CN108272769A - 一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 - Google Patents
一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 Download PDFInfo
- Publication number
- CN108272769A CN108272769A CN201810074324.8A CN201810074324A CN108272769A CN 108272769 A CN108272769 A CN 108272769A CN 201810074324 A CN201810074324 A CN 201810074324A CN 108272769 A CN108272769 A CN 108272769A
- Authority
- CN
- China
- Prior art keywords
- lycopene
- microcapsule powder
- double
- organic solvent
- fine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title claims abstract description 69
- 239000001751 lycopene Substances 0.000 title claims abstract description 69
- 235000012661 lycopene Nutrition 0.000 title claims abstract description 69
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 68
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims abstract description 66
- 229960004999 lycopene Drugs 0.000 title claims abstract description 66
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims abstract description 66
- 239000000843 powder Substances 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 25
- 239000003094 microcapsule Substances 0.000 title claims abstract description 25
- 239000003960 organic solvent Substances 0.000 title claims abstract description 16
- 239000013078 crystal Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000001694 spray drying Methods 0.000 claims abstract description 14
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 13
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 13
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims abstract description 11
- 239000000839 emulsion Substances 0.000 claims abstract description 5
- 239000006210 lotion Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 12
- 235000006708 antioxidants Nutrition 0.000 claims description 11
- 229930006000 Sucrose Natural products 0.000 claims description 10
- 239000005720 sucrose Substances 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 5
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 5
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 5
- 229960005055 sodium ascorbate Drugs 0.000 claims description 5
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- -1 sucrose ester Chemical class 0.000 claims description 4
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 3
- 229960005070 ascorbic acid Drugs 0.000 claims description 3
- 239000011668 ascorbic acid Substances 0.000 claims description 3
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 238000009826 distribution Methods 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims 1
- 241001640558 Cotoneaster horizontalis Species 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 abstract description 4
- 238000006731 degradation reaction Methods 0.000 abstract description 4
- 238000007670 refining Methods 0.000 abstract description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 241000227653 Lycopersicon Species 0.000 description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OAIJSZIZWZSQBC-UHFFFAOYSA-N (7Z,9Z,7'Z,9'Z)-ψ,ψ-carotene Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C OAIJSZIZWZSQBC-UHFFFAOYSA-N 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000008157 edible vegetable oil Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- GDSOZVZXVXTJMI-SNAWJCMRSA-N (e)-1-methylbut-1-ene-1,2,4-tricarboxylic acid Chemical compound OC(=O)C(/C)=C(C(O)=O)\CCC(O)=O GDSOZVZXVXTJMI-SNAWJCMRSA-N 0.000 description 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 2
- 241000235553 Blakeslea trispora Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000006317 isomerization reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001054 red pigment Substances 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- USEBIPUIVPERGC-UHFFFAOYSA-N Dibutylone Chemical compound CCC(N(C)C)C(=O)C1=CC=C2OCOC2=C1 USEBIPUIVPERGC-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000025844 Prostatic disease Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- GCNLQHANGFOQKY-UHFFFAOYSA-N [C+4].[O-2].[O-2].[Ti+4] Chemical compound [C+4].[O-2].[O-2].[Ti+4] GCNLQHANGFOQKY-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008601 oleoresin Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种不使用有机溶剂双层包埋番茄红素微囊粉的方法，该方法以超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂为主要原料制成乳液，再将上述乳液经过低温双流加喷雾干燥制备得到双层包埋的番茄红素微囊粉，其中，超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂的重量比例为6‑7:91‑92:0.5‑1:0.5‑1。本发明的方法所制得的产品绿色无污染、安全无变质。最终所得番茄红素微囊粉包埋率达99％以上，加工损失在2％以下；40℃，75％相对湿度条件下，样品加速考察6个月，微胶囊粉中番茄红素降解10％以内。
Description
技术领域
本发明属于制剂技术领域，具体涉及一种不使用有机溶剂双层包埋番茄红素微囊粉的方法。
背景技术
番茄红素是一种不含氧的类胡萝卜素。其分子式为C40H56，分子量为536.85，是迄今为止自然界中被发现的最强抗氧化剂之一，对防治前列腺疾病、前列腺癌、肺癌、胃癌、乳癌有奇效，有效抑制癌细胞的扩散和复制，被西方国家称为“植物黄金”。纯品为针状深红色晶体，在分子结构上有11个共轭双键和2个非共轭双键组成的直链型碳氢化合物，所以番茄红素易被氧化变质并发生异构化，大大影响其在食品、制药工业中的应用。现在市场上的番茄红素产品以番茄红素油树脂和微囊粉产品为主，以解决番茄红素稳定性差、应用范围窄、生物利用度低等技术难题。
番茄红素属于脂溶性色素，不溶于水，微溶于植物油。因此目前在研究番茄红素微囊粉时，主要采用的方式有高温熔融于食用油中或用有机溶剂溶解后分散等，这些方式不利于番茄红素的结构稳定和食品安全。
发明内容
本发明克服上述不足之处，提供一种不使用有机溶剂进行番茄红素双层包埋的方法，该方法得到的番茄红素微囊粉产品性质稳定可靠。
本发明的目的是通过以下方式实现的：
一种不使用有机溶剂双层包埋番茄红素微囊粉的方法，该方法以超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂为主要原料制成乳液，再将上述乳液经过低温双流加喷雾干燥制备得到双层包埋的番茄红素微囊粉，其中，超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂的重量比例为6-7:91-92:0.5-1:0.5-1，优选超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂的重量比例为6-7:91-92:1:1。
上述超细化的番茄红素晶体的纯度达99％以上(即全反式番茄红素占比99％以上)，粒径分布为10-100纳米。
上述保护性壁材为环糊精、变性淀粉、蔗糖、海藻酸钠中的一种或多种以任意比例组成；优选环糊精、变性淀粉、蔗糖中一种或两种组合。
上述乳化剂为吐温-20、司盘-20、蔗糖酯、单双甘油酯中的一种或多种以任意比例组成；优选司盘-20、蔗糖酯中一种或两种组合。
上述抗氧化剂为抗坏血酸钠、抗坏血酸、维生素E、丁基羟基茴香醚(BHA)、二丁基羟基甲苯(BHT)中的一种或多种以任意比例组成；优选丁基羟基茴香醚、抗坏血酸钠、抗坏血酸中一种或两种组合。
上述低温双流加喷雾干燥具体步骤为：物料采用上喷法从顶端喷雾，进风从上而下，然后风再次从下而上，最终风从喷雾干燥顶部排出，进风温度105℃，出风温度45℃。
物料从顶端喷雾的同时，从侧壁喷入适量的变性淀粉，形成二次包埋。
所述的乳液的制备过程如下：将超细化的番茄红素晶体将超细化的番茄红素晶体加入溶有保护性壁材、乳化剂、抗氧化剂的水溶液中，充分搅拌均匀制备成悬浮液，将悬浮液进行均质、研磨成超细乳液。
在制备混悬液过程中，采用充氮保护措施，在均质过程中采用冷却水控温，有效降低番茄红素的降解及异构化。
优选超细化的番茄红素晶体是通过以下方法制备得到的：
在氮气保护下，含有番茄红素晶体的干燥三孢布拉霉菌丝体与食用油混合，进行超细研磨，直至番茄红素晶体粒径达到纳米级，然后进行二氧化碳超临界萃取，萃取压力为20MPa，萃取温度为40℃，二氧化碳流量为20升/h，此条件下番茄红素得率99％以上。将含有番茄红素的二氧化碳高压溶液，通过降压装置与离心喷雾器相连，经过离心喷雾，得到超细化的番茄红素晶体，番茄红素粒径为10纳米-100纳米，全反式番茄红素占比99％以上。
与现有技术比较本发明的有益效果：
本发明不使用有机溶剂双层包埋番茄红素微囊粉的方法，本发明以番茄红素晶体、保护性壁材、乳化剂、抗氧化剂为原料，纯化水为溶剂，不添加任何有机溶剂，通过低温双流加喷雾干燥而得双层包埋的番茄红素微囊粉，该工艺所得产品品质稳定，质量上乘，成本低廉，工作环境优良，增加经济效益。
本发明低温双流加喷雾干燥的方法使得物料采用上喷法，低温进风从上而下，然后风再次从下而上，最终风从喷雾干燥顶部排出，进风温度105℃，出风温度45℃。延长干燥时间，降低初始进风温度，有效避免热敏物料番茄红素的降解，并节约能源。而且得到的产品稳定性好，番茄红素中全反式结构含量高达99％以上。
具体实施方式
以下通过具体实施例进一步说明本发明。但实施例的具体细节仅用于解释本发明，不应理解为对本发明总的技术方案的限定。
实施例1：
在氮气保护下，含有番茄红素晶体的干燥三孢布拉霉菌丝体(购自江苏阜丰生物科技有限公司)10千克与食用油100千克混合，在超细磨中进行研磨，直至番茄红素晶体粒径达到纳米级，然后进行二氧化碳超临界萃取，萃取压力为20MPa，萃取温度为40℃，二氧化碳流量为20升/h，番茄红素得率99％以上；将含有番茄红素的二氧化碳高压溶液，通过降压装置与离心喷雾器相连，经过离心喷雾，得到超细化的番茄红素晶体200克，番茄红素粒径为10纳米-100纳米，全反式番茄红素占比99％以上。
实施例2:
称取超细化的番茄红素60g溶于含有变性淀粉920g、司盘-20 5g、坏血酸10g、蔗糖酯5g的水溶液中，水用量为1000mL，水浴80℃下搅拌均匀至番茄红素晶体团块分散后得到悬浮液，将悬浮液进行均质、研磨成超细乳液；将上述乳液经过低温双流加喷雾干燥后得到成品。低温双流加喷雾干燥具体步骤为：物料采用上喷法从顶端喷雾，进风从上而下，然后风再次从下而上，最终风从喷雾干燥顶部排出，进风温度105℃，出风温度45℃。物料从顶端喷雾同时，适量的变性淀粉从侧壁喷入，形成二次包埋。6％番茄红素微胶囊粉包埋率达99％，番茄红素加工损失在2％以下，全反式结构含量达99％。
实施例3：
称取超细化番茄红素60g溶于含有环糊精320g、变性淀粉500g、蔗糖100g、司盘-2010g、抗坏血酸钠10g的水溶液中，水用量为1000mL，水浴60℃下搅拌均匀至番茄红素晶体团块分散后得到悬浮液；将悬浮液进行均质、研磨成超细乳液，将上述乳液经过低温双流加喷雾干燥后得到成品，其中低温双流加喷雾干燥条件同例1。番茄红素含量为6％，5％番茄红素微胶囊粉包埋率达99％，番茄红素加工损失在2％以下，全反式结构含量达99％。
实施例2与实施例3制得的成品在40℃，75％相对湿度条件下，样品加速稳定性考察6个月，每2周检测一次番茄红素微囊粉含量，微胶囊粉中番茄红素降解10％以内。
Claims (8)
1.一种不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于该方法以超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂为主要原料制成乳液，再将上述乳液经过低温双流加喷雾干燥制备得到双层包埋的番茄红素微囊粉，其中，超细化的番茄红素晶体、保护性壁材、乳化剂、抗氧化剂的重量比例为6-7:91-92:0.5-1:0.5-1。
2.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的超细化的番茄红素晶体的纯度达99％以上，粒径分布为10-100纳米。
3.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的保护性壁材为环糊精、变性淀粉、蔗糖、海藻酸钠中的一种或多种以任意比例组成；优选环糊精、变性淀粉、蔗糖中一种或两种组合。
4.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的乳化剂为吐温-20、司盘-20、蔗糖酯、单双甘油酯中的一种或多种以任意比例组成；优选司盘-20、蔗糖酯中一种或两种组合。
5.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的抗氧化剂为抗坏血酸钠、抗坏血酸、维生素E、丁基羟基茴香醚、二丁基羟基甲苯中的一种或多种以任意比例组成；优选丁基羟基茴香醚、抗坏血酸钠、抗坏血酸中一种或两种组合。
6.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的低温双流加喷雾干燥具体步骤为：物料采用上喷法从顶端喷雾，进风从上而下，然后风再次从下而上，最终风从喷雾干燥顶部排出，进风温度105℃，出风温度45℃。
7.根据权利要求6所述的方法，其特征在于物料从顶端喷雾的同时，从侧壁喷入适量的变性淀粉，形成二次包埋。
8.根据权利要求1所述的不使用有机溶剂双层包埋番茄红素微囊粉的方法，其特征在于所述的乳液的制备过程如下：将超细化的番茄红素晶体将超细化的番茄红素晶体加入溶有保护性壁材、乳化剂、抗氧化剂的水溶液中，充分搅拌均匀制备成悬浮液，将悬浮液进行均质、研磨成超细乳液。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810074324.8A CN108272769A (zh) | 2018-01-25 | 2018-01-25 | 一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810074324.8A CN108272769A (zh) | 2018-01-25 | 2018-01-25 | 一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108272769A true CN108272769A (zh) | 2018-07-13 |
Family
ID=62805190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810074324.8A Pending CN108272769A (zh) | 2018-01-25 | 2018-01-25 | 一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108272769A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109534944A (zh) * | 2018-11-14 | 2019-03-29 | 北京联合大学 | 一种制备番茄红素纳米粉体的方法及装置 |
| CN109601999A (zh) * | 2018-11-01 | 2019-04-12 | 华南农业大学 | 一种番茄红素纳米粉末及其制备方法 |
| CN114343062A (zh) * | 2021-12-20 | 2022-04-15 | 广州合诚三先生物科技有限公司 | 一种抗氧化组合物及其制备方法与应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070065396A1 (en) * | 2005-09-21 | 2007-03-22 | Tracie Martyn International, Llc | Topical macqui berry formulation |
| CN103406079A (zh) * | 2013-06-28 | 2013-11-27 | 大连医诺生物有限公司 | 不使用有机溶剂制备冷水分散型类胡萝卜素微囊粉的方法 |
-
2018
- 2018-01-25 CN CN201810074324.8A patent/CN108272769A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070065396A1 (en) * | 2005-09-21 | 2007-03-22 | Tracie Martyn International, Llc | Topical macqui berry formulation |
| CN103406079A (zh) * | 2013-06-28 | 2013-11-27 | 大连医诺生物有限公司 | 不使用有机溶剂制备冷水分散型类胡萝卜素微囊粉的方法 |
Non-Patent Citations (1)
| Title |
|---|
| 范青生: "《保健食品工艺学》", 30 November 2006, 中国医药科技出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601999A (zh) * | 2018-11-01 | 2019-04-12 | 华南农业大学 | 一种番茄红素纳米粉末及其制备方法 |
| CN109534944A (zh) * | 2018-11-14 | 2019-03-29 | 北京联合大学 | 一种制备番茄红素纳米粉体的方法及装置 |
| CN109534944B (zh) * | 2018-11-14 | 2021-09-28 | 北京联合大学 | 一种制备番茄红素纳米粉体的方法及装置 |
| CN114343062A (zh) * | 2021-12-20 | 2022-04-15 | 广州合诚三先生物科技有限公司 | 一种抗氧化组合物及其制备方法与应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100355837C (zh) | 一种水分散型辣椒红色素微囊及其制备方法 | |
| CN108272769A (zh) | 一种不使用有机溶剂双层包埋番茄红素微囊粉的方法 | |
| CN105747216B (zh) | 一种微胶囊β-胡萝卜素粉末及其制备方法 | |
| JP7205835B2 (ja) | 脂溶性栄養素マイクロカプセル及びその製造方法 | |
| CN101921496B (zh) | 一种制备辣椒红色素微胶囊的方法 | |
| CN100580028C (zh) | 一种粉状水分散辣椒红色素的制作方法 | |
| CN105596314B (zh) | 一种高稳定性冷水溶天然虾青素微胶囊制剂的制备方法 | |
| US9622497B2 (en) | Carotenoid oil suspension with high bioavailability and preparation method thereof | |
| CN105166862B (zh) | 高稳定性纤维素基天然食用花青素色素复合物的制备方法 | |
| EP3020396B1 (en) | Method for preparing oil-dispersible carotenoid preparation | |
| CN102773052B (zh) | 冷水可分散性类胡萝卜素微囊产品的制备方法 | |
| US6639113B2 (en) | Production of dry powders of one or more oxygenated carotenoids | |
| CN101999577B (zh) | 一种β-胡萝卜素微囊粉及其制备方法 | |
| CN106344510B (zh) | 番茄红素微乳液的工业化生产方法 | |
| Choi et al. | Microencapsulation of gallic acid through the complex of whey protein concentrate-pectic polysaccharide extracted from Ulmus davidiana | |
| CN102919857B (zh) | 食用碳酸钙微球及其制备方法 | |
| Ono et al. | Production of β-carotene nanosuspensions using supercritical CO2 and improvement of its efficiency by Z-isomerization pre-treatment | |
| CN111714466A (zh) | 一种高生物利用度高稳定性的类胡萝卜素制剂的制备方法 | |
| US9173818B2 (en) | Method for preparing stable-type vitamin A microcapsules continuously | |
| CN109156827A (zh) | 一种高生物利用度红色系β-胡萝卜素制剂的制备方法 | |
| Devi et al. | Effect of gelatin and acacia gum on anthocyanin coacervated microcapsules using double emulsion and its characterization | |
| CN1653949A (zh) | 乳化番茄红素及其制备方法 | |
| CN109646425A (zh) | H1、h2或j型虾青素聚集体水分散体系的制备方法与应用 | |
| CN113575945A (zh) | 一种纳米级高全反式类胡萝卜素干粉的制备方法 | |
| Hong et al. | Study on precipitation of astaxanthin in supercritical fluid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180713 |
|
| RJ01 | Rejection of invention patent application after publication |