CN108236723A - A kind of composition and its application as coating material - Google Patents
A kind of composition and its application as coating material Download PDFInfo
- Publication number
- CN108236723A CN108236723A CN201611229104.5A CN201611229104A CN108236723A CN 108236723 A CN108236723 A CN 108236723A CN 201611229104 A CN201611229104 A CN 201611229104A CN 108236723 A CN108236723 A CN 108236723A
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- China
- Prior art keywords
- composition
- microballoon
- preparation
- polysaccharide
- coating material
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
A kind of application the present invention relates to medicine, health products or cosmetic field more particularly to composition and its as coating material.The present invention provides a kind of composition being made of sea grass polysaccharide and sodium alginate, the composition can be coated water-soluble active ingredient as coating material.While ensureing that smaller grain size, envelop rate, drugloading rate are all higher, the stationarity of drug release ensure that.Also, due to sea grass polysaccharide and the degradable characteristic of sodium alginate, the safety of medication is improved using composition provided by the invention as coating.
Description
Technical field
The present invention relates to medicine, health products or cosmetic field more particularly to a kind of composition and its as coating material
Application.
Background technology
At present, the coating material of microballoon, micro-capsule or sustained release preparation uses high molecular material more, for example, ethene polymers, third
Olefin(e) acid resin etc., these materials are not easy to be metabolized in human body, and metabolism residue can also have an adverse effect to the health of human body.
Enteromorpha (Entermopha) is Chlorophyta (ehlorophyta) Ulvales (Ulvales) Ulvaceae (Ulvaceae)
Plant, China's wild algae is resourceful, and Enteromorpha has a long history as food materials and medicinal material.Polysaccharide is mainly having for Enteromorpha
Ingredient is imitated, is primarily present in the cell wall and iuntercellular of Enteromorpha.Numerous studies show that sea grass polysaccharide has reducing blood lipid, immune tune
Section, anti-oxidant, antibacterial, the activity of anticancer.It is another to there is result of study to show that sea grass polysaccharide has performance of keeping humidity.
Since sea grass polysaccharide itself has many physiological activity, if it is possible to as coating material, then will necessarily drop
The drug risk of low drug.It and can also be more extensive, safety for multiple fields such as food, health products, cosmetics.But
Have not yet to see report of the related sea grass polysaccharide as coating material.So further research sea grass polysaccharide as packaging material can
Row has a very important significance.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of composition and its answering as coating material
With composition provided by the invention includes sea grass polysaccharide and sodium alginate, and good biocompatibility is degradable, as coating
Material entrapped drug drugloading rate, envelop rate are all high, had good sustained release effect.
Composition provided by the invention includes sea grass polysaccharide and sodium alginate.
The mass ratio of sea grass polysaccharide and sodium alginate is (12~2) in composition provided by the invention：1.
Preferably, the mass ratio of sea grass polysaccharide and sodium alginate is (3~4)：1.
Preferably, the mass ratio of sea grass polysaccharide and sodium alginate is 3: 1.
Composition provided by the invention can have envelop rate height, drugloading rate height, and had good sustained release effect as coating material
Characteristic.Also, obtained preparation also is able to the bioactivity with sodium alginate and sea grass polysaccharide.Be as cosmetics,
Health products, drug, food preferable coating material.Experiment shows relative to only using sodium alginate as coating material, the present invention
The composition of offer can make the slow release effect of gained preparation more steady as coating material；And relative to only with sea grass polysaccharide
As coating material, composition provided by the invention can obtain the drugloading rate of gained preparation and envelop rate as coating material
It is significant to improve (p<0.01).Meanwhile it is demonstrated experimentally that under the conditions of preferred mass ratio, sea grass polysaccharide is with sodium alginate to work
The encapsulating effect of property substance is more preferable, and grain size is also smaller.
Application of the composition provided by the invention as active constituent coating material.
Heretofore described active constituent is water-soluble active ingredient.
In some embodiments, it is mould that active constituent is selected from water-soluble vitamins, salicylic acid, cephalo-type, Tetracyclines, chlorine
Plain class or polysaccharide.
The salicylic acid active material is acetylsalicylic acid；The polysaccharide active material is ganoderma lucidum polysaccharide；The chlorine
Mycin class active material is terramycin.
In one specific embodiment, active constituent is Vitamin C glycosides.
Composition is provided as the preparation of coating material using the present invention；The dosage form of the preparation is microballoon, micro-capsule, nanocapsule
Or nanosphere.
In one specific embodiment, the dosage form of preparation is microballoon.
The preparation method of said preparation is with the composition embedding active component of the present invention；The embedding is using emulsification and cross linked
Method, solvent evaporation method or spray drying process.
In one specific embodiment, the method for microballoon is prepared as emulsion-crosslinking method using the present composition.
Vc glucosides can increase the elasticity of skin, whitening, anti-inflammatory.Therefore, Vc glucosides is the perfect additive of cosmetics.Directly
Connecing external application Vc glucosides can cause the waste of Vc glucosides and assimilation effect bad, and Vc glucosides under natural lighting for a long time expose when
It will also result in the decomposition of part.And Vc glucosides is embedded using composition provided by the invention, Vc glucosides can be controlled
Release, the stability for improving Vc glucosides.Vc glucosides particle after encapsulating will be had more extensively for cosmetics or health products
Bioactivity, and the pharmaceutically-active period is also longer.
The present invention specifically provides a kind of Vitamin C glycosides microballoon, composition embedding vitamin C sugar provided by the present invention
Glycosides is made.
The preparation method of Vitamin C glycosides microballoon provided by the invention, including：
Step 1：Composition provided by the invention is dissolved in water, Coating Solution is made；
Step 2：After Vitamin C glycosides is mixed with the Coating Solution, mixed with the paraffin oil containing emulsifier；Through breast
Change, after curing, emulsion is made；
Step 3：The emulsion is after refrigerating, centrifuging, reject paraffin oil, washing.
When polysaccharide concentration is too small, polysaccharide solution cannot form preferable dispersed phase, it is impossible to be formed by curing microballoon, polysaccharide concentration
Polysaccharide solution viscosity is larger when excessive, microballoon adhesion.
The mass ratio of sea grass polysaccharide and sodium alginate is (12~2) in composition：1.
Preferably, the mass ratio of sea grass polysaccharide and sodium alginate is (3~4)：1.
Preferably, the mass ratio of sea grass polysaccharide and sodium alginate is 3：1.
In step 1, the mass fraction that composition is dissolved in water is 2%~3%.
Preferably, the mass fraction that composition is dissolved in water is 2%.
In step 2, Vitamin C glycosides is dissolved in a concentration of 0.003g/mL~0.011g/mL of Coating Solution.
Preferably, Vitamin C glycosides is dissolved in a concentration of 0.011g/mL of Coating Solution.
In step 2, Vitamin C glycosides is heated to the dissolving of VC glucosides after being dissolved in Coating Solution.
The temperature of the heating is 40 DEG C.
The mass ratio of the Vitamin C glycosides and composition is 1：1~2：11.
Preferably, the mass ratio of VC glucosides and composition is 1:2.
In some specific embodiments, the emulsifier of emulsification is SP80.
When emulsifier is continuously increased, the viscosity of system is also constantly increasing, the grain of the drop in whipping process
Diameter can be also continuously increased, and drop is not easy the increase for disperseing to lead to the coefficient of dispersion.The emulsification system that polysaccharide solution is formed is unstable
It is fixed, lead to microballoon adhesion.In embodiment, the mass fraction of emulsifier is 0.5%~6% in paraffin oil.Preferably, in paraffin oil
The mass fraction of emulsifier is 1%.
Using the paraffin oil containing emulsifier as oil phase；To dissolve the Coating Solution of VC glucosides as water phase.Oil phase ratio is excessive,
Emulsion system is unstable, and grain size becomes smaller, and the coefficient of dispersion becomes larger, and oil phase ratio is excessive, dispersed phase can be made to be mixed into continuous phase, drop
Humble ball curing and the effect of emulsification.In embodiment, the volume ratio of water phase and oil phase is 1：(10~40).Preferably, volume ratio
It is 1:10.
Temperature is excessively high or the too low formation for being all unfavorable for microballoon.Temperature is excessively high, and solution viscosity is excessive, microballoon adhesion, temperature
When spending low, polysaccharide solution is changed into gel state, is discrete phase, and polysaccharide solution after emulsification is not forming microballoon, 65 DEG C
The coefficient of dispersion and roundness of Shi Weiqiu is all preferable.
The temperature of emulsification is 50 DEG C~90 DEG C；Preferably 65 DEG C.
Mixing time is longer, and microballoon is cut that number is more, and the coefficient of dispersion is bigger, and when mixing time is smaller, microballoon is cut
Cut smaller, microballoon adhesion.In embodiment, the time of emulsification is 10min~130min；Condition is stirred for 1000r/min.It is preferred that
, emulsification times 30min.
In some specific embodiments, cured curing agent is CaCl2。
The effect of calcium chloride is curing polysaccharide microsphere, is equivalent to curing agent, can also otherwise cure polysaccharide microsphere,
Polysaccharide microsphere after such as stirring directly refrigerates curing plus glutaraldehyde, boric acid curing or adjustment polysaccharide solution is alkaline condition pair
Microballoon is cured.But calcium chloride curing is preferable, shows as the microballoon prepared under the same terms, the microballoon after calcium chloride curing
Grain size is smaller, and microballoon adhesion phenomenon is smaller.And calcium chloride is nontoxic and preferable curing agent.Curative concentration is bigger, encapsulating
Rate can be bigger, but when curative concentration is excessive can cause medicament slow release excessively slow.
Curing agent is added to the 0.9%~4.4% of emulsifier quality.
Preferably, the additive amount of curing agent is the 0.9%~1.2% of emulsion quality.
Cured temperature is 60 DEG C~70 DEG C；Preferably 65 DEG C.
The cured time is 20min；Condition is stirred for 300r/min.
In step 3, the temperature of refrigeration is 4 DEG C, time 30min.
The rotating speed of centrifugation is 3000r/min；Time is 5min.
After centrifugation, reject paraffin oil, that is, oil phase.
Washing is using distilled water.3000r/min centrifuges 5min after washing.VC glucosides microballoons are present in supernatant.
It is worked well with microballoon drug release made from the method provided by the present invention.Grain size minimum is up to 30.66 μm；Envelop rate is reachable
36.3%, drugloading rate is up to 4.5%.
The present invention provides a kind of composition being made of sea grass polysaccharide and sodium alginate, the composition can be used as coating
Material is coated water-soluble active ingredient.While ensureing that smaller grain size, envelop rate, drugloading rate are all higher, it ensure that
The stationarity of drug release.Also, due to sea grass polysaccharide and the degradable characteristic of sodium alginate, using composition provided by the invention as
Coating improves the safety of medication.
Description of the drawings
Fig. 1 shows the elution profiles of the obtained microballoon of the present invention.
Specific embodiment
A kind of application the present invention provides composition and its as coating material, those skilled in the art can use for reference this
Literary content is suitably modified technological parameter realization.In particular, it should be pointed out that all similar substitutions and modifications are to art technology
It is it will be apparent that they are considered as being included in the present invention for personnel.The method of the present invention and application are by preferable
Embodiment is described, related personnel significantly can not depart from the content of present invention, in spirit and scope to methods herein and
Using being modified or suitably change with combining, to realize and using the technology of the present invention.
Sea grass polysaccharide is a kind of active material contained in Enteromorpha；The present invention is not construed as limiting the source of sea grass polysaccharide,
Can be that self-control is also bought in market；It is implemented all within protection scope of the present invention.The Enteromorpha that present invention experiment uses is more
The preparation method of sugar is extracted for hot water, and dehydration of alcohol obtains, and preparation does not limit the source of Enteromorpha.
Active constituent of the present invention is also known as active ingredient, refers to there is the substance of medical effect or physiological activity.It can
Applied to medicine, health products, food or cosmetics.In some embodiments, active constituent refers specifically to VC glucosides.
With reference to embodiment, the present invention is further explained：
Embodiment
Take sea grass polysaccharide aqueous solution with sodium alginate aqueous solution according to 1 volume mixture of table respectively.
It weighs Vc glucosides and is heated to 40 DEG C, Vc glucosides is made to be dissolved completely in polysaccharide solution；
The polysaccharide solution containing Vc glucosides is mixed with the paraffin oil containing emulsifier respectively, at 65 DEG C, in 1000r/min
Emulsification；
It adds in calcium chloride after having emulsified to be cured, rotating speed is reduced to 300r/min, cures 20min；
Then emulsion is placed on 4 DEG C of refrigeration 30min.3000r/min centrifuges 5min；Incline upper oil phase, add in 50ml
Distillation water washing.
3000r/min centrifuges 5min；Supernatant is taken to measure light absorption value at 260nm, and Vc is calculated according to standard curve
The content of glucosides, is denoted as a1g。
Incline supernatant, in the distilled water for adding in 50ml.3000r/min centrifuges 5min, and supernatant is taken to be measured at 260nm
Light absorption value calculates Vc Glycosides Contents, is denoted as a2g。
Incline supernatant, leaves following microballoon, 4 DEG C of storages.If the dose added in is denoted as M, contained medicine in microballoon
Amount is denoted as m.M=M-a1-a2。
The dosage of dose in envelop rate=microballoon/total；
Dose/(addition of addition+sea grass polysaccharide of total dosage+sodium alginate) in drugloading rate=microballoon.
Since sea grass polysaccharide is softer, individually using sea grass polysaccharide as coating material, the matrix of microballoon is by external force such as centrifugations
Under the action of easily destroy, at this point, Vc glucosides in microballoon can quick release, lead to sea grass polysaccharide microballoon to Vc glucosides
Envelop rate is relatively low.Influence of the different sodium alginate additions to complex microsphere grain size and the coefficient of dispersion is as shown in table 1.
The microballoon of group 6~8 and group 22 is taken to detect slow release effect at 32 DEG C, medicament slow release detection method is with reference to pharmacopeia side
Method, specially：The above-mentioned microballoon prepared is placed in bag filter, bag filter is placed on the PBS of 500ml in 7.4 buffer solutions, to delay
Release temperature be 32 DEG C (32 DEG C are skin surface temperature, which is mainly used in cosmetic field to the encapsulating of Vc glucosides,
Medicament slow release is carried out used in skin surface), it often crosses 5min and 5ml is taken to measure light absorption value at 260nm, supplement 5ml after taking immediately
PBS buffer solution.After having measured a hour, often cross 30min and surveying a light absorption value, 50 hours of METHOD FOR CONTINUOUS DETERMINATION.Such as Fig. 1 institutes
Show.
As shown in the figure, medicament slow release is broadly divided into three parts, preceding 6 hours medicament slow releases are very fast, the 6th hour small to 40
When, medicament slow release is slow, and the slow release speed of medicine after 40 hours in microballoon is fainter, this may be because in microballoon
Most of medicine is all sustained.The explosion type release of preceding 6 hours is primarily due to the absorption institute of surfactants on drug
It causes.Sodium alginate addition is more, and the envelop rate of microballoon also can be bigger, but it is slower to be sustained meeting.It is the results show that provided by the invention
Microballoon release is steady, and deenergized period is long.
It the above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of composition, which is characterized in that including sea grass polysaccharide and sodium alginate.
2. composition according to claim 1, which is characterized in that the mass ratio of the sea grass polysaccharide and sodium alginate is
(12~2)：1.
3. application of the composition as active constituent coating material described in claims 1 or 2.
4. application according to claim 3, which is characterized in that the active constituent is water-soluble active ingredient.
5. application according to claim 3 or 4, which is characterized in that the active constituent is selected from water-soluble vitamins, water
Poplar acids, cephalo-type, Tetracyclines, chloromycetin or polysaccharide.
6. using the composition described in claims 1 or 2 as the preparation of coating material；The dosage form of the preparation for microballoon, micro-capsule,
Nanocapsule or nanosphere.
7. the preparation method of preparation described in claim 6, which is characterized in that embedded and lived with the composition described in claims 1 or 2
Property ingredient；The embedding is using emulsion-crosslinking method, solvent evaporation method or spray drying process.
8. a kind of Vitamin C glycosides microballoon, which is characterized in that as the composition embedding vitamin C sugar described in claims 1 or 2
Glycosides is made.
9. the preparation method of Vitamin C glycosides microballoon described in claim 8, which is characterized in that including：
Step 1：Composition described in claims 1 or 2 is dissolved in water, Coating Solution is made；
Step 2：After Vitamin C glycosides is mixed with the Coating Solution, mixed with the paraffin oil containing emulsifier；Through emulsifying,
After curing, emulsion is made；
Step 3：The emulsion is after refrigerating, centrifuging, reject paraffin oil, washing.
10. preparation method according to claim 9, which is characterized in that the cured curing agent is CaCl2。
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611229104.5A CN108236723B (en) | 2016-12-27 | 2016-12-27 | Composition and application thereof as coating material |
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| CN201611229104.5A CN108236723B (en) | 2016-12-27 | 2016-12-27 | Composition and application thereof as coating material |
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| CN108236723B CN108236723B (en) | 2021-07-06 |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219124A1 (en) * | 2003-05-01 | 2004-11-04 | Gupta Shyam K. | Cosmetic and Pharmaceutical Masks Based on Ion-Pair Delivery System |
| CN101716127A (en) * | 2009-12-04 | 2010-06-02 | 上海理工大学 | Method for preparing long-acting and controlled release microencapsulated face cream |
| US20140106001A1 (en) * | 2012-10-15 | 2014-04-17 | Commercial Marine Biology Institute, Llc | Marine extract compositions and methods of use |
| CN104222162A (en) * | 2013-06-23 | 2014-12-24 | 青岛道合生物科技有限公司 | Enteromorpha polysaccharide antimicrobial gel for preventing infectious diseases |
| CN104402101A (en) * | 2014-11-06 | 2015-03-11 | 芜湖市祥荣食品有限公司 | Corn starch blue algae processing agent and preparation method thereof |
| CN104419773A (en) * | 2013-08-28 | 2015-03-18 | 青岛医防消毒专业技术中心 | Household leather product dedicated soft sterilizing nursing agent |
| CN104666250A (en) * | 2015-03-06 | 2015-06-03 | 华南农业大学 | Preparation method of chlortetracycline sustained-release microspheres |
| CN104856963A (en) * | 2015-05-26 | 2015-08-26 | 大连理工大学 | Astaxanthin-sodium alginate sustained release microspheres as well as preparation method and application thereof |
| CN105363039A (en) * | 2014-09-01 | 2016-03-02 | 中国海洋大学 | Enteromorpha polysaccharide microcapsule and preparation method thereof |
-
2016
- 2016-12-27 CN CN201611229104.5A patent/CN108236723B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219124A1 (en) * | 2003-05-01 | 2004-11-04 | Gupta Shyam K. | Cosmetic and Pharmaceutical Masks Based on Ion-Pair Delivery System |
| CN101716127A (en) * | 2009-12-04 | 2010-06-02 | 上海理工大学 | Method for preparing long-acting and controlled release microencapsulated face cream |
| US20140106001A1 (en) * | 2012-10-15 | 2014-04-17 | Commercial Marine Biology Institute, Llc | Marine extract compositions and methods of use |
| CN104222162A (en) * | 2013-06-23 | 2014-12-24 | 青岛道合生物科技有限公司 | Enteromorpha polysaccharide antimicrobial gel for preventing infectious diseases |
| CN104419773A (en) * | 2013-08-28 | 2015-03-18 | 青岛医防消毒专业技术中心 | Household leather product dedicated soft sterilizing nursing agent |
| CN105363039A (en) * | 2014-09-01 | 2016-03-02 | 中国海洋大学 | Enteromorpha polysaccharide microcapsule and preparation method thereof |
| CN104402101A (en) * | 2014-11-06 | 2015-03-11 | 芜湖市祥荣食品有限公司 | Corn starch blue algae processing agent and preparation method thereof |
| CN104666250A (en) * | 2015-03-06 | 2015-06-03 | 华南农业大学 | Preparation method of chlortetracycline sustained-release microspheres |
| CN104856963A (en) * | 2015-05-26 | 2015-08-26 | 大连理工大学 | Astaxanthin-sodium alginate sustained release microspheres as well as preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 屠美: "《药用高分子材料及其应用》", 30 November 2006 * |
| 张超云 等: "《药剂学》", 31 October 2013 * |
| 薛巍 等: "《生物医用水凝胶》", 31 December 2012 * |
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