CN108272873A - 一种用于治疗乳腺增生的外用中草药 - Google Patents
一种用于治疗乳腺增生的外用中草药 Download PDFInfo
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Abstract
本发明是一种用于治疗乳腺增生的外用中草药，它依据中医辩证施治的原则，以大黄、土蜂房、五倍子、元胡、细辛、绷砂、麝香、冰片等原料为基本组方并结合中草药药理特性和有效成份的科学合理配伍科学加工而成，采取人体病变处直接外敷用药方法，使药物功效直接到达和渗透到患者的增生部位，通过内病外治以消肿止痛，疏肝理气，软坚散结为关键，恢复肝脏的正常疏散，从而调节人体内分泌，达到缓解和治愈为目的。本发明具有药源广泛，见效迅速，疗效高，治疗时间短，既不会造成患者皮肤过敏，又无毒副作用，并且避免了患者因长期服用药物而影响身体和生活，经多年临床应用，其有效率达到98％，治愈率达到91％。
Description
技术领域：本发明内容属于一种外用中草药，特别是一种用于治疗乳腺增生的外用中草药。
背景技术：乳腺增生属于中医的乳癖范畴。乳癖，中医认为是形容气机不畅，在乳房部位出现胀满疼痛，症状时缓时剧，疼痛时轻时重等特点，主要发病为多种原因引起的气血不畅，肝脾两虚，痰气互结，瘀滞成块，则发而为乳腺增生，情绪变化对其有着重要的影响，发病年龄多在女性25-45岁之间。现行社会由于很多女性朋友生活节奏快，工作压力大，饮食不健康，作息不规律，内分泌紊乱等方面都会诱发乳腺问题。据了解城市女性的发病率高于农村女性，特别对月经初潮年龄早的、低孕产状况的、初次怀孕年龄大的，而且未哺乳和绝精迟的妇女为本病的高发人群。目前，市场上销售的常用治疗乳腺增生的中成药琳琅满目，即《乳癖消片》、《乳增宁片》、《乳安片》、《乳宁片》等等；如：辽宁上药好护士药业(集团)有限公司生产的《乳癖消片》，该中成药组成为鹿角、蒲公英、昆布、天花粉、鸡血藤、三七、赤芍、海藻、漏芦、木香、玄参、牡丹皮、夏枯草、连翘和红花等，功能主治为软坚散结，活血消痛，清热解毒，但上述治疗乳腺增生的中成药都属于内服药；还有一些外用中药贴，如：陕西凤凰医学研究有限公司生产的菊彦牌《乳安贴》，其主要组方成分以当归、红花、丝瓜络、乳香、没药等中草药为原料，采用外用贴敷的治疗方法，且与本发明的药物组方也大不相同，因而在本技术领域中进一步探寻以获取治疗乳腺增生的高效、速效药物具有重要的意义。
发明内容：本发明的目的是针对本领域现有技术存在的缺陷，通过发掘祖国丰富的中医药资源而提供一种依据中医辩证施治的原则，并结合中草药药理特性和有效成份的合理配伍，通过内病外治以消肿止痛，疏肝理气，软坚散结为关键，恢复肝脏的正常疏泄功能，从而调节人体内分泌，达到缓解和治愈的专用于治疗乳腺增生的外用中草药。本发明精选出一些药效集中且易于人体渗透和吸收的纯天然中草药物原料成分制备成方，方中的药物由包括大黄、土蜂房、五倍子、元胡、细辛、绷砂、麝香、冰片在内的八味药物组成，全方具有消肿止痛，软坚散结，渗透力强、药效持久，科学疗效高且对人体无毒副作用，在对于乳腺增生及乳腺炎的治疗有着极好的效果，从而显著降低或消灭该病对人们健康的威胁。构成本发明所述外用中草药的各原料组分的配比量值为：大黄30-60个重量单位：土蜂房20-30个重量单位：元胡20-30个重量单位：五倍子20-30个重量单位：细辛10-20个重量单位：绷砂10-20个重量单位：麝香0.1-0.3个重量单位：冰片0.1-0.3个重量单位。经精选、清洗、去杂、切片、晒干、混合、粉碎、网筛装入袋内而成。
本发明提供的上述外用中草药各原料组分中，大黄是治疗乳腺增生的主药，具有凉血解毒、痈肿疔疮、瘀血经闭的作用；为了加强大黄解毒消肿的抑制作用，所以方中又加入土蜂房、五倍子、元胡、细辛、绷砂、麝香、冰片，这几味药物原料有较好的消肿止痛抑制作用，合而用之都具有较强的治疗作用；土蜂房能攻毒散结、祛风止痛；元胡能活血、行气、止痛；五倍子能抑制外伤出血、痈肿疮毒、皮肤湿烂；细辛能解表散寒、祛风止痛、通窍；绷砂能清热解毒、消肿防腐；麝香能活血通经、消肿止痛；冰片能开窍醒神、清热止痛的作用。
实施方式：本发明用于治疗乳腺增生的外用中草药是精选出的纯天然中草药物原料成分制备成方，方中的药物由包括大黄、土蜂房、五倍子、元胡、细辛、绷砂、麝香、冰片在内的八味药物组成，构成本发明所述制得药物有效成分的原料药材的组成按重量比例为：大黄∶土蜂房∶五倍子∶元胡∶细辛∶绷砂∶麝香∶冰片＝60∶30∶20∶30∶10∶20∶0.1∶0.3将上述中草药进行精选后，先将大黄、五倍子、元胡、细辛清洗、去杂、切片、晒干，再与土蜂房、绷砂、麝香、冰片按配比量值混合、粉碎，将粉碎后的药物经150-200孔 /cm2网筛为粉末，按照每份50g的药量装入封闭的小塑料袋内备用。使用时，先将备好的二层纱布做成与患者乳房大小的口袋状，再将预先备好的药物倒入其口袋内，进行封口；另外再加一层选用透气性能好的无纺布密封包装成型，放在患者病变乳房部位即可。每次用药外敷一个月为一疗程，每月更换一次，连续用药2-3个月。
临床观察
在本发明研制过程中，为客观评价该药物对乳腺增生的临床疗效及其对人体的安全性，申请人委托陕西西安友谊医院妇科，就其用于治疗乳腺增生的外用中草药进行了临床治疗并观察病例103例，患者年龄在19-56岁之间，其中女性96例，男性7例；多数发病起于一年以上；症状发作时为月经前后的胀痛，有结块；该临床观察方式是采取分组对照的办法，即采用本发明的外用中草药外敷治疗50例为I组(试验组)；采用内服中成药《乳癖消片》治疗30例为II 组(对照组)；采用中药贴《乳安贴》治疗23例为 III组(对照组)。
治疗方法
I组(试验组)：按照每份50g的药量密封装袋，放在患者病变乳房部位，进行外敷治疗，每次用药时间为一个月，共用2-3疗程(即2-3个月)；用药1-7 天，即感乳房胀痛减轻；治疗一个月后经乳腺超声检查，增生缩小；2-3个月超声或钼靶x线摄片检查增生消失。
II组(对照组)：采用由辽宁上药好护士药业(集团)有限公司生产的中成药《乳癖消片》内服治疗，用药量一次5-6片，一日3次；一个疗程为一个月，共服3个疗程；一个月后有效，症状减轻；三个月后乳腺增生部分缩小或消失。
III组(对照组)：采用由陕西凤凰医学研究有限公司生产的中药贴菊彦牌《乳安贴》外贴治疗，每次一贴，两天更换一次，一个月为一疗程，共用3个疗程；一个月后有效，症状减轻；三个月后乳腺增生部分缩小或消失。
治疗结果
乳腺增生外用中草药是委托人在中医传统理论内病外治法的指导下，经过长期临床观察，反复实践总结配制成方的，其用药途径简单易行而疗效显著，最快的患者用药1-3天即可消肿止痛，一个月而治愈，平均治愈时间在2-3个月。该外用中草药均采用纯天然鲜药炮制，药效能充分发挥，且无毒副作用及过敏反应，可以长时间在病变部位发挥药效，通过药物持久的渗透力达到治疗的目的。
本发明的优点是精选纯天然中草药物，采取人体病变处外敷用药的方法，使药物功效直接到达和渗透到患者的增生部位，从而达到有效内病外治的目的。本发明具有药源广泛，见效迅速，疗效高，治疗时间短，既不会造成患者皮肤过敏，又无毒副作用，且能在短时间内见到实效，并避免了患者因长期服用药物而影响身体和生活，经多年的临床应用，其有效率达到 98％，治愈率达到91％。
Claims (1)
1.一种用于治疗乳腺增生的外用中草药，其特征在于：制得药物有效成分的原料药材的组成配比量值按重量比例为：大黄30-60个重量单位：土蜂房20-30个重量单位：元胡20-30个重量单位：五倍子20-30个重量单位：细辛10-20个重量单位：绷砂10-20个重量单位：麝香0.1-0.3个重量单位：冰片0.1-0.3个重量单位，经精选、清洗、去杂、切片、晒干、混合、粉碎、网筛装入袋内。
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| ZHONG-CHAO WANG. ET AL: "2D-DIGE Proteomic Analysis of Changes in", 《MOLECULES》 * |
| 张琼等: "乳腺增生病的中医药治疗近况", 《山东中医杂志》 * |
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