CN107362447A - A kind of nervus tibialis stimulator and system - Google Patents
A kind of nervus tibialis stimulator and system Download PDFInfo
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- CN107362447A CN107362447A CN201710704443.2A CN201710704443A CN107362447A CN 107362447 A CN107362447 A CN 107362447A CN 201710704443 A CN201710704443 A CN 201710704443A CN 107362447 A CN107362447 A CN 107362447A
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- 230000005540 biological transmission Effects 0.000 claims abstract description 11
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- 238000010168 coupling process Methods 0.000 claims abstract description 10
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- 238000005424 photoluminescence Methods 0.000 claims abstract description 7
- 230000002159 abnormal effect Effects 0.000 claims description 19
- 229910052751 metal Inorganic materials 0.000 claims description 19
- 239000002184 metal Substances 0.000 claims description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 15
- 238000004891 communication Methods 0.000 claims description 15
- 239000000741 silica gel Substances 0.000 claims description 15
- 229910002027 silica gel Inorganic materials 0.000 claims description 15
- 230000004936 stimulating effect Effects 0.000 claims description 15
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- 230000000638 stimulation Effects 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 3
- 238000002513 implantation Methods 0.000 claims description 3
- 238000005457 optimization Methods 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 210000005036 nerve Anatomy 0.000 abstract description 7
- 230000008602 contraction Effects 0.000 abstract description 5
- 210000000278 spinal cord Anatomy 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 230000027939 micturition Effects 0.000 description 6
- 238000002651 drug therapy Methods 0.000 description 5
- 210000003423 ankle Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- 206010020853 Hypertonic bladder Diseases 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 2
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- 239000000203 mixture Substances 0.000 description 2
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- 206010021639 Incontinence Diseases 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
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- Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses a kind of nervus tibialis stimulator and system, wherein nerve stimulator includes resonance coupling module, signal demodulation module, waveform control module and the electrode output module being sequentially connected, the resonance coupling module, for obtaining the spatial electromagnetic ripple of corresponding frequency band, the energy transmission that the resonance coupling module will be coupled into gives each module, the resonance signal that will be coupled into is handled through signal demodulation module, the signal after being demodulated；The output signal that waveform control module modulates signals into module is converted into electric impulse signal, and electro photoluminescence is transmitted to nervus tibialis through electrode output module.The nervus tibialis stimulator that the present invention is implanted in nervus tibialis position will couple energy and demodulated stimulus signal, it is eventually converted into electric pulse and puts on nervus tibialis position, so as to produce electric pulse between the nerve of spinal cord, improve detrusor contractions and the filling of bladder sense of patient, and then treat, improve the effect of OAB symptoms.
Description
Technical field
The invention belongs to nerve stimulation field, more particularly to a kind of nervus tibialis stimulator and system.
Background technology
Overactive bladder (overactive bladder, OAB) by the world urinate control be defined as urgent urination, with or not
With urge incontinence, generally entail frequent micturition and enuresis nocturna, and not can prove that infection or other obvious pathological states in the presence of
A kind of syndrome.OAB pathogenesis is complex, and urination process is by higher nervous center (such as cerebral cortex, pons, spinal cord)
Controlled with peripheral neverous system (autonomic nerve, somatic nerves), lower urinary tract sensory nerve also assists in urination regulation and control.Any of the above portion
Bit function is likely to cause OAB extremely, and different pathophysiological mechanisms may cause similar symptoms.OAB general character includes few
Intravesical pressure rises obvious, detrusor autonomic activities enhancing, tetanic contraction, stimulate the reaction threshold value is reduced, be flat when amount is full
Sliding myocyte's ultrastructural change etc..OAB makes patient's doings, trip, sleep quality etc. impacted, seriously reduces patient
Quality of life, and the longer ongoing expense of the course of disease is higher.Therefore, effectively, easily treatment means can make patient be easier to receive.
Treatment OAB main method has Behavioral training and drug therapy at present, and drug therapy is likely to occur not tolerable side effect,
Behavioral training method non-evident effect, it is invalid or be not resistant to the patient of drug therapy for drug therapy, sacrum god can be used
The methods of adjusted, peripheral nerve regulation, botulinum toxin injection.Domestic and international correlative study shows that nervus tibialis, which stimulates, to help OAB to suffer from
Person improves frequent micturition, urgent urination and incontinence.
It is well known that it is raw to carry out extracellular electro photoluminescence to such as neuron or meat fiber normal neuronal can be replaced to stimulate
The common knowledge of thing physics circle.It is existing to realize that basic mode is, apply the arteries and veins of enough electric charges to human body by a stimulating electrode
Any combination of electric current and duration are rushed, induces the region of transmembrane current polarization cell membrane, it is reached from rest potential can
The threshold value for opening the sodium-ion channel of neural axon, the effect for transmitting action potential is just reached.Stimulation point is placed on ankle
Near the nervus tibialis in joint, so as to produce electric pulse between the nerve of spinal cord, improve detrusor contractions and the filling of bladder of patient
Sense, and then treat, improve OAB symptoms.
The percutaneous nervus tibialis electronic stimulation of in general, which continues for some time rear skin surface impedance, can increase patient perceivable's drop
It is low, thereby increases and it is possible to the abnormal contraction of foot can be caused to act；In general sacral nerve stimulator volume is larger and needs longer lead
Electrode, stimulator electricity can often occur and exhaust the problems such as stimulator or the fracture loosening of electrode connecting terminal are changed in needs operation；
In general medicinal treatment also often occurs invalid or be not resistant to phenomenon for drug therapy.
The content of the invention
In view of this, it is an object of the invention to propose a kind of nervus tibialis stimulator and system, minimally invasive implant surgery is utilized
Nervus tibialis stimulator is implanted near the nervus tibialis trunk of patient's ankle-joint, vitro program controlled transmitter is worn on patient's ankle
Opening position, energy and boost pulse are excited with radio frequency format of field by vitro program controlled transmitter by setting related stimulus parameter
Go out, energy and demodulated stimulus signal will be coupled by being implanted in the nervus tibialis stimulator at nervus tibialis position, be eventually converted into electric pulse
Nervus tibialis position is put on, so as to produce electric pulse between the nerve of spinal cord, improves detrusor contractions and the filling of bladder of patient
Sense, and then treat, improve the effect of OAB symptoms.
To reach above-mentioned purpose, the invention provides a kind of nervus tibialis stimulator, including the resonance coupled mode being sequentially connected
Block, signal demodulation module, waveform control module and electrode output module, the resonance coupling module, for obtaining corresponding frequency band
Spatial electromagnetic ripple, the energy transmission that the resonance coupling module will be coupled into gives each module, the resonance signal warp that will be coupled into
Signal demodulation module processing, the signal after being demodulated；
The output signal that the waveform control module modulates signals into module is converted into electric impulse signal, and mould is exported through electrode
Block transmits electro photoluminescence to nervus tibialis.
Preferably, the nervus tibialis stimulator is cylindrical, a diameter of 3.5mm, a height of 10mm.
Preferably, using the platinumiridio stimulating electrode of high-boron-silicon glass encapsulating structure, in addition to cylindric upper and lower ends.
Preferably, the output charge scope through electrode output module transmission electro photoluminescence is 0.02uC~4.9uC, maximum
Voltage amplitude is 16V, and pulse width is 40us~370us, and frequency of stimulation is 0~50Hz.
Based on above-mentioned purpose, present invention also offers a kind of nervus tibialis stimulating system, including above-mentioned nervus tibialis stimulator, goes back
Including vitro program controlled transmitter, vitro program controlled instrument and silica gel retainer plate,
Wherein, the vitro program controlled transmitter and the wireless telecommunications of nervus tibialis stimulator and transmission energy；It is described vitro program controlled
Instrument sends instruction to control nervus tibialis stimulator to export to vitro program controlled transmitter；
The vitro program controlled transmitter includes control module, low-power consumption bluetooth communication module, power module, discharge and recharge mould
Block, real-time clock module, memory module, LCD MODULE, key-press module, signal driver module, radio-frequency modulations transmitter module,
Overcurrent protection module, overtemperature protection module, abnormal metal detection module, sound and light alarm module, wherein,
The control module and low-power consumption bluetooth communication module, power module, charge-discharge modules, real-time clock module, deposit
Store up module, LCD MODULE, key-press module, signal driver module, radio-frequency modulations transmitter module, overcurrent protection module, overheat
Protection module, abnormal metal detection module, sound and light alarm module connect respectively, each module are controlled or input and output, extremely
Include MSP430 single-chip microcomputers less；
The charge-discharge modules are connected respectively with control module and power module, and power module is connected with each module, charge and discharge
After electric module is charged, power management is carried out by power module, each module is powered；
The low-power consumption bluetooth communication module is connected with control module, is turned after the instruction of vitro program controlled instrument is received and parsed through
Rf modulated signal is changed to be exported, at the same the electric current and temperature that radio-frequency modulations transmitter module is exported be back to it is vitro program controlled
Instrument；
The real-time clock module is connected with control module, for providing correct time；
The memory module is connected with control module, for storing stimulus signal template parameter；
The LCD MODULE is connected with control module, by stimulation parameter, state, treatment waveform, battery electric quantity, treatment
Time showing；
The key-press module is connected with the input of control module, for by different button carry out stimulation parameter setting,
Time adjustment, train template-setup, be turned on and off sound and light alarm；
The signal driver module is connected with control module output end, and the CMOS level drivers of control module output are changed
After export and give rear class radio-frequency modulations transmitter module；
The radio-frequency modulations transmitter module, radiofrequency signal output is carried out according to the parameter set, radio frequency is using frequency range
6.78MHz；
The overcurrent protection module, overtemperature protection module, abnormal metal detection module and control module and radio-frequency modulations hair
Penetrate module to be connected, for analog signal amount to be sampled, judge excessively stream, overheat, abnormal metal close to situation；
The sound and light alarm module is connected with control module output end, in overcurrent protection, overtemperature protection, abnormal metal detection
After triggering alarm signal, warning indicators are carried out by sound and light signal；
The silica gel fixes ring around the nervus tibialis stimulator, is fixed in implantation position.
Preferably, the vitro program controlled instrument includes low-power consumption bluetooth module and special Android program control module, wherein,
The low-power consumption bluetooth module and the low-power consumption bluetooth communication module of vitro program controlled transmitter carry out data transmission；
The special Android program control module is used to control vitro program controlled transmitter.
Preferably, the charge-discharge modules include 18650 lithium battery groups.
Preferably, the power module exports 2.85V, 3.3V, 5V, 12V respectively.
Preferably, the radio-frequency modulations transmitter module comprises at least E power-like amplifiers and transmitting antenna, the E classes work(
Rate amplifier uses pulse width modulation and noise optimization；The transmitting antenna is 8 font double-round complementation flexible antennas.
Preferably, the silica gel retainer plate uses MED-4870 silica gel.
The beneficial effects of the present invention are：Nervus tibialis stimulator provided by the invention is the implant of current minimum volume,
There is no larger implant and long wire of the conventional needle to the sacral nerve stimulation system of OAB patient, by being implanted directly into target god
Through-nervus tibialis position, the tradition such as wire Joint failure caused by being pullled due to motion etc. are effectively avoided to be chronically implanted asking for body
Topic.System is fixed by the nervus tibialis stimulator near implantation human body nervus tibialis, vitro program controlled transmitter, vitro program controlled instrument and silica gel
Circle composition；The energy and radio frequency letter that nervus tibialis stimulator volume essence is small, is sent without internal battery, the vitro program controlled transmitter of reception
Number, vitro program controlled transmitter is independently arranged by key-press module to stimulate template parameter and exports to nervus tibialis stimulator, can also
Stimulation parameter is set by vitro program controlled instrument, and vitro program controlled transmitter is transferred to by low-power consumption bluetooth module, then according to
Instruction output boost pulse and energy, can freely select occupation mode, patient can train n daily according to actual conditions
Secondary, training burden is accumulated in each m minutes, the situation reflection according to n*m patient's day, assesses therapeutic effect；Global design is fine, convenient
Wear simultaneously small and beautiful.
Brief description of the drawings
In order that the purpose of the present invention, technical scheme and beneficial effect are clearer, the present invention provides drawings described below and carried out
Explanation：
Fig. 1 is the structured flowchart of the nervus tibialis stimulator of the embodiment of the present invention；
Fig. 2 is the structured flowchart of the nervus tibialis stimulating system of the embodiment of the present invention；
Fig. 3 is the structural representation of the nervus tibialis stimulating system of the embodiment of the present invention；
Fig. 4 is the concrete structure schematic diagram of the nervus tibialis stimulating system of the embodiment of the present invention；
Fig. 5 is vitro program controlled transmitter and the vitro program controlled instrument structural frames of the nervus tibialis stimulating system of the embodiment of the present invention
Figure；
Fig. 6 is the partial circuit schematic diagram of the nervus tibialis stimulating system of the embodiment of the present invention；
Fig. 7 is that the nervus tibialis stimulator of the embodiment of the present invention loads the waveform at both ends in the equivalent human bodies of 1k Ω.
Embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
Referring to Fig. 1, the invention discloses a kind of nervus tibialis stimulator, a kind of nervus tibialis stimulator 10, including be sequentially connected
Resonance coupling module 101, signal demodulation module 102, waveform control module 103 and electrode output module 104, resonance coupled mode
Block 101, for obtaining the spatial electromagnetic ripple of corresponding frequency band, the energy transmission that resonance coupling module 101 will be coupled into gives each module,
The resonance signal that will be coupled into is handled through signal demodulation module 102, the signal after being demodulated；
The output signal that waveform control module 103 modulates signals into module 102 is converted into electric impulse signal, is exported through electrode
Module 104 transmits electro photoluminescence to nervus tibialis.
In specific embodiment, nervus tibialis stimulator 10 is cylindrical, a diameter of 3.5mm, a height of 10mm.
Nervus tibialis stimulator 10 uses high-boron-silicon glass encapsulating structure, includes the platinumiridio thorn of cylindric upper and lower ends
Swash electrode.
The electric impulse signal that is applied to around nervus tibialis tissue as shown in fig. 7, output charge scope be 0.02uC~
4.9uC, maximum voltage amplitude 16V, pulse width are 40us~370us, and frequency of stimulation is 0~50Hz.
Based on corresponding to above-described embodiment, present invention also offers a kind of nervus tibialis stimulating system, referring to Fig. 2-4, including
Above-mentioned nervus tibialis stimulator 10, in addition to vitro program controlled transmitter 20, vitro program controlled instrument 30 and silica gel retainer plate 40,
Wherein, vitro program controlled transmitter 20 and the wireless telecommunications of nervus tibialis stimulator 10 and transmission energy；Vitro program controlled instrument 30
Instruction is sent to vitro program controlled transmitter 20 to control nervus tibialis stimulator 10 to export；The output of control nervus tibialis stimulator 10 has two
Kind mode of operation：Vitro program controlled transmitter 20 " off line " work, is not connected with vitro program controlled instrument 30, passes through vitro program controlled transmitter
Button on 20 key-press modules 210 carries out parameter setting output radiofrequency signal；Another kind is by the connector of vitro program controlled instrument 30
The low-power consumption bluetooth communication module 202 of outer program control transmitter 20, and then external journey is transferred to by the arrange parameter of vitro program controlled instrument 30
Transmitter 20 is controlled, then exports radiofrequency signal to nervus tibialis stimulator 10, default mode is to be controlled using vitro program controlled instrument 30
System output.
Nervus tibialis stimulator 10 combines with silica gel retainer plate 40, and silica gel retainer plate 40 is respectively from nervus tibialis stimulator about 10
Both ends are inserted in, will using operation suture thread when nervus tibialis stimulator 10 is positioned at the nervus tibialis trunk near ankle
Silica gel retainer plate 40 is sutured in the top layer of nervus tibialis trunk, and displacement is prevented for fixing nervus tibialis stimulator 10；11 in Fig. 4
For the magnetic induction line 11 around nervus tibialis stimulator 10.
In specific embodiment, referring to Fig. 5, vitro program controlled transmitter 20 includes control module 201, low-power consumption bluetooth communication mould
Block 202, power module 204, charge-discharge modules 203, real-time clock module 208, memory module 209, LCD MODULE 205,
Key-press module 210, signal driver module 206, radio-frequency modulations transmitter module 207, overcurrent protection module 211, overtemperature protection module
212nd, abnormal metal detection module 213, sound and light alarm module 214, wherein,
Control module 201 and low-power consumption bluetooth communication module 202, power module 204, charge-discharge modules 203, real-time clock
Module 208, memory module 209, LCD MODULE 205, key-press module 210, signal driver module 206, radio-frequency modulations transmitting
Module 207, overcurrent protection module 211, overtemperature protection module 212, abnormal metal detection module 213, sound and light alarm module 214 are divided
Do not connect, each module is controlled or input and output, including at least MSP430 single-chip microcomputers；
Charge-discharge modules 203 are connected respectively with control module 201 and power module 204, power module 204 and each module phase
Even, after charge-discharge modules 203 are charged, power management is carried out by power module 204, each module is powered；
Low-power consumption bluetooth communication module 202 is connected with control module 201, is receiving and parsing through the instruction of vitro program controlled instrument 30
After be converted to rf modulated signal and exported, while electric current and temperature that radio-frequency modulations transmitter module 207 is exported are back to
Vitro program controlled instrument 30；
Real-time clock module 208 is connected with control module 201, for providing correct time；Including DS1302 clock chips,
32.768KHz wrist-watches crystal oscillator and embedded CR2032 button cells, ensure to ensure that the time is accurate under shutdown and running status.
Memory module 209 is connected with control module 201, for storing stimulus signal template parameter；For in control module 201
Special memory block 256Byte FlashA and FlashB, the template parameter set every time occupy 8Byte, can also use extend out
EEPROM module carry out template parameter storage, such as AT24C08, AT24C16 etc..
LCD MODULE 205 is connected by SPI communication port and 8 line FPDPs with control module 201, will be stimulated
Parameter, state, treatment waveform, battery electric quantity, treatment time display；If patient's selection is used outside the control volume of vitro program controlled instrument 30
Program control transmitter 20, then bluetooth symbol can be shown on LCD MODULE 205, now control module 201 switches to such a mould
The related key of key-press module 210 under formula on the vitro program controlled panel of transmitter 20 is unavailable；If patient selects independently to use body
Outer program control transmitter 20 carries out local side control, need not now use vitro program controlled instrument 30, on LCD MODULE 205 not
Bluetooth symbol is shown, both control models are liked according to patient and scope of activities can be non-interference with unrestricted choice, give tacit consent to mould
Formula is to be controlled output using vitro program controlled instrument 30；
Key-press module 210 is connected with the input of control module 201, is set for carrying out stimulation parameter by different buttons
Put, the time adjusts, trains template-setup, is turned on and off sound and light alarm；Including 3 buttons.
Referring to Fig. 6, signal driver module 206 is connected with the output end of control module 201, and control module 201 is exported
Exported after the conversion of CMOS level drivers to rear class radio-frequency modulations transmitter module 207；Signal driver module 206 includes LTC4440-5
Or LTC7003 chips composition high speed, high voltage, high side gate drive circuit, the 3.3V CMOS that control module 201 is exported
Level PWM signal exports with 6.78MHz active crystals oscillator, then the high frequency square wave Jing Guo Schmidt trigger circuit shaping is defeated
Enter to 74LVG08 logical AND gates and carry out logic and operation, using 6.78MHz high frequency square wave as carrier modulation, logic and operation
Signal afterwards inputs to LTC4440-5 chips and is driven enhancing, final output 5V brewed PWM ripples.
Radio-frequency modulations transmitter module 207, radiofrequency signal output is carried out according to the parameter set, radio frequency is using frequency range
6.78MHz；Use the E power-like amplifiers after optimization noise, its principle not occurred according to electric current and voltage in synchronization
Come what is designed, actual efficiency about 90%, due to power MOSFET Q5 and non-ideal switching device, the saturation conduction stage has one
Fixed conducting resistance is present, therefore can consume certain power, and signal driver module 206 puts on work(as gate electrode drive signals
On rate MOSFET Q5, the component of the models such as IRLR024, IRLR510, Si7852 can be used in MOSFET Q5, according to difference
Signal edge characteristics requirement and caloric value chosen.The drain electrode inductance upper end of the E power-like amplifier circuits seals in one
Schottky fly-wheel diode, π types are inserted between the output of signal driver module 206 and the input of radio-frequency modulations transmitter module 207
Filter network 2067 suppresses the noise of input signal, the output of signal driver module 206 to radio-frequency modulations transmitter module 207 it is defeated
Enter to hold cabling it is near it is possible it is short avoid the reflection and interference of high speed signal on a printed circuit, in order to allow radiofrequency signal with compared with
Small decay is propagated in spatial field, introduces transmitting antenna 2071 in the rear end of E power-like amplifiers, transmitting antenna 2071 is
Class " 8 font " double-round complementation flexible antennas, tuning rear end antenna impedance are 50 Ω, impedance-tumed Web vector graphic LC connection in series-parallel nets
Network, in order to be lowered into the short resonant noise component of the impedance-tumed networks of 50 Ω, inserted in the impedance-tumed network of LC connection in series-parallel
Possesses the power magnetic bead of special frequency channel decay, to suppress correlated noise, the loop diameter of transmitting antenna 2071 is that 3-4cm uses 3 layers
Symmetric circuit designs, and top layer, bottom are stratum, and transmitting antenna 2071 is placed in intermediate layer, and spoke caused by impedance inequality is reduced with this
Transmitting is penetrated, while avoids the generation of eddy current effect around the loop of transmitting antenna 2071 using " semiclosed bag ground " processing, is dropped simultaneously
Low EMI noise, antenna are far below 1.6W/Kg to external radiation SAR value, transmitting antenna 2071 can be imbedded in it is elastic it is freely regulated from
Paste in sleeve.
Overcurrent protection module 211, overtemperature protection module 212, abnormal metal detection module 213 and control module 201 and penetrate
Frequency modulation transmitter module 207 is connected, and for analog signal amount to be sampled, judges excessively stream, overheat, abnormal metal close to situation；Cross
Stream protection module 211 is used to sample the electric current in radio-frequency modulations transmitter module 207, and electric current increases sharply after preventing short circuit；Overtemperature protection
Module 212 is used to sample MOSFET temperature in radio-frequency modulations transmitter module 207, prevents MOSFET temperature rises are larger from causing MOSFET devices
Part damages；Abnormal metal detection module 213 can identify human body impedance or metal according to the curent change situation of load end
Abnormal contact, if wearing metal jewelry at patient's ankle, abnormal metal detection module 213 can identify and prompt patient to train
Period removes this thing.
Sound and light alarm module 214 is connected with the output end of control module 201, in overcurrent protection, overtemperature protection, abnormal metal inspection
Survey triggering alarm signal after, by yellow led with 2Hz frequency scintillation simultaneously buzzer will dichloro-diphenyl-dichlorothane send warning sound
Carry out warning indicators, LCD MODULE 205 or vitro program controlled instrument 30 and pop-up is shown into warning classification；
Vitro program controlled instrument 30 includes low-power consumption bluetooth module 301 and special Android program control module 302, wherein,
Low-power consumption bluetooth module 301 and the low-power consumption bluetooth communication module 202 of vitro program controlled transmitter carry out data transmission；
Special Android program control module 302 is used to control vitro program controlled transmitter 20.
In specific embodiment, charge-discharge modules 203 include 18650 lithium battery groups and TP5100 charging management chips, use
12V DC control source charges, maximum charging current 2A, and maximum is full of voltage 8.2V~8.4V；
Power module 204 exports 2.85V, 3.3V, 5V, 12V respectively, including LT1117-3.3LDO chips carry out voltage and turned
Shift to after 3.3V again by common mode rejection circuit supply control module 201, low-power consumption bluetooth communication module 202, real-time clock mould
Block 208, memory module 209；Voltage conversion is carried out to 2.85V supply LCD MODULEs including LT1117-2.85LDO chips
205；Voltage conversion is carried out to 5V supply signal driver modules 206 including LM2940-5LDO chips；Carried out including LM3478 chips
Boost boost conversions supply the E power-like amplifiers of radio-frequency modulations transmitter module 207 to 12V.
Silica gel retainer plate 40 uses MED-4870 silica gel.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
Cross above preferred embodiment the present invention is described in detail, it is to be understood by those skilled in the art that can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (10)
1. a kind of nervus tibialis stimulator, it is characterised in that including resonance coupling module, signal demodulation module, the ripple being sequentially connected
Shape control module and electrode output module, the resonance coupling module are described humorous for obtaining the spatial electromagnetic ripple of corresponding frequency band
The energy transmission that the coupling module that shakes will be coupled into gives each module, and the resonance signal that will be coupled into is handled through signal demodulation module, obtained
Signal after to demodulation；
The output signal that the waveform control module modulates signals into module is converted into electric impulse signal, is passed through electrode output module
Electro photoluminescence is passed to nervus tibialis.
2. nervus tibialis stimulator as claimed in claim 1, it is characterised in that the nervus tibialis stimulator is cylindrical, diameter
For 3.5mm, a height of 10mm.
3. nervus tibialis stimulator as claimed in claim 2, it is characterised in that using high-boron-silicon glass encapsulating structure, in addition to
The platinumiridio stimulating electrode of cylindric upper and lower ends.
4. nervus tibialis stimulator as claimed in claim 1, it is characterised in that transmit electro photoluminescence through the electrode output module
Output charge scope is 0.02uC~4.9uC, maximum voltage amplitude 16V, and pulse width is 40us~370us, frequency of stimulation
For 0~50Hz.
A kind of 5. system for including one of 1-4 nervus tibialis stimulators, it is characterised in that also including vitro program controlled transmitter,
Vitro program controlled instrument and silica gel retainer plate,
Wherein, the vitro program controlled transmitter and the wireless telecommunications of nervus tibialis stimulator and transmission energy；The vitro program controlled instrument to
Vitro program controlled transmitter sends instruction to control nervus tibialis stimulator to export；
The vitro program controlled transmitter includes control module, low-power consumption bluetooth communication module, power module, charge-discharge modules, reality
When clock module, memory module, LCD MODULE, key-press module, signal driver module, radio-frequency modulations transmitter module, excessively stream
Protection module, overtemperature protection module, abnormal metal detection module, sound and light alarm module, wherein,
The control module and low-power consumption bluetooth communication module, power module, charge-discharge modules, real-time clock module, storage mould
Block, LCD MODULE, key-press module, signal driver module, radio-frequency modulations transmitter module, overcurrent protection module, overtemperature protection
Module, abnormal metal detection module, sound and light alarm module connect respectively, each module are controlled or input and output, at least wrap
Include MSP430 single-chip microcomputers；
The charge-discharge modules are connected respectively with control module and power module, and power module is connected with each module, discharge and recharge mould
After block is charged, power management is carried out by power module, each module is powered；
The low-power consumption bluetooth communication module is connected with control module, is converted to after the instruction of vitro program controlled instrument is received and parsed through
Rf modulated signal is exported, while electric current and temperature that radio-frequency modulations transmitter module is exported are back to vitro program controlled instrument；
The real-time clock module is connected with control module, for providing correct time；
The memory module is connected with control module, for storing stimulus signal template parameter；
The LCD MODULE is connected with control module, by stimulation parameter, state, treatment waveform, battery electric quantity, treatment time
Display；
The key-press module is connected with the input of control module, for carrying out stimulation parameter setting, time by different buttons
Adjust, train template-setup, be turned on and off sound and light alarm；
The signal driver module is connected with control module output end, will be defeated after the CMOS level drivers conversion of control module output
Go out and give rear class radio-frequency modulations transmitter module；
The radio-frequency modulations transmitter module, radiofrequency signal output is carried out according to the parameter set, radio frequency is using frequency range
6.78MHz；
The overcurrent protection module, overtemperature protection module, abnormal metal detection module and control module and radio-frequency modulations transmitting mould
Block is connected, and for analog signal amount to be sampled, judges excessively stream, overheat, abnormal metal close to situation；
The sound and light alarm module is connected with control module output end, in overcurrent protection, overtemperature protection, abnormal metal detection triggering
After alarm signal, warning indicators are carried out by sound and light signal；
The silica gel fixes ring around the nervus tibialis stimulator, is fixed in implantation position.
6. nervus tibialis stimulating system as claimed in claim 5, it is characterised in that the vitro program controlled instrument includes low-power consumption bluetooth
Module and special Android program control module, wherein,
The low-power consumption bluetooth module and the low-power consumption bluetooth communication module of vitro program controlled transmitter carry out data transmission；
The special Android program control module is used to control vitro program controlled transmitter.
7. nervus tibialis stimulating system as claimed in claim 5, it is characterised in that the charge-discharge modules include 18650 lithiums electricity
Pond group.
8. nervus tibialis stimulating system as claimed in claim 5, it is characterised in that the power module export respectively 2.85V,
3.3V、5V、12V。
9. nervus tibialis stimulating system as claimed in claim 5, it is characterised in that the radio-frequency modulations transmitter module comprises at least
E power-like amplifiers and transmitting antenna, the E power-like amplifiers use pulse width modulation and noise optimization；The transmitting
Antenna is 8 font double-round complementation flexible antennas.
10. nervus tibialis stimulating system as claimed in claim 5, it is characterised in that the silica gel retainer plate uses MED-4870
Silica gel.
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| CN201710704443.2A CN107362447A (en) | 2017-08-17 | 2017-08-17 | A kind of nervus tibialis stimulator and system |
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|---|---|---|---|
| CN201710704443.2A CN107362447A (en) | 2017-08-17 | 2017-08-17 | A kind of nervus tibialis stimulator and system |
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| CN201710704443.2A Pending CN107362447A (en) | 2017-08-17 | 2017-08-17 | A kind of nervus tibialis stimulator and system |
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| US10953225B2 (en) | 2017-11-07 | 2021-03-23 | Neurostim Oab, Inc. | Non-invasive nerve activator with adaptive circuit |
| CN113181551A (en) * | 2021-04-28 | 2021-07-30 | 浙江帝诺医疗科技有限公司 | High-energy stimulator for preventing deep venous thrombosis by applying nerve regulation and control technology |
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| CN113181551A (en) * | 2021-04-28 | 2021-07-30 | 浙江帝诺医疗科技有限公司 | High-energy stimulator for preventing deep venous thrombosis by applying nerve regulation and control technology |
| CN113457014A (en) * | 2021-08-03 | 2021-10-01 | 苏州景昱医疗器械有限公司 | External program controller and control circuit and program control system thereof |
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