CN108211934A - One kind has mixing functional reagent box - Google Patents
One kind has mixing functional reagent box Download PDFInfo
- Publication number
- CN108211934A CN108211934A CN201711225426.7A CN201711225426A CN108211934A CN 108211934 A CN108211934 A CN 108211934A CN 201711225426 A CN201711225426 A CN 201711225426A CN 108211934 A CN108211934 A CN 108211934A
- Authority
- CN
- China
- Prior art keywords
- reagent
- tubular container
- reagent box
- mixing
- box body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
- B01F29/32—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor
- B01F29/321—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor of test-tubes or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
- B01F29/31—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles the containers being supported by driving means, e.g. by rotating rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/40—Parts or components, e.g. receptacles, feeding or discharging means
- B01F29/401—Receptacles, e.g. provided with liners
- B01F29/402—Receptacles, e.g. provided with liners characterised by the relative disposition or configuration of the interior of the receptacles
- B01F29/4022—Configuration of the interior
- B01F29/40221—Configuration of the interior provided with baffles, plates or bars on the wall or the bottom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/80—Mixers with rotating receptacles rotating about a substantially vertical axis
- B01F29/82—Mixers with rotating receptacles rotating about a substantially vertical axis the receptacle comprising a rotary part, e.g. the bottom, and a stationary part, e.g. the wall, with optional use of a stirrer; the receptacle comprising parts moving in opposite directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
It is open a kind of with mixing functional reagent box the present invention relates to kit technical field, including reagent box body and tubular container；The reagent box body separates for five, and reagent box body can agree with reagent rotor separation, and one of compartment is through-hole, for assembling tubular container, it is characterised in that：The spoiler in rotating flow direction is provided perpendicular on the inner wall of the tubular container, the tangential direction of the spoiler and the axis direction of tubular container are in 0~90 ° of angle.Blending manner of the present invention is easy, and reagent is at any time in mixing state, and be avoided that cross contamination between reagent.
Description
Technical field
The present invention relates to kit technical fields, more specifically, more particularly to a kind of to have mixing functional reagent box.
Background technology
Immuno magnetic cell separation technology is to be combined the high degree of specificity of immunological response with the distinctive magnetic responsiveness of magnetic bead
A kind of immunological technique, core are in antibody of the magnetic bead surfaces coating with immunologic specificity, carry out antigen-antibody and combine instead
Should, label cell is made to be combined with magnetic bead.The cell for combining magnetic bead is placed under powerful magnetic field, is not combined with other thin
Born of the same parents divide group, and magnetism disappears immediately after having the magnetic bead disengaging magnetic field of superpower paramagnetic field, can screen or remove by this method label
Cell.To ensure the quality of antigen-antibody reaction, before magnetic bead reagent is extracted, it need to ensure that immunomagnetic beads are in complete mixing shape
State, existing market sell analytical instrument and mainly take following several method to magnetic bead mixing：
（1）Mechanical agitation mixing.Mixing reagent is treated with mix rod agitation kit, this process needs a set of individually scalable
The mixing arm of rotation, and need to clean stirring rod, to avoid cross contamination between reagent.
（2）Shake table mixing.It treats a shake table to be installed, but shake table is complicated at mixing position in reagent, and
It easily malfunctions in practice.
（3）Ultrasonic mixing.Install ultrasonic generator additional on reagent needle, before drawing reagent, using ultrasound to reagent into
Row mixing is both needed to carry out mixing before each use, than relatively time-consuming and it cannot be guaranteed that efficiency.
（4）Suction nozzle mixing.With the special reagent needle for installing suction nozzle additional, inhale to put repeatedly and treat mixing reagent, abundant mixing.The mixing
Method needs to consume more disposable tip to avoid cross contamination between reagent.
More than mixing method is respectively provided with certain advantage and disadvantage, it is still desirable to and it is a kind of simpler convenient, it can avoid between reagent
The mode of cross contamination.
Invention content
It is an object of the invention to solve the above problem of prior art appearance, provide a kind of with mixing functional reagent
Box.
One kind has mixing functional reagent box, including reagent box body and tubular container.The reagent box body is five points
Every reagent box body can agree with reagent rotor separation, and one of compartment is through-hole, for assembling tubular container.It is described
It is provided perpendicular to the spoiler in rotating flow direction on the inner wall of tubular container, the tangential direction of the spoiler and tubular container
Axis direction is in 0~90 ° of angle.Spoiler can make reagent reach better mixed effect.
Further, centrum is equipped in the middle part of the lower end of tubular container, which is integrally formed on tubular container, with into one
Step reduces the rotational resistance of tubular container.
Compared with prior art, blending manner of the present invention is easy, reagent at any time in mixing state, and be avoided that reagent it
Between cross contamination.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is kit bulk junction composition of the present invention；
Fig. 2 is tubular container structure chart of the present invention；
Fig. 3 is spoiler diagrammatic cross-section of the present invention；
Fig. 4 is the general construction schematic diagram of mixing mechanism of the present invention.
Specific embodiment
The preferred embodiment of the present invention is described in detail below in conjunction with the accompanying drawings, so that advantages and features of the invention energy
It is easier to be readily appreciated by one skilled in the art, so as to make a clearer definition of the protection scope of the present invention.
The structure diagram of the present invention is as shown in Figure 1.One kind has mixing functional reagent box, including reagent box body and pipe
Shape container.The reagent box body separates for five, and reagent box body can agree with reagent rotor separation, and one of compartment is
Through-hole, for assembling tubular container.The spoiler in rotating flow direction is provided perpendicular on the inner wall of the tubular container, this is disturbed
The tangential direction of flowing plate and the axis direction of tubular container are in 0~90 ° of angle.Spoiler can make reagent reach preferably mixed
Even effect.
Further, centrum is equipped in the middle part of the lower end of tubular container, which is integrally formed on tubular container, with into one
Step reduces the rotational resistance of tubular container.
Reagent cartridge configuration described in the present embodiment mainly includes reagent box body and tubular container.Reagent box body is according to hair
Reagent situation needed for light immunoassay and kit test volume separate situation with reference to reagent rotor, design five separations.Ontology has
There is larger capacity, reagent rotor separation can be agreed with, convenient for placing fixed reagent box body.One of compartment is logical
Hole, for assembling tubular container.Kit body construction, is shown in Fig. 1.
Being placed in independent tubular container needs the magnetic bead reagent of mixing, and tubular container is driven around certainly by the rotation of reagent rotor
Body axle center rotates, and interior reagent is made to generate centrifugal movement, by the abundant mixing of reagent.Several plectrums and tubulose on reagent rotor
The type gear shape plectrum engagement set on container, when reagent rotor rotates, plectrum stirs the plectrum of tubular container on disk body, completes
Transmission.Tubular container structure, is shown in Fig. 2.
The spoiler in rotating flow direction is provided perpendicular on the inner wall of tubular container, spoiler can reach reagent
Better mixed effect.Spoiler can be the axis of single or multiple spirals/straight panel shape, tangential direction and tubular container
Direction is in 0~90 ° of angle.Spoiler cross-section structure, is shown in Fig. 3.
Centrum is equipped in the middle part of the lower end of tubular container, which is integrally formed on tubular container, to be further reduced pipe
The rotational resistance of shape container.This design principle be：As long as reduce the contact area of tubular container and evenly mixing device, so that it may reduce
The rotational resistance of tubular container.With designing little groove on the corresponding position at tubular container tip on reagent disc, it can cause tubulose
Container rotation is more stable.
The general construction schematic diagram of the mixing mechanism, is shown in Fig. 4.Reagent disc is multi-turn reagent disc, respectively by different driving horses
It is rotated up to driving.Reagent disc is placed in agent bin, and agent bin is made of warehouse and warehouse lid, and warehouse lid part corresponds to tubular container
Plectrum is provided on position, this is the driving link in the mixing structure.
Tubular container is nested in the through-hole of reagent box body, forms test kit.Kit is placed on reagent rotor
When middle, the plectrum on tubular container covers plectrum with agent bin and engages.When drive motor drives reagent rotor rotation, tubulose holds
Device follows kit around reagent rotor axis rotation, while the plectrum on tubular container is engaged with the plectrum that agent bin covers, pipe
Shape container is driven to be rotated around Pivot Point Center, so as to which the magnetic bead reagent of all kits in reagent rotor be made to be in ready-to-use
Suspended state.
Mixing method includes the following steps：1. reagent is positioned in tubular container, and tubular container is installed on reagent
In box body；2. kit is installed in the mounting groove of reagent disc；3. driver drives reagent disc to any direction
Rotate a circle, then in the same direction or reversely kit is rotated to nearest absorption position.
Although being described in conjunction with the accompanying embodiments of the present invention, patent owner can be in appended claims
Within the scope of make various deformations or amendments, as long as no more than the present invention the described protection domain of claim, all should
Within protection scope of the present invention.
Claims (2)
1. one kind has mixing functional reagent box, including reagent box body and tubular container；The reagent box body separates for five,
Reagent box body can agree with reagent rotor separation, and one of compartment is through-hole, and for assembling tubular container, feature exists
In：The spoiler in rotating flow direction, the tangential direction and pipe of the spoiler are provided perpendicular on the inner wall of the tubular container
The axis direction of shape container is in 0~90 ° of angle.
2. kit according to claim 1, it is characterised in that：Centrum is equipped in the middle part of the lower end of the tubular container, it should
Centrum is integrally formed on tubular container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711225426.7A CN108211934A (en) | 2017-11-29 | 2017-11-29 | One kind has mixing functional reagent box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711225426.7A CN108211934A (en) | 2017-11-29 | 2017-11-29 | One kind has mixing functional reagent box |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108211934A true CN108211934A (en) | 2018-06-29 |
Family
ID=62653584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711225426.7A Withdrawn CN108211934A (en) | 2017-11-29 | 2017-11-29 | One kind has mixing functional reagent box |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108211934A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117470741A (en) * | 2023-12-27 | 2024-01-30 | 深圳市和来生物技术有限公司 | Kit for blood cell analysis and blood cell analyzer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857879A (en) * | 2015-06-04 | 2015-08-26 | 海尔施生物医药股份有限公司 | Kit with uniform mixing function and information reading method |
| CN204768452U (en) * | 2015-06-04 | 2015-11-18 | 海尔施生物医药股份有限公司 | Take kit of mixing function |
-
2017
- 2017-11-29 CN CN201711225426.7A patent/CN108211934A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857879A (en) * | 2015-06-04 | 2015-08-26 | 海尔施生物医药股份有限公司 | Kit with uniform mixing function and information reading method |
| CN204768452U (en) * | 2015-06-04 | 2015-11-18 | 海尔施生物医药股份有限公司 | Take kit of mixing function |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117470741A (en) * | 2023-12-27 | 2024-01-30 | 深圳市和来生物技术有限公司 | Kit for blood cell analysis and blood cell analyzer |
| CN117470741B (en) * | 2023-12-27 | 2024-04-05 | 深圳市和来生物技术有限公司 | Kit for blood cell analysis and blood cell analyzer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180629 |
|
| WW01 | Invention patent application withdrawn after publication |