CN108254371A - Portable detection analyzer - Google Patents
Portable detection analyzer Download PDFInfo
- Publication number
- CN108254371A CN108254371A CN201711433438.9A CN201711433438A CN108254371A CN 108254371 A CN108254371 A CN 108254371A CN 201711433438 A CN201711433438 A CN 201711433438A CN 108254371 A CN108254371 A CN 108254371A
- Authority
- CN
- China
- Prior art keywords
- pedestal
- sample rack
- light source
- cuvette
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 25
- 230000007246 mechanism Effects 0.000 claims abstract description 34
- 238000004458 analytical method Methods 0.000 claims abstract description 12
- 230000009471 action Effects 0.000 claims abstract description 5
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 82
- 239000000758 substrate Substances 0.000 claims description 31
- 238000010438 heat treatment Methods 0.000 claims description 16
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000003760 magnetic stirring Methods 0.000 claims description 7
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 230000005389 magnetism Effects 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 8
- 239000011324 bead Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000008450 motivation Effects 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7783—Transmission, loss
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a portable detection analyzer, which comprises a sample rack and a detection device, wherein the sample rack is provided with a sample inlet and a sample outlet; the sample rack is provided with a plurality of cuvette slots at intervals along the transverse direction, and each cuvette slot can be inserted and used for accommodating one cuvette; the detection device is used for detecting and analyzing the samples in the cuvettes and comprises a light source assembly and a receiving assembly, wherein the light source assembly and the receiving assembly are respectively arranged at the front side and the rear side of the sample rack and respectively move to the positions opposite to the cuvettes along the transverse direction under the action of a first driving mechanism and a second driving mechanism. According to the technical scheme, the sample rack is arranged into a long strip type structure, so that the colorimetric cup slots are arranged in a straight line, the light source assembly and the receiving assembly are respectively and oppositely arranged on two sides of the sample rack through the driving mechanisms, and the light source assembly and the receiving assembly are respectively driven by the two driving mechanisms to sequentially move to the positions opposite to the colorimetric cups for detection and analysis.
Description
Technical field
The present invention relates to medical detecting Instrument technical field, more particularly to a kind of portable inspectiont analyzer.
Background technology
The structure of biochemistry detection analytical equipment is typically to use turntable structure, and circle distribution has multiple cuvettes to insert on turntable
Slot, detection device be arranged on on one of matched position of cuvette slot, by rotary turnplate and successively to multiple
Cuvette in slot is detected, and structure is complex, and design accuracy is more demanding, and cost is big, is unfavorable for being generalized to
In She Kang centers or small medical mechanism；
And biochemistry detection analytical equipment generally use scattering immunoturbidimetry principle or projection immunoturbidimetry principle are come
Be detected analysis to sample, but the fixed setting of the light source of existing biochemistry detection analyzer and cannot adjust, i.e. light source
The path channels that the light sent out is passed through are changeless, so as to take into account above two detection and analysis mode, are used
There are limitations.
In addition, the structure of existing biochemistry detection analyzer is typically using carousel mode, circle distribution has more on turntable
A cuvette slot, sample and corresponding chemical reagent are needed with sample needle after cuvette is added to by sample and chemistry
Reagent hand operated mixing uniformly or by the suction repeatedly of sample needle after automatic stir evenly, is being detected, either
Hand operated mixing or automatic stirring are required for being stirred one by one, and mixing speed is slow, is examined to great amount of samples
Detection speed is seriously affected during survey.
Invention content
It is an object of the invention to solve deficiency of the prior art at least to some extent, a kind of portable inspectiont is provided
Analyzer.
To achieve the above object, portable inspectiont analyzer provided by the invention, including：
Sample rack, the sample rack is laterally spaced to offer multiple cuvette slots, and each cuvette slot can
One cuvette of receiving of grafting, the cuvette are used for the chemistry examination for containing sample to be detected and being reacted with the sample
Agent；
Detection device, for being detected analysis to the sample in each cuvette, the detection device includes
Light source assembly and receiving unit, the light source assembly and receiving unit are separately positioned on the front and rear sides of the sample rack, and
The light source assembly and receiving unit can respectively under the action of the first driving mechanism and the second driving mechanism, laterally move to
The position opposite with each cuvette.
Preferably, the light source assembly includes the first pedestal for being connect with first driving mechanism and with described first
The second pedestal that pedestal is transversely arranged side by side, second pedestal can carry out rotation adjusting relative to the first pedestal around a shaft,
And the axis direction of the shaft extends transversely；
Between the front and rear wall of first pedestal at least one first path channels, first light path are offered along level
Channel is provided with the first lens close to one end of the sample rack, and one end far from the sample rack is provided with first light source；
At least one second path channels are offered between the front and rear wall of second pedestal, second path channels are leaned on
One end of the nearly sample rack is provided with the second lens, and one end far from the sample rack is provided with second light source；Described second
The irradiating angle of path channels is adjusted by the rotation angle of second pedestal.
Preferably, a locating part is provided between first pedestal and the second pedestal, to limit second pedestal
Rotation angle；
Second pedestal is transversely perforative to offer arc slide opening, and the center of circle of the arc slide opening is located at the shaft
Axial line on；
The locating part is a stop screw, and first pedestal is towards being provided with along horizontal stroke on the end face of second pedestal
To the threaded hole of extension, the stop screw passes through the arc slide opening and is connected in the threaded hole, and by described second
Pedestal is fixed on first pedestal.
Preferably, the sample rack is logical in offering opposite first on the front and rear sides wall of each cuvette slot respectively
Unthreaded hole and the second light hole, first light hole are the bar hole vertically extended, and the second light hole is circular through hole.
Preferably, first driving mechanism includes the first driving motor being arranged on described substrate transverse direction one end, sets
Put the substrate transverse direction other end and by the first driving belt and matched first synchronizing wheel of first driving motor,
Setting on the substrate and the first sliding rail for extending transversely and is slidably arranged on first sliding rail and by described the
First sliding block of one driving belt driving, is provided with first be fixedly connected with first driving belt on first sliding block
Connector, first connector fix first pedestal by the first supports support.
Preferably, the receiving unit includes the third pedestal being connect with second driving mechanism and is arranged on institute
Third pedestal is stated towards the detector of the sample rack side.
Preferably, second driving mechanism includes the second driving motor being arranged on described substrate transverse direction one end, sets
Put the substrate transverse direction other end and by the second driving belt and matched second synchronizing wheel of second driving motor,
Setting on the substrate and the second sliding rail for extending transversely and is slidably arranged on second sliding rail and by described the
Second sliding block of two driving belts driving, is provided with second be fixedly connected with second driving belt on second sliding block
Connector, second connector fix the third pedestal by the second supports support.
Preferably, substrate, the sample rack and the first driving mechanism have been further included and the second driving mechanism is arranged at
On the substrate, it is provided with to promote the sample in each cuvette and chemistry examination between the sample rack and the substrate
Agent is sufficiently mixed the magnetic stirring apparatus of reaction.
Preferably, the both ends of the sample rack transversely are fixed on the substrate respectively by support plate, the magnetic force
Agitating device includes being rotatably arranged on magnetic stripe between two support plates, is rotated around its center line for driving the magnetic stripe
Several magnetic beads or iron shot placed in electric rotating machine and each cuvette；The two-stage magnetism of the magnetic stripe with it is described in
Heart line is vertical.
Preferably, the bottom of the sample rack is additionally provided with heating component, and the heating component includes being fitted in the sample
The heating film of this bottom surface and the fixed plate that the heating film is fixed on to the sample rack bottom surface.
Technical solution of the present invention makes multiple cuvette slots be in line row by the way that sample rack is arranged to long strip type structure
Row, and light source assembly and receiving unit utilize two driving machines respectively by the opposite both sides for being mounted on sample rack of driving mechanism
Structure, which respectively drives light source assembly and receiving unit and is moved to successively on the position opposite with each cuvette, to be tested and analyzed, and is tied
Structure is simple, at low cost, and detection speed is fast.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Structure according to these attached drawings obtains other attached drawings.
Fig. 1 is the structure diagram of portable inspectiont analyzer of the present invention；
Fig. 2 is the attachment structure schematic diagram of light source assembly of the present invention and the first driving mechanism；
Fig. 3 is the structure diagram of light source assembly of the present invention；
Fig. 4 is the decomposition texture schematic diagram of Fig. 3；
Fig. 5 is the cross-sectional view of the first path channels of the invention；
Fig. 6 is the cross-sectional view of the second path channels of the invention；
Fig. 7 is the attachment structure schematic diagram of receiving unit of the present invention and the second driving mechanism；
Fig. 8 is the structure diagram of receiving unit of the present invention；
Fig. 9 is the structure diagram of sample of the present invention frame and magnetic stirring apparatus；
Figure 10 is the structure diagram of heating component of the present invention.
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific embodiment
The embodiment of the present invention is described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning to end
Same or similar label represents same or similar element or the element with same or like function.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention, based on this
Embodiment in invention, the every other reality that those of ordinary skill in the art are obtained without creative efforts
Example is applied, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", " on ", " under ", "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom " " interior ", " outer ", " up time
The orientation or position relationship of the instructions such as needle ", " counterclockwise " " axial direction ", " circumferential direction ", " radial direction " be based on orientation shown in the drawings or
Position relationship is for only for ease of the description present invention and simplifies description rather than instruction or imply that signified device or element must
There must be specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are only used for description purpose, and it is not intended that instruction or hint relative importance
Or the implicit quantity for indicating indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more this feature.In the description of the present invention, " multiple " are meant that two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected；It can be machine
Tool is connected or is electrically connected；It can be directly connected, can also be indirectly connected by intermediary, can be two members
Connection inside part.For the ordinary skill in the art, above-mentioned term can be understood in this hair as the case may be
Concrete meaning in bright.
In the present invention unless specifically defined or limited otherwise, fisrt feature second feature it " on " or it " under "
It can be in direct contact including the first and second features, it is not to be in direct contact but pass through it that can also include the first and second features
Between other characterisation contact.Moreover, fisrt feature second feature " on ", " top " and " above " including first spy
Sign is right over second feature and oblique upper or is merely representative of fisrt feature level height higher than second feature.Fisrt feature exists
Second feature " under ", " lower section " and " following " immediately below second feature and obliquely downward or be merely representative of including fisrt feature
Fisrt feature level height is less than second feature.
The portable inspectiont analyzer of the embodiment of the present invention is described in detail with reference to the accompanying drawings.
As shown in Figures 1 to 10, the portable inspectiont analyzer of the embodiment of the present invention, including substrate 100 and is arranged on
Sample rack 10, detection device and magnetic stirring apparatus 70 on substrate.
Wherein, the sample rack 10 is laterally spaced offers multiple cuvette slots 11, each cuvette slot
11 one cuvette 60 of plug-in receiving, the cuvette 60 are used to contain sample to be detected and react with the sample
Chemical reagent；And sample rack 10 in offering the first opposite thang-kng respectively on the front and rear sides wall of each cuvette slot 11
12 and second light hole 13 of hole.
The detection device to the sample in each cuvette 60 for being detected analysis, the detection device packet
Light source assembly 20 and receiving unit 30 are included, the light source assembly 20 and receiving unit 30 are oppositely arranged on the sample rack respectively
10 front and rear sides, and the light source assembly 20 and receiving unit 30 can be respectively in the first driving mechanism 40 and the second driving mechanisms
Under the action of 50, laterally move to the position opposite with each cuvette 60.
It should be noted that the detection device of the present invention, magnetic stirring apparatus 70, the first driving mechanism 40 and second are driven
Motivation structure 50 is electrically connected in control unit (not shown), and the control unit of the present embodiment can be the control being disposed on the substrate
Circuit board processed, or host computer (such as computer or mobile phone equipment).
Portable inspectiont analyzer according to embodiments of the present invention, to the cuvette in one of cuvette slot 11
60 when being detected, and is loaded with sample and chemical reagent in the cuvette 60, light source assembly 20 and receiving unit 30 exist respectively
It is moved on the position opposite with the cuvette slot 11 under the action of first driving mechanism 40 and the second driving mechanism 50, light source
The light that component 20 is emitted sequentially pass through the first light hole 12, cuvette 60 and second with unthreaded hole and by receiving unit 30 into
Row receives, to be detected analysis to the sample in the cuvette 60.It it is to be appreciated that in practical application, can be in sample
All cuvette slots 11 are all placed with cuvette 60 on frame 10, and the light source assembly 20 and receiving unit 30 of detection device can divide
Not under the drive of the first driving mechanism 40 and the second driving mechanism 50, all cuvettes 60 are carried out detecting automatically successively and be divided
Analysis.
In one embodiment of the invention, as shown in Figures 2 to 4, the light source assembly 20 includes driving with described first
The first pedestal 21 that motivation structure 40 connects and with first pedestal 21 transversely arranged side by side the second pedestal 22, described the
Two pedestals 22 can carry out rotation adjusting, and the axis direction of the shaft 214 is transversely relative to the first pedestal 21 around a shaft 214
Extension.
Wherein, it with reference to shown in Fig. 5 and Fig. 6, is offered between the front and rear wall of first pedestal 21 along level at least one
First path channels 212, first path channels 212 are provided with the first lens 24A close to one end of the sample rack 10, far
One end from the sample rack 10 is provided with first light source 25A.At least one is offered between the front and rear wall of second pedestal 22
A second path channels 223, second path channels 223 are provided with the second lens 24B close to one end of the sample rack 10,
One end far from the sample rack 10 is provided with second light source 25B；The irradiating angle of second path channels 223 passes through described
The rotation angle of second pedestal 22 is adjusted.Accordingly, first light hole 12 is the bar hole vertically extended,
Second light hole 13 is circular through hole.
It should be noted that LED light source, laser diode or halogen can be used in first light source 25A and second light source 25B
Lamp, and the receiving unit 30 includes the third pedestal 31 that is connect with second driving mechanism 50 and is arranged on described the
Three pedestals 31 towards 10 side of sample rack detector 32, as shown in Figure 8；The detector 32 is spectrometer or silicon photoelectricity
Pond can receive the light that first light source 25A or second light source 25B are emitted, and be converted into electric signal according to the light received
And it is sent to the content parameter of detection substance required for control unit obtains.
Specifically, the first path channels 212 on first pedestal 21 of the present embodiment have there are four and are mutually parallel, corresponding
First light source 25A also there are four, and the wavelength of light that is sent out of each first light source 25A is different；Second on second pedestal 22
The tool of path channels 223 there are two and be mutually parallel, corresponding second light source 25B also there are two, and two second light source 25B are sent out
The wavelength of light gone out is different.That is, the portable inspectiont analyzer of the present embodiment can according to scattering immunoturbidimetry or thoroughly
Immunoturbidimetry principle is penetrated to determine to be irradiated, and according to inspection using first light source 25A or using second light source 25B
Survey the light source needed to select corresponding wavelength；For example, according to scattering immunoturbidimetry principle come when being detected, using the second base
First light hole 12 of the second path channels 223 alignment sample rack 10 on seat 22, the light that second light source 25B is emitted
After the first light hole 12 being passed through to inject cuvette 60 with a predetermined angle along second path channels 223, light is by sample
Complex particle refraction deflects and projects from the second light hole 13 and examined by the reception of detector 32 of receiving unit 30
Survey analysis；If according to transmission immunological turbidimetry method principle come when being detected, using first light on the first pedestal 21
Paths 212 are directed at the first light hole 12 of sample rack 10, and the light that second light source 25B is emitted is along horizontal through cuvette 60
And analysis is detected by the reception of detector 32.
Further, as shown in Figures 3 and 4, a locating part is provided between 21 and second pedestal 22 of the first pedestal, with
The rotation angle of second pedestal 22 is limited, and the rotation angle for limiting the second pedestal 22 is exactly to limit the second path channels
223 angle so that the incident ray of second light source 25B along the second path channels 223 with acclivitous irradiation, and the second light
The angle of paths 223 and horizontal plane is adjustable between 10-37 °.
Specifically, second pedestal 22 is transversely perforative offers arc slide opening 222, the arc slide opening 222
The center of circle is located on the axial line of the shaft 214；The locating part is a stop screw 23, and first pedestal 21 is towards described
The threaded hole 211 extended transversely is provided on the end face of second pedestal 22, the stop screw 23 passes through the arc slide opening
222 and be connected in the threaded hole 211, and second pedestal 22 is fixed on first pedestal 21.
Shaft 214 is arranged on the first pedestal 21, and is transversely prolonged from the first pedestal 21 towards 22 direction of the second pedestal protrusion
It stretches, and the distance between the axle center of shaft 214 and the axle center of threaded hole 211 are equal to the radius of arc slide opening 222；Second pedestal 22
In transversely offering one on the center of circle of arc slide opening 222 for being arranged the axis hole 221 of shaft 214；During installation, the second pedestal 22
Axis hole 221 is transversely made to be sleeved in shaft 214, and the screw rod of stop screw 23 is threaded in spiral shell across arc slide opening 222
On pit 211 so that the head of stop screw 23 by 22 pressing of the second pedestal on the first pedestal 21, so as to by the second pedestal 22
It is fixed with the first pedestal 21；When the angle for needing the second path channels 223 for adjusting the second pedestal 22, limiting spiral shell is slightly unclamped
Nail 23, make the second pedestal 22 around the shaft 214 axis rotation to required angle, then stop screw 23 is tightened and fixes second
Pedestal 22.
Each first light source 25A and second light source 25B is respectively installed by a light source mounting base 26 and a connecting tube 27
In corresponding first path channels, 212 and second path channels 223, one end of light source mounting base 26 offers light source mounting hole
261, the other end offers the intercommunicating pore 262 being connect with light source mounting hole 261, and one end plugged and fixed of the connecting tube 27 is even
It is in through-hole 262 and opposite with the first light source 25A in light source mounting hole 261 or second light source 25B, connecting tube 27 it is another
Plugged and fixed is held on described first path channels, 212 or second one end of path channels 223 far from sample rack 10, and is each connected
The optical fiber 271 at its both ends is provided through on the central axis of take over 27；In this way, the first light source in light source mounting base 26 can be made
The light that 25A or second light source 25B are sent out enters after optical fiber 271 in corresponding path channels, and the focusing through lens
It acts on and is radiated on cuvette 60.
First pedestal 21 is corresponded in the one end for being plugged with connecting tube 27 and is offered and the first light in each first path channels 212
First locking screw holes 213 of 212 vertical connection of paths, the second pedestal 22 correspond to each second in the one end for being plugged with connecting tube 27
Offer the second locking screw holes 224 with 223 vertical connection of the second path channels in path channels 223, and light source mounting base 26
The third locking screw holes 263 with 262 vertical connection of intercommunicating pore are offered in the one end for being plugged with connecting tube 27；The one of connecting tube 27
After intercommunicating pore 262 is inserted at end, it is connected in third locking screw holes 263 using lock-screw and compresses connecting tube 27 and make connecting tube 27
It is fixed with light source mounting base 26；After the other end of connecting tube 27 is inserted into the first path channels 212 or the second path channels 223, profit
It is connected in corresponding first locking screw holes, 213 or second locking screw holes 224 with lock-screw and compresses connecting tube 27 and make connection
Pipe 27 is fixed with the first pedestal 21 or the second pedestal 22.
Light source installing plate 264 is provided on one end of each 26 corresponding light source mounting hole 261 of light source mounting base, to by
One light source 25A or second light source 25B is fixed in the light source mounting hole 261 of corresponding light source mounting base 26.
Each first path channels, 212 and second path channels 223 offer lens close to one end of sample rack 10
Mounting hole, the first pedestal 21 and the second pedestal 22 correspond to and are provided with lens mounting plate 28 on one end of each lens mounting hole, to
First lens 24A and the second lens 24B are fixed on to the lens of each correspondence the first path channels 212 and the second path channels 223
In mounting hole, and the through hole 281 opposite with lens mounting hole is offered on each lens mounting plate 28.
In some embodiments of the invention, as shown in Fig. 2, first driving mechanism 40 includes being arranged on the substrate
The first driving motor 41 on 100 lateral one end is arranged on the lateral other end of the substrate 100 and by the first driving belt 43
With 41 matched first synchronizing wheel 44 of the first driving motor, be arranged on the substrate 100 and extend transversely
One sliding rail 45 and the first sliding block for being slidably arranged on first sliding rail 45 and being driven by first driving belt 43
46, it is provided with the first connector 47 being fixedly connected with first driving belt 43 on first sliding block 46, described first
Connector 47 passes through fixed first pedestal 21 of the first support element 48 support.Specifically, the output shaft of the first driving motor 41
On be arranged with the first driving wheel 42, the ring set of the first driving belt 43 tensioning on the first driving wheel 42 and the first synchronizing wheel 44,
The first driving belt 43 can be driven to rotate by the first driving wheel 42 when the first driving motor 41 rotates as a result, and then driven solid
The first sliding block 46 being scheduled on the first driving belt 43 is moved along the first sliding rail 45, so as to which the first sliding block 46 be made to pass through the first support
Part 48 drives the first pedestal 21 of light source assembly 20 transversely to move.
Further, as shown in fig. 7, second driving mechanism 50 includes being arranged on the lateral one end of the substrate 100
The second driving motor 51, be arranged on the lateral other end of the substrate 100 and driven by the second driving belt 53 with described second
Dynamic 51 matched second synchronizing wheel 54 of motor, the second sliding rail 55 for being arranged on the substrate 100 and extending transversely and
The second sliding block 56 for being slidably arranged on second sliding rail 55 and being driven by second driving belt 53, second sliding block
The second connector 57 being fixedly connected with second driving belt 53 is provided on 56, second connector 57 passes through second
The fixed third pedestal 31 of the support of support element 58.Specifically, second is arranged on the output shaft of the second driving motor 51 actively
Wheel 52, the ring set of the second driving belt 53 tensioning is on the second driving wheel 52 and the second synchronizing wheel 54, the second driving motor as a result,
The second driving belt 53 can be driven to rotate by the second driving wheel 52, and then drive and be fixed on the second driving belt 53 during 51 rotation
On the second sliding block 56 moved along the second sliding rail 55, so as to make the second sliding block 56 pass through the second support element 58 drive receiving unit 30
Third pedestal 31 transversely move.
In some embodiments of the invention, as shown in figure 9, the magnetic stirring apparatus 70 is arranged on the sample rack 10
Between the substrate 100, for being sufficiently mixed instead using the sample in each cuvette 60 of magnetic force promotion and chemical reagent
It should.Specifically, the both ends of the sample rack 10 transversely are fixed on by support plate 71 on the substrate 100 respectively, the magnetic
Power agitating device 70 includes being rotatably arranged on magnetic stripe 72 between two support plates 71, for driving the magnetic stripe 72 around wherein
Several magnetic beads or iron shot placed in the electric rotating machine 74 of heart line rotation and each cuvette 60；The magnetic stripe 72
Two-stage magnetism and the central axis.
That is, magnetic stripe 72 is the string configuration being laterally extended, both ends are rotatably supported in respectively by rotation axis
In two support plates 71, and one of rotation axis is pierced by after support plate 71 through the output shaft of shaft coupling 73 and electric rotating machine 74 company
It connects, the center line of the magnetic stripe 72 is the axis of rotation axis, and the N poles of magnetic stripe 72 are located at one side, and the S poles of magnetic stripe 72 are located at
Its opposite side；In this way, when electric rotating machine 74 drives magnetic stripe 72 to be rotated around center line, due to sample rack 10 upward of magnetic stripe 72
The magnetic pole in direction constantly changes between N poles and S poles, so as to drive magnetic bead or the iron shot rolling in each cuvette 60, reaches
Sample in each cuvette 60 is thoroughly mixed to the purpose reacted with chemical reagent simultaneously, stirring is fast and safely.
In some embodiments of the invention, as shown in Figure 10, the bottom of the sample rack 10 is additionally provided with heating component
80, the heating component 80 includes being fitted in the heating film 81 of 10 bottom surface of sample rack and fixes the heating film 81
Fixed plate 82 in 10 bottom surface of sample rack.Specifically, heating film 81 is also to extend transversely, each 11 equal position of cuvette slot
In the top of heating film 81, in detection and analysis, heated by heating film 81, so that the cuvette in cuvette slot 11
Liquid to be detected is heated and maintained at the temperature of setting in 60, to ensure that liquid to be detected is examined within the scope of suitable temperature
Analysis is surveyed, ensures accuracy of detection.
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of the invention, every at this
The equivalent structure transformation made under the inventive concept of invention using description of the invention and accompanying drawing content or directly/utilization indirectly
It is included in the scope of patent protection of the present invention in other related technical areas.
Claims (10)
1. a kind of portable inspectiont analyzer, which is characterized in that including：
Sample rack, the sample rack is laterally spaced to offer multiple cuvette slots, and each cuvette slot is pluggable
One cuvette of receiving, the cuvette is for containing sample to be detected and the chemical reagent reacted with the sample；
Detection device, for being detected analysis to the sample in each cuvette, the detection device includes light source
Component and receiving unit, the light source assembly and receiving unit are separately positioned on the front and rear sides of the sample rack, and described
Light source assembly and receiving unit can respectively under the action of the first driving mechanism and the second driving mechanism, laterally move to it is each
The opposite position of the cuvette.
2. portable inspectiont analyzer as described in claim 1, which is characterized in that the light source assembly includes and described first
First pedestal of driving mechanism connection and the second pedestal being transversely arranged side by side with first pedestal, second pedestal
Rotation adjusting can be carried out, and the axis direction of the shaft extends transversely around a shaft relative to the first pedestal；
Between the front and rear wall of first pedestal at least one first path channels, first path channels are offered along level
One end of the sample rack is provided with the first lens, one end far from the sample rack is provided with first light source；
At least one second path channels are offered between the front and rear wall of second pedestal, second path channels are close to institute
The one end for stating sample rack is provided with the second lens, and one end far from the sample rack is provided with second light source；Second light path
The irradiating angle of channel is adjusted by the rotation angle of second pedestal.
3. portable inspectiont analyzer as claimed in claim 2, which is characterized in that between first pedestal and the second pedestal
A locating part is provided with, to limit the rotation angle of second pedestal；
Second pedestal is transversely perforative to offer arc slide opening, and the center of circle of the arc slide opening is located at the axis of the shaft
On heart line；
The locating part is a stop screw, and first pedestal transversely prolongs towards being provided on the end face of second pedestal
The threaded hole stretched, the stop screw pass through the arc slide opening and are connected in the threaded hole, and by second pedestal
It is fixed on first pedestal.
4. portable inspectiont analyzer as claimed in claim 2, which is characterized in that the sample rack is in each cuvette slot
Front and rear sides wall on offer opposite the first light hole and the second light hole respectively, first light hole is along vertical side
To the bar hole of extension, the second light hole is circular through hole.
5. portable inspectiont analyzer as claimed in claim 2, which is characterized in that first driving mechanism includes being arranged on
The first driving motor on described substrate transverse direction one end, be arranged on the substrate transverse direction other end and by the first driving belt with
Matched first synchronizing wheel of first driving motor, setting on the substrate and extend transversely the first sliding rail, with
And the first sliding block for being slidably arranged on first sliding rail and being driven by first driving belt, it sets on first sliding block
The first connector being fixedly connected with first driving belt is equipped with, first connector is consolidated by the first supports support
Fixed first pedestal.
6. portable inspectiont analyzer as described in claim 1, which is characterized in that the receiving unit includes and described second
The third pedestal and be arranged on the third pedestal towards the detector of the sample rack side that driving mechanism connects.
7. portable inspectiont analyzer as claimed in claim 6, which is characterized in that second driving mechanism includes being arranged on
The second driving motor on described substrate transverse direction one end, be arranged on the substrate transverse direction other end and by the second driving belt with
Matched second synchronizing wheel of second driving motor, setting on the substrate and extend transversely the second sliding rail, with
And the second sliding block for being slidably arranged on second sliding rail and being driven by second driving belt, it sets on second sliding block
The second connector being fixedly connected with second driving belt is equipped with, second connector is consolidated by the second supports support
The fixed third pedestal.
8. portable inspectiont analyzer as described in claim 1, which is characterized in that further included substrate, the sample rack with
And first driving mechanism and the second driving mechanism be respectively provided on the substrate, be provided between the sample rack and the substrate
For sample in each cuvette and chemical reagent to be promoted to be sufficiently mixed the magnetic stirring apparatus of reaction.
9. portable inspectiont analyzer as claimed in claim 4, which is characterized in that the both ends difference of the sample rack transversely
It is fixed on the substrate by support plate, the magnetic stirring apparatus includes the magnetic being rotatably arranged between two support plates
Item, several magnetic for the magnetic stripe to be driven to be placed in the electric rotating machine that its center line rotates and each cuvette
Pearl or iron shot；The two-stage magnetism of the magnetic stripe and the central axis.
10. portable inspectiont analyzer as claimed in claim 4, which is characterized in that the bottom of the sample rack is additionally provided with
Heating component, the heating component include being fitted in the heating film of the sample rack bottom surface and are fixed on the heating film
The fixed plate of the sample rack bottom surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711433438.9A CN108254371B (en) | 2017-12-26 | 2017-12-26 | Portable detection analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711433438.9A CN108254371B (en) | 2017-12-26 | 2017-12-26 | Portable detection analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108254371A true CN108254371A (en) | 2018-07-06 |
| CN108254371B CN108254371B (en) | 2024-02-09 |
Family
ID=62723946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711433438.9A Active CN108254371B (en) | 2017-12-26 | 2017-12-26 | Portable detection analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108254371B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108918243A (en) * | 2018-09-14 | 2018-11-30 | 东软威特曼生物科技（沈阳）有限公司 | Agitating device and Biochemical Analyzer |
| CN109632658A (en) * | 2018-12-14 | 2019-04-16 | 北京倍肯恒业科技发展股份有限公司 | Modularization Physico-chemical tests system |
| CN110672618A (en) * | 2019-09-25 | 2020-01-10 | 上海智觉光电科技有限公司 | System and method for detecting bright surface of part appearance based on multi-angle light source |
| CN111595823A (en) * | 2020-03-09 | 2020-08-28 | 宁波普瑞柏生物技术股份有限公司 | Scattering turbidimetry measuring instrument |
| CN111795930A (en) * | 2020-08-09 | 2020-10-20 | 泰州市博泰电子有限公司 | Universal test fixture for mobile communication circuit board |
| CN112881720A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer, laser module |
| CN113391058A (en) * | 2021-05-25 | 2021-09-14 | 安徽惠邦生物工程有限公司 | Intelligent upper heating module of dry-type urine analyzer |
| CN113884453A (en) * | 2021-09-30 | 2022-01-04 | 太原理工大学 | Detection device based on smartphone immunoturbidimetry and application of detection device in rapid detection of myocardial infarction marker |
| CN116908117A (en) * | 2023-09-13 | 2023-10-20 | 中国科学院水生生物研究所 | On-line detection device and detection method for biological pollution of water body |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3800161A (en) * | 1972-12-19 | 1974-03-26 | Atomic Energy Commission | Portable dynamic multistation photometer-fluorometer |
| USB450521I5 (en) * | 1974-03-12 | 1976-02-17 | ||
| CN203053986U (en) * | 2013-01-17 | 2013-07-10 | 深圳凯为生物科技有限公司 | Cuvette loading structure and full-automatic analyzer |
| US20130228675A1 (en) * | 2012-03-02 | 2013-09-05 | Laxco, Inc. | Multichannel analytical instruments for use with specimen holders |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| CN104865202A (en) * | 2015-05-23 | 2015-08-26 | 深圳德夏生物医学工程有限公司 | Single-channel biochemical and specific protein analyzer provided with full-wavelength rotary lamp discs and silicon photocells |
| CN104880413A (en) * | 2015-05-23 | 2015-09-02 | 深圳德夏生物医学工程有限公司 | Multichannel biochemistry and specific protein analyzer with full wavelength light source and spectrometer |
| US20160242674A1 (en) * | 2012-02-01 | 2016-08-25 | Invoy Technologies, Llc | Portable breath analyzer for multiple accurate readings |
| WO2016182382A1 (en) * | 2015-05-14 | 2016-11-17 | 바디텍메드(주) | Station, used for test apparatus, having integrated reaction and detection means |
| WO2017128806A1 (en) * | 2016-01-27 | 2017-08-03 | 广州万孚生物技术股份有限公司 | Automatic fluorescence quantitative immunoassay analyzer and detection method |
| CN207798687U (en) * | 2017-12-26 | 2018-08-31 | 深圳德夏生物医学工程有限公司 | Portable detection analyzer |
-
2017
- 2017-12-26 CN CN201711433438.9A patent/CN108254371B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3800161A (en) * | 1972-12-19 | 1974-03-26 | Atomic Energy Commission | Portable dynamic multistation photometer-fluorometer |
| USB450521I5 (en) * | 1974-03-12 | 1976-02-17 | ||
| US20160242674A1 (en) * | 2012-02-01 | 2016-08-25 | Invoy Technologies, Llc | Portable breath analyzer for multiple accurate readings |
| US20130228675A1 (en) * | 2012-03-02 | 2013-09-05 | Laxco, Inc. | Multichannel analytical instruments for use with specimen holders |
| CN203053986U (en) * | 2013-01-17 | 2013-07-10 | 深圳凯为生物科技有限公司 | Cuvette loading structure and full-automatic analyzer |
| CN104483499A (en) * | 2014-12-30 | 2015-04-01 | 深圳市汇松科技发展有限公司 | Full-automatic particular protein analyzer |
| WO2016182382A1 (en) * | 2015-05-14 | 2016-11-17 | 바디텍메드(주) | Station, used for test apparatus, having integrated reaction and detection means |
| CN104865202A (en) * | 2015-05-23 | 2015-08-26 | 深圳德夏生物医学工程有限公司 | Single-channel biochemical and specific protein analyzer provided with full-wavelength rotary lamp discs and silicon photocells |
| CN104880413A (en) * | 2015-05-23 | 2015-09-02 | 深圳德夏生物医学工程有限公司 | Multichannel biochemistry and specific protein analyzer with full wavelength light source and spectrometer |
| WO2017128806A1 (en) * | 2016-01-27 | 2017-08-03 | 广州万孚生物技术股份有限公司 | Automatic fluorescence quantitative immunoassay analyzer and detection method |
| CN207798687U (en) * | 2017-12-26 | 2018-08-31 | 深圳德夏生物医学工程有限公司 | Portable detection analyzer |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108918243A (en) * | 2018-09-14 | 2018-11-30 | 东软威特曼生物科技（沈阳）有限公司 | Agitating device and Biochemical Analyzer |
| CN109632658A (en) * | 2018-12-14 | 2019-04-16 | 北京倍肯恒业科技发展股份有限公司 | Modularization Physico-chemical tests system |
| CN110672618A (en) * | 2019-09-25 | 2020-01-10 | 上海智觉光电科技有限公司 | System and method for detecting bright surface of part appearance based on multi-angle light source |
| CN110672618B (en) * | 2019-09-25 | 2023-03-03 | 上海智觉光电科技有限公司 | System and method for detecting bright surface of part appearance based on multi-angle light source |
| CN112881720A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer, laser module |
| CN111595823A (en) * | 2020-03-09 | 2020-08-28 | 宁波普瑞柏生物技术股份有限公司 | Scattering turbidimetry measuring instrument |
| WO2021179407A1 (en) * | 2020-03-09 | 2021-09-16 | 宁波普瑞柏生物技术股份有限公司 | Scattered light turbidimeter |
| CN111795930A (en) * | 2020-08-09 | 2020-10-20 | 泰州市博泰电子有限公司 | Universal test fixture for mobile communication circuit board |
| CN113391058A (en) * | 2021-05-25 | 2021-09-14 | 安徽惠邦生物工程有限公司 | Intelligent upper heating module of dry-type urine analyzer |
| CN113884453A (en) * | 2021-09-30 | 2022-01-04 | 太原理工大学 | Detection device based on smartphone immunoturbidimetry and application of detection device in rapid detection of myocardial infarction marker |
| CN113884453B (en) * | 2021-09-30 | 2024-05-14 | 太原理工大学 | Detection device based on smart phone immune turbidimetry |
| CN116908117A (en) * | 2023-09-13 | 2023-10-20 | 中国科学院水生生物研究所 | On-line detection device and detection method for biological pollution of water body |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108254371B (en) | 2024-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108254371A (en) | Portable detection analyzer | |
| CN207798687U (en) | Portable detection analyzer | |
| US7332128B2 (en) | Fiber-optic dissolution systems devices, and methods | |
| US7854891B2 (en) | Method of specimen analysis and specimen analyzer | |
| EP0289861B1 (en) | Detector assembly for analyzer instrument | |
| CN105759066B (en) | Full automatic blood-coagulation detection analysis instrument, method | |
| US4940332A (en) | Fluorescent analysis apparatus | |
| CN108020507B (en) | Special detection device of urine iodine analyzer | |
| JP5748782B2 (en) | Automatic analyzer | |
| CN112051253A (en) | Method and device for measuring nitrate nitrogen content of soil | |
| EP0426729B1 (en) | Automatic multiple-sample multiple-reagent chemical analyzer | |
| CN113447663B (en) | Multi-method coagulation analyzer | |
| CN108120683A (en) | Adjustable light source device for biochemical analyzer | |
| CN207798646U (en) | adjustable light source device for biochemical analyzer | |
| JP2006105610A (en) | Measuring instrument and method using total reflection attenuation | |
| WO2022190471A1 (en) | Light source and automatic analysis device | |
| JPS6113158A (en) | Biochemical analyser | |
| CN209606327U (en) | Formaldehyde examination device | |
| CN110823838A (en) | Optical detection device of specific protein immunoassay analyzer and use method thereof | |
| JPS60115867A (en) | Automatic analyzer | |
| KR20230043886A (en) | biochemical analyzer | |
| CN210571922U (en) | Full-automatic biochemical analyzer of double-light-path detection system | |
| CN207502400U (en) | A kind of fluorescent analysis apparatus and water quality on-line monitoring instrument device | |
| CN110632288A (en) | Specific protein analyzer and testing method based on same | |
| CN221224575U (en) | Near infrared spectrum analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |