CN108245522A - Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 - Google Patents

Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 Download PDF

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Publication number
CN108245522A
CN108245522A CN201810140325.8A CN201810140325A CN108245522A CN 108245522 A CN108245522 A CN 108245522A CN 201810140325 A CN201810140325 A CN 201810140325A CN 108245522 A CN108245522 A CN 108245522A
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administration
salt
gln
brain
galantamine
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CN201810140325.8A
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Chinese (zh)
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阿尔弗雷德·梅里克
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Neurodyn Life Sciences Inc
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Neurodyn Life Sciences Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
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    • A61K9/2846—Poly(meth)acrylates
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CN201810140325.8A 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 Pending CN108245522A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261676348P 2012-07-27 2012-07-27
EP12178187 2012-07-27
EP12178187.6 2012-07-27
US61/676,348 2012-07-27
CN201380039870.3A CN104507461A (zh) 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380039870.3A Division CN104507461A (zh) 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度

Publications (1)

Publication Number Publication Date
CN108245522A true CN108245522A (zh) 2018-07-06

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Application Number Title Priority Date Filing Date
CN201810140325.8A Pending CN108245522A (zh) 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用
CN201380039870.3A Pending CN104507461A (zh) 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度

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CN201380039870.3A Pending CN104507461A (zh) 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度

Country Status (12)

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US (1) US20150190401A1 (https=)
EP (2) EP3417862B1 (https=)
JP (2) JP6272857B2 (https=)
CN (2) CN108245522A (https=)
AU (1) AU2013294917B2 (https=)
CA (1) CA2878135C (https=)
DK (2) DK2877165T3 (https=)
ES (1) ES2700473T3 (https=)
HK (1) HK1206242A1 (https=)
IN (1) IN2015DN00229A (https=)
PL (2) PL3417862T3 (https=)
WO (1) WO2014016430A1 (https=)

Families Citing this family (12)

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US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
ES2880399T3 (es) * 2012-07-27 2021-11-24 Neurodyn Life Sciences Inc Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos
AU2015258814B2 (en) 2014-05-16 2018-04-05 Synaptec Development Llc Clearance of amyloid ss
JP2020033304A (ja) * 2018-08-30 2020-03-05 医療法人ふじいやさか 薬剤又はサプリメント、組成物、及び水素供給器の使用
AU2020302992A1 (en) * 2019-06-28 2022-02-03 The Trustees Of The University Of Pennsylvania Intranasal dantrolene administration for treatment of Alzheimer's Disease
EP4029867A1 (en) 2021-01-13 2022-07-20 Alpha Cognition Inc. Solid forms of galantamine benzoate gluconate
JP2024516911A (ja) * 2021-05-14 2024-04-17 アルファ コグニション インコーポレイティド アルファ－１０６２投与に関する自己保存性組成物及び多回使用型ディスペンサー
US12589099B2 (en) 2021-11-26 2026-03-31 Alpha Cognition Inc. Alpha-1062 for treating traumatic brain injury
EP4186509A1 (en) 2021-11-26 2023-05-31 Alpha Cognition Inc. Alpha-1062 for treating traumatic brain injury
EP4719426A1 (en) * 2023-05-25 2026-04-08 Alpha Cognition Inc. Benzgalantamine for treating persistent post-concussion symptoms
US12208167B1 (en) * 2024-02-06 2025-01-28 Alpha Cognition Inc. Coated tablets for pH-dependent release of benzgalantamine
US12551491B1 (en) * 2025-07-23 2026-02-17 Alpha Cognition Inc. Dosage regimens for benzgalantamine

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US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20090253654A1 (en) * 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
CN102007129A (zh) * 2008-04-14 2011-04-06 加兰托斯医药有限责任公司 用作治疗人类脑疾病的前药的雪花胺衍生物

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US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20090253654A1 (en) * 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
CN102007129A (zh) * 2008-04-14 2011-04-06 加兰托斯医药有限责任公司 用作治疗人类脑疾病的前药的雪花胺衍生物

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JP2018100272A (ja) 2018-06-28
IN2015DN00229A (https=) 2015-06-12
CN104507461A (zh) 2015-04-08
PL2877165T3 (pl) 2019-05-31
PL3417862T3 (pl) 2021-11-22
EP2877165A1 (en) 2015-06-03
EP3417862B1 (en) 2021-05-05
JP2015524423A (ja) 2015-08-24
DK3417862T3 (da) 2021-07-12
EP3417862A1 (en) 2018-12-26
DK2877165T3 (da) 2019-01-02
CA2878135A1 (en) 2014-01-30
HK1206242A1 (en) 2016-01-08
JP6272857B2 (ja) 2018-01-31
US20150190401A1 (en) 2015-07-09
ES2700473T3 (es) 2019-02-18
JP6574002B2 (ja) 2019-09-11
EP2877165B1 (en) 2018-09-05
AU2013294917A1 (en) 2015-01-22
AU2013294917B2 (en) 2016-12-15
CA2878135C (en) 2019-12-03
WO2014016430A1 (en) 2014-01-30

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