CN108210735A - A kind of antitumor particle of the tongue grass tuber of multiflower knotweed - Google Patents

A kind of antitumor particle of the tongue grass tuber of multiflower knotweed Download PDF

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CN108210735A
CN108210735A CN201810070847.5A CN201810070847A CN108210735A CN 108210735 A CN108210735 A CN 108210735A CN 201810070847 A CN201810070847 A CN 201810070847A CN 108210735 A CN108210735 A CN 108210735A
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multiflower knotweed
particle
tongue grass
tuber
mouse
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高峰
卫培峰
欧莉
李敏
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Shaanxi University of Chinese Medicine
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Shaanxi University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Abstract

The invention discloses a kind of antitumor particles of the tongue grass tuber of multiflower knotweed, are prepared from the following materials：Oldenlandia diffusa 20g, fleece-flower root 15g, Radix Astragali 30g, edible tulip 15g, Paris polyphylla 10g, Radix Codonopsis 20g, Poria cocos 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Angelicae Sinensis 15g, fruit of glossy privet 15g, honey-fried licorice root 10g.The method can significantly improve the phagocytic activity that suppressed mouse phagocyte is immunized；The WBC and PLT that immune suppressed rat can be significantly improved are horizontal；The formation of normal mouse hemolysin, periphery blood T cell percentage and Function of lymphocyte transform can be obviously promoted.

Description

A kind of antitumor particle of the tongue grass tuber of multiflower knotweed
Technical field
The present invention relates to field of traditional Chinese, and in particular to a kind of antitumor particle of the tongue grass tuber of multiflower knotweed.
Background technology
Tumour has become one of lethal important arch-criminal of global disease, the disease of serious threat human health and social development Disease.According to statistics, just there are 173 people in every 100,000 people of the new tumor patient in the whole world, there are 110 people in every 100,000 people of China.Current China Cancer morbidity, the death rate are in sustainable growth trend.More severe, this impetus is not contained effectively.Third Secondary national residents cause of death investigation result shows that the tumor mortality composition of urban and rural residents of China is changing, with ring In apparent ascendant trend, tumour is prevented for the related lung cancer of border, life style, liver cancer, colorectal cancer, breast cancer, bladder mortality of carcinoma The situation is tense for control, it has also become a public health problem that must pay much attention to or even social concern.
There are many means for treatment of the doctor trained in Western medicine to tumour at present：(1) operative treatment；But it easily recurs and is not easy prognosis.(2) The shortcomings of chemotherapy, the liver function with damage big with side effect.(3) radiotherapy；It is more steady to be adapted to the cancer state of an illness It is fixed, it is no to shift, and without other complication patient.(4) biological therapy；Some biological response modifiers can enhance disease The resistance of people achievees the purpose that killing and inhibition cancer cell, can with chemotherapy combined application, although biological therapy significant effect And toxic side effect is small, but does not indicate that it is suitble to all cancer patients, such as：It is cachexia caused by advanced liver cancer tumour, outer All too low patients of blood picture, organ transplantation person, AIDS patient, uncontrollable severe infections person etc..Although all polytherapies of doctor trained in Western medicine The effects that tumor patient there is control progression of the disease, alleviate symptom, but often to body's immunity while treatment Apparent influence is generated, inhibits also to have damaged body autoimmunity cell function while tumour, thus causes patient and is immunized Power declines, and the probability of accompanying infection greatly increases.
In contrast, have now been found that traditional Chinese medicine for treating tumour with some superiority in clinic, often can sample it is simultaneous Control, especially with after doctor trained in Western medicine chemicotherapy method fit applications, it is antitumor, mitigate chemicotherapy caused by body damage, improve machine Body immunity function and aspect curative effect are ideal, have many advantages, such as good effect, few side effects, therefore research and develop to have and assist The Chinese medicine for treating tumour is necessary.
Invention content
To solve the above problems, the present invention provides a kind of antitumor particle of the tongue grass tuber of multiflower knotweed, can significantly improve immune suppressed The phagocytic activity of mouse phagocyte；The WBC and PLT that immune suppressed rat can be significantly improved are horizontal；It can be obviously promoted normal small The formation of mouse hemolysin, periphery blood T cell percentage and Function of lymphocyte transform.
To achieve the above object, the technical solution taken of the present invention is：
A kind of antitumor particle of the tongue grass tuber of multiflower knotweed, is prepared from the following materials：
It is oldenlandia diffusa 20g, fleece-flower root 15g, Radix Astragali 30g, edible tulip 15g, Paris polyphylla 10g, Radix Codonopsis 20g, Poria cocos 20g, white Art 20g, Radix Angelicae Sinensis 15g, fruit of glossy privet 15g, honey-fried licorice root 10g.
The invention has the advantages that：
Body's immunity can be improved, the side effect after Radiotherapy chemotherapy is reduced, so as to extend the life cycle of patient and raising The life quality of patient, thus illustrate that traditional Chinese medicine has very big advantage in the auxiliary treatment to tumour.Oldenlandia diffusa can Clearing heat and detoxicating, Radix Astragali can replenish qi to invigorate the spleen, and the two is monarch drug in a prescription altogether in side；Edible tulip and Paris polyphylla can clearing heat and detoxicating, carbuncle that disappears dissipating bind, The benefits of oldenlandia diffusa carbuncle that disappears dissipating bind can be enhanced, for ministerial drug in side, Radix Codonopsis, Poria cocos, Rhizoma Atractylodis Macrocephalae can strengthening the spleen and replenishing qi, can enhance The work(of Radix Astragali strengthening QI of middle-JIAO is also ministerial drug in side；The fleece-flower root, Radix Angelicae Sinensis, the fruit of glossy privet can help essence and blood, replenishing the vital essence and the blood can be enhanced Work(, in side be adjutant；Honey-fried licorice root can mediation property of medicine, make medicine in Fang Zhongwei.Complete square compatibility 5 is precise and appropriate, plays altogether clearing heat and detoxicating, beneficial The work(of gas yin-nourishing.The immune functional state of body tumour Radiotherapy chemotherapy and it is postoperative can drastically decline, by improving immune function To inhibit tumour and prevent from shifting to be main mechanism therein.
Specific embodiment
In order to which objects and advantages of the present invention are more clearly understood, the present invention is carried out with reference to embodiments further It is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair It is bright.
Experimental example
Animal：Outbreeding system Kunming mouse, male, 25~28g of weight；Adult SD rats, male and female dual-purpose, Female Body Weight (250 ± 50) g, male Body Weight (340 ± 50) g, divides cage to feed, free diet；Kunming mouse, weight 18-22g, male and female are each Half, it is provided by The Fourth Military Medical University's Experimental Animal Center.
Tongue grass tuber of multiflower knotweed particle cleans up the phagocytosis that inertia carbon granule in suppressed mouse blood flow is immunized the influence of ability
40 mouse are randomly divided into following 4 groups, respectively blank control group, model control group, tongue grass tuber of multiflower knotweed particle it is low, High dose group, each group animal etc. holds the continuous 14d of gavage.In the 10th day of administration, model group, high and low dose group animal were uniform CY100mg/kg weight is injected intraperitoneally in secondary property, replicates immunologic hypofunction model, blank control group injection normal saline.In After last dose 1h, the equal tail vein of each mouse injects diluted india ink 0.1ml/10g weight, after prepared Chinese ink is injected 30s and 5min takes blood 0.025ml from small rathole corner of the eyes veniplex respectively, is blown into 0.1%Na at once2CO3In liquid 3ml, suction pipe is inhaled in the liquid Enter, blow out for several times fully to wash out the blood of suction pipe wall attachment.Blood is taken to finish with 0.025ml normal mouse blood school zero, in point Phagocytic index K and phagocytosis factor alpha (correction phagocytic index) is calculated as follows in colorimetric at light photometer 675nm.
Influence of the tongue grass tuber of multiflower knotweed particle to immune suppressed rat peripheral blood picture, immune organ weight
For the grouping of SD rats with experiment 2.1, the 5th, 6, the 7 day model group, tongue grass tuber of multiflower knotweed particle high and low dose group in experiment are equal CY30mg/kg weight, blank control group injection normal saline is injected intraperitoneally.In experiment the 11st day, the big rathole corner of the eyes of each group was quiet Arteries and veins takes blood, measures peripheral hemogram, takes animal thymus, spleen, scales/electronic balance weighing, note calculates organ coefficient, with organ weights (g) with every 100g weight ratio as thymus gland, index and spleen index.
The influence that tongue grass tuber of multiflower knotweed Granules on Mouse hemolysin is formed
Mouse 50 is taken, is randomly divided into 5 groups, respectively blank control group, positive controls (QINGCHUN BAO), the tongue grass tuber of multiflower knotweed Grain high dose group, middle dose group, low dose group.5% (V/V) chicken red blood cell physiology salt is injected intraperitoneally per mouse after the 1st administration Aqueous 0.2ml is immunized, and in administration the 7th day, is plucked eyeball and is taken mouse blood, is centrifuged, and detaches serum, serum physiological saline 1: After 100 dilutions, 1ml is taken to be uniformly mixed with 5% chicken red blood cell suspension 0.5ml and 10% complement 0.5ml, 37 DEG C of incubators are incubated It educates 30 minutes, stopped reaction in ice water, supernatant colorimetric at 72-1 spectrophotometers 540nm is taken, to be not added with complement instead The blank tube zeroising of physiological saline surveys each pipe trap.
The influence of tongue grass tuber of multiflower knotweed Granules on Mouse peripheral blood T cells percentage
Animal specification, grouping and administration are the same as experiment 3.3 days before administration, add intramuscular injection PHA 10mg/kg per mouse daily, It cuts tail within 8th day, takes blood push jack, Incubating Solution, 37 DEG C of incubation 3h are immersed after dry, tap water washes away sediment, and filter paper blots droplet, 1% malachite green solution is added to dye, tap water rinses, and dries rear micro- sem observation, calculates the percentage of T lymphocytes.
The influence of tongue grass tuber of multiflower knotweed Granules on Mouse lymphocyte transformation
Grouping and administration are the same as experiment 4.Respectively at first 3 days of administration, add intramuscular injection PHA10mg/kg per mouse daily, in administration The 8th day afterwards, mouse cut tail and takes blood, push jack, Wright's staining, micro- sem observation, calculating lymphocyte transformation percentage.
Data processing
Experimental data using SPSS11.0 carry out variance analysis, as a result withIt represents, P ＜ 0.05 think have significantly Property.
Result of the test
Tongue grass tuber of multiflower knotweed particle cleans up the phagocytosis that inertia carbon granule in suppressed mouse blood flow is immunized the influence of ability
As a result it shows：Compared with blank control group, phagocytic index K and phagocytosis factor alpha are decreased obviously model control group, are had Significant difference (P ＜ 0.05).Tongue grass tuber of multiflower knotweed particle high and low dose group can significantly improve K values and α compared with model control group Value, difference is statistically significant (P ＜ 0.05), and display tongue grass tuber of multiflower knotweed particle can significantly improve immune suppressed mouse phagocyte Phagocytic activity.Specific test data refers to table 1.
Influence of the 1 tongue grass tuber of multiflower knotweed particle of table to immune suppressed mouse phagocytic function
Note：Compared with model group, * P ＜ 0.05.
Model control group is compared with blank control group, and phagocytic index K and phagocytosis factor alpha are decreased obviously, and there were significant differences (P ＜ 0.05).Tongue grass tuber of multiflower knotweed particle high and low dose group can significantly improve K values and α values, difference compared with model control group Statistically significant (P ＜ 0.05), the phagocytosis that display tongue grass tuber of multiflower knotweed particle can significantly improve immune suppressed mouse phagocyte are lived Property.
Influence of the tongue grass tuber of multiflower knotweed particle to immune suppressed rat peripheral blood picture, immune organ weight
Influence of the tongue grass tuber of multiflower knotweed particle to immune suppressed rat peripheral blood picture.
As a result it shows：High and low dose of group of tongue grass tuber of multiflower knotweed particle, leucocyte (WBC), the blood platelet of model control group rat (PLT) quantity significantly reduces, and difference has significant statistical significance compared with blank control group.And high dose control group with Model control group is compared, WBC and PLT quantity increases, significant difference (P ＜ 0.05).Show that the high agent of tongue grass tuber of multiflower knotweed particle can be significantly Improve WBC and the PLT level that suppressed rat is immunized.Model control group red blood cell and hemoglobin have compared with blank control group Declined, but not significantly (P ＞ 0.05).Compared with model control group, RBC and HBG have tongue grass high and low dose of group of tuber of multiflower knotweed particle Different degrees of raising, but difference nonsignificance (P ＞ 0.05).Specific data refer to table 2.
Influence (X ± S) of the 2 tongue grass tuber of multiflower knotweed particle of table to immune suppressed rat peripheral blood picture
Note：Compared with model control group, * P ＜ 0.05；Compared with blank control group, Δ P ＜ 0.05.
Influence of the tongue grass tuber of multiflower knotweed particle to immune suppressed immune organs of rats weight
Tongue grass tuber of multiflower knotweed particle high and low dose group, model group index and spleen index, thymus index compared with blank control group to be low, Middle model control group declines significantly, and difference has significant statistical significance (P ＜ 0.05) compared with blank control group.Tongue grass is first Black particle is low, high dose group organ index is higher than model control group, high dose group and poor different significantly (the P ＜ of model control group 0.05).It the results are shown in Table 3.
3 tongue grass tuber of multiflower knotweed particle of table to be immunized suppressed immune organs of rats weight influence (X±S)
Note：The * P ＜ 0.05 compared with model control group.
The influence that tongue grass tuber of multiflower knotweed Granules on Mouse hemolysin is formed
The tongue grass tuber of multiflower knotweed particle of high, medium and low dosage can be obviously promoted normal mouse hemolysin and be formed as can be seen from Table 4, Can significantly improve 0D values.Specific data are referred in table 4.
The influence that 4 tongue grass tuber of multiflower knotweed Granules on Mouse hemolysin of table is formed
Note：* represent physiological saline group than P ＞ 0.05；* is represented with physiological saline group than P ＜ 0.05；* * are represented and physiology Brine group is than P ＜ 0.01.
The influence of tongue grass tuber of multiflower knotweed Granules on Mouse peripheral blood T cells percentage
Middle dosage tongue grass tuber of multiflower knotweed particle group can significantly improve normal mouse periphery blood T cell percentage as can be seen from Table 5, low Dosage group is remarkably improved.In 5.
The influence of 5 tongue grass tuber of multiflower knotweed Granules on Mouse peripheral blood T cells percentage of table
Note：* represent physiological saline group than P ＞ 0.05；* is represented with physiological saline group than P ＜ 0.05；* * are represented and physiology Brine group is than P ＜ 0.01.
The influence of tongue grass tuber of multiflower knotweed Granules on Mouse lymphocyte transformation
As can be seen from Table 6, the tongue grass tuber of multiflower knotweed particle of high, medium and low dosage can be obviously promoted the lymphocyte of normal mouse Conversion.
The influence of 6 tongue grass tuber of multiflower knotweed Granules on Mouse lymphocyte transformation of table
Note：* represent physiological saline group than P ＞ 0.05；* is represented with physiological saline group than P ＜ 0.05；* * are represented and physiology Brine group is than P ＜ 0.01.
In conclusion this experiment replicates immunologic hypofunction model by the way that CY is injected intraperitoneally, tongue grass tuber of multiflower knotweed particle pair is observed Ability and peripheral hemogram, the influence of immune organ weight and right are cleaned up in the phagocytosis that inertia carbon granule in suppressed animal blood flow is immunized Intact animal hemolysin is formed, variation of peripheral blood T cells percentage and lymphocyte transformation rate etc. reflects the drug Influence to body's immunity, it is seen then that tongue grass tuber of multiflower knotweed particle can significantly improve the immune function of experimental animal.Phagocytic index The phagocytic activity of cell is reflected with phagocytosis coefficient, the phagocytic activity of macrophage is to weigh body non-specific immune function One of mark, it has phagocytosis, processing and processing antigenic substance, and antigen is passed to lymphocyte, its is made to generate antibody Or lymphokine, strengthen the ability of killing cancer cell, after india ink is injected intravenously mouse, mainly settled down in liver rapidly It swallows and removes with the macrophage of spleen.Periphery blood T lymphocyte be reflect human immunity state important indicator, lymph Cell transformation test is the important indicator for evaluating vivo immunization responsing reaction function.In body they Each performs its own functions, pass through ratio The variations such as example, function maintain the stabilization of environment in immunity of organism.The raising prompting body of T cent lymphocytes is immunized Competent cell increases, immune function enhancing.So as to improve the immune function of body.This result of the test is shown, first in application tongue grass After black granule therapy, model group phagocytic index K, phagocytosis factor alpha, leucocyte (WBC), blood platelet (PLT), index and spleen index and chest Gland index is low compared with blank control group, and wherein model control group declines apparent, and difference has significantly compared with blank control group Statistical significance (P ＜ 0.05) illustrates modeling success.Administration group can significantly improve K values and α compared with model control group Value, difference is statistically significant (P ＜ 0.05), illustrates that tongue grass tuber of multiflower knotweed particle can improve immune suppressed mouse to a certain extent The phagocytic activity of macrophage, the most important system of defense of body are reticuloendothelial system (RES, mononuclear phagocyte system), Increase the defence capability of body, and then increase Cellular Immunity power.
Thymus gland is immune organ important in body, and spleen is both critically important immune organ, also there is certain pass with hematopoiesis System, spleen can the hematopoiesis of compensatory ground when hemopoietic function of bone marrow is damaged.The raising prompting immunity of organism work(of thymus gland and index and spleen index The raising of energy.Tongue grass tuber of multiflower knotweed particle high dose group WBC and PLT quantity increases in this experiment, organ index raising, significant difference (P ＜ 0.05).Speculate that the high agent of tongue grass tuber of multiflower knotweed particle is that WBC, PLT of immune suppressed rat are improved by improving organ index Level, so as to enhance the immune function of body.Leucocyte (WBC) is immunocyte, is had actively to the healing ability of body injury Influence, blood platelet (PLT) plays a significant role in hemostasis.Cancer patient passes through long-term chemotherapy or drug therapy, body Interior leucocyte and platelet levels is below normal value, and above-mentioned experimental result shows that tongue grass tuber of multiflower knotweed particle can exempt from by improving Epidemic disease shoot formation and serum hemolysin improve cancer patient's Radiotherapy chemotherapy or postoperative humoral immunity ability.
Treatment for tumour, either operation or chemicotherapy, the immunity of patient can all be influenced accordingly, and Relatively low immunity is the major reason that remaining tumor cells is made to revive, so improving the immune of patient over the course for the treatment of Power is extremely important.This experimental studies results shows adjuvant therapy medicaments of the tongue grass tuber of multiflower knotweed particle as tumor chemoradiotherapy, can be bright It is aobvious to improve the Immune Organs Indexes such as thymus gland, spleen, activating macrophage, T lymphocytes, bone-marrow-derived lymphocyte, so as to improve body Immune function, thus this should be one of major function of this drug adjunct antineoplastic.In short, this experimental result is tongue grass The clinical practice of tuber of multiflower knotweed particle provides certain experiment basis.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, without departing from the principle of the present invention, several improvements and modifications can also be made, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (1)

1. a kind of antitumor particle of the tongue grass tuber of multiflower knotweed, which is characterized in that be prepared from the following materials：
Oldenlandia diffusa 20g, fleece-flower root 15g, Radix Astragali 30g, edible tulip 15g, Paris polyphylla 10g, Radix Codonopsis 20g, Poria cocos 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Angelicae Sinensis 15g, fruit of glossy privet 15g, honey-fried licorice root 10g.
CN201810070847.5A 2018-01-22 2018-01-22 A kind of antitumor particle of the tongue grass tuber of multiflower knotweed Pending CN108210735A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569307A (en) * 2020-11-17 2021-03-30 广州中医药大学第一附属医院 Traditional Chinese medicine composition for strengthening body resistance and eliminating tumor as well as preparation method and application thereof

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Publication number Priority date Publication date Assignee Title
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Application publication date: 20180629