CN108233919B - Fire alarm double rail logic circuit and implementation method based on strand displacement - Google Patents
Fire alarm double rail logic circuit and implementation method based on strand displacement Download PDFInfo
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Abstract
The invention proposes a kind of fire alarm double rail logic circuit and implementation method based on strand displacement, reaction mechanism based on DNA chain displacement constructs the fire alarm circuit system of four inputs, cigarette sense is built, warming, light sensation, the Digital Logical Circuits for the fire alarm circuit operation operation that hand reporting device four inputs, Digital Logical Circuits is converted to double rail logic circuit using double rail logic thought, seesaw biochemistry logic circuit is then converted by double rail logic circuit, it, which is verified, finally by Visual DSD simulation software exports result, and analyze and determine whether there is fire behavior.Circuit design of the invention is effective, and has very high accuracy and sensitivity；Basic theoretical basis is provided for the arithmetic operation of large-scale intelligent alarm apparatus system design, the reliability of biocomputer logic circuit is improved, promotes the development of biocomputer.
Description
Technical field
The present invention relates to the technical field of logic circuit more particularly to a kind of fire alarm double rail logics based on strand displacement
Circuit and implementation method.
Background technique
In current fast-developing computer age, traditional Logic Circuit Design is no longer satisfied people's normally safety
Needs in life, such as circuitry lead to aging circuit because of complicated operation, and warning device system judges fire inaccurate
Really etc., fire problem is the big problem that current China compares attention, how could timely and accurately be judged whether there is hidden
Suffer from the presence of the direction that will be research.It is a new research field in conjunction with the DNA of scientific computer and molecular biosciences subject calculating.
DNA has solved the problems, such as very much, such as Hamilton path and maximal clique problem etc. as a kind of new calculating instrument.DNA
Self assembly is an important support technology of DNA nanotechnology, has the characteristics that predictability and programmability, in application field
Both features all have good development prospect in terms of self assembly.DNA chain displacement technique is also played the part of in biological computation field
A kind of dynamic DNA nanotechnology.DNA chain displacement technique is due to itself having a series of spontaneities, sensitivity and accurate
The characteristics of property, nano-machines, molecular logic circuit, Nano medication and other in terms of be widely used.In recent years, biological
Computer scientist's extensive concern by many from different field, and molecular logic circuit is the weight of biocomputer
Want component part.Therefore, the construction method of logic circuit plays an important role in biocomputer.
DNA calculating has been processed by a large amount of such as self assembly, fluorescent marker, strand displacement and probe machine molecule manipulations.DNA chain
Replacement technique be grow up on the basis of DNA self-assembling technique, so, DNA self-assembling technique and DNA chain displacement technique are
The big important support technology of the two of researching DNA nanotechnology.And DNA chain displacement technique is very suitable for constructing molecular logic electricity
Road, in traditional electronic logic circuit, high level and low level are typically expressed as the "true" and "false" of Boolean logic.Based on chain
The cascade reaction of replacement technique has been realized in the Dynamic link library of neighbor logic module, and extensive, multiple for researcher's building
Miscellaneous logic circuit is possibly realized.In addition, DNA chain displacement technique relies on high content information accumulation, high performance parallel computation, programming
And the advantage of emulation, in-depth study has been obtained in molecular computing, nano-machines, diagnosis and disease treatment field.DNA
Strand displacement technology also has very big research significance in terms of solving mathematical problem, management nano-machines and life course is discussed.
In addition, the building of the biochemistry logic circuit based on DNA chain displacement also anticipates to the grasp of design program with important research
Justice.Based on DNA chain displacement technique strategy intelligent stimuli responsive material, nanoelectronic circuits and device, biosensor and
The fields such as nanosecond medical science have great application prospect.
Summary of the invention
In order to promote the development of biocomputer, the present invention proposes that a kind of fire alarm double track based on DNA chain displacement is patrolled
Circuit and implementation method are collected, the digital circuit of fire alarm double rail logic is first designed, then by Digital Logical Circuits double track
Logical thought construct fire alarm double rail logic circuit, finally convert biochemical logic circuit for double rail logic circuit, be used in combination
Visual DSD simulation software analyzes the correctness of fire alarm double rail logic circuit, with very high sensitivity and reliably
Property.
In order to achieve the above object, the technical scheme of the present invention is realized as follows: a kind of fire report based on strand displacement
Alert double rail logic circuit, including four input chains, amplification door, integrated door, the first DNA threshold value door, the 2nd DNA threshold value door and output
Chain, each input chain have two states: indicating that the state that logic is opened is A1、B1、C1And D1, indicate that the state of logic pass is
A0、B0、C0And D0；It is respectively Y that output chain, which includes two states,1And Y0；Amplifying door has an input and three outputs, amplifies door
In threshold concentration be less than 1n mol/L, integrated door includes the three of three inputs, one output inputting integrated doors and four inputs one
The four of a output input integrated door；The threshold concentration of first DNA threshold value door is less than 1n mol/L, the threshold value of the 2nd DNA threshold value door
Concentration is greater than 1；The state A of the input chain1、B1、C1、D1、A0、B0、C0And D0As input signal respectively with an amplification door phase
Connection, the output end for amplifying door pass through DNA signal respectively and are connected from the different integrated doors of three inputs, and four three input integrated door
It inputs integrated door by the first DNA threshold value Men Yuyi four respectively to be connected, four, which input integrated door, passes through the 2nd DNA threshold value
Door obtains output signal Y0；The integrated door of four three inputs passes through a 2nd DNA threshold value door respectively and another four input is integrated
Door is connected, another integrated door of four inputs obtains output signal Y by the first DNA threshold value door1。
The input chain A0It is connected with amplification door I, inputs chain A1It is connected with amplification door II, inputs chain B0With amplification door
III is connected, and inputs chain B1It is connected with amplification door IV, inputs chain C0It is connected with amplification door V, inputs chain C1With amplification door VI
It is connected, inputs chain D0It is connected with amplification door VII, inputs chain D1It is connected with amplification door VIII；First output end of amplification door I,
Amplify the first output end of door III, the first output end for amplifying door V inputs integrated door I with three and is connected, the of amplification door II
One output end, the first output end for amplifying door IV, the first output end for amplifying door VI input integrated door II with three and are connected, and put
The second output terminal at gate I, the second output terminal for amplifying door III, the first output end for amplifying door VII input integrated door III with three
It is connected, the second output terminal for amplifying door II, the second output terminal for amplifying door IV, equal three input of the first output end for amplifying door VIII
Integrated door IV is connected, the third output end for amplifying door I, the second output terminal for amplifying door V, the second output terminal for amplifying door VII
Equal three, which input integrated door V, is connected, the third output end for amplifying door II, the second output terminal for amplifying door VI, amplification door VIII the
Two output ends equal three input integrated door VI and are connected, the third output end for amplifying door III, the third output end for amplifying door V, amplification
The third output end of door VII equal three inputs integrated door VII and is connected, and third output end, the third of amplification door VI for amplifying door IV are defeated
Outlet, the third output end for amplifying door VIII equal three inputs integrated door VIII and is connected；Finally, the integrated input of door I, three of three inputs is integrated
Door III, three inputs the integrated integrated door VII of the input of door V, three and inputs integrated II phase of door by a first DNA threshold value Men Yusi respectively
Connection, four, which input integrated a 2nd DNA threshold value door of door II and, is connected, to obtain output signal Y0；Three input integrated door
II, the integrated door IV, three of three inputs inputs integrated door VI and is connected respectively by an integrated door I of the 2nd DNA threshold value Men Yusi input
It connects, four, which input integrated a first DNA threshold value door of door I and, is connected, to obtain output signal Y1。
The initial concentration of fuel is twice that output signal binds concentration in the amplification door；The threshold concentration of amplification door is set
It is set to 0.2 n mol/L, the fuel concentration for amplifying door is set as 6 n mol/L；When the concentration of input chain is 1.2 n mol/L
When, the output concentration for amplifying the output end of door is 1 n mol/L；The threshold concentration of the first DNA threshold value door is 0.6 n
Mol/L, the threshold concentration of the 2nd DNA threshold value door are 2.4 n mol/L.
The step of its implementation are as follows:
Step 1: do not have to realize under enzyme or the room temperature of transcription mechanism in DNA chain displacement reaction, the end structure of chain will be inputted
Domain and part signal chain reaction simultaneously carry out branch migration, until single-stranded by extraneous single-stranded substitution in double-strand next time, finally
Newly single-stranded is formed as output chain；
Step 2: the fire alarm system of four kinds of detectable signals input is constructed using the reaction mechanism of basic DNA chain displacement
It unites the Digital Logical Circuits that double rail logic circuit output signal is Y, the logical operation state in Digital Logical Circuits uses two respectively
Binary value 0 and 1 indicates；
Step 3: each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、
D0And D1, output signal Y, which exports operation result, Y0And Y1Two states are turned Digital Logical Circuits using double rail logic thought
The double rail logic circuit for turning to the four kinds of detectable signals input operation borrowed using no low level, thus according to designed
Double rail logic circuit counting two different binary numbers operations, it is determined whether have fire alarm signal generation；
Step 4: the element using seesaw circuit as molecular logic circuit unit, by double rail logic electricity
Logic gate in road is converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtains
Seesaw logic circuit；
Step 5: it is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1It is put respectively as difference
The input chain at gate, increases the integrated door to match before seesaw logic gate, converts seesaw for seesaw logic circuit
Biochemical logic electricity.
If generating new structural domain in double-strand in the step 1, occurs and react similar reaction, and be up to
Dynamic equilibrium；If not generating new aiming field, reaction terminates.
The Digital Logical Circuits includes five and tetra- door, A, B, C and D input signals, an output signal Y；First
Input signal A, B and C are carried out and arithmetic operation, operation result value R1It indicates；Input signal A, B and D are carried out and arithmetic operation,
Operation result value R2It indicates；Input signal A, C and D are carried out and arithmetic operation, operation result value R3It indicates；Input signal B, C
With D progress and arithmetic operation, operation result value R4It indicates；Finally by preceding operation output valve R1、R2、R3、R4Next stage is carried out again
And arithmetic operation, operation result value indicated with Q, obtain final logical operation output result Y, i.e. Y=Q={ R1 ∧R2 ∧
R3 ∧ R4 }。
In the input signal, A, B, C and D are that cigarette sense, warming, light sensation and four kinds of input signals of hand reporting device are corresponding respectively
Binary number input, Y be judge whether there is fire generation double rail logic circuit operation output as a result, also with two into
Number 0 and 1 processed indicates that the value of output result Y has fire if 1, does not otherwise have fire.
The double rail logic circuit includes five logical AND gates and five logic sum gates, input signal include A0、A1、B0、
B1、C0、C1、D0And D1, output signal Y0And Y1；Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、
B1、C1With logical AND gate K2It is connected, input signal A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1
With logical AND gate K4It is connected, input signal A0、C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With patrol
It collects and door K6It is connected, input signal B0、C0And D0With logic sum gate K7It is connected, input signal B1、C1And D1And logical AND
Door K8It is connected；Logic sum gate K1、K3、K5、K7Output result with logic four input signal and door K9It is connected, obtains defeated
Signal Y out0；Logic sum gate K2、K4、K6、K8Output result with the logic sum gate K of four input signals10It is connected, obtains defeated
Signal Y out1。
Beneficial effects of the present invention: the number of the fire alarm system of four kinds of detectable signals input is constructed based on strand displacement
Digital Logical Circuits arithmetic operation is converted to the fire report of four kinds of detectable signals input using double rail logic thought by logic circuit
The double rail logic circuit of alert system, is then converted into seesaw biochemistry logic circuit by double rail logic circuit, finally by
Visual DSD simulation software verifies its output as a result, and according to analysis of simulation result judgement when four kinds of detectable signal stochastic inputs
When whether have fire behavior.Simulation result shows that the present invention realizes the double track of the fire alarm system of four kinds of detectable signals input
Logic circuit is effective, and has very high accurate sensitivity and reliability.The present invention is more complicated, extensive to designing in the future
Logic circuit arithmetic operation provides basic theoretical basis, improves the reliability of biocomputer logic circuit, promotes
The development of biocomputer.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is that the present invention is based on the Digital Logical Circuits numbers of the fire alarm system of strand displacement.
Fig. 2 is that the present invention is based on the double rail logic circuits of the fire alarm system of strand displacement.
Fig. 3 is the abstract graph of seesaw logic gate of the present invention conversion.
Fig. 4 is that the present invention is based on the seesaw biochemistry logic circuits of the fire alarm system of strand displacement.
Fig. 5 is that Visual DSD Software of the present invention exports result analogous diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under that premise of not paying creative labor
Embodiment shall fall within the protection scope of the present invention.
A kind of the step of implementation method of the fire alarm double rail logic circuit based on strand displacement are as follows:
Step 1: DNA chain displacement reaction is realized under no enzyme or the room temperature of transcription mechanism, will input the end structure of chain
Domain and part signal chain reaction, and branch migration is carried out, until single-stranded by extraneous single-stranded substitution in double-strand next time, finally
Newly single-stranded is formed as output chain.
DNA self-assembling technique in bioengineering logic circuit using more and more extensive, and DNA chain displacement technique is originated from
DNA self-assembling technique, due to basic double-spiral structure complementary pairing rule, a plurality of single-stranded spontaneous orderly carry out multidimensional group of DNA
Dress.Reaction mechanism based on DNA chain displacement devises a kind of new logic circuit, including cigarette sense, warming, light sensation, hand reporting device
The fire alarm logic circuit of four kinds of input signals, the input and output logical relation of corresponding DNA strand displacement, by four kinds of detectable signals
As input terminal, fire condition generation has been indicated whether with output end.This reaction mechanism circuit based on DNA chain displacement
Design philosophy is applied to specifically to live in circuit design, and the accuracy and high sensitivity having have application well
Value, being capable of safety that promptly and accurately guarantors live really.
Step 2: the fire alarm system of four kinds of detectable signals input is constructed using the reaction mechanism of basic DNA chain displacement
It unites the Digital Logical Circuits that double rail logic circuit output signal is Y, the logical operation state in Digital Logical Circuits uses two respectively
Binary value 0 and 1 indicates.
In Digital Logical Circuits, logical operation state is used 0 and 1 indicate respectively.If the value of two input states is all
0, otherwise it is 1 that the value of logic sum gate, which is 0,.If the value of two input states is all 1, the value of logic sum gate is 1, otherwise for
0.By using the double rail logic electricity for the fire alarm system operation that four kinds of detectable signals that no low level borrows input
Road calculates two different binary numbers.According to different input signals, output signal may be identical.In these input signals
In, A, B, C and D are the corresponding cigarette sense of fire alarm system Digital Logical Circuits, warming, light sensation and four kinds of hand reporting device spies respectively
The input of signal is surveyed, Y is the defeated of the fire alarm system Digital Logical Circuits of four kinds of detectable signals input based on DNA chain displacement
It is otherwise that no fire behavior occurs out as a result, output end value has fire if 1.I.e. the Digital Logical Circuits has and sentences
The fixed effect for whether thering is fire behavior to occur.
As shown in Figure 1, Digital Logical Circuits include four with three input with logic gate and four input signals
With logic gate, four input signals are respectively A, B, C and D, and an output signal is Y；Input signal A, B, C first is carried out and behaviour
Make operation, operation result R1It indicates；Then input signal A, B, D is carried out and arithmetic operation, operation export end value R2Table
Show；Input signal A, C, D are carried out and operation, operation result R3It indicates；Then input signal B, C and D is carried out and is operated
Operation exports end value R4It indicates；Finally by the output end value R with operation of front1、R2、R3And R4Progress and operation
Operation obtains final logical operation output result i.e. Y={ R1 With R2 With R3 With R4}。
Step 3: each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、
D0And D1, output signal Y, which exports operation result, Y0And Y1Two states are turned Digital Logical Circuits using double rail logic thought
The double rail logic circuit for turning to the four kinds of detectable signals input operation borrowed using no low level, is patrolled to carry out double track
Circuit operation operation is collected, determines whether that fire is generated according to the simulation result of the binary number exported.
In the double rail logic circuit of the fire alarm system operation of four kinds of detectable signals input based on DNA chain displacement
In, the double track of the fire alarm system operation of four kinds of detectable signals input of DNA chain displacement is devised using double track method
Logic Circuit Design and the double-deck logic circuit of realization, the use of double rail logic algorithm can be avoided the output signal of mistake,
Determining operation result can be obtained in the presence of input signal is incomplete.In conjunction with digital circuit figure building double rail logic electricity
Road, as shown in Figure 2.It is each original defeated in order to ensure the input signal of all situations can be identified in double rail logic circuit
Two input signals can be converted by entering signal, and wherein each is illustrated as logic "ON" or "off" state.Such as
Fruit input signal A cannot participate in reacting, then A1And A0State logic "ON" and logic are respectively indicated as in double rail logic circuit
"Off".In addition, should all pass through a pair of of "AND" logic gate and "or" with the logic function of door and/or door in double rail logic circuit
Logic gate is realized.According to the input signal of different conditions, the state of output signal is also different.The output knot of its output signal Y
There are two types of situations in total for fruit, i.e. output operation result is Y1And Y1 0.Specific reaction process are as follows: input signal A0、B0、C0、D0、
A1、B1、C1、D1By K2、K4、K6、K8Four and door and K1、K3、K5、K7Four or progress logical operation, four and door
Output result Q2、Q4、Q6、Q8Indicate, four or output result Q1、Q3、Q5、Q7It indicates, then exports result Q1、
Q3、Q5、Q7Using with door K9Progress and operation finally obtain output result Y0.Export result K2、K4、K6、K8Using or door
K10Progress or operation finally obtain output result Y1。
As shown in Fig. 2, double rail logic circuit includes five logical AND gates and five logic sum gates, input signal include A0、
A1、B0、B1、C0、C1、D0And D1, output signal Y0And Y1；According to the sequence of double rail logic circuit from top to bottom, from left to right,
Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、B1、C1With logical AND gate K2It is connected, input letter
Number A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1With logical AND gate K4It is connected, input signal A0、
C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With logical AND gate K6It is connected, input signal B0、C0And D0
With logic sum gate K7It is connected, input signal B1、C1And D1With logical AND gate K8It is connected；Logic sum gate K1Output result
Q1, logic sum gate K3Output result Q3, logic sum gate K5Output result Q5With logic sum gate K7Output result Q7With patrol
Volume four input signals with door K9It is connected, obtains output signal Y0；Logic sum gate K2Output result Q2, logic sum gate K4It is defeated
Result Q out4, logic sum gate K6Output result Q6With logic sum gate K8Output result Q8With the logic sum gate of four input signals
K10It is connected, obtains output signal Y1。
Example explanation:
1) when ABCD be 0101, i.e. A0=1、B1=1、C0=1、D1=1、A1=0、B0=0、C1=0、D0When=0, A0=1、B0=0、C0=1
By first logic sum gate K1Progress or operation export result Q1It indicates, i.e. Q1=[(A0=1)∨(B0=0)∨(C0=1)]=
1, A1=0、B1=1、C1=0 passes through first logical AND gate K2Progress and operation export result Q2It indicates, i.e. Q2=[(A1=0)∧
(B1=1)∧(C1=0)]=0, A0=1、B0=0、D0=0 passes through second logic sum gate K3Progress or operation export result Q3Table
Show, i.e. Q3=[(A0=1)∨(B0=0)∨(D0=0)]=1；A1=0、B1=1、D1=1 passes through second logical AND gate K4Progress and operation,
Export result Q4It indicates, i.e. Q4=[(A1=0)∧(B1=1)∧(D1=1)]=0；A0=1、C0=1、D0=0 by third logic or
Door K5Progress or operation export result Q5It indicates, i.e. Q5=[(A0=1)∨(C0=1)∨(D0=0)]=1；A1=0、C1=0、D1=1 warp
Cross third logical AND gate K6Progress and operation export result Q6It indicates, i.e. Q6=[(A1=0)∧(C1=0)∧(D1=1)]=0；
B0=0、C0=1、D0=0 passes through the 4th logic sum gate K7Progress or operation export result Q7It indicates, i.e. Q7=[(B0=0)∨(C0=
1)∨(D0=0)]=1；B1=1、C1=0、D1=1 passes through the 4th logical AND gate K8Progress and operation export result Q8It indicates, i.e.,
Q8=[(B1=1)∧(C1=0)∧(D1=1)]=0.Then result Q is exported1、Q3、Q5And Q7Carry out next stage logical AND gate K9Carry out with
Operation exports result Q9It indicates, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7=1)]=1, therefore last
Export result Y0=1.Then result Q is exported2、Q4、Q6And Q8Carry out next stage logic sum gate K10Progress or operation, output
As a result Q is used10It indicates, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8]=0, therefore last output result Y=0)1=0.By
As a result Y value is it is found that the probability of the fire alarm system fire behavior appearance of four kinds of detectable signal inputs is relatively low.
2) when ABCD be 1101, i.e. A1=1、B1=1、C0=1、D1=1、A0=0、B0=0、C1=0、D0When=0, A0=0、B0=0、C0=1
By first gate logic or door K1Progress or operation export result Q1It indicates, i.e. Q1=[(A0=0)∨(B0=0)∨(C0=1)]
=1；A1=1、B1=1、C1=0 by second gate logic and door K2Progress and operation export result Q2It indicates, i.e. Q2=[(A1=1)
∧(B1=1)∧(C1=0)]=0; A0=0、B0=0、D0=0 passes through third gate logic or door K3It carries out or operation, output result is used
Q3It indicates, i.e. Q3=[(A0=0)∨(B0=0)∨(D0=0)]=0；A1=1、B1=1、D1=1 by the 4th gate logic and door K4It carries out
With operation, result Q is exported4It indicates, i.e. Q4=[(A1=1)∧(B1=1)∧(D1=1)]=1；A0=0、C0=1、D0=0 passes through the 5th
Gate logic or door K5Progress or operation export result Q5It indicates, i.e. Q5=[(A0=0)∨(C0=1)∨(D0=0)]=1；A1=1、C1=
0、D1=1 by the 6th gate logic and door K6Progress and operation export result Q6It indicates, i.e. Q6=[(A1=1)∧(C1=0)∧
(D1=1)]=0；B0=0、C0=1、D0=0 passes through the 7th gate logic or door K7Progress or operation export result Q7It indicates, i.e. Q7=
[(B0=0)∨(C0=1)∨(D0=0)]=1；B1=1、C1=0、D1=1 by the 8th gate logic and door K8Progress and operation, output
As a result Q is used8It indicates, i.e. Q8=[(B1=1)∧(C1=0)∧(D1=1)]=0.Then result Q is exported1、Q3、Q5And Q7Carry out next stage
Logical AND gate K9Progress and operation export result Q9It indicates, i.e. Q9=[(Q1=1)∧(Q3=0)∧(Q5=1)∧(Q7=
]=0, therefore last output result Y 1)0=0.Then result Q is exported2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out
Or operation, export result Q10It indicates, i.e. Q10=[(P2=0)∨(P4=1)∨(P6=0)∨(P8=0)]=1, therefore last
Output result Y1=1.By result Y value it is found that the probability that the fire alarm system fire behavior of four kinds of detectable signal inputs occurs compares
It is high.
(3) when ABCD be 0010, i.e. A0=1、B0=1、C1=1、D0=1、A1=0、B1=0、C0=0、D1When=0, A0=1、B0=1、C0=
0 passes through first gate logic or door K1Progress or operation export result Q1It indicates, i.e. Q1=[(A0=1)∨(B0=1)∨(C0=
0)]=1；A1=0、B1=0、C1=1 by second gate logic and door K2Progress and operation export result Q2It indicates, i.e. Q2=[(A1
=0)∧(B1=0)∧(C1=1)]=0；A0=1、B0=1、D0=1 passes through third gate logic or door K3Progress or operation export result
Use Q3It indicates, i.e. Q3=[(A0=1)∨(B0=1)∨(D0=1)]=1；A1=0、B1=0、D1=0 by the 4th gate logic and door K4Into
Capable and operation exports result Q4It indicates, i.e. Q4=[(A1=0)∧(B1=0)∧(D1=0)]=0；A0=1、C0=0、D0=1 passes through the 5th
A gate logic or door K5Progress or operation export result Q5It indicates, i.e. Q5=[(A0=1)∨(C0=0)∨(D0=1)]=1；A1=0、
C1=1、D1=0 by the 6th gate logic and door K6Progress and operation export result Q6It indicates, i.e. Q6=[(A1=0)∧(C1=1)
∧(D1=0)]=0；B0=1、C0=0、D0=1 passes through the 7th gate logic or door K7Progress or operation export result Q7It indicates, i.e.,
Q7=[(B0=1)∨(C0=0)∨(D0=1)]=1；B1=0、C1=1、D1=0 by the 8th gate logic and door K8Progress and operation, it is defeated
Result Q out8It indicates, i.e. Q8=[(B1=0)∧(C1=1)∧(D1=0)]=0.Then result Q is exported1、Q3、Q5And Q7It carries out next
Grade logical AND gate K9Progress and operation export result Q9It indicates, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7
]=1, therefore last output result Y=1)0=1.Then Q2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out or operation is transported
It calculates, exports result Q10It indicates, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8]=0, therefore last output knot=0)
Fruit Y1=0.By result Y value it is found that the probability of the fire alarm system fire behavior appearance of four kinds of detectable signal inputs is relatively low.
(4) when ABCD be 0111, i.e. A0=1、B1=1、C1=1、D1=1、A1=0、B0=0、C0=0、D0When=0, A0=1、B0=0、C0=
0 passes through first gate logic or door K1Progress or operation export result Q1It indicates, i.e. Q1=[(A0=1)∨(B0=0)∨(C0=
0)]=0；A1=0、B1=1、C1=1 by second gate logic and door K2Progress and operation export result Q2It indicates, i.e. Q2=[(A1
=0)∧(B1=1)∧(C1=1)]=0；A0=1、B0=0、D0=0 passes through third gate logic or door K3Progress or operation export result
Use Q3It indicates, i.e. Q3=[(A0=1)∨(B0=0)∨(D0=0)]=1；A1=0、B1=1、D1=1 by the 4th gate logic and door K4Into
Capable and operation exports result Q4It indicates, i.e. Q4=[(A1=0)∧(B1=1)∧(D1=1)]=0；A0=1、C0=0、D0=0 passes through the 5th
A gate logic or door K5Progress or operation export result Q5It indicates, i.e. Q5=[(A0=1)∨(C0=0)∨(D0=0)]=1；A1=0、
C1=1、D1=1 by the 6th gate logic and door K6Progress and operation export result Q6It indicates, i.e. Q6=[(A1=0)∧(C1=1)
∧(D1=1)]=0；B0=0、C0=0、D0=0 passes through the 7th gate logic or door K7Progress or operation export result Q7It indicates, i.e.,
Q7=[(B0=0)∨(C0=0)∨(D0=0)]=0；B1=1、C1=1、D1=1 by the 8th gate logic and door K8Progress and operation, it is defeated
Result Q out8It indicates, i.e. Q8=[(B1=1)∧(C1=1)∧(D1=1)]=1.Then result Q is exported1、Q3、Q5And Q7It carries out next
Grade logical AND gate K9Progress and operation export result Q9It indicates, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7
]=0, therefore last output result Y=0)0=0.Then result Q is exported2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out
Or operation, export result Q10It indicates, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8=1)]=1, therefore last
Output result Y1=1.By result Y value it is found that the probability that the fire alarm system fire behavior of four kinds of detectable signal inputs occurs compares
It is high.
Step 4: the element using seesaw circuit as molecular logic circuit unit, by double rail logic electricity
Logic gate in road is converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtains
Seesaw logic circuit.
Element using seesaw circuit as molecular logic circuit unit is made of six DNA chain: input
Chain, output chain, threshold value chain, fuel chain, logic door chain and strand displacement chain.As shown in figure 3, seesaw logic gate is by input signal
Chain, output signal chain, threshold value chain and fuel chain cotransformation form.Blacken some nodes in digital representation node or strand displacement
The mark of interface, the relative concentration of the different initial DNA types of digital representation in node or on line.Each species play in door
Specific effect (for example, input signal), and there is unique title (for example, w2,5) in strand displacement.Grey lines represent
DNA chain, its 3 ' end of arrow mark, uneven color indicate different DNA sequence dnas.S2, S5 and S6 correspond to the chain of node 2,5 and 6
Long (15 nucleotide) identifies domain；S7 does not interact one for reacting, and being to maintain signal chains with other nodes in strand displacement
Cause property.T is short (5- nucleotide) fulcrum structure domain；T* is Watson-Crick complement code of T etc.；S2* is the nucleotide of 3 ' ends.
For the expression of the vivider biochemical circuit of description, two-part circular node respectively indicates each DNA logic gate,
And every line is respectively used for representing each DNA signal.Double rail logic circuit should be converted to seesaw logic circuit, and in anti-
The first stage answered.It is converted to seesaw logic circuit, it is different for the relationship being more clearly visible that between Different Logic door
Line respectively indicate different gate operations in entire seesaw logical circuitry.
Step 5: it is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1It is put respectively as difference
The input chain at gate, increases the integrated door to match before seesaw logic gate, converts seesaw for seesaw logic circuit
Biochemical logic circuit.
As shown in figure 4, a kind of fire alarm double rail logic circuit based on DNA chain displacement, including input chain A0、A1、B0、
B1、C0、C1、D0And D1, and match with input chain amplification door, integrated door, the first DNA threshold value door, the 2nd DNA threshold value door and
Export chain.Each input chain A, B, C, D have two states, indicate that the state that logic is opened is A1、B1、C1And D1, indicate logic
The state of pass is A0、B0、C0And D0；It is respectively Y that output chain, which includes two states,0And Y1；Amplifying door has an input and three
Output amplifies and is equipped with threshold value in door and has multiple fuel to export, amplifies the threshold concentration of door less than 1 n mol/L.Input signal
Total concentration be greater than threshold concentration, then obtain output signal concentration be 1n mol/L, otherwise export concentration be 0 n mol/L.Collection
Door is integrated at four inputs that door includes one output of the integrated door of three inputs and four inputs that three inputs one export, is finally led to
The relationship between expression of the first DNA threshold value door and the 2nd DNA threshold value door is crossed, end value Y is exported1And Y0.The threshold value of first DNA threshold value door
Concentration is greater than 1 n mol/L less than 1 n mol/L, the threshold concentration of the 2nd DNA threshold value door.The shape of described input chain A, B, C, D
State A0、A1、B0、B1、C0、C1、D0And D1It is connected respectively with amplification door as input signal, the output end for amplifying door passes through respectively
DNA signal inputs integrated door from different three and is connected, four three input integrated door pass through respectively a first DNA threshold value door with
One four inputs integrated door and is connected, and four, which input integrated door, obtains output signal Y by the 2nd DNA threshold value door0；Four three inputs
Integrated door passes through the integrated door of Men Yuyi four input of a 2nd DNA threshold value respectively and is connected, and four, which input integrated door, passes through first
DNA threshold value door obtains output signal Y1。
Amplify door for receiving an input signal, and is integrated into three output signals after the reaction.It is inputted in amplification door
The total concentration of signal is greater than threshold concentration, then can obtain output signal, and otherwise exporting concentration is 0 n mol/L, in order to promote
Output signal discharges completely, and the initial concentration of fuel is twice that output signal binds concentration.The threshold concentration for amplifying door is 0.2
N mol/L, the fuel concentration for amplifying door is 6 n mol/L；When the signal for inputting chain is 1, the output for amplifying the output end of door is dense
Degree is 1 n mol/L.Have the function of input 1, input 2 and input the integrated door of 3 three signals and amplify door to be opposite, collection
At door for receiving multiple input signals, and it is integrated into an output signal after the reaction.In seesaw biochemistry logic circuit
This process can be executed by threshold value door and and/or logical operation.The function of threshold value door can pass through the amplitude tune of concentration
Input signal is adjusted in section.If the total concentration of input signal is greater than threshold concentration, output signal can produce, otherwise
Output concentration is 0 n mol/L.In the present invention, in order to promote output signal to discharge completely, experimental Theoretical Design is wanted
It asks, the threshold concentration of the first DNA threshold value door is 0.6 n mol/L, and the threshold concentration of the 2nd DNA threshold value door is 2.4 n mol/L.
Output signal concentration due to integrating door is 1 n mol/L, the effect of the first DNA threshold value door be logic or effect, the
The effect of two DNA threshold value doors is the effect of logical AND.
Preferably, amplification door includes amplification door I, amplification door II, amplification door III, amplification door IV, amplification door V, amplification door
VI, amplify door VII and amplification door VIII, each amplification door includes an input terminal and three output ends.Four, which input integrated door, includes
Four, which input integrated door I and four, inputs integrated door II.Three, which input integrated door, inputs integrated door II, three including the integrated door I, three of three inputs
It inputs integrated door III, three and inputs integrated door IV, three and input integrated door V, three and input integrated door VI, three and input integrated door VII and three
Input integrated door VIII.Input chain A0It is connected with amplification door I, inputs chain A1It is connected with amplification door II, inputs chain B0With amplification door
III is connected, and inputs chain B1It is connected with amplification door IV, inputs chain C0It is connected with amplification door V, inputs chain C1With amplification door VI
It is connected, inputs chain D0It is connected with amplification door VII, inputs chain D1It is connected with amplification door VIII；First output end of amplification door I,
Amplify the first output end of door III, the first output end for amplifying door V inputs integrated door I with three and is connected, the of amplification door II
One output end, the first output end for amplifying door IV, the first output end for amplifying door VI input integrated door II with three and are connected, and put
The second output terminal at gate I, the second output terminal for amplifying door III, the first output end for amplifying door VII input integrated door III with three
It is connected, the second output terminal for amplifying door II, the second output terminal for amplifying door IV, equal three input of the first output end for amplifying door VIII
Integrated door IV is connected, the third output end for amplifying door I, the second output terminal for amplifying door V, the second output terminal for amplifying door VII
Equal three, which input integrated door V, is connected, the third output end for amplifying door II, the second output terminal for amplifying door VI, amplification door VIII the
Two output ends equal three input integrated door VI and are connected, the third output end for amplifying door III, the third output end for amplifying door V, amplification
The third output end of door VII equal three inputs integrated door VII and is connected, and third output end, the third of amplification door VI for amplifying door IV are defeated
Outlet, the third output end for amplifying door VIII equal three inputs integrated door VIII and is connected.Finally, the integrated input of door I, three of three inputs is integrated
Door III, three inputs the integrated integrated door VII of the input of door V, three and inputs integrated II phase of door by a first DNA threshold value Men Yusi respectively
Connection, four, which input integrated a 2nd DNA threshold value door of door II and, is connected, to obtain output signal Y0；Three input integrated door
II, three inputs integrate the integrated input of door VI and three of the input of door IV, three and integrate door VIII respectively by a 2nd DNA threshold value Men Yusi
It inputs integrated door I to be connected, four, which input integrated a first DNA threshold value door of door I and, is connected, to obtain output signal Y1。
The logic function of seesaw biochemistry logic circuit is identical as double rail logic circuit, when inputting chain signal is 1, amplification
Three output ends of door can obtain output signal, indicate life when the input terminal that four input integrated door is 4 n mol/L
Change reaction, output signal 1.The input terminal of first DNA threshold value door is that 3 n mol/L can obtain output signal, and reaction continues
It carries out.Each input terminal concentration of 2nd DNA threshold value door is 1n mol/L, and output concentration is 0 n mol/L, reaction terminating.
The fire alarm system Digital Logic that the present invention inputs four kinds of detectable signals of DNA chain displacement with double track thought
Circuit is first converted into double rail logic circuit, then is converted into seesaw biochemistry logic circuit by double rail logic circuit, finally obtains
Two kinds of result Y of output signal0And Y1, and verified with Visual DSD simulation software, as shown in figure 5, the result of verifying
The judgement demand for meeting fire generation, can be applied to whether analytical judgment has fire behavior.Therefore, the present invention is based on cigarette sense,
The fire alarm system double rail logic circuit design that warming, light sensation, hand reporting device four input is effective, and has very high standard
True property and sensitivity.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of fire alarm double rail logic circuit based on strand displacement, which is characterized in that including four input chains, amplification door,
Integrated door, the first DNA threshold value door, the 2nd DNA threshold value door and output chain, each input chain have two states: indicating logic
The state opened is A1、B1、C1And D1, indicate that the state that logic is closed is A0、B0、C0And D0；It is respectively Y that output chain, which includes two states,1
And Y0；Amplifying door has an input and three outputs, and the threshold concentration amplified in door is less than 1n mol/L, and integrating door includes three
The three of a one output of input input integrated door and four input the four of an output and input integrated door；First DNA threshold value door
Threshold concentration is less than 1n mol/L, and the threshold concentration of the 2nd DNA threshold value door is greater than 1n mol/L；The state A of the input chain1、
B1、C1、D1、A0、B0、C0And D0It is connected respectively with an amplification door as input signal, the output end for amplifying door passes through respectively
DNA signal inputs integrated door from different three and is connected, four three input integrated door pass through respectively a first DNA threshold value door with
One four inputs integrated door and is connected, and four, which input integrated door, obtains output signal Y by the 2nd DNA threshold value door0；Four three inputs
Integrated door passes through a 2nd DNA threshold value door respectively and is connected with another integrated door of four inputs, another integrated door of four inputs
Output signal Y is obtained by the first DNA threshold value door1；
The input chain A0It is connected with amplification door I, inputs chain A1It is connected with amplification door II, inputs chain B0With amplification III phase of door
Connection inputs chain B1It is connected with amplification door IV, inputs chain C0It is connected with amplification door V, inputs chain C1It is connected with amplification door VI
It connects, inputs chain D0It is connected with amplification door VII, inputs chain D1It is connected with amplification door VIII；Amplify the first output end, the amplification of door I
First output end of door III, the first output end for amplifying door V input integrated door I with three and are connected, and the first of amplification door II is defeated
Outlet, the first output end for amplifying door IV, the first output end for amplifying door VI input integrated door II with three and are connected, and amplify door
I second output terminal, the second output terminal for amplifying door III, the first output end for amplifying door VII input integrated door III with three and are connected
It connects, the second output terminal for amplifying door II, the second output terminal for amplifying door IV, equal three input of the first output end of amplification door VIII are integrated
Door IV is connected, the third output end for amplifying door I, the second output terminal for amplifying door V, the second output terminal equal three for amplifying door VII
It inputs integrated door V to be connected, the third output end for amplifying door II, amplifies the second defeated of door VIII at the second output terminal for amplifying door VI
Outlet equal three inputs integrated door VI and is connected, the third output end for amplifying door III, the third output end for amplifying door V, amplification door VII
Third output end equal three input integrated door VII and be connected, the third output end for amplifying door IV, the third output end for amplifying door VI,
The third output end equal three for amplifying door VIII inputs integrated door VIII and is connected；Finally, the integrated door III of the integrated input of door I, three of three inputs,
The integrated door V, three of three inputs inputs integrated door VII and is connected respectively by an integrated door II of the first DNA threshold value Men Yusi input,
Four, which input integrated a 2nd DNA threshold value door of door II and, is connected, to obtain output signal Y0；Three input integrated door II, three
The integrated door IV, three of input inputs integrated door VI and is connected respectively by an integrated door I of the 2nd DNA threshold value Men Yusi input, and four
It inputs integrated a first DNA threshold value door of door I and to be connected, to obtain output signal Y1。
2. the fire alarm double rail logic circuit according to claim 1 based on strand displacement, which is characterized in that the amplification
The initial concentration of fuel is twice that output signal binds concentration in door；The threshold concentration of amplification door is set as 0.2 n mol/L,
The fuel concentration of amplification door is set as 6 n mol/L；When the concentration for inputting chain is 1.2 n mol/L, amplify the output end of door
Output concentration be 1 n mol/L；The threshold concentration of the first DNA threshold value door is 0.6 n mol/L, the 2nd DNA threshold value door
Threshold concentration be 2.4 n mol/L.
3. the fire alarm double rail logic circuit according to claim 1 based on strand displacement, which is characterized in that its realization side
The step of method are as follows:
Step 1: not having to realize under enzyme or the room temperature of transcription mechanism in DNA chain displacement reaction, will input the terminal domains of chain with
Part signal chain reaction simultaneously carries out branch migration, until the single-stranded single-stranded substitution by the external world in double-strand next time, ultimately forms
New is single-stranded for output chain；
Step 2: the fire alarm system for constructing the input of four kinds of detectable signals using the reaction mechanism of basic DNA chain displacement is double
Rail logic circuit output signal is the Digital Logical Circuits of Y, and the logical operation state in Digital Logical Circuits uses binary system respectively
Numerical value 0 and 1 indicates；
Step 3: each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、D0With
D1, output signal Y, which exports operation result, Y0And Y1Two states are converted Digital Logical Circuits to using double rail logic thought
Using the double rail logic circuit for four kinds of detectable signals input operation that no low level borrows, thus according to designed pair
Rail logic circuit calculates two different binary number operations, it is determined whether has fire alarm signal generation；
Step 4: the element using seesaw circuit as molecular logic circuit unit, it will be in double rail logic circuit
Logic gate be converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtain lifting up
Plate logic circuit；
Step 5: it is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1Respectively as different amplification doors
Input chain, increase the integrated door to match before seesaw logic gate, by seesaw logic circuit be converted into seesaw biochemistry
Logic circuit.
4. the fire alarm double rail logic circuit according to claim 3 based on strand displacement, which is characterized in that the step
If generating new structural domain in double-strand in one, occurs and react similar reaction, and be up to dynamic equilibrium；If no
New aiming field is generated, then reaction terminates.
5. the fire alarm double rail logic circuit according to claim 3 based on strand displacement, which is characterized in that the number
Logic circuit includes five and tetra- door, A, B, C and D input signals, an output signal Y；Input signal A, B and C first into
Capable and arithmetic operation, operation result value R1It indicates；Input signal A, B and D are carried out and arithmetic operation, operation result value R2Table
Show；Input signal A, C and D are carried out and arithmetic operation, operation result value R3It indicates；Input signal B, C and D grasp with operation
Make, operation result value R4It indicates；Finally by preceding operation output valve R1、R2、R3、R4Carry out again next stage and arithmetic operation, fortune
Calculate end value is indicated with Q, obtains final logical operation output result Y, i.e. Y=Q={ R1 ∧R2 ∧ R3 ∧ R4 }。
6. the fire alarm double rail logic circuit according to claim 5 based on strand displacement, which is characterized in that believe in input
In number, A, B, C and D are that cigarette sense, warming, light sensation and the corresponding binary number input of four kinds of input signals of hand reporting device, Y are respectively
The output of the operation of the double rail logic circuit of fire generation is judged whether there is as a result, also indicated with binary number 0 and 1, it is defeated
The value of result Y has fire if 1 out, does not otherwise have fire.
7. the fire alarm double rail logic circuit according to claim 3 based on strand displacement, which is characterized in that the double track
Logic circuit includes five logical AND gates and five logic sum gates, input signal include A0、A1、B0、B1、C0、C1、D0And D1, output
Signal is Y0And Y1；Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、B1、C1With logical AND gate K2
It is connected, input signal A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1With logical AND gate K4It is connected
It connects, input signal A0、C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With logical AND gate K6It is connected, it is defeated
Enter signal B0、C0And D0With logic sum gate K7It is connected, input signal B1、C1And D1With logical AND gate K8It is connected；Logic or
Door K1、K3、K5、K7Output result with logic four input signal and door K9It is connected, obtains output signal Y0；Logic sum gate
K2、K4、K6、K8Output result with the logic sum gate K of four input signals10It is connected, obtains output signal Y1。
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| CN106027033A (en) * | 2016-05-23 | 2016-10-12 | 郑州轻工业学院 | Design method of light-activated logic circuit based on DNA double-helix structure |
| CN107395196A (en) * | 2017-08-23 | 2017-11-24 | 郑州轻工业学院 | Matrix-vector multiplication double rail logic circuit and its method based on the compound strand displacements of DNA |
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| CN106027033A (en) * | 2016-05-23 | 2016-10-12 | 郑州轻工业学院 | Design method of light-activated logic circuit based on DNA double-helix structure |
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