CN108233919A - Fire alarm double rail logic circuit and implementation method based on strand displacement - Google Patents
Fire alarm double rail logic circuit and implementation method based on strand displacement Download PDFInfo
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Abstract
The present invention proposes a kind of fire alarm double rail logic circuit and implementation method based on strand displacement, reaction mechanism based on DNA chain displacement constructs the fire alarm circuit system of four inputs, cigarette sense is built, warming, light sensation, the Digital Logical Circuits for the fire alarm circuit operation operation that hand reporting device four inputs, Digital Logical Circuits is converted to double rail logic circuit using double rail logic thought, seesaw biochemistry logic circuit is then converted by double rail logic circuit, verify that it exports result finally by Visual DSD simulation softwares, and analyze and determine whether there is fire behavior.The circuit design of the present invention is effective, and with very high accuracy and sensitivity；Basic theoretical foundation is provided for the arithmetic operation of large-scale intelligent alarm apparatus system design, the reliability of biocomputer logic circuit is improved, promotes the development of biocomputer.
Description
Technical field
Technical field more particularly to a kind of fire alarm double rail logic based on strand displacement the present invention relates to logic circuit
Circuit and implementation method.
Background technology
In current fast-developing computer age, traditional Logic Circuit Design cannot meet people's normally safety
Needs in life, such as circuitry lead to aging circuit because of complicated operation, and warning device system judges fire inaccurate
Really etc., fire problem is the big problem that current China compares attention, how could timely and accurately be judged whether there is hidden
Suffer from the presence of the direction that will be research.It is a new research field with reference to the DNA of scientific computer and molecular biosciences subject calculating.
DNA has solved the problems, such as very much, such as Hamilton path and maximal clique problem etc. as a kind of new calculating instrument.DNA
Self assembly is an important support technology of DNA nanometer technologies, has the characteristics that predictability and programmability, in application field
Both features all have good development prospect in terms of self assembly.DNA chain displacement technique is also played the part of in biological computation field
A kind of dynamic DNA nanometer technologies.DNA chain displacement technique is due to itself having a series of spontaneities, sensitivity and accurate
The characteristics of property, nano-machines, molecular logic circuit, Nano medication and other in terms of be widely used.In recent years, it is biological
Computer is by scientist extensive concern of many from different field, and molecular logic circuit is the weight of biocomputer again
Want component part.Therefore, the construction method of logic circuit plays an important role in biocomputer.
DNA calculating has been processed by a large amount of such as self assembly, fluorescent marker, strand displacement and probe machines and divides sub-operation.DNA chain
Replacement technique is grown up on the basis of DNA self-assembling techniques, so, DNA self-assembling techniques and DNA chain displacement technique are
Two big important support technologies of researching DNA nanometer technology.And DNA chain displacement technique is very suitable for building molecular logic electricity
Road, in traditional electronic logic circuit, high level and low level are typically expressed as the "true" and "false" of Boolean logic.Based on chain
The cascade reaction of replacement technique has been realized in the Dynamic link library of neighbor logic module, and extensive, multiple for researcher's structure
Miscellaneous logic circuit is possibly realized.In addition, DNA chain displacement technique is by high content information accumulation, high performance parallel computation, programming
And the advantage of emulation, in-depth study has been obtained in molecular computing, nano-machines, diagnosis and disease treatment field.DNA
Strand displacement technology also has very big research significance in terms of solving mathematical problem, management nano-machines and life course is discussed.
In addition, the structure of the biochemistry logic circuit based on DNA chain displacement also there is important research to anticipate the grasp of design program
Justice.Based on DNA chain displacement technique strategy intelligent stimuli responsive material, nanoelectronic circuits and device, biosensor and
The fields such as nanosecond medical science have great application prospect.
Invention content
In order to promote the development of biocomputer, the present invention proposes that a kind of fire alarm double track based on DNA chain displacement is patrolled
Circuit and implementation method are collected, the digital circuit of fire alarm double rail logic is first designed, then by Digital Logical Circuits double track
Logical thought structure fire alarm double rail logic circuit, double rail logic circuit is finally converted into biochemical logic circuit, is used in combination
Visual DSD simulation softwares analyze the correctness of fire alarm double rail logic circuit, with very high sensitivity and reliably
Property.
In order to achieve the above object, the technical proposal of the invention is realized in this way：A kind of fire report based on strand displacement
Alert double rail logic circuit, including four input chains, amplification door, integrated door, the first DNA threshold values door, the 2nd DNA threshold values door and output
Chain, each chain that inputs have two states：Represent that the state that logic is opened is A1、B1、C1And D1, represent that the state that logic is closed is
A0、B0、C0And D0；It is respectively Y that chain, which is exported, including two states1And Y0；Amplify door tool there are one input and three outputs, amplify door
In threshold concentration be less than 1n mol/L, integrate door include three inputs, one output the integrated door of three inputs and four inputs one
The integrated door of four inputs of a output；The threshold concentration of first DNA threshold value doors is less than 1n mol/L, the threshold value of the 2nd DNA threshold value doors
Concentration is more than 1；The state A of the input chain1、B1、C1、D1、A0、B0、C0And D0Amplify door phase with one respectively as input signal
Connection, the output terminal for amplifying door are connected respectively by DNA signals from the different integrated doors of three inputs, the integrated door of four three inputs
It is connected respectively by the integrated door of Men Yuyi four input of a first DNA threshold value, the integrated door of four inputs passes through the 2nd DNA threshold values
Door obtains output signal Y0；The integrated door of four three inputs is integrated by a 2nd DNA threshold values door and another four input respectively
Door is connected, another integrated door of four inputs obtains output signal Y by the first DNA threshold value doors1。
The input chain A0It is connected with amplification door I, input chain A1It is connected with amplification door II, input chain B0With amplifying door
III is connected, input chain B1It is connected with amplification door IV, input chain C0It is connected with amplification door V, input chain C1With amplifying door VI
It is connected, input chain D0It is connected with amplification door VII, input chain D1It is connected with amplification door VIII；First output terminal of amplification door I,
The first output terminal for amplifying door III, the first output terminal for amplifying door V are connected with the three integrated doors I of input, and the of amplification door II
One output terminal, the first output terminal for amplifying door IV, the first output terminal for amplifying door VI are connected with the three integrated doors II of input, put
The second output terminal at gate I, the second output terminal for amplifying door III, amplify the first output terminal of door VII with the integrated door III of three inputs
It is connected, the second output terminal for amplifying door II, the second output terminal for amplifying door IV, equal three input of the first output terminal for amplifying door VIII
Integrated door IV is connected, the third output terminal for amplifying door I, the second output terminal for amplifying door V, the second output terminal for amplifying door VII
The integrated door V of equal three input is connected, the third output terminal for amplifying door II, the second output terminal for amplifying door VI, amplification door VIII the
The equal integrated door VI of three inputs of two output terminals is connected, the third output terminal for amplifying door III, the third output terminal for amplifying door V, amplification
The equal integrated door VII of three inputs of third output terminal of door VII is connected, and third output terminal, the third of amplification door VI for amplifying door IV are defeated
Equal three input of third output terminal of outlet, amplification door VIII integrates door VIII and is connected；Finally, the integrated input of door I, three of three inputs is integrated
The integrated integrated door VII of the input of door V, three of III, three input of door passes through the first DNA threshold values Men Yusi inputs II phase of integrated door respectively
Connection, the integrated door II of four inputs is connected with a 2nd DNA threshold value door, so as to obtain output signal Y0；The integrated door of three inputs
IIth, the integrated integrated door VI of the input of door IV, three of three inputs is connected respectively by an integrated door I of the 2nd DNA threshold values Men Yusi inputs
It connects, the integrated door I of four inputs is connected with a first DNA threshold value door, so as to obtain output signal Y1。
The initial concentration of fuel is bound twice of concentration for output signal in the amplification door；The threshold concentration of amplification door is set
It is set to 0.2 n mol/L, the fuel concentration for amplifying door is set as 6 n mol/L；As a concentration of 1.2 n mol/L of input chain
When, amplify a concentration of 1 n mol/L of output of the output terminal of door；The threshold concentration of the first DNA threshold value doors is 0.6 n
Mol/L, the threshold concentration of the 2nd DNA threshold value doors is 2.4 n mol/L.
The step of its implementation is：
Step 1：Do not have to realize under enzyme or the room temperature of transcription mechanism in DNA chain displacement reaction, will input the terminal domains of chain with
Part signal chain reaction simultaneously carries out branch migration, until the single-stranded single-stranded substitution by the external world in double-strand next time, ultimately forms
New is single-stranded for output chain；
Step 2：The fire alarm system that four kinds of detectable signal inputs are built using the reaction mechanism of basic DNA chain displacement is double
Rail logic circuit output signal is the Digital Logical Circuits of Y, and the logical operation state in Digital Logical Circuits uses binary system respectively
Numerical value 0 and 1 represents；
Step 3：Each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、D0With
D1, output signal Y, which exports operation result, Y0And Y1Digital Logical Circuits is converted by two states using double rail logic thought
The double rail logic circuit of four kinds of detectable signals input operation borrowed using no low level, so as to according to designed pair
Rail logic circuit calculates two different binary number operations, it is determined whether has fire alarm signal generation；
Step 4：It, will be in double rail logic circuit using element of the seesaw circuit as molecular logic circuit unit
Logic gate be converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtain lifting up
Plate logic circuit；
Step 5：It is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1Respectively as different amplifications
The input chain of door, increases the integrated door to match before seesaw logic gate, and seesaw logic circuit is converted into seesaw life
Change logic electricity.
If generating new structural domain in double-strand in the step 1, the reaction similar with reacting occurs, and be up to
Dynamic equilibrium；If not generating new aiming field, reaction terminates.
The Digital Logical Circuits includes five and tetra- door, A, B, C and D input signals, an output signal Y；First
Input signal A, B and C are carried out and arithmetic operation, operation result value R1It represents；Input signal A, B and D are carried out and arithmetic operation,
Operation result value R2It represents；Input signal A, C and D are carried out and arithmetic operation, operation result value R3It represents；Input signal B, C
With D progress and arithmetic operation, operation result value R4It represents；Finally by preceding operation output valve R1、R2、R3、R4Next stage is carried out again
And arithmetic operation, operation result value represented with Q, obtain final logical operation output result Y, i.e. Y=Q={ R1 ∧R2 ∧
R3 ∧ R4 }。
In the input signal, A, B, C and D are that cigarette sense, warming, light sensation and four kinds of input signals of hand reporting device are corresponding respectively
Binary number input, Y be judge whether there is fire generation double rail logic circuit operation output as a result, also with two into
Number 0 and 1 processed represents that the value of output result Y has fire if 1, does not otherwise have fire.
The double rail logic circuit includes five logical AND gates and five logic sum gates, and input signal includes A0、A1、B0、
B1、C0、C1、D0And D1, output signal Y0And Y1；Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、
B1、C1With logical AND gate K2It is connected, input signal A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1
With logical AND gate K4It is connected, input signal A0、C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With patrolling
It collects and door K6It is connected, input signal B0、C0And D0With logic sum gate K7It is connected, input signal B1、C1And D1And logical AND
Door K8It is connected；Logic sum gate K1、K3、K5、K7Output result with four input signal of logic and door K9It is connected, obtains defeated
Go out signal Y0；Logic sum gate K2、K4、K6、K8Output result with the logic sum gate K of four input signals10It is connected, obtains defeated
Go out signal Y1。
Beneficial effects of the present invention：The number of the fire alarm system of four kinds of detectable signal inputs is constructed based on strand displacement
Digital Logical Circuits arithmetic operation is converted to the fire report of four kinds of detectable signal inputs using double rail logic thought by logic circuit
The double rail logic circuit of alert system, seesaw biochemistry logic circuit is then converted by double rail logic circuit, finally by
Visual DSD simulation softwares verify that it is exported as a result, and judging according to analysis of simulation result when four kinds of detectable signal stochastic inputs
When whether have fire behavior.Simulation result shows that the present invention realizes the double track of the fire alarm system of four kinds of detectable signal inputs
Logic circuit is effective, and with very high accurate sensitivity and reliability.The present invention is more complicated, extensive to designing in the future
Logic circuit arithmetic operation provides basic theoretical foundation, improves the reliability of biocomputer logic circuit, promotes
The development of biocomputer.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is the Digital Logical Circuits number of the fire alarm system the present invention is based on strand displacement.
Fig. 2 is the double rail logic circuit of the fire alarm system the present invention is based on strand displacement.
Fig. 3 is the abstract graph of seesaw logic gate of the present invention conversion.
Fig. 4 is the seesaw biochemistry logic circuit of the fire alarm system the present invention is based on strand displacement.
Fig. 5 exports result analogous diagram for Visual DSD Software of the present invention.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of not making the creative labor
Embodiment shall fall within the protection scope of the present invention.
A kind of the step of implementation method of fire alarm double rail logic circuit based on strand displacement is：
Step 1：DNA chain displacement reaction realizes under no enzyme or the room temperature of transcription mechanism, will input the terminal domains of chain with
Part signal chain reaction, and branch migration is carried out, until the single-stranded single-stranded substitution by the external world in double-strand next time, ultimately form
New is single-stranded for output chain.
Application of the DNA self-assembling techniques in bioengineering logic circuit is more and more extensive, and DNA chain displacement technique is originated from
DNA self-assembling techniques, due to basic double-spiral structure complementary pairing rule, a plurality of single-stranded spontaneous orderly carry out multidimensional groups of DNA
Dress.Reaction mechanism based on DNA chain displacement devises a kind of new logic circuit, including cigarette sense, warming, light sensation, hand reporting device
The fire alarm logic circuit of four kinds of input signals, the input and output logical relation of corresponding DNA strand displacement, by four kinds of detectable signals
As input terminal, fire condition generation has been indicated whether with output terminal.This reaction mechanism circuit based on DNA chain displacement
Design philosophy is applied to specifically to live in circuit design, with accuracy and high sensitivity with good application
Value, being capable of safety that promptly and accurately guarantors live really.
Step 2：The fire alarm system of four kinds of detectable signal inputs is built using the reaction mechanism of basic DNA chain displacement
It unites the Digital Logical Circuits that double rail logic circuit output signal is Y, the logical operation state in Digital Logical Circuits is respectively with two
Binary value 0 and 1 represents.
In Digital Logical Circuits, logical operation state is represented respectively with 0 and 1.If the value of two input states is all
0, the value of logic sum gate is 0, is otherwise 1.If the value of two input states, all for 1, the value of logic sum gate is 1, otherwise for
0.The double rail logic of the fire alarm system operation electricity inputted by using four kinds of detectable signals that no low level borrows
Road calculates two different binary numbers.According to different input signals, output signal may be identical.In these input signals
In, A, B, C and D are four kinds of corresponding cigarette sense of fire alarm system Digital Logical Circuits, warming, light sensation and hand reporting device spies respectively
The input of signal is surveyed, Y is the defeated of the fire alarm system Digital Logical Circuits of four kinds of detectable signals input based on DNA chain displacement
Go out as a result, export end value has fire if 1, be otherwise that no fire behavior occurs.I.e. the Digital Logical Circuits has and sentences
The fixed effect for whether thering is fire behavior to occur.
As shown in Figure 1, Digital Logical Circuits include four it is that there are three inputs with logic gate and four input signal
With logic gate, four input signals are respectively A, B, C and D, and an output signal is Y；Input signal A, B, C first is carried out and behaviour
Make operation, operation result R1It represents；Then input signal A, B, D is carried out and arithmetic operation, operation export end value R2Table
Show；Input signal A, C, D are carried out and operation, operation result R3It represents；Then input signal B, C and D is carried out and is operated
Operation, output end value R4It represents；Finally by the output end value R with operation of front1、R2、R3And R4Progress and operation
Operation obtains final logical operation output result i.e. Y={ R1 With R2 With R3 With R4}。
Step 3：Each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、
D0And D1, output signal Y, which exports operation result, Y0And Y1Two states are turned Digital Logical Circuits using double rail logic thought
The double rail logic circuit of four kinds of detectable signals input operation borrowed using no low level is turned to, is patrolled so as to carry out double track
Circuit operation operation is collected, determines whether that fire generates according to the simulation result of the binary number exported.
In the double rail logic circuit of the fire alarm system operation of four kinds of detectable signals input based on DNA chain displacement
In, using double track method devise DNA chain displacement four kinds of detectable signals input fire alarm system operation double track
Logic Circuit Design and the double-deck logic circuit of realization, the use of double rail logic algorithm can avoid the output signal of mistake,
Determining operation result can be obtained in the presence of input signal is incomplete.With reference to digital circuit figure structure double rail logic electricity
Road, as shown in Figure 2.In double rail logic circuit, it can be identified in order to ensure the input signal of all situations, it is each original defeated
Two input signals can be converted by entering signal, and wherein each is illustrated as logic "ON" or "off" state.Such as
Fruit input signal A cannot participate in reacting, then A1And A0State logic "ON" and logic are respectively indicated as in double rail logic circuit
"Off".In addition, it should all pass through a pair of of "AND" logic gate and "or" with the logic function of door and/or door in double rail logic circuit
Logic gate is realized.According to the input signal of different conditions, the state of output signal is also different.The output knot of its output signal Y
There are two types of situations in total for fruit, that is, it is Y to export operation result1And Y1 0.Specifically reaction process is：Input signal A0、B0、C0、D0、
A1、B1、C1、D1By K2、K4、K6、K8Four and door and K1、K3、K5、K7Four or progress logical operation, four and door
Output result Q2、Q4、Q6、Q8Represent, four or output result Q1、Q3、Q5、Q7It represents, then exports result Q1、
Q3、Q5、Q7Using with door K9Progress and operation finally obtain output result Y0.Export result K2、K4、K6、K8Using or door
K10Progress or operation finally obtain output result Y1。
As shown in Fig. 2, double rail logic circuit includes five logical AND gates and five logic sum gates, input signal includes A0、
A1、B0、B1、C0、C1、D0And D1, output signal Y0And Y1；According to the sequence of double rail logic circuit from top to bottom, from left to right,
Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、B1、C1With logical AND gate K2It is connected, input letter
Number A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1With logical AND gate K4It is connected, input signal A0、
C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With logical AND gate K6It is connected, input signal B0、C0And D0
With logic sum gate K7It is connected, input signal B1、C1And D1With logical AND gate K8It is connected；Logic sum gate K1Output result
Q1, logic sum gate K3Output result Q3, logic sum gate K5Output result Q5With logic sum gate K7Output result Q7With patrolling
Volume four input signals with door K9It is connected, obtains output signal Y0；Logic sum gate K2Output result Q2, logic sum gate K4It is defeated
Go out result Q4, logic sum gate K6Output result Q6With logic sum gate K8Output result Q8With the logic sum gate of four input signals
K10It is connected, obtains output signal Y1。
Example explanation：
1）When ABCD be 0101, i.e. A0=1、B1=1、C0=1、D1=1、A1=0、B0=0、C1=0、D0When=0, A0=1、B0=0、C0=1 warp
Cross first logic sum gate K1Progress or operation, output result Q1It represents, i.e. Q1=[(A0=1)∨(B0=0)∨(C0=1)]=1,
A1=0、B1=1、C1=0 passes through first logical AND gate K2Progress and operation, output result Q2It represents, i.e. Q2=[(A1=0)∧(B1=
1)∧(C1=0)]=0, A0=1、B0=0、D0=0 passes through second logic sum gate K3Progress or operation, output result Q3It represents, i.e.,
Q3=[(A0=1)∨(B0=0)∨(D0=0)]=1；A1=0、B1=1、D1=1 passes through second logical AND gate K4Progress and operation, output
As a result Q is used4It represents, i.e. Q4=[(A1=0)∧(B1=1)∧(D1=1)]=0；A0=1、C0=1、D0=0 by third logic sum gate K5
Progress or operation, output result Q5It represents, i.e. Q5=[(A0=1)∨(C0=1)∨(D0=0)]=1；A1=0、C1=0、D1=1 by the
Three logical AND gate K6Progress and operation, output result Q6It represents, i.e. Q6=[(A1=0)∧(C1=0)∧(D1=1)]=0；B0=0、
C0=1、D0=0 passes through the 4th logic sum gate K7Progress or operation, output result Q7It represents, i.e. Q7=[(B0=0)∨(C0=1)∨
(D0=0)]=1；B1=1、C1=0、D1=1 passes through the 4th logical AND gate K8Progress and operation, output result Q8It represents, i.e. Q8=
[(B1=1)∧(C1=0)∧(D1=1)]=0.Then output result Q1、Q3、Q5And Q7Carry out next stage logical AND gate K9It carries out and grasps
Make operation, output result Q9It represents, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7=1) it is]=1, therefore last defeated
Go out result Y0=1.Then output result Q2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out or operation, output is tied
Fruit Q10It represents, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8]=0, therefore last output result Y=0)1=0.By tying
Fruit Y value is it is found that the likelihood ratio of the fire alarm system fire behavior appearance of four kinds of detectable signal inputs is relatively low.
2）When ABCD be 1101, i.e. A1=1、B1=1、C0=1、D1=1、A0=0、B0=0、C1=0、D0When=0, A0=0、B0=0、C0=1
By first gate logic or door K1Progress or operation, output result Q1It represents, i.e. Q1=[(A0=0)∨(B0=0)∨(C0=1)]
=1；A1=1、B1=1、C1=0 by second gate logic and door K2Progress and operation, output result Q2It represents, i.e. Q2=[(A1=1)
∧(B1=1)∧(C1=0)]=0; A0=0、B0=0、D0=0 passes through third gate logic or door K3It carries out or operation, output result is used
Q3It represents, i.e. Q3=[(A0=0)∨(B0=0)∨(D0=0)]=0；A1=1、B1=1、D1=1 by the 4th gate logic and door K4It carries out
With operation, output result Q4It represents, i.e. Q4=[(A1=1)∧(B1=1)∧(D1=1)]=1；A0=0、C0=1、D0=0 passes through the 5th
Gate logic or door K5Progress or operation, output result Q5It represents, i.e. Q5=[(A0=0)∨(C0=1)∨(D0=0)]=1；A1=1、C1=
0、D1=1 by the 6th gate logic and door K6Progress and operation, output result Q6It represents, i.e. Q6=[(A1=1)∧(C1=0)∧
(D1=1)]=0；B0=0、C0=1、D0=0 passes through the 7th gate logic or door K7Progress or operation, output result Q7It represents, i.e. Q7=
[(B0=0)∨(C0=1)∨(D0=0)]=1；B1=1、C1=0、D1=1 by the 8th gate logic and door K8Progress and operation, output
As a result Q is used8It represents, i.e. Q8=[(B1=1)∧(C1=0)∧(D1=1)]=0.Then output result Q1、Q3、Q5And Q7Carry out next stage
Logical AND gate K9Progress and operation, output result Q9It represents, i.e. Q9=[(Q1=1)∧(Q3=0)∧(Q5=1)∧(Q7=
]=0, therefore last output result Y 1)0=0.Then output result Q2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out
Or operation, output result Q10It represents, i.e. Q10=[(P2=0)∨(P4=1)∨(P6=0)∨(P8=0) it is]=1, therefore last
Output result Y1=1.By result Y value it is found that the probability that the fire alarm system fire behavior of four kinds of detectable signal inputs occurs compares
It is high.
（3）When ABCD be 0010, i.e. A0=1、B0=1、C1=1、D0=1、A1=0、B1=0、C0=0、D1When=0, A0=1、B0=1、C0=
0 passes through first gate logic or door K1Progress or operation, output result Q1It represents, i.e. Q1=[(A0=1)∨(B0=1)∨(C0=
0)]=1；A1=0、B1=0、C1=1 by second gate logic and door K2Progress and operation, output result Q2It represents, i.e. Q2=[(A1
=0)∧(B1=0)∧(C1=1)]=0；A0=1、B0=1、D0=1 passes through third gate logic or door K3Progress or operation export result
Use Q3It represents, i.e. Q3=[(A0=1)∨(B0=1)∨(D0=1)]=1；A1=0、B1=0、D1=0 by the 4th gate logic and door K4Into
Row and operation, output result Q4It represents, i.e. Q4=[(A1=0)∧(B1=0)∧(D1=0)]=0；A0=1、C0=0、D0=1 passes through the 5th
A gate logic or door K5Progress or operation, output result Q5It represents, i.e. Q5=[(A0=1)∨(C0=0)∨(D0=1)]=1；A1=0、
C1=1、D1=0 by the 6th gate logic and door K6Progress and operation, output result Q6It represents, i.e. Q6=[(A1=0)∧(C1=1)
∧(D1=0)]=0；B0=1、C0=0、D0=1 passes through the 7th gate logic or door K7Progress or operation, output result Q7It represents, i.e.,
Q7=[(B0=1)∨(C0=0)∨(D0=1)]=1；B1=0、C1=1、D1=0 by the 8th gate logic and door K8Progress and operation, it is defeated
Go out result Q8It represents, i.e. Q8=[(B1=0)∧(C1=1)∧(D1=0)]=0.Then output result Q1、Q3、Q5And Q7It carries out next
Grade logical AND gate K9Progress and operation, output result Q9It represents, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7
]=1, therefore last output result Y=1)0=1.Then Q2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out or operation is transported
It calculates, output result Q10It represents, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8]=0, therefore last output knot=0)
Fruit Y1=0.By result Y value it is found that the likelihood ratio of the fire alarm system fire behavior appearance of four kinds of detectable signal inputs is relatively low.
（4）When ABCD be 0111, i.e. A0=1、B1=1、C1=1、D1=1、A1=0、B0=0、C0=0、D0When=0, A0=1、B0=0、C0=
0 passes through first gate logic or door K1Progress or operation, output result Q1It represents, i.e. Q1=[(A0=1)∨(B0=0)∨(C0=
0)]=0；A1=0、B1=1、C1=1 by second gate logic and door K2Progress and operation, output result Q2It represents, i.e. Q2=[(A1
=0)∧(B1=1)∧(C1=1)]=0；A0=1、B0=0、D0=0 passes through third gate logic or door K3Progress or operation export result
Use Q3It represents, i.e. Q3=[(A0=1)∨(B0=0)∨(D0=0)]=1；A1=0、B1=1、D1=1 by the 4th gate logic and door K4Into
Row and operation, output result Q4It represents, i.e. Q4=[(A1=0)∧(B1=1)∧(D1=1)]=0；A0=1、C0=0、D0=0 passes through the 5th
A gate logic or door K5Progress or operation, output result Q5It represents, i.e. Q5=[(A0=1)∨(C0=0)∨(D0=0)]=1；A1=0、
C1=1、D1=1 by the 6th gate logic and door K6Progress and operation, output result Q6It represents, i.e. Q6=[(A1=0)∧(C1=1)
∧(D1=1)]=0；B0=0、C0=0、D0=0 passes through the 7th gate logic or door K7Progress or operation, output result Q7It represents, i.e.,
Q7=[(B0=0)∨(C0=0)∨(D0=0)]=0；B1=1、C1=1、D1=1 by the 8th gate logic and door K8Progress and operation, it is defeated
Go out result Q8It represents, i.e. Q8=[(B1=1)∧(C1=1)∧(D1=1)]=1.Then output result Q1、Q3、Q5And Q7It carries out next
Grade logical AND gate K9Progress and operation, output result Q9It represents, i.e. Q9=[(Q1=1)∧(Q3=1)∧(Q5=1)∧(Q7
]=0, therefore last output result Y=0)0=0.Then output result Q2、Q4、Q6And Q8Carry out next stage logic sum gate K10It carries out
Or operation, output result Q10It represents, i.e. Q10=[(P2=0)∨(P4=0)∨(P6=0)∨(P8=1) it is]=1, therefore last
Output result Y1=1.By result Y value it is found that the probability that the fire alarm system fire behavior of four kinds of detectable signal inputs occurs compares
It is high.
Step 4：Using element of the seesaw circuit as molecular logic circuit unit, by double rail logic electricity
Logic gate in road is converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtains
Seesaw logic circuit.
Using element of the seesaw circuit as molecular logic circuit unit, it is made of six DNA chain：Input
Chain, output chain, threshold value chain, fuel chain, logic door chain and strand displacement chain.As shown in figure 3, seesaw logic gate is by input signal
Chain, output signal chain, threshold value chain and fuel chain cotransformation form.Blacken some nodes in digital representation node or strand displacement
The mark of interface, the relative concentration of the different initial DNA types of digital representation in node or on line.Each species play in door
Specific effect（For example, input signal）, and there is unique title in strand displacement（For example, w2,5）.Grey lines represent
DNA chain, its 3 ' end of arrow mark, uneven color represent different DNA sequence dnas.S2, S5 and S6 correspond to the chain of node 2,5 and 6
It is long（15 nucleotide）Identify domain；S7 is not interacted with other nodes in strand displacement to react, and is to maintain the one of signal chains
Cause property.T is short（5- nucleotide）Fulcrum structure domain；T* is Watson-Crick complement codes of T etc.；S2* is the nucleotide of 3 ' ends.
For the expression of the vivider biochemical circuit of description, two-part circular node represents each DNA logic gates respectively,
And every line is respectively used for representing each DNA signals.Double rail logic circuit should be converted to seesaw logic circuit, and in anti-
The first stage answered.Seesaw logic circuit is converted to, it is different for the relationship being more clearly visible that between Different Logic door
Line represent different gate operations respectively in entire seesaw logical circuitry.
Step 5：It is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1It is put respectively as difference
The input chain at gate, increases the integrated door to match before seesaw logic gate, and seesaw logic circuit is converted into seesaw
Biochemical logic circuit.
As shown in figure 4, a kind of fire alarm double rail logic circuit based on DNA chain displacement, including inputting chain A0、A1、B0、
B1、C0、C1、D0And D1And match with input chain amplification door, integrated door, the first DNA threshold values door, the 2nd DNA threshold values door and
Export chain.Each input chain A, B, C, D have two states, represent that the state that logic is opened is A1、B1、C1And D1, represent logic
The state of pass is A0、B0、C0And D0；It is respectively Y that chain, which is exported, including two states0And Y1；Amplifying door tool, there are one input and three
Output amplifies and threshold value is equipped in door and has multiple fuel to export, and the threshold concentration for amplifying door is less than 1 n mol/L.Input signal
Total concentration be more than threshold concentration, then obtain a concentration of 1n mol/L of output signal, otherwise export a concentration of 0 n mol/L.Collection
Include the integrated door of four inputs of one output of the integrated door of three inputs and four inputs of three inputs, one output into door, finally lead to
Cross the relationship between expression of the first DNA threshold values door and the 2nd DNA threshold value doors, output end value Y1And Y0.The threshold value of first DNA threshold value doors
Concentration is less than 1 n mol/L, and the threshold concentration of the 2nd DNA threshold value doors is more than 1 n mol/L.The shape of described input chain A, B, C, D
State A0、A1、B0、B1、C0、C1、D0And D1It is connected respectively with amplification door as input signal, the output terminal for amplifying door passes through respectively
DNA signals are connected from the different integrated doors of three inputs, the integrated door of four three inputs respectively by a first DNA threshold values door with
The integrated door of one four input is connected, and the integrated door of four inputs obtains output signal Y by the 2nd DNA threshold value doors0；Four three inputs
Integrated door is connected respectively by the integrated door of Men Yuyi four input of a 2nd DNA threshold value, and the integrated door of four inputs passes through first
DNA threshold value doors obtain output signal Y1。
Amplify door for receiving an input signal, and be integrated into three output signals after the reaction.It is inputted in amplification door
The total concentration of signal is more than threshold concentration, then can obtain output signal, a concentration of 0 n mol/L otherwise be exported, in order to promote
Output signal discharges completely, and the initial concentration of fuel is bound twice of concentration for output signal.The threshold concentration for amplifying door is 0.2
N mol/L, the fuel concentration for amplifying door are 6 n mol/L；When the signal for inputting chain is 1, the output for amplifying the output terminal of door is dense
It spends for 1 n mol/L.It is opposite, collection to have the function of input 1, input 2 and input the integrated door of 3 three signals and amplification door
It is used to receive multiple input signal, and be integrated into after the reaction in an output signal into door.In seesaw biochemistry logic circuit
This process can by threshold value door come perform with and/or logical operation.The function of threshold value door can pass through the amplitude tune of concentration
Input signal is adjusted in section.If the total concentration of input signal is more than threshold concentration, output signal can be generated, otherwise
Export a concentration of 0 n mol/L.In the present invention, in order to which output signal is promoted to discharge completely, experimental Theoretical Design will
It asks, the threshold concentration of the first DNA threshold value doors is 0.6 n mol/L, and the threshold concentration of the 2nd DNA threshold value doors is 2.4 n mol/L.
Due to integrating a concentration of 1 n mol/L of output signal of door, the first DNA threshold value doors act as logic or effect, the
The effect for acting as logical AND of two DNA threshold value doors.
Preferably, amplification door includes amplification door I, amplification door II, amplification door III, amplification door IV, amplification door V, amplification door
VIth, amplify door VII and amplification door VIII, each door that amplifies includes an input terminal and three output terminals.The integrated door of four inputs includes
The integrated integrated door II of the input of door I and four of four inputs.The integrated door of three inputs includes the integrated integrated door II, three of the input of door I, three of three inputs
The integrated integrated door VII and three of the input of door VI, three of the integrated input of door V, three of the integrated input of door IV, three of the integrated input of door III, three of input
The integrated door VIII of input.Input chain A0It is connected with amplification door I, input chain A1It is connected with amplification door II, input chain B0With amplifying door
III is connected, input chain B1It is connected with amplification door IV, input chain C0It is connected with amplification door V, input chain C1With amplifying door VI
It is connected, input chain D0It is connected with amplification door VII, input chain D1It is connected with amplification door VIII；First output terminal of amplification door I,
The first output terminal for amplifying door III, the first output terminal for amplifying door V are connected with the three integrated doors I of input, and the of amplification door II
One output terminal, the first output terminal for amplifying door IV, the first output terminal for amplifying door VI are connected with the three integrated doors II of input, put
The second output terminal at gate I, the second output terminal for amplifying door III, amplify the first output terminal of door VII with the integrated door III of three inputs
It is connected, the second output terminal for amplifying door II, the second output terminal for amplifying door IV, equal three input of the first output terminal for amplifying door VIII
Integrated door IV is connected, the third output terminal for amplifying door I, the second output terminal for amplifying door V, the second output terminal for amplifying door VII
The integrated door V of equal three input is connected, the third output terminal for amplifying door II, the second output terminal for amplifying door VI, amplification door VIII the
The equal integrated door VI of three inputs of two output terminals is connected, the third output terminal for amplifying door III, the third output terminal for amplifying door V, amplification
The equal integrated door VII of three inputs of third output terminal of door VII is connected, and third output terminal, the third of amplification door VI for amplifying door IV are defeated
Equal three input of third output terminal of outlet, amplification door VIII integrates door VIII and is connected.Finally, the integrated input of door I, three of three inputs is integrated
The integrated integrated door VII of the input of door V, three of III, three input of door passes through the first DNA threshold values Men Yusi inputs II phase of integrated door respectively
Connection, the integrated door II of four inputs is connected with a 2nd DNA threshold value door, so as to obtain output signal Y0；The integrated door of three inputs
IIth, the integrated integrated door VIII of the input of door VI and three of the integrated input of door IV, three of three inputs passes through a 2nd DNA threshold values Men Yusi respectively
The integrated door I of input is connected, and the integrated door I of four inputs is connected with a first DNA threshold value door, so as to obtain output signal Y1。
The logic function of seesaw biochemistry logic circuit is identical with double rail logic circuit, when it is 1 to input chain signal, amplification
Three output terminals of door can obtain output signal, and life is indicated when the input terminal of the integrated door of four inputs is 4 n mol/L
Change reaction, output signal 1.The input terminal of first DNA threshold value doors can obtain output signal for 3 n mol/L, and reaction continues
It carries out.Each input terminal concentration of 2nd DNA threshold value doors is 1n mol/L, exports a concentration of 0 n mol/L, reaction terminating.
The fire alarm system Digital Logic that the present invention inputs four kinds of detectable signals of DNA chain displacement with double track thought
Circuit is first converted into double rail logic circuit, then is converted into seesaw biochemistry logic circuit by double rail logic circuit, finally obtains
Two kinds of result Y of output signal0And Y1, and verified with Visual DSD simulation softwares, as shown in figure 5, the result of verification
Meet the judgement demand of fire generation, can be applied to whether analytical judgment has fire behavior.Therefore, the present invention is based on cigarette sense,
The fire alarm system double rail logic circuit design that warming, light sensation, hand reporting device four input is effective, and with very high standard
True property and sensitivity.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (8)
1. a kind of fire alarm double rail logic circuit based on strand displacement, which is characterized in that including four input chains, amplification door,
Integrated door, the first DNA threshold values door, the 2nd DNA threshold values door and output chain, each chain that inputs have two states：Represent logic
The state opened is A1、B1、C1And D1, represent that the state that logic is closed is A0、B0、C0And D0；It is respectively Y that chain, which is exported, including two states1
And Y0；Amplify door tool there are one input and three outputs, the threshold concentration amplified in door is less than 1n mol/L, integrates door and includes three
The integrated door of four inputs of one output of the integrated door of three inputs and four inputs of a one output of input；First DNA threshold value doors
Threshold concentration is less than 1n mol/L, and the threshold concentration of the 2nd DNA threshold value doors is more than 1n mol/L；The state A of the input chain1、
B1、C1、D1、A0、B0、C0And D0It is connected respectively with an amplification door as input signal, the output terminal for amplifying door passes through respectively
DNA signals are connected from the different integrated doors of three inputs, the integrated door of four three inputs respectively by a first DNA threshold values door with
The integrated door of one four input is connected, and the integrated door of four inputs obtains output signal Y by the 2nd DNA threshold value doors0；Four three inputs
Integrated door is connected respectively by a 2nd DNA threshold values door with another integrated door of four inputs, another integrated door of four inputs
Output signal Y is obtained by the first DNA threshold value doors1。
2. the fire alarm double rail logic circuit according to claim 1 based on strand displacement, which is characterized in that the input
Chain A0It is connected with amplification door I, input chain A1It is connected with amplification door II, input chain B0It is connected with amplification door III, input chain B1
It is connected with amplification door IV, input chain C0It is connected with amplification door V, input chain C1It is connected with amplification door VI, input chain D0With
Amplification door VII is connected, input chain D1It is connected with amplification door VIII；Amplify the first output terminal of door I, amplify the first defeated of door III
Outlet, the first output terminal for amplifying door V are connected with the three integrated doors I of input, amplify the first output terminal, the amplification door of door II
IV the first output terminal, the first output terminal of amplification door VI are connected with the integrated door II of three inputs, the second output of amplification door I
It holds, the first output terminal of the second output terminal of amplification door III, amplification door VII is connected with the integrated door III of three inputs, amplification door II
Second output terminal, the second output terminal for amplifying door IV, the integrated door IV of equal three input of the first output terminal that amplifies door VIII be connected,
The third output terminal for amplifying door I, the second output terminal for amplifying door V, the equal integrated door V of three inputs of second output terminal for amplifying door VII
It is connected, the third output terminal for amplifying door II, the second output terminal for amplifying door VI, equal three input of second output terminal for amplifying door VIII
Integrated door VI is connected, the third output terminal for amplifying door III, the third output terminal for amplifying door V, the third output terminal for amplifying door VII
The integrated door VII of equal three input is connected, the third output terminal for amplifying door IV, the third output terminal for amplifying door VI, amplification door VIII the
The equal integrated door VIII of three inputs of three output terminals is connected；Finally, the integrated integrated door of the input of door III, three of the integrated input of door I, three of three inputs
Vth, the integrated door VII of three inputs is connected respectively by an integrated door II of the first DNA threshold values Men Yusi inputs, the integrated door of four inputs
II is connected with a 2nd DNA threshold value door, so as to obtain output signal Y0；The integrated door IV of the integrated input of door II, three of three inputs,
The three integrated doors VI of input are connected respectively by an integrated door I of the 2nd DNA threshold values Men Yusi inputs, the integrated door I of four inputs with
One the first DNA threshold value door is connected, so as to obtain output signal Y1。
3. the fire alarm double rail logic circuit according to claim 1 based on strand displacement, which is characterized in that the amplification
The initial concentration of fuel is bound twice of concentration for output signal in door；The threshold concentration of amplification door is set as 0.2 n mol/L,
The fuel concentration of amplification door is set as 6 n mol/L；As a concentration of 1.2 n mol/L for inputting chain, amplify the output terminal of door
A concentration of 1 n mol/L of output；The threshold concentration of the first DNA threshold value doors be 0.6 n mol/L, the 2nd DNA threshold value doors
Threshold concentration be 2.4 n mol/L.
4. the fire alarm double rail logic circuit according to claim 1 or 2 based on strand displacement, which is characterized in that in fact
Now the step of method is：
Step 1：Do not have to realize under enzyme or the room temperature of transcription mechanism in DNA chain displacement reaction, will input the terminal domains of chain with
Part signal chain reaction simultaneously carries out branch migration, until the single-stranded single-stranded substitution by the external world in double-strand next time, ultimately forms
New is single-stranded for output chain；
Step 2：The fire alarm system that four kinds of detectable signal inputs are built using the reaction mechanism of basic DNA chain displacement is double
Rail logic circuit output signal is the Digital Logical Circuits of Y, and the logical operation state in Digital Logical Circuits uses binary system respectively
Numerical value 0 and 1 represents；
Step 3：Each input signal is converted into the opposite input signal A of two states0And A1、B0And B1、C0And C1、D0With
D1, output signal Y, which exports operation result, Y0And Y1Digital Logical Circuits is converted by two states using double rail logic thought
The double rail logic circuit of four kinds of detectable signals input operation borrowed using no low level, so as to according to designed pair
Rail logic circuit calculates two different binary number operations, it is determined whether has fire alarm signal generation；
Step 4：It, will be in double rail logic circuit using element of the seesaw circuit as molecular logic circuit unit
Logic gate be converted into the seesaw logic gate for having input signal chain, output signal chain, threshold value chain and fuel chain, obtain lifting up
Plate logic circuit；
Step 5：It is reacted based on DNA chain displacement by input signal A0、A1、B0、B1、C0、C1、D0And D1Respectively as different amplification doors
Input chain, increase the integrated door to match before seesaw logic gate, by seesaw logic circuit be converted into seesaw biochemistry
Logic electricity.
5. the fire alarm double rail logic circuit according to claim 4 based on strand displacement, which is characterized in that the step
If generating new structural domain in double-strand in one, the reaction similar with reacting occurs, and be up to dynamic equilibrium；If no
New aiming field is generated, then reaction terminates.
6. the fire alarm double rail logic circuit according to claim 4 based on strand displacement, which is characterized in that the number
Logic circuit includes five and tetra- door, A, B, C and D input signals, an output signal Y；Input signal A, B and C first into
Row and arithmetic operation, operation result value R1It represents；Input signal A, B and D are carried out and arithmetic operation, operation result value R2Table
Show；Input signal A, C and D are carried out and arithmetic operation, operation result value R3It represents；Input signal B, C and D grasped with operation
Make, operation result value R4It represents；Finally by preceding operation output valve R1、R2、R3、R4Carry out again next stage and arithmetic operation, fortune
It calculates end value to be represented with Q, obtains final logical operation output result Y, i.e. Y=Q={ R1 ∧R2 ∧ R3 ∧ R4 }。
7. the fire alarm double rail logic circuit according to claim 6 based on strand displacement, which is characterized in that believe in input
In number, A, B, C and D are that cigarette sense, warming, light sensation and the corresponding binary number input of four kinds of input signals of hand reporting device, Y are respectively
The output of the operation of the double rail logic circuit of fire generation is judged whether there is as a result, also being represented with binary number 0 and 1, it is defeated
The value for going out result Y has fire if 1, does not otherwise have fire.
8. the fire alarm double rail logic circuit according to claim 4 based on strand displacement, which is characterized in that the double track
Logic circuit includes five logical AND gates and five logic sum gates, and input signal includes A0、A1、B0、B1、C0、C1、D0And D1, output
Signal is Y0And Y1；Input signal A0、B0、C0With logic sum gate K1It is connected, input signal A1、B1、C1With logical AND gate K2
It is connected, input signal A0、B0、D0With logic sum gate K3It is connected, input signal A1、B1、D1With logical AND gate K4It is connected
It connects, input signal A0、C0、D0With logic sum gate K5It is connected, input signal A1、C1、D1With logical AND gate K6It is connected, it is defeated
Enter signal B0、C0And D0With logic sum gate K7It is connected, input signal B1、C1And D1With logical AND gate K8It is connected；Logic or
Door K1、K3、K5、K7Output result with four input signal of logic and door K9It is connected, obtains output signal Y0；Logic sum gate
K2、K4、K6、K8Output result with the logic sum gate K of four input signals10It is connected, obtains output signal Y1。
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