CN108245178A - A kind of blood flowing speed computational methods based on X ray coronary angiography image - Google Patents
A kind of blood flowing speed computational methods based on X ray coronary angiography image Download PDFInfo
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- CN108245178A CN108245178A CN201810025465.0A CN201810025465A CN108245178A CN 108245178 A CN108245178 A CN 108245178A CN 201810025465 A CN201810025465 A CN 201810025465A CN 108245178 A CN108245178 A CN 108245178A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
Abstract
The invention discloses a kind of blood flowing speed computational methods based on X ray coronary angiography image, step is as follows：It is loaded into X ray coronary angiography image；Obtain patient heart rate；Contrastographic picture information is extracted, and the three-dimensional generated data of two-dimentional blood vessel is obtained based on three-dimensional synthesis methods；Calculate the frame number that image is passed by a cardiac cycle；The frame number passed by by image in a cardiac cycle, it obtains the starting point and end point of a cardiac cycle respectively on two-dimentional start frame and the corresponding image of end frame, then intercepts the length of vessel of a cardiac cycle in three-dimensional generated data by starting point and end point；Calculate blood flowing speed；It the advantage is that through the starting point and end point on start frame in one cardiac cycle of identification and the image corresponding to end frame, and the length of vessel obtained based on three-dimensional reconstruction, it determines the average flow velocity of blood in a cardiac cycle, for doctor provides a kind of computational methods of more accurately coronary artery blood flowing speed.
Description
Technical field
The invention belongs to technical field of medical image processing, more particularly, to a kind of based on X ray coronary angiography image
Blood flowing speed computational methods.
Background technology
Blood flowing speed in blood vessel is the important parameter and index of health, can reflect many disease incidences
Intermediate link or sign early period.Therefore, the blood flowing speed in blood vessel is accurately measured, doctor is contributed to carry out more the state of an illness
Good analysis has important clinical value and meaning.
As technology develops, X-ray contrastographic picture is more and more clear, and blood vessel structure can be clearly seen using contrast agent.Mesh
Preceding conventional image measurement blood flowing speed method is to choose one section of blood vessel, measure length of vessel and pass through number of image frames
It determines the time, blood flowing speed is obtained with this.This mode there are one it is apparent the shortcomings that be, in selected length
In, cardiac cycle is indefinite, and blood flowing speed changes always in Heart Beat procedure, and this mode can not be accurately anti-
The blood flowing speed in a cardiac cycle is answered, there is certain limitation.
Invention content
The present invention seeks to：A kind of blood flowing speed computational methods based on X ray coronary angiography image are provided, not only
It is easy to operate, and pass through the starting point on start frame in one cardiac cycle of identification and the image corresponding to end frame and end
Point, and the length of vessel obtained based on the three-dimensional reconstruction in coronary angiography image, to determine the flat of blood in a cardiac cycle
Equal flowing velocity provides a kind of computational methods of more accurately coronary artery blood flowing speed for doctor.
The technical scheme is that：A kind of blood flowing speed computational methods based on X ray coronary angiography image, packet
Include following steps：
Step S1：It is loaded into X ray coronary angiography image；
Step S2：It monitors and obtains the patient heart rate specified；
Step S3：Contrastographic picture information is extracted, and the three-dimensional generated data of two-dimentional blood vessel is obtained based on three-dimensional synthesis methods；
Step S4：Calculate the frame number that image is passed by a cardiac cycle；
Step S5：The frame number passed by by image in a cardiac cycle, it is corresponding in two-dimentional start frame and end frame
The starting point and end point of a cardiac cycle is obtained on image respectively, then by starting point and end point in three-dimensional composite number
According to the length of vessel of one cardiac cycle of middle interception；
Step S6：Calculate blood flowing speed.
As preferred technical solution, three-dimensional generated data described in step S3 includes caliber, center line, the profile of blood vessel
And length data.
As preferred technical solution, the specific side of frame number that image is passed by a cardiac cycle is calculated in step S4
Method is as follows：
It is H beats/min to obtain the patient heart rate specified, and it is S frames/second that picture frequency is obtained from contrastographic picture information,
The calculation formula of frame number X is as follows：
X=(1 ÷ (H ÷ 60)) × S.
As preferred technical solution, the specific method that blood flowing speed is calculated in step S6 is as follows：
Assuming that the length of vessel of interception is L, the time used in a cycle is P, passes through formula 1：P=X ÷ S；Formula 2：V=
L ÷ P, obtain blood flowing speed V.
It is an advantage of the invention that：
1. the method for the present invention is not only easy to operate, but also by identifying start frame and end frame institute in a cardiac cycle
Starting point and end point on corresponding image, and the length of vessel obtained based on the three-dimensional reconstruction in coronary angiography image are come
It determines the average flow velocity of blood in a cardiac cycle, a kind of more accurately coronary artery blood flowing speed is provided for doctor
Computational methods.
Description of the drawings
The invention will be further described with reference to the accompanying drawings and embodiments：
Fig. 1 is the structure flow chart of the present invention；
Fig. 2 is the start frame of the embodiment of the present invention 1 and the corresponding image schematic diagram of end frame；
Fig. 3 is the start frame of the embodiment of the present invention 2 and the corresponding image schematic diagram of end frame；
Fig. 4 is the start frame of the embodiment of the present invention 3 and the corresponding image schematic diagram of end frame；
Fig. 5 is the start frame of the embodiment of the present invention 4 and the corresponding image schematic diagram of end frame；
Fig. 6 is the start frame of the embodiment of the present invention 5 and the corresponding image schematic diagram of end frame；
Fig. 7 is the blood flowing speed contrast schematic diagram of the embodiment of the present invention 1 to 5.
Specific embodiment
With reference to shown in Fig. 1, the present invention is based on the blood flowing speed computational methods of X ray coronary angiography image, including such as
Lower step：
Step S1：It is loaded into X ray coronary angiography image；
Step S2：It monitors and obtains the patient heart rate specified；
Step S3：Contrastographic picture information is extracted, and the three-dimensional generated data of two-dimentional blood vessel is obtained based on three-dimensional synthesis methods,
The three-dimensional generated data includes caliber, center line, profile and the length data of blood vessel；
Step S4：The frame number X that image is passed by a cardiac cycle is calculated, specific method is as follows：
It is H beats/min to obtain the patient heart rate specified, and it is S frames/second that picture frequency is obtained from contrastographic picture information,
The calculation formula of frame number X is as follows：
X=(1 ÷ (H ÷ 60)) × S；
Step S5：The frame number X to be passed by by image in a cardiac cycle, it is corresponding in two-dimentional start frame and end frame
The starting point and end point of a cardiac cycle is obtained on image respectively, then by starting point and end point in three-dimensional composite number
According to the length of vessel of one cardiac cycle of middle interception；
Step S6：Calculate blood flowing speed, it is assumed that the length of vessel of interception is L, and the time used in a cycle is P, is led to
Cross formula 1：P=X ÷ S；Formula 2：V=L ÷ P, obtain blood flowing speed V.
Example 1 below is 100 beats/min to patient heart rate in 5, is preset, and image FPS is 15 frames/second, by calculating
Into a heart beat cycle, image passes through 9 frames, 0.6 second time used.
Embodiment 1：With reference to shown in Fig. 2, acquisition start frame is 11 frames, and it is 20 frames to determine end frame.In two-dimentional start frame and
The starting point and end point of a cardiac cycle is obtained on corresponding two image of end frame respectively, from three-dimensional center line data acquisition
Corresponding length is 39 millimeters, final flow rate 65mm/s.
Embodiment 2：With reference to shown in Fig. 3, acquisition start frame is 12 frames, and it is 21 frames to determine end frame.In two-dimentional start frame and
The starting point and end point of a cardiac cycle is obtained on corresponding two image of end frame respectively, from three-dimensional center line data acquisition
Corresponding length is 38.3442 millimeters, final flow rate 64mm/s.
Embodiment 3：With reference to shown in Fig. 4, acquisition start frame is 13 frames, and it is 22 frames to determine end frame.In two-dimentional start frame and
The starting point and end point of a cardiac cycle is obtained on corresponding two image of end frame respectively, from three-dimensional center line data acquisition
Corresponding length is 38.5965 millimeters, final flow rate 64mm/s.
Embodiment 4：With reference to shown in Fig. 5, acquisition start frame is 14 frames, and it is 23 frames to determine end frame.In two-dimentional start frame and
The starting point and end point of a cardiac cycle is obtained on corresponding two image of end frame respectively, from three-dimensional center line data acquisition
Corresponding length is 36.8805 millimeters, final flow rate 61mm/s.
Embodiment 5：With reference to shown in Fig. 6, acquisition start frame is 15 frames, and it is 24 frames to determine end frame.In two-dimentional start frame and
The starting point and end point of a cardiac cycle is obtained on corresponding two image of end frame respectively, from three-dimensional center line data acquisition
Corresponding length is 39.9525 millimeters, final flow rate 67mm/s.
With reference to Fig. 7 and integrated embodiment 1 to 5, final statistical result showed, blood in a heart beat cycle of the method measuring and calculating
The error of liquid flowing velocity is 4%~5%, more accurately can provide effective blood flowing speed numerical value for doctor.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (4)
1. a kind of blood flowing speed computational methods based on X ray coronary angiography image, which is characterized in that including walking as follows
Suddenly：
Step S1：It is loaded into X ray coronary angiography image；
Step S2：It monitors and obtains the patient heart rate specified；
Step S3：Contrastographic picture information is extracted, and the three-dimensional generated data of two-dimentional blood vessel is obtained based on three-dimensional synthesis methods；
Step S4：Calculate the frame number that image is passed by a cardiac cycle；
Step S5：The frame number passed by by image in a cardiac cycle, in two-dimentional start frame and the corresponding image of end frame
The upper starting point and end point for obtaining a cardiac cycle respectively, then by starting point and end point in three-dimensional generated data
Intercept the length of vessel of a cardiac cycle；
Step S6：Calculate blood flowing speed.
2. the blood flowing speed computational methods according to claim 1 based on X ray coronary angiography image, feature exist
In three-dimensional generated data described in step S3 includes caliber, center line, profile and the length data of blood vessel.
3. the blood flowing speed computational methods according to claim 1 based on X ray coronary angiography image, feature exist
In the specific method of frame number that image is passed by one cardiac cycle of calculating in step S4 is as follows：
It is H beats/min to obtain the patient heart rate specified, and picture frequency is obtained from contrastographic picture information as S frames/second, frame number X
Calculation formula it is as follows：
X=(1 ÷ (H ÷ 60)) × S.
4. the blood flowing speed computational methods according to claim 1 based on X ray coronary angiography image, feature exist
In the specific method that blood flowing speed is calculated in step S6 is as follows：
Assuming that the length of vessel of interception is L, the time used in a cycle is P, passes through formula 1：P=X ÷ S；Formula 2：V=L ÷
P obtains blood flowing speed V.
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| CN110367965A (en) * | 2018-09-19 | 2019-10-25 | 苏州润迈德医疗科技有限公司 | The method, apparatus and system of convenient measurement coronary artery assessment parameters |
| CN110786842A (en) * | 2019-11-04 | 2020-02-14 | 苏州润迈德医疗科技有限公司 | Method, device, system and storage medium for measuring diastolic blood flow velocity |
| CN110929604A (en) * | 2019-11-11 | 2020-03-27 | 苏州润迈德医疗科技有限公司 | Screening method, device and system based on flow velocity of contrast image and storage medium |
| CN111166316A (en) * | 2018-11-13 | 2020-05-19 | 苏州润迈德医疗科技有限公司 | Method for calculating instantaneous contrast wave-free ratio and contrast diastolic pressure ratio based on contrast images |
| CN111166317A (en) * | 2018-11-13 | 2020-05-19 | 苏州润迈德医疗科技有限公司 | Method for calculating contrast blood flow reserve fraction and resting state pressure ratio based on contrast image |
| CN111166315A (en) * | 2018-11-13 | 2020-05-19 | 苏州润迈德医疗科技有限公司 | Method for calculating instantaneous mode-free ratio and resting state diastolic pressure ratio based on contrast image |
| CN112384136A (en) * | 2018-11-13 | 2021-02-19 | 苏州润迈德医疗科技有限公司 | Method, device and system for obtaining blood vessel evaluation parameters based on radiography images |
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Application publication date: 20180706 |