelly
Or the step of urine is smelly and above-mentioned cited OR9Q2 antagonist coexists.
In an embodiment of the method for aforementioned present invention, by that will be selected from the presence of paracresol is smelly or urine is smelly
It is at least one kind of applied to object in above-mentioned cited OR9Q2 antagonists, it is smelly total with the antagonist to keep paracresol smelly or urinate
It deposits.As a result, the OR9Q2 of the object and the antagonist in conjunction with and inhibit the OR9Q2 of the object to be directed to the activation of paracresol, therefore it is logical
Olfactory receptor antagonism is crossed to inhibit paracresol smelly or urinate smelly.
In the method for aforementioned present invention, as above-mentioned object, can enumerate must inhibit paracresol smelly or the smelly object of urine,
It is preferred that can enumerate must utilize olfactory receptor antagonism to inhibit the object that paracresol is smelly or urine is smelly.As long as the object is dynamic for lactation
Object is then not particularly limited, preferably the mankind.More specifically, paracresol must be inhibited smelly as in the method for the present invention
Or urinate smelly object example, can enumerate absorbent commodity (for example, infant or by care-giver's diaper, light incontinence urine
The light incontinences such as cloth or urine absorbent pad articles for use, physiological articles for women) user, patient or the elderly nursing staff, keep a public place clean
Member, the people etc. for being engaged in garbage collection operations.
In an embodiment of the method for aforementioned present invention, above-mentioned OR9Q2 antagonists possible are being will produce to first
It is applied in advance under the environment that phenol is smelly or urine is smelly.When generating that paracresol is smelly in the present context as a result, or the smelly situation of urine, this to first
Phenol is smelly or urine it is smelly in the presence of the OR9Q2 antagonists are applied to object, therefore can be inhibited pair by olfactory receptor antagonism
Cresols is smelly or urine is smelly.
In an embodiment of the method for aforementioned present invention, the allotment of above-mentioned OR9Q2 antagonists is in containing paracresol
In compound or composition.Thereby, it is possible to reduce activity of the olfactory receptor to paracresol contained in the compound or composition,
And inhibits the paracresol in object smelly or urinate smelly identification, as a result inhibit paracresol smelly or urinate smelly.In addition, in another implementation form
In, the allotment of above-mentioned OR9Q2 antagonists is in may will produce in paracresol or the smelly compound or composition of urine.The antagonism as a result,
Agent reduces activity of the olfactory receptor OR9Q2 to the paracresol generated by the compound or composition, inhibits the paracresol in object
As a result identification smelly or that urine is smelly inhibits paracresol smelly or urinates smelly.As paracresol or the smelly compound or group of urine may be will produce
The example for closing object can enumerate urine, absorbent commodity (for example, infant or by care-giver's diaper, light incontinence diaper or suction
The light incontinences such as diaper articles for use, physiological articles for women), bedding, mattress, sheet, woollen blanket, underpants, closestool, toilet seat pad,
Lavatory cushion, the wall of lavatory or flooring board etc..Therefore, the another way as the present invention can provide a kind of containing choosing
From at least one kind of absorbent commodity in the group that above-mentioned OR9Q2 antagonists are formed (for example, infant or being urinated by care-giver
The light incontinences articles for use such as cloth, light incontinence diaper or urine absorbent pad, physiological articles for women), bedding, mattress, sheet, woollen blanket,
Underpants, closestool, toilet seat pad, lavatory cushion, the wall of lavatory or flooring board, the deodorant of lavatory or aromatic, lavatory
The lotion or softening agent of remover or underpants or diaper used.In addition, in these articles, above-mentioned OR9Q2 antagonists
Object is closed can also to can be used as fragrance while functioning as the inhibition ingredient that paracresol is smelly or urine is smelly and function.
As the illustrative embodiment of the present invention, and then substance below, manufacturer are disclosed in the present specification
Method, purposes or method.But the present invention is not limited to these embodiments.
[1] the smelly inhibitor of a kind of paracresol, using following Table As record compound in it is at least one kind of as active ingredient.
[Table A]
Vertofix coeur；
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone；
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls；
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol；
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol
[2] at least one kind of compound in the compound that above-mentioned Table A is recorded is for the use in inhibiting paracresol smelly
On the way.
[3] at least one kind of compound in the compound that above-mentioned Table A is recorded is for manufacturing in the smelly inhibitor of paracresol
Purposes.
[4] a kind of suppressing method that paracresol is smelly comprising will be at least one kind of in the compound that above-mentioned Table A is recorded
Applied to the object that paracresol must be inhibited smelly.
[5] the smelly inhibitor of a kind of urine, using at least one kind of as active ingredient in the compound that above-mentioned Table A is recorded.
[6] at least one kind of compound in the compound that above-mentioned Table A is recorded is for the purposes in inhibiting urine smelly.
[7] at least one kind of compound in the compound that above-mentioned Table A is recorded is for manufacturing the use in urinating smelly inhibitor
On the way.
[8] the smelly suppressing method of a kind of urine comprising be applied at least one kind of in the compound that above-mentioned Table A is recorded
It must inhibit to urinate smelly object.
[9] in any one of above-mentioned [5]~[8], it is by pissing or adopting after urine through after a period of time that preferably above-mentioned urine is smelly
Stink that urine afterwards is sent out, by splashing and stink that the urine of drying is sent out, the absorbability by being attached with urine in wearing or after
The stink for the urine that article is sent out, the stink of the urine that β glycuronidases are acted on or its extract or the urine due to paracresol
It is smelly.
[10] a kind of for OR9Q2 or the antagonist with its olfactory receptor polypeptide with same function, it is upper to be selected from
It states at least one kind of as active ingredient in the compound of Table A record.
[11] at least one kind of compound in the compound that above-mentioned Table A is recorded is used as OR9Q2 or with it and has together
Etc. the antagonist of the olfactory receptor polypeptide of functions purposes.
[12] at least one kind of compound in the compound recorded by above-mentioned Table A is directed to OR9Q2 in manufacture or has with it
There is the purposes in the receptor active antagonist of the olfactory receptor polypeptide of same function.
[13] in any one of above-mentioned [10]~[12],
It is preferred that OR9Q2 is the olfactory receptor polypeptide that the amino acid sequence represented by sequence number 2 is constituted, and
It is preferred that it is the amino acid sequence represented by with sequence number 2 to have the olfactory receptor polypeptide of same function with OR9Q2
Amino acid sequence at least 80% homogeneity is constituted, and with for paracresol it is smelly or urinate the smell of smelly responsiveness by
Body polypeptide.
[14] in above-mentioned [13], it includes by 3 institute of sequence number preferably to have the olfactory receptor polypeptide of same function with OR9Q2
The polypeptide that the polypeptide and the amino acid sequence represented by sequence number 4 that the amino acid sequence of expression is constituted are constituted.
[15] in above-mentioned [13], preferably above-mentioned urine is smelly to be sent out through urine after a period of time after urine by pissing or adopting
Stink, the stink that the urine of drying is sent out, the urine sent out by the absorbent commodity for being attached with urine in wearing or after by splashing
Stink, the urine that β glycuronidases are acted on or its extract stink or smelly due to the urine of paracresol.
[embodiment]
Hereinafter, showing embodiment, more specific description further is carried out to the present invention.
By used in the present embodiment urine sordes matter and substances be shown in following table 1.
[table 1]
The identification of 1 paracresol receptor of embodiment
1) making of olfactory receptor expression cell
Human olfactory receptor and is utilized with human genome DNA women based on the sequence information for being registered in GenBank
(G1521：Promega it) is carried out as the PCR of model (Polymerase Chain Reaction, PCR) method
Clone.The gene expanded using PCR methods is set into pENTR carriers (Invitrogen) according to handbook, and utilizes and is present in
The NotI of the position NotI, AscI on pENTR carriers and the making of the downstream of the Flag-Rho sequence labels on pME18S carriers,
The positions AscI recombinate.In addition, making the olfactory receptor matter made into the cell in culture be moved to cell membrane surface coding
The gene of protein, that is, mankind RTP1S is set into the position EcoRI, XhoI of another pME18S carriers.
The reaction solution formed shown in table 2 is prepared, after standing 15 minutes in bacteria-and dust-free workbench, is added to 96 orifice plates
(BD) in each hole.Then, the HEK293 cells (3 × 10 of 90 μ L are sowed in each hole respectively5Cell/cm2), keep 37 DEG C,
5%CO2Incubator in culture 24 hours.As a contrast, the cell (Mock) that olfactory receptor will not be made to express has been prepared.
[table 2]
Reaction solution forms：Each hole of 96 orifice plates
2) luciferase detects
The G α s of olfactory receptor and cell internality expressed by HEK293 cells are conjugated and adenyl cyclase are made to activate,
Thus increase intracellular cAMP amounts.Paracresol response in this research used in measuring using the increase of intracellular cAMP amounts as
The luciferase-reporter inspection that luminous value from firefly luciferase gene (fluc2P-CRE-hygro) is monitored
It surveys.In addition, channel genes make Renilla luciferase Gene Fusion gene (hRluc- made of CMV promoter downstream simultaneously
CMV the internal standard of the error of efficiency or cell number), and as corrective gene is imported.
Culture medium is removed from above-mentioned 1) the middle culture made, and add modulation in new culture medium includes specific
The 75 μ L of substances solution of the paracresol of concentration.By cell in CO2Culture 3 hours, make luciferase gene exist in incubator
It fully expresses into the cell.About the determination of activity of luciferase, Dual-Glo is usedTMLuciferase Assay System
(Promega) and according to the operation manual of product it is measured.It calculates and is originated from the firefly luciferin through paracresol stimulation induction
The luminous value of enzyme divided by the value not carried out obtained by the intracellular luminous value of paracresol stimulation are used as increase multiple (fold
Increase), and it is set as the index of response intensity.
3) result
To making the raji cell assay Raji that 387 kinds of olfactory receptors are respectively expressed be directed to the response of paracresol, as a result as to first
The receptor of phenol activation is found that OR9Q2.OR9Q2 expression cells have concentration dependence (Fig. 1) for the response of paracresol.According to
OR9Q2 as a result, are accredited as the paracresol receptor of identification paracresol by these.
The identification of embodiment 2OR9Q2 antagonists
1) luciferase detects
With sequence same as Example 1, experimental investigation substance is detected by using the luciferase of OR9Q2 expression cells
Influence to the paracresol response of OR9Q2 expression cells.The concentration of paracresol is set as 100 μM.The response of OR9Q2 expression cells is strong
Degree calculates as follows.About various incentive conditions, calculates the luminous value from firefly luciferase divided by be originated from
Value fLuc/hRluc obtained by the luminous value of Renilla luciferase.The fLuc/hRluc values of induction will be individually stimulated through paracresol
(X) divided by same receptor and the intracellular fLuc/hRluc values (Y) that are not stimulated are imported, finds out and is individually pierced by paracresol
The receptor active for swashing gained increases multiple (X/Y).Similarly, by by using the mixture of paracresol and substances into assassination
The intracellular fLuc/hRluc values (Y) for swashing the fLuc/hRluc values (Z) of gained divided by not stimulated, find out addition trier
Receptor active (Z/Y) when matter.According to following calculating formula calculate addition substances when receptor active (Z/Y) with respect to
Paracresol individually stimulates the ratio of the receptor active (X/Y) of gained, finds out the response intensity (response %) in the presence of substances.
Independent experiment is carried out 3 times, the average value of each experiment is obtained.
Response (%)=(Z/Y)/(X/Y) × 100
2) result
Acetyl cedrene, Amber Core (registered trademark), isolongitolanone, nerolidol and Asiatic sweet leaf determining alcohol phase
The paracresol response for inhibiting to closing property OR9Q2 expression cells, to be judged as OR9Q2 antagonists (Fig. 2).
Embodiment 3 is by the paracresol that OR9Q2 antagonists generate is smelly and the smelly rejection ability of urine
It is tested by function and confirms that the paracresol generated by the OR9Q2 antagonists identified in embodiment 2 is smelly and urinates smelly suppression
Effect processed.
As urine sordes matter, it is prepared for the extract of the urine through β glucuronic acid enzymatic treatments.Utilize the β of 25units/mL
Glycuronidase TypeVII-A to 400mL human urines handle within 2 hours at 37 DEG C, then uses the hydrochloric acid of 37 mass %
After being adjusted to pH value 4 or so, extracted using dichloromethane.1M sodium hydroxide water is added into the dichloromethane layer obtained
Solution extracts after so that acid ingredient is moved to water layer, and neutral component is removed.The water layer system that will be obtained using hydrochloric acid
After acidity, is extracted again using diethyl ether, extract is obtained after being concentrated.It will be equivalent to the amount of urine stoste 80mL
Extract is dissolved in the ethyl alcohol of 1mL, and then will be diluted the lysate in the way of as 1.25% by mineral oil
Obtained dilution is used as urine extract.As paracresol, 1% (v/v) aqueous solution of distilled water is used.It will be in embodiment 2
The agonist compounds identified, which are dissolved in mineral oil (Sigma), prepares 1% (v/v) solution, and is used as substances solution.
2 cotton balls are put into the vial (Maruemu, No.6) of 20mL capacity, 30 μ L paracresol aqueous solutions or urine are made
Extract is penetrated into 1 cotton balls, and any substances solution of 30 μ L is made to penetrate into another cotton balls.Cotton balls will be put into
Glass cap upper cover and after standing 1 hour at 37 DEG C, as test specimen for testing.It is identified in example 2
In agonist compounds, it is directed to paracresol respectively and prepares 4 test specimens, for urine 2 test specimens of smelly preparation.It is only right to prepare
Cresols or urine extract are used as authentic specimen, preparation only mineral oil (solvent) sample as a contrast.
Function experiment is carried out with single blind by 9 or 10 estimators.Experiment be from after meal pass through 1 and a half hours with
On 14 points after start.Smell is spread in order to prevent, and experiment substantially carries out near ventilation opening.In order to exclude adaptation pair
The influence of smell suitably confirms in test the cognition intensity of the stench from authentic specimen, rests when needing.Test specimen
Be be replaced with after 3 estimators evaluate it is new.In the evaluation of test specimen, the benchmark for setting following 5 grades is " right
The stench of elephant is 1：Perception less than；2：It can perceive；3：Slightly perceive；4：Consumingly perceive；5：Consumingly perceive
And can not endure ", using 9 grades from 1.0 as unit of 0.5 until 5.0 to by the stench intensity in authentic specimen
The stench intensity from each test specimen when being set as 3 is evaluated.
The result for the evaluation result tested using the function of each estimator is shown in Fig. 3.Tested OR9Q2 antagonists are equal
Show that paracresol is smelly and the smelly inhibition of urine.It is smelly about paracresol, it shows in 9 testees, whole members are to acetyl group
Cedrene, 7 people answer out and individually sucking pair Amber Core (registered trademark) and isolongitolanone nerolidol, 5 people
The inhibition of the smelly intensity of the weaker paracresol of situation phase (score is less than 3) of cresols.By various antagonists and used time
The median of the smelly intensity of paracresol is：Acetyl cedrene is 2, nerolidol 2.5, and Amber Core (registered trademark) are
2.5, isolongitolanone 2.5 is the value for indicating intensity decline when independent compared to paracresol.It is smelly about urinating, 10 subjects
In the person of testing, relative to 8 people, acetyl cedrene and Amber Core (registered trademark) show inhibition.Median is：Second
Acyl group cedrene is that 2, Amber Core (registered trademark) are 2, be indicate compared to urine extract it is independent when intensity decline
Value.According to the present embodiment as a result, showing that the inhibition smelly to paracresol and urine of tested OR9Q2 agonist compounds has
Effect.In addition, the OR9Q2 agonist compounds used in the present embodiment are fragrance material, inhibit to first in function experiment
Phenol is smelly, the fragrance of another aspect holding itself, to inhibit paracresol smelly, and is functioned as fragrance.
Sequence table
<110>Kao Corp
<120>Urinate smelly inhibitor
<130> KS1466
<150> JP 2015-228522
<151> 2015-11-24
<150> JP 2016-218693
<151> 2016-11-09
<160> 4
<170>Patent version 3 .5
<210> 1
<211> 945
<212> DNA
<213>Homo sapiens
<220>
<223>The DNA of encoding human OR9Q2
<400> 1
atggctgaaa ggaattacac cgtagtgacg gagttcttcc ttactgcatt tactgaacat 60
ctccagtgga gggttcctct cttcctcata tttttgagtt tctatcttgc cactatgtta 120
gggaacacag gcatgatcct cctgatccgt ggcgatcgtc ggctccacac cccgatgtac 180
ttcttcctca gccacctttc cttggtggac atctgctact cgtccgccat catccctcag 240
atgctggctg tgctgtggga gcacggcaca accatctccc aggctcgctg tgcagctcag 300
ttcttcctct tcaccttctt tgcctccatc gactgctacc ttctggccat catggcctat 360
gaccgctaca cggccgtgtg ccagcccctg ctttatgtca ccatcataac cgagaaggcc 420
cgctggggcc tagtcactgg ggcttacgtt gctggttttt tcagtgcctt tgttcgaacg 480
gtcacagcct tcactctctc cttttgtgga aacaatgaga tcaacttcat tttctgtgac 540
ctccctcctc tattaaaact ctcctgtggg gacagctaca ctcaggaagt ggtgattatt 600
gtgtttgctc ttttcgtcat gcctgcctgt atcttggtga tcttggtatc ctacctgttt 660
atcattgtgg ccatcctgca gatccactct gctggaggcc gggccaagac cttctccacc 720
tgcgcctccc acctcactgc cgtcgctctt ttctttggca ccctcatctt catgtacctg 780
cgagacaaca caggccagtc ctccgaggga gaccgagtgg tgtctgtgct ctacacggtg 840
gtgaccccaa tgctgaatcc ccttatctat agcctgagaa acaaggaggt aaaagaggcc 900
actaggaaag ccctgagcaa atcaaagcct gctagaagac cctaa 945
<210> 2
<211> 314
<212> PRT
<213>Homo sapiens
<220>
<223>Mankind OR9Q2
<400> 2
Met Ala Glu Arg Asn Tyr Thr Val Val Thr Glu Phe Phe Leu Thr Ala
1 5 10 15
Phe Thr Glu His Leu Gln Trp Arg Val Pro Leu Phe Leu Ile Phe Leu
20 25 30
Ser Phe Tyr Leu Ala Thr Met Leu Gly Asn Thr Gly Met Ile Leu Leu
35 40 45
Ile Arg Gly Asp Arg Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser
50 55 60
His Leu Ser Leu Val Asp Ile Cys Tyr Ser Ser Ala Ile Ile Pro Gln
65 70 75 80
Met Leu Ala Val Leu Trp Glu His Gly Thr Thr Ile Ser Gln Ala Arg
85 90 95
Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Ala Ser Ile Asp Cys
100 105 110
Tyr Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Thr Ala Val Cys Gln
115 120 125
Pro Leu Leu Tyr Val Thr Ile Ile Thr Glu Lys Ala Arg Trp Gly Leu
130 135 140
Val Thr Gly Ala Tyr Val Ala Gly Phe Phe Ser Ala Phe Val Arg Thr
145 150 155 160
Val Thr Ala Phe Thr Leu Ser Phe Cys Gly Asn Asn Glu Ile Asn Phe
165 170 175
Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Gly Asp Ser
180 185 190
Tyr Thr Gln Glu Val Val Ile Ile Val Phe Ala Leu Phe Val Met Pro
195 200 205
Ala Cys Ile Leu Val Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala
210 215 220
Ile Leu Gln Ile His Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr
225 230 235 240
Cys Ala Ser His Leu Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile
245 250 255
Phe Met Tyr Leu Arg Asp Asn Thr Gly Gln Ser Ser Glu Gly Asp Arg
260 265 270
Val Val Ser Val Leu Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu
275 280 285
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Thr Arg Lys Ala
290 295 300
Leu Ser Lys Ser Lys Pro Ala Arg Arg Pro
305 310
<210> 3
<211> 314
<212> PRT
<213>Mouse
<220>
<223> Olfr1497
<400> 3
Met Ala Gly Arg Asn Tyr Thr Phe Val Thr Glu Phe Phe Leu Thr Ala
1 5 10 15
Phe Thr Glu His Pro Glu Trp Gly Leu Pro Leu Phe Leu Leu Phe Leu
20 25 30
Ser Phe Tyr Leu Ala Thr Leu Leu Gly Asn Thr Gly Met Ile Ile Leu
35 40 45
Ile Gln Lys Asn Arg Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser
50 55 60
His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Ile Ile Pro Gln
65 70 75 80
Met Leu Ala Val Leu Trp Glu His Gly Ser Thr Ile Ser Gln Val Arg
85 90 95
Cys Ala Val Gln Phe Phe Leu Phe Thr Phe Phe Ala Ser Ile Asp Cys
100 105 110
Tyr Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Gln
115 120 125
Pro Leu Leu Tyr Val Thr Ile Met Thr Glu Lys Ala Arg Val Gly Leu
130 135 140
Val Thr Gly Ala Tyr Val Ala Gly Phe Ser Ser Gly Phe Ile Arg Thr
145 150 155 160
Val Thr Ala Phe Thr Leu Ser Phe Cys Gly Asn Asn Glu Ile Asn Phe
165 170 175
Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Val Cys Gly Asp Ser
180 185 190
Tyr Ile Gln Glu Val Val Ile Ile Val Phe Ala Ile Phe Val Met Pro
195 200 205
Ala Cys Ile Val Val Ile Ser Val Ser Tyr Leu Phe Ile Ile Val Ala
210 215 220
Ile Met Gln Ile Arg Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr
225 230 235 240
Cys Thr Ser His Leu Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile
245 250 255
Phe Met Tyr Leu Arg Asp Asn Thr Asp Gln Phe Ser Glu Arg Asp Arg
260 265 270
Val Val Ser Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu
275 280 285
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ile Thr Lys Ser
290 295 300
Leu Arg Arg Ser Lys Ile Ser Arg Ala Pro
305 310
<210> 4
<211> 314
<212> PRT
<213>Rat
<220>
<223> Olfr377
<400> 4
Met Ala Gly Lys Asn Tyr Thr Phe Val Thr Gln Phe Phe Leu Thr Ala
1 5 10 15
Phe Thr Glu His Pro Glu Trp Gly Leu Pro Leu Phe Leu Leu Phe Leu
20 25 30
Ser Phe Tyr Leu Ser Thr Leu Leu Gly Asn Thr Gly Met Ile Ile Leu
35 40 45
Ile Gln Lys Asn Arg Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser
50 55 60
His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Ile Ile Pro Gln
65 70 75 80
Met Leu Ala Val Leu Trp Glu His Gly Thr Thr Ile Ser Gln Val Arg
85 90 95
Cys Ala Val Gln Phe Phe Leu Phe Thr Phe Phe Ala Ser Ile Asp Cys
100 105 110
Tyr Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Gln
115 120 125
Pro Leu Leu Tyr Val Thr Ile Met Thr Glu Lys Ala Cys Val Gly Leu
130 135 140
Val Thr Gly Ala Tyr Val Ala Gly Phe Ser Ser Gly Phe Ile Arg Thr
145 150 155 160
Val Thr Ala Phe Thr Leu Ser Phe Cys Gly Ser Asn Glu Ile Asn Phe
165 170 175
Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Val Cys Gly Asn Ser
180 185 190
Tyr Val Gln Glu Val Val Ile Ile Val Phe Ala Ile Phe Val Met Pro
195 200 205
Ala Cys Ile Val Val Ile Ser Val Ser Tyr Leu Phe Ile Ile Val Ala
210 215 220
Ile Met Gln Ile Arg Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr
225 230 235 240
Cys Thr Ser His Leu Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile
245 250 255
Phe Met Tyr Leu Arg Asn Asn Thr Asp Gln Phe Ser Glu Arg Asp Arg
260 265 270
Val Val Ser Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu
275 280 285
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ile Ile Lys Ser
290 295 300
Leu Arg Arg Ser Lys Ile Ser Arg Gly Asn
305 310
Claims (21)
1. a kind of smelly inhibitor of paracresol, wherein
The smelly inhibitor of paracresol is using at least one kind of as active ingredient in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
2. a kind of smelly inhibitor of urine, wherein
The smelly inhibitor of the urine is using at least one kind of as active ingredient in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
3. urinating smelly inhibitor as claimed in claim 2, wherein
The smelly urine for being due to paracresol of urine is smelly.
4. a kind of being directed to OR9Q2 or the antagonist with its olfactory receptor polypeptide with same function, wherein
The antagonist is using at least one kind of as active ingredient in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
5. antagonist as claimed in claim 4, wherein
The OR9Q2 is the olfactory receptor polypeptide that the amino acid sequence represented by sequence number 2 is constituted, and is had with the OR9Q2
The olfactory receptor polypeptide of same function is ammonia of the amino acid sequence at least 80% homogeneity represented by with sequence number 2
Base acid sequence constitute, and with for paracresol it is smelly or urinate smelly responsiveness olfactory receptor polypeptide.
6. such as claim 5 antagonist, wherein
With the OR9Q2 there is the olfactory receptor polypeptide of same function to be the amino acid sequence represented by with sequence number 2 has
What the amino acid sequence of at least 90% homogeneity was constituted, and with smelly or urinate the olfactory receptor of smelly responsiveness for paracresol
Polypeptide.
7. at least one kind of compound in following compounds is for manufacturing the purposes in the smelly inhibitor of paracresol：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
8. at least one kind of compound in following compounds is for manufacturing the purposes in urinating smelly inhibitor：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
9. purposes as claimed in claim 8, wherein
The smelly urine for being due to paracresol of urine is smelly.
10. at least one kind of compound in following compounds is for manufacturing the purposes in receptor active antagonist, wherein
The receptor active antagonist for OR9Q2 or with its olfactory receptor polypeptide with same function,
The compound is：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
11. purposes as claimed in claim 10, wherein
The OR9Q2 is the olfactory receptor polypeptide that the amino acid sequence represented by sequence number 2 is constituted, and is had with the OR9Q2
The olfactory receptor polypeptide of same function is ammonia of the amino acid sequence at least 80% homogeneity represented by with sequence number 2
Base acid sequence constitute and with for paracresol it is smelly or urinate smelly responsiveness olfactory receptor polypeptide.
12. purposes as claimed in claim 11, wherein
With the OR9Q2 there is the olfactory receptor polypeptide of same function to be the amino acid sequence represented by with sequence number 2 has
The amino acid sequence of at least 90% homogeneity constitutes and with smelly or to urinate the olfactory receptor of smelly responsiveness more for paracresol
Peptide.
13. purposes of at least one kind of compound in the inhibition smelly for paracresol in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
14. at least one kind of compound in following compounds is for urinating the purposes in smelly inhibition：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
15. purposes as claimed in claim 14, wherein
The smelly urine for being due to paracresol of urine is smelly.
16. purposes of at least one kind of compound as antagonist in following compounds, wherein
The antagonist for OR9Q2 or with its olfactory receptor polypeptide with same function,
The compound is：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
17. purposes as claimed in claim 16, wherein
The OR9Q2 is the olfactory receptor polypeptide that the amino acid sequence represented by sequence number 2 is constituted, and is had with the OR9Q2
The olfactory receptor polypeptide of same function is ammonia of the amino acid sequence at least 80% homogeneity represented by with sequence number 2
Base acid sequence constitute, and with for paracresol it is smelly or urinate smelly responsiveness olfactory receptor polypeptide.
18. purposes as claimed in claim 17, wherein
With the OR9Q2 there is the olfactory receptor polypeptide of same function to be the amino acid sequence represented by with sequence number 2 has
What the amino acid sequence of at least 90% homogeneity was constituted, and with smelly or urinate the olfactory receptor of smelly responsiveness for paracresol
Polypeptide.
19. a kind of suppressing method that paracresol is smelly, wherein
Include to needing the smelly object of paracresol is inhibited to use at least one kind of in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
20. a kind of suppressing method that urine is smelly, wherein
Include to need to inhibit to urinate smelly object use it is at least one kind of in following compounds：
Vertofix coeur,
2,2,7,7- tetramethyl tricyclics [6.2.1.01,6] hendecane -5- ketone,
12 carbon -1,6,10- triolefin -3- alcohol of 3,7,11- trimethyls,
(E) -2- ethyls -4- (the amyl- 3- alkenyls of 2,2,3- trimethyl -1- rings) but-2-ene -1- alcohol and
1- (2- tert-butylcyclohexyls) oxygroup butane -2- alcohol.
21. method as claimed in claim 20, wherein
The smelly urine for being due to paracresol of urine is smelly.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| JP2015228522 | 2015-11-24 | ||
| JP2015-228522 | 2015-11-24 | ||
| JP2016218693A JP6831674B2 (en) | 2015-11-24 | 2016-11-09 | Urine odor suppressant |
| JP2016-218693 | 2016-11-09 | ||
| PCT/JP2016/084196 WO2017090518A1 (en) | 2015-11-24 | 2016-11-18 | Urine odor suppressor |
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| Publication Number | Publication Date |
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| CN108289973A true CN108289973A (en) | 2018-07-17 |
| CN108289973B CN108289973B (en) | 2021-03-30 |
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| CN201680068619.3A Expired - Fee Related CN108289973B (en) | 2015-11-24 | 2016-11-18 | Urine odor inhibitor |
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| JP (1) | JP6831674B2 (en) |
| CN (1) | CN108289973B (en) |
| TW (1) | TW201726181A (en) |
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| WO2021235360A1 (en) | 2020-05-18 | 2021-11-25 | 高砂香料工業株式会社 | Fragrance composition, and food and beverage |
| JP7488709B2 (en) | 2020-07-15 | 2024-05-22 | 花王株式会社 | Cat defecation behavior inhibitor |
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| TW201726181A (en) | 2017-08-01 |
| CN108289973B (en) | 2021-03-30 |
| JP6831674B2 (en) | 2021-02-17 |
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