CN108272764A - A kind of praziquantel tablets that can independently search for food containing phagostimulant - Google Patents
A kind of praziquantel tablets that can independently search for food containing phagostimulant Download PDFInfo
- Publication number
- CN108272764A CN108272764A CN201810289540.4A CN201810289540A CN108272764A CN 108272764 A CN108272764 A CN 108272764A CN 201810289540 A CN201810289540 A CN 201810289540A CN 108272764 A CN108272764 A CN 108272764A
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- CN
- China
- Prior art keywords
- praziquantel
- phagostimulant
- food containing
- starch
- punch die
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
Abstract
The invention discloses a kind of praziquantel tablets that can independently search for food containing phagostimulant, are made of following agents according to weight ratio：100-200mg of praziquantel, 50-100mg of phagostimulant, 100-200mg of starch, 100-150mg of auxiliary element.The present invention's has the advantages that：The effect for improving or shielding drug bitter or peculiar smell allows animal to be easier to swallow.
Description
Technical field
The invention belongs to animal medicament technical field, specifically a kind of praziquantel that can independently search for food containing phagostimulant
Piece.
Background technology
Since the taste of part chemicals for animals in oral preparation for animals (tablet, pulvis, pre-mixing agent etc.) is extremely bitter or has
, easily there is the phenomenon that spuing again after being difficult to independently swallow or swallowing reluctantly, cause in the peculiar smell that animal should not receive, when animal-use drug
Treatment failure or curative effect of medication decline, and in order to overcome problem above, in the case where not affecting the treatment, my company is quasi- to praziquantel
Piece is added phagostimulant of abiotic active material etc. and carries out technical finesse, then by regulation preparation process production, changes to reach
Kind or shielding drug bitter or peculiar smell effect.
Invention content
In order to solve above-mentioned the deficiencies in the prior art, the present invention provides a kind of pyrrole that can independently search for food containing phagostimulant
Easily there is the phenomenon that spuing again after being difficult to independently swallow or swallowing reluctantly in quinoline ketone piece when solving animal-use drug.
In order to achieve the above object, the technical solution adopted by the present invention is：
A kind of praziquantel tablets that can independently search for food containing phagostimulant, are made of following agents according to weight ratio：
100-200mg of praziquantel, 50-100mg of phagostimulant, 100-200mg of starch, 100-150mg of auxiliary element.
To further description of the present invention, it is made of according to weight ratio following agents：
Praziquantel 100mg, phagostimulant 50mg, starch 100mg, auxiliary element 100mg.
To further description of the present invention, it is made of according to weight ratio following agents：
Praziquantel 150mg, phagostimulant 80mg, starch 150mg, auxiliary element 125mg.
To further description of the present invention, it is made of according to weight ratio following agents：
Praziquantel 200mg, phagostimulant 100mg, starch 200mg, auxiliary element 150mg.
To further description of the present invention, including following preparation process：
(1) raw material pre-treatment：The feelings such as the supplementary material name of an article, specification, lot number, date of manufacture should be first checked before dispensing by material requistion
Condition, 100-200m of praziquantel, 50-100mg of phagostimulant, 100-200mg of starch, 100-150mg of auxiliary element；
(2) it mixes：The dry-mixed time is 15 minutes, and the wet mixing time is 15 minutes, thoroughly will mixing at the end of mixing granulation
Material on the inner wall of device, agitating paddle and lid scrapes totally, to reduce loss, eliminates the risk of cross contamination；
(3) it pelletizes：When granulation, it is necessary to be uniformly mixed supplementary material by regulation, adhesive is added, takes starch that 5-8% is made
Starch gelatin slurry, particle it is elastic consistent.Granulation mesh number 12-14 mesh；
(4) drying and granulating postposition heated-air circulation oven is dried, and 60-70 DEG C of drying temperature, every layer of overlay thickness is paved into
Thickness 2-3 ㎝.4 hours drying times, overturning number are overturn 1 time per 30min, particle water content 2-3%；
(5) whole grain with mix：Lubricant is added when whole grain.Mixing machine is always mixed, and is once a lot number per mixer,
Incorporation time 15min.In mixing machine generally no more than the machine total capacity 2/3:；
(6) tabletting：The pressure of tabletting is that 40-80KN tablettings room keeps negative relative, dust to be arranged by dust exhaust apparatus with mistress
It removes, tabletting workshop section carries out verification, detection, repair, keeping and the granting of punch die.It establishes punch die and uses archives and punch die cleaning maintenance
Management system ensures punch die quality, improves punch die utilization rate, kind, specification, finish should all be checked before and after punch die use, examines
Un-grooved has been looked into, volume skin, unfilled corner, has burst and wears, reason should be traced and replace in time by pinpointing the problems.For anti-limited step weight and thickness
Difference, it is necessary to control punch length, pressure testing, and coupon weight, hardness, thickness, disintegration, appearance are answered before tabletting, when necessary may be used
It is required according to kind, increases and survey content, dissolution rate or the uniformity, could drive after meeting the requirements, timing is answered after driving, and (longest does not surpass
Cross 30min) average piece weight, tablet weight variation are surveyed sample, hardness should meet the requirements, and the charging of tablet press machine preferably uses sealed feeding to fill
It sets, reduces dust from flying, the semi-finished product suppressed are placed in the dry container of cleaning, should all have label inside and outside container, write product exactly
Then name, specification, lot number, weight, operator's name send semi-finished product room, taken out in tableting processes for test or other purposes
Tablet should not be put back in finished product.
(7) it packs：Vinyon bottle.
To further description of the present invention, the metering of lubricant is that 1-3kg is added to moisten per 100kg whole grains in the step (5)
Lubrication prescription.
To further description of the present invention, drying temperature is 60-70 DEG C in the step (4).
The present invention's has the advantages that：The effect for improving or shielding drug bitter or peculiar smell, allows animal to be easier
It swallows.
Description of the drawings
Fig. 1 is the preparation flow figure of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without creative efforts
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of praziquantel tablets that can independently search for food containing phagostimulant, are made of following agents according to weight ratio：Praziquantel
100mg, phagostimulant 50mg, starch 100mg, auxiliary element 100mg.
A kind of optimal technical scheme of the present embodiment, including following preparation process：
(1) raw material pre-treatment：The feelings such as the supplementary material name of an article, specification, lot number, date of manufacture should be first checked before dispensing by material requistion
Condition, praziquantel 100mg, phagostimulant 50mg, starch 100mg, auxiliary element 100mg；
(2) it mixes：The dry-mixed time is 15 minutes, and the wet mixing time is 15 minutes, thoroughly will mixing at the end of mixing granulation
Material on the inner wall of device, agitating paddle and lid scrapes totally, to reduce loss, eliminates the risk of cross contamination；
(3) it pelletizes：When granulation, it is necessary to be uniformly mixed supplementary material by regulation, adhesive is added, takes starch that 5-8% is made
Starch gelatin slurry, elastic consistent, the mesh number 12-14 mesh of pelletizing of particle；
(4) dry：Granulation postposition heated-air circulation oven is dried, and every layer of overlay thickness is paved into thickness 2-3 ㎝, when dry
Between 4 hours, overturning number per 30min overturn 1 time, particle water content 2-3%；
(5) whole grain with mix：Lubricant is added when whole grain, mixing machine is always mixed, and is once a lot number per mixer,
Incorporation time 15min, in mixing machine generally no more than the machine total capacity 2/3；
(6) tabletting：The pressure of tabletting is that 40-80KN tablettings room keeps negative relative, dust to be arranged by dust exhaust apparatus with mistress
It removes, tabletting workshop section carries out verification, detection, repair, keeping and the granting of punch die.It establishes punch die and uses archives and punch die cleaning maintenance
Management system ensures punch die quality, improves punch die utilization rate, kind, specification, finish should all be checked before and after punch die use, examines
Un-grooved has been looked into, volume skin, unfilled corner, has burst and wears, reason should be traced and replace in time by pinpointing the problems.For anti-limited step weight and thickness
Difference, it is necessary to control punch length, pressure testing, and coupon weight, hardness, thickness, disintegration, appearance are answered before tabletting, when necessary may be used
It is required according to kind, increases and survey content, dissolution rate or the uniformity, could drive after meeting the requirements, timing is answered after driving, and (longest does not surpass
Cross 30min) average piece weight, tablet weight variation are surveyed sample, hardness should meet the requirements, and the charging of tablet press machine preferably uses sealed feeding to fill
It sets, reduces dust from flying, the semi-finished product suppressed are placed in the dry container of cleaning, should all have label inside and outside container, write product exactly
Then name, specification, lot number, weight, operator's name send semi-finished product room, taken out in tableting processes for test or other purposes
Tablet should not be put back in finished product.
(7) it packs：With vinyon bottle.
A kind of optimal technical scheme of the present embodiment, the metering of lubricant is to add per 100kg whole grains in the step (5)
1-3kg lubricants.
A kind of optimal technical scheme of the present embodiment, drying temperature is 60-70 DEG C in the step (4).
Embodiment 2：
A kind of praziquantel tablets that can independently search for food containing phagostimulant, are made of following agents according to weight ratio：Praziquantel
150mg, phagostimulant 80mg, starch 150mg, auxiliary element 125mg.
A kind of optimal technical scheme of the present embodiment, including following preparation process：
(1) raw material pre-treatment：The feelings such as the supplementary material name of an article, specification, lot number, date of manufacture should be first checked before dispensing by material requistion
Condition, praziquantel 150mg, phagostimulant 80mg, starch 150mg, auxiliary element 125mg.
(2) it mixes：The dry-mixed time is 15 minutes, and the wet mixing time is 15 minutes, thoroughly will mixing at the end of mixing granulation
Material on the inner wall of device, agitating paddle and lid scrapes totally, to reduce loss, eliminates the risk of cross contamination；
(3) it pelletizes：When granulation, it is necessary to be uniformly mixed supplementary material by regulation, adhesive is added, takes starch that 5-8% is made
Starch gelatin slurry, elastic consistent, the mesh number 12-14 mesh of pelletizing of particle；
(4) dry：Granulation postposition heated-air circulation oven is dried, and every layer of overlay thickness is paved into thickness 2-3 ㎝, when dry
Between 4 hours, overturning number per 30min overturn 1 time, particle water content 2-3%；
(5) whole grain with mix：Lubricant is added when whole grain, mixing machine is always mixed, and is once a lot number per mixer,
Incorporation time 15min, in mixing machine generally no more than the machine total capacity 2/3；
(6) tabletting：The pressure of tabletting is that 40-80KN tablettings room keeps negative relative, dust to be arranged by dust exhaust apparatus with mistress
It removes, tabletting workshop section carries out verification, detection, repair, keeping and the granting of punch die.It establishes punch die and uses archives and punch die cleaning maintenance
Management system ensures punch die quality, improves punch die utilization rate, kind, specification, finish should all be checked before and after punch die use, examines
Un-grooved has been looked into, volume skin, unfilled corner, has burst and wears, reason should be traced and replace in time by pinpointing the problems.For anti-limited step weight and thickness
Difference, it is necessary to control punch length, pressure testing, and coupon weight, hardness, thickness, disintegration, appearance are answered before tabletting, when necessary may be used
It is required according to kind, increases and survey content, dissolution rate or the uniformity, could drive after meeting the requirements, timing is answered after driving, and (longest does not surpass
Cross 30min) average piece weight, tablet weight variation are surveyed sample, hardness should meet the requirements, and the charging of tablet press machine preferably uses sealed feeding to fill
It sets, reduces dust from flying, the semi-finished product suppressed are placed in the dry container of cleaning, should all have label inside and outside container, write product exactly
Then name, specification, lot number, weight, operator's name send semi-finished product room, taken out in tableting processes for test or other purposes
Tablet should not be put back in finished product.
(7) it packs：With vinyon bottle.
A kind of optimal technical scheme of the present embodiment, the metering of lubricant is to add per 100kg whole grains in the step (5)
1-3kg lubricants.
A kind of optimal technical scheme of the present embodiment, drying temperature is 60-70 DEG C in the step (4).
Embodiment 3：
A kind of praziquantel tablets that can independently search for food containing phagostimulant, are made of following agents according to weight ratio：Praziquantel
200mg, phagostimulant 100mg, starch 200mg, auxiliary element 150mg.
A kind of optimal technical scheme of the present embodiment, including following preparation process：
(1) raw material pre-treatment：The feelings such as the supplementary material name of an article, specification, lot number, date of manufacture should be first checked before dispensing by material requistion
Condition, praziquantel 200mg, phagostimulant 100mg, starch 200mg, auxiliary element 150mg；
(2) it mixes：The dry-mixed time is 15 minutes, and the wet mixing time is 15 minutes, thoroughly will mixing at the end of mixing granulation
Material on the inner wall of device, agitating paddle and lid scrapes totally, to reduce loss, eliminates the risk of cross contamination；
(3) it pelletizes：When granulation, it is necessary to be uniformly mixed supplementary material by regulation, adhesive is added, takes starch that 5-8% is made
Starch gelatin slurry, elastic consistent, the mesh number 12-14 mesh of pelletizing of particle；
(4) dry：Granulation postposition heated-air circulation oven is dried, and every layer of overlay thickness is paved into thickness 2-3 ㎝, when dry
Between 4 hours, overturning number per 30min overturn 1 time, particle water content 2-3%；
(5) whole grain with mix：Lubricant is added when whole grain, mixing machine is always mixed, and is once a lot number per mixer,
Incorporation time 15min, in mixing machine generally no more than the machine total capacity 2/3；
(6) tabletting：The pressure of tabletting is that 40-80KN tablettings room keeps negative relative, dust to be arranged by dust exhaust apparatus with mistress
It removes, tabletting workshop section carries out verification, detection, repair, keeping and the granting of punch die.It establishes punch die and uses archives and punch die cleaning maintenance
Management system ensures punch die quality, improves punch die utilization rate, kind, specification, finish should all be checked before and after punch die use, examines
Un-grooved has been looked into, volume skin, unfilled corner, has burst and wears, reason should be traced and replace in time by pinpointing the problems.For anti-limited step weight and thickness
Difference, it is necessary to control punch length, pressure testing, and coupon weight, hardness, thickness, disintegration, appearance are answered before tabletting, when necessary may be used
It is required according to kind, increases and survey content, dissolution rate or the uniformity, could drive after meeting the requirements, timing is answered after driving, and (longest does not surpass
Cross 30min) average piece weight, tablet weight variation are surveyed sample, hardness should meet the requirements, and the charging of tablet press machine preferably uses sealed feeding to fill
It sets, reduces dust from flying, the semi-finished product suppressed are placed in the dry container of cleaning, should all have label inside and outside container, write product exactly
Then name, specification, lot number, weight, operator's name send semi-finished product room, taken out in tableting processes for test or other purposes
Tablet should not be put back in finished product.
(7) it packs：With vinyon bottle.
A kind of optimal technical scheme of the present embodiment, the metering of lubricant is to add per 100kg whole grains in the step (5)
1-3kg lubricants.
A kind of optimal technical scheme of the present embodiment, drying temperature is 60-70 DEG C in the step (4).
By the Contrast on effect of above-described embodiment, find 2 best results of embodiment, embodiment 3 secondly, 1 effect of embodiment
It is more with obvious effects than other similar products on the market not as good as embodiment 3, but still.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (7)
1. a kind of praziquantel tablets that can independently search for food containing phagostimulant, which is characterized in that by following agents according to weight ratio group
At：
100-200mg of praziquantel, 50-100mg of phagostimulant, 100-200mg of starch, 100-150mg of auxiliary element.
2. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 1, which is characterized in that under
Row medicament is formed according to weight ratio：
Praziquantel 100mg, phagostimulant 50mg, starch 100mg, auxiliary element 100mg.
3. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 1, which is characterized in that under
Row medicament is formed according to weight ratio：
Praziquantel 150mg, phagostimulant 80mg, starch 150mg, auxiliary element 125mg.
4. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 1, which is characterized in that under
Row medicament is formed according to weight ratio：
Praziquantel 200mg, phagostimulant 100mg, starch 200mg, auxiliary element 150mg.
5. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 1, which is characterized in that including
Following preparation process：
(1) raw material pre-treatment：Situations such as supplementary material name of an article, specification, lot number, date of manufacture should first be checked before dispensing by material requistion,
100-200m of praziquantel, 50-100mg of phagostimulant, 100-200mg of starch, 100-150mg of auxiliary element；
(2) it mixes：The dry-mixed time is 15 minutes, and the wet mixing time is 15 minutes, at the end of mixing granulation, thoroughly by mixer
Material on inner wall, agitating paddle and lid scrapes totally, to reduce loss, eliminates the risk of cross contamination；
(3) it pelletizes：When granulation, it is necessary to be uniformly mixed supplementary material by regulation, adhesive is added, takes starch that the shallow lake of 5-8% is made
Powder gelatine size, the elastic of particle will be unanimously.Granulation mesh number 12-14 mesh；
(4) drying and granulating postposition heated-air circulation oven is dried, and 60-70 DEG C of drying temperature, every layer of overlay thickness is paved into thickness
2-3㎝.4 hours drying times, overturning number are overturn 1 time per 30min, particle water content 2-3%；
(5) whole grain with mix：Lubricant is added when whole grain.Mixing machine is always mixed, and is once a lot number, mixing per mixer
Time 15min.In mixing machine generally no more than the machine total capacity 2/3:；
(6) tabletting：The pressure of tabletting is that 40-80KN tablettings room keeps negative relative, dust to be excluded by dust exhaust apparatus with mistress, is pressed
Piece workshop section carries out verification, detection, repair, keeping and the granting of punch die.It establishes punch die and uses archives and punch die cleaning maintenance care
System ensures punch die quality, improves punch die utilization rate, should all check that kind, specification, finish, inspection have before and after punch die use
Un-grooved, bursts and wears volume skin, unfilled corner, and reason should be traced and replace in time by pinpointing the problems.For anti-limited step weight and thickness difference
It is different, it is necessary to punch length is controlled, pressure testing, and coupon weight, hardness, thickness, disintegration, appearance are answered before tabletting, it when necessary can root
It is required according to kind, increases and survey content, dissolution rate or the uniformity, could drive after meeting the requirements, should periodically (be no longer than after driving
Average piece weight, tablet weight variation 30min) are surveyed sample, hardness should meet the requirements, and the charging of tablet press machine preferably uses sealed feeding to fill
It sets, reduces dust from flying, the semi-finished product suppressed are placed in the dry container of cleaning, should all have label inside and outside container, write product exactly
Then name, specification, lot number, weight, operator's name send semi-finished product room, taken out in tableting processes for test or other purposes
Tablet should not be put back in finished product.
(7) it packs：Vinyon bottle.
6. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 5, which is characterized in that described
The metering of lubricant is to add 1-3kg lubricants per 100kg whole grains in step (5).
7. a kind of praziquantel tablets that can independently search for food containing phagostimulant according to claim 5, which is characterized in that described
Drying temperature is 60-70 DEG C in step (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810289540.4A CN108272764A (en) | 2018-04-03 | 2018-04-03 | A kind of praziquantel tablets that can independently search for food containing phagostimulant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810289540.4A CN108272764A (en) | 2018-04-03 | 2018-04-03 | A kind of praziquantel tablets that can independently search for food containing phagostimulant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108272764A true CN108272764A (en) | 2018-07-13 |
Family
ID=62811189
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810289540.4A Pending CN108272764A (en) | 2018-04-03 | 2018-04-03 | A kind of praziquantel tablets that can independently search for food containing phagostimulant |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110151714A (en) * | 2019-05-28 | 2019-08-23 | 上海同仁药业股份有限公司 | A kind of pet Cimitidine Tablets and preparation method thereof |
| CN111467315A (en) * | 2020-05-09 | 2020-07-31 | 青海省畜牧兽医科学院 | Wild canine cestoda parasite expelling chewable tablet and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099973A (en) * | 1993-09-08 | 1995-03-15 | 四川省医学科学院寄生虫病防治研究所 | Compound vermifuge for animals |
| CN107157944A (en) * | 2017-05-24 | 2017-09-15 | 武威牛满加药业有限责任公司 | A kind of expelling parasite tablet for animals containing phagostimulant |
-
2018
- 2018-04-03 CN CN201810289540.4A patent/CN108272764A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099973A (en) * | 1993-09-08 | 1995-03-15 | 四川省医学科学院寄生虫病防治研究所 | Compound vermifuge for animals |
| CN107157944A (en) * | 2017-05-24 | 2017-09-15 | 武威牛满加药业有限责任公司 | A kind of expelling parasite tablet for animals containing phagostimulant |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110151714A (en) * | 2019-05-28 | 2019-08-23 | 上海同仁药业股份有限公司 | A kind of pet Cimitidine Tablets and preparation method thereof |
| CN111467315A (en) * | 2020-05-09 | 2020-07-31 | 青海省畜牧兽医科学院 | Wild canine cestoda parasite expelling chewable tablet and preparation method thereof |
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Application publication date: 20180713 |
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