CN108272746A - A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof - Google Patents
A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof Download PDFInfo
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- CN108272746A CN108272746A CN201810183443.7A CN201810183443A CN108272746A CN 108272746 A CN108272746 A CN 108272746A CN 201810183443 A CN201810183443 A CN 201810183443A CN 108272746 A CN108272746 A CN 108272746A
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- milligrams
- pressure
- master controller
- western medicine
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The invention belongs to biopharmaceutical technologies, a kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof is disclosed, is made of because of 28 milligrams of 16 milligrams, 14 milligrams of prilocaine, 54 milligrams of thickener, 20 milligrams of wetting agent, 16 milligrams of azone, 9 milligrams of Kathon CG, 560 milliliters of distilled water and lidocaine 10 milligrams of lidocaine hydrochloride, salt acid cut.The thickener is carboxymethyl cellulose, Macrogol 6000 mixture.The wetting agent is propylene glycol, glycerol mixture.The doctor trained in Western medicine surgery is that a kind of osmosis to mucous membrane, skin is strong, rapid-action, non-stimulated or allergic reaction, and can maintain certain timeliness with skin analgesia cream, and novel surface at low cost anaesthetizes the preparation method of cream.
Description
Technical field
The invention belongs to biopharmaceutical technology more particularly to a kind of doctor trained in Western medicine surgery skin analgesia cream and its preparation sides
Method.
Background technology
Currently, in clinical operation, it is elimination pain when performing a surgical operation when anesthesia is or carries out diagnostic test operation, protects
The various methods for hindering patient safety, creating good surgical condition and taking.Patient perform the operation or diagnostic test operation
When, it can feel pain, need to be allowed to swound with arcotic or other modes.Operation checks that operation can also cause essence
Refreshing nervous and reflectivity adverse reaction, as gastrointestinal surgery can cause Nausea and vomiting.Prolonged uncomfortable position (is such as bowed
Clinostatism), can increase patient does not accommodate pain, therefore should make patient in comfortable, quiet environment, to pessimal stimulation without anti-
It answers, undergos surgery in the case of being temporarily lost with memory.Currently, generally using injecting anesthetic or carrying out surface fiber crops by pad pasting
It is liquor-saturated.Existing anesthesia method operation is comparatively laborious, while also having anesthetic risks.Therefore, it is badly in need of in the market during a kind of anesthesia uses
Drug composition.
In conclusion problem of the existing technology is：Currently, generally using injecting anesthetic or carrying out table by pad pasting
Facial anesthesia.Existing anesthesia method operation is comparatively laborious, while also having anesthetic risks.Therefore, it is badly in need of a kind of anesthesia in the market
Use Chinese medicine composition.
Invention content
In view of the problems of the existing technology, the present invention provides a kind of doctor trained in Western medicine surgery skin analgesia cream and its preparation sides
Method.
The invention is realized in this way a kind of doctor trained in Western medicine surgery skin analgesia cream, the doctor trained in Western medicine surgery skin analgesia cream
By 10 milligrams of lidocaine hydrochloride, salt acid cut because 16 milligrams, 14 milligrams of prilocaine, 54 milligrams of thickener, 20 milligrams of wetting agent,
28 milligrams of 16 milligrams of azone, 9 milligrams of Kathon CG, 560 milliliters of distilled water and lidocaine compositions.
Another object of the present invention is to provide a kind of preparation method of the doctor trained in Western medicine surgery skin analgesia cream, the west
The preparation method of doctor's surgery skin analgesia cream includes the following steps：
Step 1, take 10 milligrams of lidocaine hydrochloride, salt acid cut because 16 milligrams, 14 milligrams of prilocaine, the milli of thickener 54
Gram, 20 milligrams of wetting agent, 16 milligrams of azone, 9 milligrams of Kathon CG, 560 milliliters of distilled water and 28 milligrams of lidocaine；
Step 2, lidocaine hydrochloride, salt acid cut because, prilocaine, lidocaine be dissolved in distilled water, then add thickening
Agent, azone are heated to 60~80 DEG C, and stirring makes Macrogol 6000 dissolve, and adds distilled water while hot, are cooled to 40 DEG C and card is added
Pine；
Step 3, by compounding substances temperature be 50 DEG C, pressure be 30Mpa under conditions of carry out homogeneous, homogeneous 3 times；
Step 4 freezes 6h by the mixed liquor after homogeneous under the conditions of -20 DEG C, then presses 12kg/m in useful load2, work
Make to dry under conditions of pressure 80Pa, parsing pressure 20Pa, 40 DEG C of temperature, mixed raw material is made；
Step 5 crushes the mixed raw material after drying, grain size 300um, and mixed raw material powder is made；
Wetting agent is added into mixed raw material powder in step 6, is deployed into paste, and anesthesia cream is made in sizing.
Further, the thickener is carboxymethyl cellulose, Macrogol 6000 mixture.
Further, the wetting agent is propylene glycol, glycerol mixture.
Further, homogeneous industrial park homogenizer pressure automatic controller automatically controls executing agency pair according to setting
The homogenization pressure of homogenizer carries out automatically controlling；
The homogenizer pressure automatic controller, including with lower part：One master controller；One pressure transmitter is used
In sending the pressure value of material to the master controller；One electric machine controller receives the control signal of the master controller,
Control the operating of actuating motor；
Master controller receives the material pressure signal of pressure transmitter acquisition, and executes electricity by electric machine controller to control
The operating of machine drives pressure regulating device that material pressure is adjusted by actuating motor；
It further include a display controller being connected with the master controller；
The pressure transmitter is analog output transmitter, is connected with the master controller by an AD converter
It connects；
The master controller is microcontroller；
The cycle covariant function of the reception signal of the master controller includes：
The material pressure signal contains the MPSK material pressure signals for obeying S α S partition noises, can be expressed as：
Wherein E is the mean power of material pressure signal, Q (t) indicates that rectangular pulse waveform, T indicate symbol period, fcIndicate carrier frequency, φ0Indicate initial phase,
If whether need to add condition herein：W (t) is the non-Gaussian noise for obeying S α S distributions, then its autocovariance function is defined as：
Wherein (x (t- τ))<p-1>=| x (t- τ) |p-2X* (t- τ), γx(t-τ)It is the coefficient of dispersion of x (t), then x (t) is followed
Ring co-variation is defined as：
Wherein ε is known as cycle frequency, and T is a code-element period；
The cycle co-variation spectrum for receiving material pressure signal is carried out as follows：
Cycle co-variation spectrum is to recycle the Fourier transformation of covariant function, is expressed as：
The cycle co-variation spectrum of its PSK material pressure signal is derived as：
As M >=4,Place,
As M=2,
Wherein Q (f) is the Fourier transformation of q (t), and
The master controller is estimated the jumping moment of each jump using clustering algorithm and is respectively jumped corresponding normalized mixed
When closing matrix column vector, Hopping frequencies, include the following steps：
The first step, at p (p=0,1,2 ... the P-1) moment,Indicate the response of p moment time-frequencies
Corresponding frequency indices when non-zero,The frequency values of expression are clustered, obtained cluster centre numberIndicate that the p moment exists
Carrier frequency number,A cluster centre then indicates the size of carrier frequency, uses respectivelyIt indicates；
Second step utilizes clustering algorithm pair to each sampling instant p (p=0,1,2 ... P-1)It is clustered,
It is same availableA cluster centre is usedIt indicates；
Third walks, to allIt averages and rounding, obtains the estimation of source signal numberI.e.
4th step, finds outAt the time of, use phIt indicates, to the p of each section of continuous valuehIntermediate value is sought, is usedIndicate the l sections of p that are connectedhIntermediate value, thenIndicate the estimation at first of frequency hopping moment；
5th step is obtained according to estimation in second stepAnd the 4th estimate to obtain in step
The frequency hopping moment estimate it is each jump it is correspondingA hybrid matrix column vectorSpecifically formula is：
HereIt is corresponding to indicate that l is jumpedA mixing
Matrix column vector estimated value；
6th step is estimated the corresponding carrier frequency of each jump, is usedIt is corresponding to indicate that l is jumpedA frequency estimation, calculation formula are as follows：
Further include that multiple program selector switches are connected with master controller, can select to switch accordingly as needed, make
Controller control homogenizer executes scheduled program automatically；
Further include that design of pressure button is connected with master controller.
Advantages of the present invention and good effect are：The doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof, outside the doctor trained in Western medicine
Section is that a kind of osmosis to mucous membrane, skin is strong, rapid-action, non-stimulated or allergic reaction, and can maintain with skin analgesia cream
Certain timeliness, novel surface at low cost anaesthetize the preparation method of cream.
Description of the drawings
Fig. 1 is the production procedure signal of doctor trained in Western medicine surgery skin analgesia cream provided in an embodiment of the present invention and preparation method thereof
Figure.
Specific implementation mode
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and coordinate attached drawing
Detailed description are as follows.
The structure of the present invention is explained in detail below in conjunction with the accompanying drawings.
Doctor trained in Western medicine surgery provided in an embodiment of the present invention is with skin analgesia cream by 10 milligrams of lidocaine hydrochloride, salt acid cut because of 16
Milligram, 14 milligrams of prilocaine, 54 milligrams of thickener, 20 milligrams of wetting agent, 16 milligrams of azone, 9 milligrams of Kathon CG, distilled water 560
28 milligrams of compositions of milliliter and lidocaine.
The thickener is carboxymethyl cellulose, Macrogol 6000 mixture.The wetting agent is propylene glycol, glycerine is mixed
Close object.
The preparation method of doctor trained in Western medicine surgery skin analgesia cream provided in an embodiment of the present invention includes the following steps：
S101：Take 10 milligrams of lidocaine hydrochloride, salt acid cut because 16 milligrams, 14 milligrams of prilocaine, 54 milligrams of thickener,
28 milligrams of 20 milligrams of wetting agent, 16 milligrams of azone, 9 milligrams of Kathon CG, 560 milliliters of distilled water and lidocaine；
S102：Lidocaine hydrochloride, salt acid cut because, prilocaine, lidocaine be dissolved in distilled water, then add thickener,
Azone is heated to 60~80 DEG C, and stirring makes Macrogol 6000 dissolve, and adds distilled water while hot, is cooled to 40 DEG C or so and card is added
Pine；
S103：By compounding substances temperature be 50 DEG C, pressure be 30Mpa under conditions of carry out homogeneous, homogeneous 3 times；
S104：By the mixed liquor after homogeneous under the conditions of -20 DEG C, 6h is freezed, then presses 12kg/m in useful load2, work
It is dry under conditions of pressure 80Pa, parsing pressure 20Pa, 40 DEG C of temperature, mixed raw material is made；
S105：Mixed raw material after drying is crushed, grain size 300um, mixed raw material powder is made；
S106：Wetting agent is added into mixed raw material powder, is deployed into paste, anesthesia cream is made in sizing.
Homogeneous industrial park homogenizer pressure automatic controller automatically controls executing agency to homogenizer according to setting
Homogenization pressure carries out automatically controlling；
The homogenizer pressure automatic controller, including with lower part：One master controller；One pressure transmitter is used
In sending the pressure value of material to the master controller；One electric machine controller receives the control signal of the master controller,
Control the operating of actuating motor；
Master controller receives the material pressure signal of pressure transmitter acquisition, and executes electricity by electric machine controller to control
The operating of machine drives pressure regulating device that material pressure is adjusted by actuating motor；
It further include a display controller being connected with the master controller；
The pressure transmitter is analog output transmitter, is connected with the master controller by an AD converter
It connects；
The master controller is microcontroller；
Further include that multiple program selector switches are connected with master controller, can select to switch accordingly as needed, make
Controller control homogenizer executes scheduled program automatically；
Further include that design of pressure button is connected with master controller.
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Every any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (5)
1. a kind of doctor trained in Western medicine surgery skin analgesia cream, which is characterized in that the doctor trained in Western medicine surgery is with skin analgesia cream by hydrochloric acid benefit
10 milligrams of cacaine, salt acid cut because 16 milligrams, 14 milligrams of prilocaine, 54 milligrams of thickener, 20 milligrams of wetting agent, the milli of azone 16
Gram, 9 milligrams of Kathon CG, 560 milliliters of distilled water and 28 milligrams of lidocaine composition.
2. a kind of preparation method of doctor trained in Western medicine surgery skin analgesia cream as described in claim 1, which is characterized in that outside the doctor trained in Western medicine
Section is included the following steps with the preparation method of skin analgesia cream：
Step 1, take 10 milligrams of lidocaine hydrochloride, salt acid cut because 16 milligrams, 14 milligrams of prilocaine, 54 milligrams of thickener, profit
28 milligrams of 20 milligrams of humectant, 16 milligrams of azone, 9 milligrams of Kathon CG, 560 milliliters of distilled water and lidocaine；
Step 2, lidocaine hydrochloride, salt acid cut because, prilocaine, lidocaine be dissolved in distilled water, then add thickener, nitrogen
Ketone is heated to 60~80 DEG C, and stirring makes Macrogol 6000 dissolve, and adds distilled water while hot, is cooled to 40 DEG C of addition Kathon CGs；
Step 3, by compounding substances temperature be 50 DEG C, pressure be 30Mpa under conditions of carry out homogeneous, homogeneous 3 times；
Step 4 freezes 6h by the mixed liquor after homogeneous under the conditions of -20 DEG C, then presses 12kg/m in useful load2, operating pressure
It is dry under conditions of 80Pa, parsing pressure 20Pa, 40 DEG C of temperature, mixed raw material is made；
Step 5 crushes the mixed raw material after drying, grain size 300um, and mixed raw material powder is made；
Wetting agent is added into mixed raw material powder in step 6, is deployed into paste, and anesthesia cream is made in sizing.
3. the preparation method of doctor trained in Western medicine surgery skin analgesia cream as claimed in claim 2, which is characterized in that the thickener is
Carboxymethyl cellulose, Macrogol 6000 mixture.
4. the preparation method of doctor trained in Western medicine surgery skin analgesia cream as claimed in claim 2, which is characterized in that the wetting agent is
Propylene glycol, glycerol mixture.
5. the preparation method of doctor trained in Western medicine surgery skin analgesia cream as claimed in claim 2, which is characterized in that the homogeneous industry
Garden homogenizer pressure automatic controller automatically controls executing agency according to setting and is controlled automatically to the homogenization pressure of homogenizer
System；
The homogenizer pressure automatic controller, including with lower part：One master controller；One pressure transmitter, being used for will
The pressure value of material sends the master controller to；One electric machine controller receives the control signal of the master controller, control
The operating of actuating motor；
Master controller receives the material pressure signal of pressure transmitter acquisition, and controls actuating motor by electric machine controller
Operating drives pressure regulating device that material pressure is adjusted by actuating motor；
It further include a display controller being connected with the master controller；
The pressure transmitter is analog output transmitter, is connected with the master controller by an AD converter；
The master controller is microcontroller；
The cycle covariant function of the reception signal of the master controller includes：
The material pressure signal contains the MPSK material pressure signals for obeying S α S partition noises, can be expressed as：
Wherein E is the mean power of material pressure signal,M=2k, m=
1,2 ... M, q (t) indicate that rectangular pulse waveform, T indicate symbol period, fcIndicate carrier frequency, φ0Indicate initial phase, if
Whether need to add condition herein：W (t) is the non-Gaussian noise for obeying S α S distributions, then its autocovariance function is defined as：
Wherein (x (t- τ))<p-1>=| x (t- τ) |p-2X* (t- τ), γx(t-τ)It is the coefficient of dispersion of x (t), then the cycle of x (t) is total
Change is defined as：
Wherein ε is known as cycle frequency, and T is a code-element period；
The cycle co-variation spectrum for receiving material pressure signal is carried out as follows：
Cycle co-variation spectrum is to recycle the Fourier transformation of covariant function, is expressed as：
The cycle co-variation spectrum of its PSK material pressure signal is derived as：
As M >=4,Place,
As M=2,
Wherein Q (f) is the Fourier transformation of q (t), and
The master controller estimates the jumping moment of each jump using clustering algorithm and respectively jumps corresponding normalized mixed moment
When array vector, Hopping frequencies, include the following steps：
The first step, at p (p=0,1,2 ... the P-1) moment,Indicate the response of p moment time-frequencies
Corresponding frequency indices when non-zero,The frequency values of expression are clustered, obtained cluster centre numberIndicate that the p moment exists
Carrier frequency number,A cluster centre then indicates the size of carrier frequency, uses respectivelyIt indicates；
Second step utilizes clustering algorithm pair to each sampling instant p (p=0,1,2 ... P-1)It is clustered, equally
It is availableA cluster centre is usedIt indicates；
Third walks, to allIt averages and rounding, obtains the estimation of source signal numberI.e.
4th step, finds outAt the time of, use phIt indicates, to the p of each section of continuous valuehIntermediate value is sought, is used
Indicate the l sections of p that are connectedhIntermediate value, thenIndicate the estimation at first of frequency hopping moment；
5th step is obtained according to estimation in second stepp≠phAnd the 4th frequency for estimating in step
It is corresponding that jumping moment estimates each jumpA hybrid matrix column vectorSpecifically formula is：
HereIt is corresponding to indicate that l is jumpedA hybrid matrix
Column vector estimated value；
6th step is estimated the corresponding carrier frequency of each jump, is usedIt is corresponding to indicate that l is jumpedIt is a
Frequency estimation, calculation formula are as follows：
Further include that multiple program selector switches are connected with master controller, can select to switch accordingly as needed, make control
Instrument control homogenizer executes scheduled program automatically；
Further include that design of pressure button is connected with master controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810183443.7A CN108272746A (en) | 2018-03-06 | 2018-03-06 | A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810183443.7A CN108272746A (en) | 2018-03-06 | 2018-03-06 | A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN108272746A true CN108272746A (en) | 2018-07-13 |
Family
ID=62809126
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|---|---|---|---|
| CN201810183443.7A Pending CN108272746A (en) | 2018-03-06 | 2018-03-06 | A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385153A (en) * | 2001-05-11 | 2002-12-18 | 张国智 | Preparation process for surfacce anesthesia cream |
| CN201107669Y (en) * | 2007-09-11 | 2008-08-27 | 上海申鹿均质机有限公司 | Homogeneous machine pressure automatic control instrument |
| CN103051367A (en) * | 2012-11-27 | 2013-04-17 | 西安电子科技大学 | Clustering-based blind source separation method for synchronous orthogonal frequency hopping signals |
| CN104038454A (en) * | 2014-06-20 | 2014-09-10 | 西安电子科技大学 | Method for estimating carrier frequency of PSK (phase shift keying) signal in Alpha-stable distribution noise |
| CN104187236A (en) * | 2014-07-15 | 2014-12-10 | 柴华 | Manufacturing method for amur grape jelly powder |
| CN107049464A (en) * | 2017-06-07 | 2017-08-18 | 任小宝 | A kind of cable formula inner fixing device for orthopaedics |
| CN107458596A (en) * | 2017-08-16 | 2017-12-12 | 重庆华凤衣道文化创意有限公司 | A kind of imperial shape solar energy and air energy composite aircraft |
-
2018
- 2018-03-06 CN CN201810183443.7A patent/CN108272746A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385153A (en) * | 2001-05-11 | 2002-12-18 | 张国智 | Preparation process for surfacce anesthesia cream |
| CN201107669Y (en) * | 2007-09-11 | 2008-08-27 | 上海申鹿均质机有限公司 | Homogeneous machine pressure automatic control instrument |
| CN103051367A (en) * | 2012-11-27 | 2013-04-17 | 西安电子科技大学 | Clustering-based blind source separation method for synchronous orthogonal frequency hopping signals |
| CN104038454A (en) * | 2014-06-20 | 2014-09-10 | 西安电子科技大学 | Method for estimating carrier frequency of PSK (phase shift keying) signal in Alpha-stable distribution noise |
| CN104187236A (en) * | 2014-07-15 | 2014-12-10 | 柴华 | Manufacturing method for amur grape jelly powder |
| CN107049464A (en) * | 2017-06-07 | 2017-08-18 | 任小宝 | A kind of cable formula inner fixing device for orthopaedics |
| CN107458596A (en) * | 2017-08-16 | 2017-12-12 | 重庆华凤衣道文化创意有限公司 | A kind of imperial shape solar energy and air energy composite aircraft |
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Application publication date: 20180713 |