CN108254913A - A kind of fluorescence microscope lighting system for circulating tumor cell detection - Google Patents
A kind of fluorescence microscope lighting system for circulating tumor cell detection Download PDFInfo
- Publication number
- CN108254913A CN108254913A CN201711203389.XA CN201711203389A CN108254913A CN 108254913 A CN108254913 A CN 108254913A CN 201711203389 A CN201711203389 A CN 201711203389A CN 108254913 A CN108254913 A CN 108254913A
- Authority
- CN
- China
- Prior art keywords
- stent
- light source
- conductor barrel
- fluorescence microscope
- lighting system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 title claims abstract description 22
- 238000001514 detection method Methods 0.000 title claims abstract description 20
- 239000004020 conductor Substances 0.000 claims abstract description 32
- 230000008878 coupling Effects 0.000 claims abstract description 6
- 238000010168 coupling process Methods 0.000 claims abstract description 6
- 238000005859 coupling reaction Methods 0.000 claims abstract description 6
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 10
- 230000005611 electricity Effects 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000011528 liquid biopsy Methods 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
Abstract
A kind of fluorescence microscope lighting system for circulating tumor cell detection, including top plate, vertical position adjustable davit is set on the top plate, the bottom of two davits is fixedly connected with stent, one end setting conductor barrel of stent, the inside of the conductor barrel sets positive pole contact and power cathode contact, the other end setting motor of stent by compressed spring；The middle part of stent is horizontally disposed with lamp axis by bearing bracket stand, and one end setting of lamp axis adjusts lamp holder, and the other end is fixedly connected by shaft coupling with the output shaft Detachable of motor；The periphery for adjusting lamp holder is evenly equipped with multiple LED light sources, it adjusts lamp holder and tactile disk is set close to one end of conductor barrel, the tactile disk is evenly equipped with a light source cathode contact and multiple light source conductive contacts that can be selectively connect with positive pole contact in lamp axis rotary course on the end face of conductor barrel, the positive and negative electrode of multiple light sources conductive contact and light source cathode contact respectively with multiple LED light sources is connected, while light source cathode contact is inconsistent with power cathode contact always.
Description
Technical field
The present invention relates to a kind of fluorescence microscope lighting system, particularly a kind of fluorescence for circulating tumor cell detection
Microscope illumination system.
Background technology
In view of the deficiency of routine tumor examination means, clinician not only need more accurately to be used for tumour in itself at present
The data of property assessment are more badly in need of accurately assessing the reliable parameter of oncotherapy curative effect accuracy and validity.
Circulating tumor cell (CTC) is the tumour cell that peripheral blood is shedded by primary or metastatic lesion, as one
" liquid biopsy " means reflect whether tumour occurs invasion transfer to kind in real time.The experimental results are prompted, and hemal ring swells in blood
The occurrence and development of oncocyte and cancer have a direct relation, the single or a small amount of circulating tumor cell in detection and analysis peripheral blood
To evaluating, assessing patient for treatment's reaction, the recurrence of prediction tumour and transfer, examinations oncotherapy effect, instruct tumour
The assessment that drug resistance of tumor, Index for diagnosis and the accuracy of prediction and validity were accurately treated, monitored to individuation is very crucial.
Existing CTC detection fluorescence microscope system lighting system is illuminated using mercury lamp or halogen lamp, volume, again
Amount, power are larger, and more huge too fat to move so as to cause whole system, the mercury lamp service life is also shorter, it is often necessary to which replacement brings whole
Body cost is larger, and inconvenient debugging during light source position deviation, but CTC detections are higher to position accuracy demand.
Invention content
The technical problems to be solved by the invention are, in view of the shortcomings of the prior art, providing a kind of small, gravimetric power
It is small, and light source position debugging is easily for the fluorescence microscope lighting system of circulating tumor cell detection.
In order to solve the above technical problems, the technical solution adopted by the present invention is：It is a kind of to be directed to what circulating tumor cell detected
Fluorescence microscope lighting system sets two vertical positions adjustable including the top plate being fixedly connected with mirror body, on the top plate
Davit, the bottoms of two davits are fixedly connected with stent, one end setting adjustable conductor barrel in horizontal position of stent, in the conductor barrel
Two conducting wires being connect respectively with power supply positive and negative electrode are set, and the other end of two conducting wires sets positive pole contact and electricity respectively
Source cathode contact, and connected between power supply positive and negative electrode contact and conductor barrel by compressed spring, the other end setting electricity of stent
Machine, the output shaft of the motor are oppositely arranged after stretching into stent with conductor barrel；The middle part of stent is horizontally disposed with by bearing bracket stand and axis
The lamp axis of bolster clearance fit, lamp axis set multiple adjustable adjusting lamp holders of front and back position close to one end of conductor barrel, and lamp axis leans on
One end of nearly motor is fixedly connected by shaft coupling with the output shaft Detachable of motor；Each periphery for adjusting lamp holder is set respectively
LED light source, and adjust lamp holder and tactile disk is set close to one end of conductor barrel, which is evenly equipped with multiple on the end face of conductor barrel
The light source conductive contact of connection, multiple light sources conductive contact can be selectively contradicted with positive pole contact in lamp axis rotary course
The anode with multiple LED light sources is connected respectively, and tactile disk is additionally provided with a light source cathode contact on the end face of conductor barrel, should
Light source cathode contact is inconsistent with power cathode contact always while the cathode with multiple LED light sources is connected.
In said program, cam is provided on the output shaft of the motor, stroke is set to open on stent corresponding with cam
It closes, the controller of the trip switch connection fluorescence microscope, and during cam touching travel switch, one in multiple LED light sources
It just lights, and is just rotated to the collimating mirror focal point of fluorescence microscope with positive pole contact portion.It is thus fluorescence
Microscope sets a rudimentary check position, every time during detection, needs first to adjust fluorescence microscope to initial position just open
Begin.
In said program, the davit wears top plate by the first pedestal, passes through the first locking screw between pedestal and davit
Nail locking positioning, makes the vertical position of LED light source can adjust above and below.
In said program, the conductor barrel is arranged in one end of stent, and by the second pedestal being fixed on stent
It is fixedly connected between two pedestals and conductor barrel by the second lock-screw.Institute is equipped with by bearing clearance on the bearing bracket stand
State lamp axis.The shaft coupling is fixed by third lock-screw and the output axis connection of lamp axis, motor.In this way so that lamp axis is horizontal
Position is adjustable, i.e. the horizontal position of LED light source is adjustable.
In said program, each adjusting lamp holder is distributed in described lamp axis one end, and each lamp holder that adjusts passes through screw thread and lamp
Axis connection, in this way by adjusting being threaded in or out for lamp holder, the forward and backward position that can make LED light source is adjustable.
Inventor for CTC as shown in Figure 5 illumination and imaging system principle schematic (in addition to LED light source,
System in this figure is the prior art), its lighting source is set into LED light source, LED light source passes through collimating mirror, Ran Houtong first
Excitation optical filtering and dichronic mirror (in order to ensure that lighting system and imaging system are total to aperture) are crossed, sample is radiated at finally by object lens
On, to ensure the effect of Uniform Illumination.In addition, the present invention is needed for CTC detection lighting system light sources using a variety of different waves
Section, thus there is provided the different multiple LED light sources of wavelength, it is also contemplated that the meeting under identical optical system of the light source of different-waveband
Aberration is generated, reaches similary illuminating effect under different-waveband on sample to ensure, thus present invention design LED light source is away from collimation
The up, down, left, right, before and after of mirror is apart from adjustable.
Compared with prior art, the advantageous effect of present invention is that：
1st, due to the present invention using compact low-power consumption LED light source, thus the present invention can reduce CTC detecting systems power consumption,
Volume, weight, so as to reduce cost；
2nd, LED light source position of the present invention is adjustable, and simple operation.
3rd, LED light source of the present invention uses mechanical initial alignment, simple accurate, simplify control program.
Description of the drawings
Fig. 1 removes the dimensional structure diagram after top plate for the present invention.
Fig. 2 is schematic cross-sectional view of the present invention.
Fig. 3 is partial enlarged view at the A of Fig. 2.
Fig. 4 is the circuit diagram of LED light source of the present invention.
Fig. 5 is the fluorescence microscope optical schematic diagram using LED light source.
Specific embodiment
As Figure 1-Figure 4, the present invention is for one embodiment of fluorescence microscope lighting system of circulating tumor cell detection
Including the top plate 1 being fixedly connected with mirror body, two davits are set by the first lock-screw 2 and the first pedestal 3 on the top plate 1
4, the first lock-screw 2 is unscrewed, davit 4 can be moved up and down with respect to top plate 1.The bottom of two davits 4 is fixedly connected with stent 5.Branch
One end of frame 5 is fixedly connected with conductor barrel 6 by the second lock-screw 22 with the second pedestal 23, two pieces points of setting in the conductor barrel 6
The conducting wire 7 not connect with power supply positive and negative electrode, the other end corresponding power positive and negative electrode setting positive pole contact of two conducting wires 7 and
Power cathode contact 8, and connected between power supply positive and negative electrode contact 8 and conductor barrel 6 by compressed spring 9.The other end of stent 5
Motor 10 is set, and the output shaft of the motor 10 stretches into stent 5 and is oppositely arranged with conductor barrel 6.The middle part setting bearing of stent 5
Frame 11 sets lamp axis 12 on the bearing bracket stand 11 by 24 clearance fit of bearing, and one end of the close conductor barrel 6 of lamp axis 12 passes through spiral shell
Four adjusting lamp holders 13 of line connection setting, one end of the separate conductor barrel of lamp axis 12 passes through shaft coupling 14 and the output shaft of motor 10
It is fixedly connected, which is fixed by third lock-screw 15 and the output axis connection of lamp axis 12, motor 10.It is each to adjust lamp
The periphery of seat 13 is respectively arranged with LED light source 16, adjusts the round tactile disk 17 of one end setting of the close conductor barrel 6 of lamp holder 13, should
It is uniformly distributed on the end face of the close conductor barrel 6 of round tactile disk 17 that there are four can be with positive pole contact 10 in 12 rotary course of lamp axis
Selectivity contradicts the light source conductive contact 18 of connection, four light source conductive contacts 18 anode phase with four LED light sources 16 respectively
Connection, the end face middle part of the close conductor barrel 6 of round tactile disk 17 are additionally provided with light source cathode contact 19, and light source cathode contact 19 exists
With power cathode contact it is inconsistent while be connected with the cathode of four LED light sources 16.It is provided on the output shaft of motor 10
Cam 20, with setting travel switch 21 on 20 corresponding stent 5 of cam, when cam 20 touches travel switch 21, four LED lights
One in source 16 just connect with positive pole contact 8 and lights, and the LED light source lighted 16 is just rotated to fluorescence microscopy
The collimating mirror focal point of mirror, initial LED light source position can be confirmed as by adjusting the position of lamp holder 13 at this time, and travel switch 21 detects
To after this signal, signal is fed back to the controller of fluorescence microscope, and records the initial position, is i.e. fluorescence microscope initial bit
Calibration is put, so that fluorescence microscope works normally.
The present invention makes on adjusting lamp holder 13 in use, first have to correct initial LED light source position, i.e. electric rotating machine 10
One LED light source 16 is rotated to the collimating mirror of face fluorescence microscope, and is connected and lighted with positive pole contact 8, in addition, passing through
Davit 4 adjusts the upper and lower position of lamp holder 13, and the horizontal position of lamp holder 13 is adjusted by second and third lock-screw 22,15
It puts, makes the forward and backward position of LED light source adjustable, and then be in the LED light source lighted 16 by adjusting being screwed into of lamp holder, back-outing
The collimating mirror focal point of fluorescence microscope realizes initial position correction, can proceed by detection.
It, can be by adjusting davit vertical height simultaneously if LED light source deviates collimation mirror foci when toggle lights
Locking ensures that LED light source is in located horizontally from the emitter with collimating mirror focus；In next step by adjusting lamp axis horizontal position and locking
Tightly, it is ensured that LED light source is not eccentric with collimating mirror, then the forward and backward position for being screwed into, back-outing adjusting LED light source by adjusting lamp holder
It puts, until the LED light source of selection is adjusted to collimating mirror focal point and just can reach best illuminating effect.
After LED light source of the present invention is adjusted to initial position, since the anode annular of LED light source is distributed on circumference, bear
Pole then comes together in the center of circle, thus round tactile disk is often rotated by 90 ° with motor, then next LED light source connects work, shines, remaining
In the case of LED light source do not work.
It is illustrated by taking four LED light sources as an example in the present embodiment, however, it is not limited to this, in a particular application, can root
According to the wavelength requirement of required detection light source, the LED light source of multiple and different wave bands, such as three, five, six etc. are set.
Claims (7)
1. a kind of fluorescence microscope lighting system for circulating tumor cell detection, including the top plate being fixedly connected with mirror body
(1), which is characterized in that two adjustable davits of vertical position (4) are set on the top plate, and the bottom of two davits is fixedly connected with branch
Frame (5), one end setting adjustable conductor barrel in horizontal position (6) of stent, the interior setting two of the conductor barrel are positive and negative with power supply respectively
The conducting wire (7) of pole connection, the other end of two conducting wires set positive pole contact and power cathode contact (8), and power supply respectively
It is connected between positive and negative electrode contact and conductor barrel by compressed spring (9), the other end setting motor (10) of stent, the motor
Output shaft is oppositely arranged after stretching into stent with conductor barrel；The middle part of stent is horizontally disposed with and bearing bracket stand gap by bearing bracket stand (11)
The lamp axis (12) of cooperation, lamp axis set multiple front and back positions are adjustable to adjust lamp holder (13) close to one end of conductor barrel, and lamp axis leans on
One end of nearly motor is fixedly connected by shaft coupling (14) with the output shaft Detachable of motor；Each periphery for adjusting lamp holder is set respectively
LED light source (16) is put, adjusts lamp holder close to one end of conductor barrel setting tactile disk (17), the tactile disk is equal on the end face of conductor barrel
Multiple light source conductive contacts (18) that can selectively contradict connection with positive pole contact in lamp axis rotary course are furnished with, it is multiple
Anode of the light source conductive contact respectively with multiple LED light sources is connected, and tactile disk is additionally provided with a light on the end face of conductor barrel
Source cathode contact (19), the light source cathode contact while cathode with multiple LED light sources is connected always with power cathode
Contact is inconsistent.
2. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 1, feature
It is, cam (20) is provided on the output shaft of the motor, travel switch (21), the row are set on stent corresponding with cam
The controller of Cheng Kaiguan connection fluorescence microscopes, and during cam touching travel switch, one in multiple LED light sources just with electricity
Source cathode contact connection is lighted, and just rotate to the collimating mirror focal point of fluorescence microscope.
3. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 1, feature
It is, the davit wears top plate by the first pedestal (3), is locked and fixed by the first lock-screw (2) between pedestal and davit
Position.
4. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 1, feature
It is, the conductor barrel is arranged in one end of stent by the second pedestal (24) being fixed on stent, and the second pedestal is with leading
It is fixedly connected between spool by the second lock-screw (22).
5. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 1, feature
It is, the lamp axis is equipped with by bearing clearance on the bearing bracket stand.
6. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 5, feature
It is, the shaft coupling is fixed by third lock-screw (15) and the output axis connection of lamp axis, motor.
7. a kind of fluorescence microscope lighting system for circulating tumor cell detection according to claim 6, feature
It is, each adjusting lamp holder is distributed in described lamp axis one end, and each lamp holder that adjusts passes through screw thread and lamp axis connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711203389.XA CN108254913A (en) | 2017-11-27 | 2017-11-27 | A kind of fluorescence microscope lighting system for circulating tumor cell detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711203389.XA CN108254913A (en) | 2017-11-27 | 2017-11-27 | A kind of fluorescence microscope lighting system for circulating tumor cell detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108254913A true CN108254913A (en) | 2018-07-06 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711203389.XA Pending CN108254913A (en) | 2017-11-27 | 2017-11-27 | A kind of fluorescence microscope lighting system for circulating tumor cell detection |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0872771A2 (en) * | 1997-04-14 | 1998-10-21 | Canon Kabushiki Kaisha | Photosensitive member, process for its production, image forming apparatus having the photosensitive member, and image forming process |
| JP2003279861A (en) * | 2002-03-27 | 2003-10-02 | Nikon Corp | Illuminator for microscope |
| JP2009025549A (en) * | 2007-07-19 | 2009-02-05 | Claro Inc | Microscope apparatus |
| CN101576652A (en) * | 2009-04-13 | 2009-11-11 | 宁波舜宇仪器有限公司 | Cursor module for microscope |
| CN105445919A (en) * | 2015-12-25 | 2016-03-30 | 宁波市教学仪器有限公司 | Light source device of fluorescence microscope |
| CN105583486A (en) * | 2016-02-25 | 2016-05-18 | 西北工业大学 | Optical fiber and light source butt welding device |
| CN205703205U (en) * | 2016-05-23 | 2016-11-23 | 中山市光维光电科技有限公司 | A kind of compound lens intelligence centering coaxial device |
| CN207718068U (en) * | 2017-11-27 | 2018-08-10 | 湖南宏动光电有限公司 | A kind of fluorescence microscope lighting system for circulating tumor cell detection |
-
2017
- 2017-11-27 CN CN201711203389.XA patent/CN108254913A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0872771A2 (en) * | 1997-04-14 | 1998-10-21 | Canon Kabushiki Kaisha | Photosensitive member, process for its production, image forming apparatus having the photosensitive member, and image forming process |
| JP2003279861A (en) * | 2002-03-27 | 2003-10-02 | Nikon Corp | Illuminator for microscope |
| JP2009025549A (en) * | 2007-07-19 | 2009-02-05 | Claro Inc | Microscope apparatus |
| CN101576652A (en) * | 2009-04-13 | 2009-11-11 | 宁波舜宇仪器有限公司 | Cursor module for microscope |
| CN105445919A (en) * | 2015-12-25 | 2016-03-30 | 宁波市教学仪器有限公司 | Light source device of fluorescence microscope |
| CN105583486A (en) * | 2016-02-25 | 2016-05-18 | 西北工业大学 | Optical fiber and light source butt welding device |
| CN205703205U (en) * | 2016-05-23 | 2016-11-23 | 中山市光维光电科技有限公司 | A kind of compound lens intelligence centering coaxial device |
| CN207718068U (en) * | 2017-11-27 | 2018-08-10 | 湖南宏动光电有限公司 | A kind of fluorescence microscope lighting system for circulating tumor cell detection |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Jia Honghui Inventor after: Liu Lianjun Inventor after: Lu Xiaowei Inventor before: Liu Lianjun Inventor before: Lu Xiaowei |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180706 |