CN108210709A - A kind of Chinese medicine bulbus fritilariae snow pear lozenge and preparation method thereof - Google Patents
A kind of Chinese medicine bulbus fritilariae snow pear lozenge and preparation method thereof Download PDFInfo
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- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to a kind of Chinese medicine bulbus fritilariae snow pear lozenges and preparation method thereof, belong to technical field of traditional Chinese medicines.The lozenge includes the following raw material in parts by weight：100 ~ 120 parts of pyrus nivalis, 8 ~ 10 parts of tendril-leaved fritillary bulb, 5 ~ 8 parts of Radix Ophiopogonis, 6 ~ 9 parts of campanulaceae, 4 ~ 8 parts of tussilago, 50 ~ 60 parts of granulated sugar, 2 ~ 4 parts of film-coating liquid.It is prepared by five traditional Chinese medicine extraction, pear syrup processed, sugar refinery, granulation and coating steps.Present invention process is simple, obtained bulbus fritilariae snow pear lozenge can containing take, mouthfeel is good, has effects that moisten the lung and relieve the cough, resolving sputum and relieving asthma；Patient is using Chinese medicine bulbus fritilariae snow pear lozenge of the invention, is not only able to be accurately controlled taking dose, and the effectiveness time is longer, easy to use, is easy to preserve.
Description
Technical field
The invention discloses a kind of Chinese medicine bulbus fritilariae snow pear lozenges and preparation method thereof, belong to technical field of traditional Chinese medicines.
Background technology
Cough respiratory tract infection as caused by various viruses, bacterium and other microorganism infections.If localized infection is in ring
It is more than shape cartilage, the as infection of the upper respiratory tract；If infection is developed to annular cartilage hereinafter, as lower respiratory tract infection.
If
Vivid analogy is done with big tree, is turned around setting greatly, more than tree root is the upper respiratory tract, is lower respiratory tract below tree root, trunk
It is gas
Guan branch is bronchus, leaf stalk is capillary bronchus, and leaf is alveolar, and leaf gap is exactly interstitial lung.Entirely exhale
Inhaling road can all invade by various foeign elements and pathological change occurs, these foeign elements are not viral, bacterium merely,
It can also be various microorganisms, various chemical factors, environmental factor etc. or since virus, bacterium and various factors cause
Respiratory mucosa occur lesion, it is impossible to virus, the extinction of bacterium and various microorganisms and improve, lead to respiratory mucosa
The damage of itself function is formed the cough not recovered for a long time.Therefore, it is difficult when many even if using very advanced antibiotic
With the crux for the treatment of cough, it is necessary to improve the function of respiratory mucosa in itself, cough could be effected a radical cure.
At present, Western medicine and infusion cannot all solve the problems, such as that rapid healing is coughed, but the advantage of Chinese medicine in this respect is just
It highlights.Most of pyrus nivalis product of existing treatment cough is paste currently on the market, and shortcoming is：（1）
It uses
When, it is impossible to taking dose is accurately controlled, and inconvenient to use；（2）The effectiveness time is short, can not for a long time stop in affected part
It stays；
（3）Not easy to maintain, easy microbiological contamination after opening is taken for the first time；（4）Loading amount specification is big, and repeatedly taking can just be finished, not portable.
Therefore, the problem of how overcome the deficiencies in the prior art is current technical field of traditional Chinese medicines urgent need to resolve.
Invention content
The purpose of the present invention is to solve deficiencies of the prior art, provide a kind of Chinese medicine bulbus fritilariae snow pear lozenge and its system
Preparation Method, Chinese medicine bulbus fritilariae snow pear lozenge when in use, can be accurately controlled taking dose, and during effectiveness made from the method for the present invention
Between it is longer.
To achieve these goals, the present invention uses following technical scheme：
A kind of Chinese medicine bulbus fritilariae snow pear lozenge, it is characterised in that including the following raw material in parts by weight：Pyrus nivalis 100 ~ 120
Part, river
8 ~ 10 parts of shellfish, 5 ~ 8 parts of Radix Ophiopogonis, 6 ~ 9 parts of campanulaceae, 4 ~ 8 parts of tussilago, 50 ~ 60 parts of granulated sugar, 2 ~ 4 parts of film-coating liquid.
The further preferably described film-coating liquid includes the following raw material in parts by weight：Hydroxypropyl methyl is fine
12 ~ 18 parts of dimension element, 4 ~ 8 parts of glycerine, 10 ~ 20 parts of propylene glycol, 5 ~ 10 parts of magnesium stearate, 600 ~ 700 parts of deionized water.
The present invention also provides a kind of preparation methods of Chinese medicine bulbus fritilariae snow pear lozenge, it is characterised in that includes the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 2 ~ 3 hours, and amount of water is pears slag quality
1 ~ 2 times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 50 ~ 60%, heating is dissolved, and is boiled, and is tempered to liquid glucose in gold
Yellow is degree, obtains sugar refinery；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, uses film
Clothing liquid is to step（7）It obtaining snow pear slice plain piece and carries out film coating, coating temperature is 50~60 DEG C, is finally packed,
Obtain the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention.
The mechanism of action of product of the present invention：The pyrus nivalis that the present invention selects：Moistening lung is dry clearly, relieving cough and reducing sputum, nourishing blood and promoting granulation；River
Shellfish：It moistens the lung and relieve the cough, resolving sputum and relieving asthma；Radix Ophiopogonis：Yin-nourishing and body fluid promoting moistens the lung and relieve the cough；Campanulaceae：Facilitaing lung relieving sore-throat, eliminating the phlegm apocenosis, benefit of fostering the spirit of nobility
Gas；
Tussilago：Gas under antibechic, moistening lung eliminating the phlegm；Granulated sugar：It moistens the lung and relieve the cough, Yin-nourishing and body fluid promoting and middle beneficial lung, irritability of releiving.
The present invention Chinese medicine high by compounding above-mentioned several nutritive values, produces Chinese medicine bulbus fritilariae snow pear lozenge, can be effective
Ground moistens the lung and relieve the cough, resolving sputum and relieving asthma, Yin-nourishing and body fluid promoting.
Product of the present invention is lozenge, when buccal, the active ingredient energy slow release in lozenge, and long duration of action is in trouble
Place, it is significant in efficacy.Therefore compared with Traditional Chinese medicine snow pear cream, the effectiveness time is not only increased, also enhances therapeutic effect.
Compared with prior art, the present invention advantage is：（1）The bulbus fritilariae snow pear lozenge of the present invention can containing clothes
With mouthfeel is good, has effects that moisten the lung and relieve the cough, resolving sputum and relieving asthma；（2）Patient is using Chinese medicine bulbus fritilariae snow pear lozenge of the invention,
It is not only able to be accurately controlled taking dose, and the effectiveness time is longer, affected part can be acted on long lasting for ground；（3）This hair
Bright Chinese medicine bulbus fritilariae snow pear lozenge is easy to use, is easy to preserve；（4）Preparation method of the present invention is simple, application easy to spread.
Specific embodiment
A kind of Chinese medicine bulbus fritilariae snow pear lozenge, including the following raw material in parts by weight：100 ~ 120 parts of pyrus nivalis, tendril-leaved fritillary bulb 8
~ 10 parts, 5 ~ 8 parts of Radix Ophiopogonis, 6 ~ 9 parts of campanulaceae, 4 ~ 8 parts of tussilago, 50 ~ 60 parts of granulated sugar, 2 ~ 4 parts of film-coating liquid.The film-coating
Liquid includes the following raw material in parts by weight：12 ~ 18 parts of hydroxypropyl methyl cellulose, 4 ~ 8 parts of glycerine, propylene glycol 10 ~ 20
Part, 5 ~ 10 parts of magnesium stearate, 600 ~ 700 parts of deionized water.
The preparation method of the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention, includes the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 2 ~ 3 hours, and amount of water is pears slag quality
1 ~ 2 times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 50 ~ 60%, heating is dissolved, and is boiled, and is tempered to liquid glucose in gold
Yellow is degree, obtains sugar refinery；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, uses film
Clothing liquid is to step（7）It obtaining snow pear slice plain piece and carries out film coating, coating temperature is 50~60 DEG C, is finally packed,
Obtain the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention.The invention will be further described With reference to embodiment.
Embodiment 1
A kind of Chinese medicine bulbus fritilariae snow pear lozenge, including the following raw material in parts by weight：100 parts of pyrus nivalis, 8 parts of tendril-leaved fritillary bulb, Radix Ophiopogonis 5
Part, 6 parts of campanulaceae, 4 parts of tussilago, 50 parts of granulated sugar, 2 parts of film-coating liquid.
Weigh 4 parts of 12 parts of hydroxypropyl methyl cellulose, glycerine, 10 parts of propylene glycol, the magnesium stearate 5 in terms of parts by weight
Part, 600 parts of deionized water are stirred to being completely dissolved to get film-coating liquid, are placed it in spare in high-efficiency coating pot.
The preparation method of the Chinese medicine bulbus fritilariae snow pear lozenge of the present embodiment, includes the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 2 hours, and amount of water is the 1 of pears slag quality
Times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 50%, heating is dissolved, and is boiled, and is tempered to liquid glucose in golden yellow
For degree, sugar refinery is obtained；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, uses film
Clothing liquid is to step（7）Obtain snow pear slice plain piece carry out film coating, coating temperature be 50 DEG C, finally packed to get
To the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention.Embodiment 2
A kind of Chinese medicine bulbus fritilariae snow pear lozenge, including the following raw material in parts by weight：120 parts of pyrus nivalis, 10 parts of tendril-leaved fritillary bulb, Radix Ophiopogonis
8 parts, 9 parts of campanulaceae, 8 parts of tussilago, 60 parts of granulated sugar, 4 parts of film-coating liquid.
Weigh 8 parts of 18 parts of hydroxypropyl methyl cellulose, glycerine, 20 parts of propylene glycol, the magnesium stearate in terms of parts by weight
10 parts, 700 parts of deionized water are stirred to being completely dissolved to get film-coating liquid, are placed it in spare in high-efficiency coating pot.
The preparation method of the Chinese medicine bulbus fritilariae snow pear lozenge of the present embodiment, includes the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 3 hours, and amount of water is the 2 of pears slag quality
Times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 60%, heating is dissolved, and is boiled, and is tempered to liquid glucose in golden yellow
For degree, sugar refinery is obtained；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, uses film
Clothing liquid is to step（7）Obtain snow pear slice plain piece carry out film coating, coating temperature be 60 DEG C, finally packed to get
To the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention.
Embodiment 3
A kind of Chinese medicine bulbus fritilariae snow pear lozenge, including the following raw material in parts by weight：110 parts of pyrus nivalis, 9 parts of tendril-leaved fritillary bulb, Radix Ophiopogonis 6
Part, 8 parts of campanulaceae, 5 parts of tussilago, 55 parts of granulated sugar, 3 parts of film-coating liquid.
Weigh 6 parts of 16 parts of hydroxypropyl methyl cellulose, glycerine, 15 parts of propylene glycol, the magnesium stearate in terms of parts by weight
8 parts, 660 parts of deionized water are stirred to being completely dissolved to get film-coating liquid, are placed it in spare in high-efficiency coating pot.
The preparation method of the Chinese medicine bulbus fritilariae snow pear lozenge of the present embodiment, includes the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 2.4 hours, and amount of water is pears slag quality
1.5 times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 55%, heating is dissolved, and is boiled, and is tempered to liquid glucose in golden yellow
For degree, sugar refinery is obtained；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, uses film
Clothing liquid is to step（7）Obtain snow pear slice plain piece carry out film coating, coating temperature be 55 DEG C, finally packed to get
To the Chinese medicine bulbus fritilariae snow pear lozenge of the present invention.
The quality index of product of the present invention：
1st, organoleptic indicator
This product is Film coated tablets, sweet.
2nd, physical and chemical index
Tablet hardness is 5.00 ± 0.01kg/cm3；
Disintegration time≤30min.
3rd, microbiological indicator
Bacterial population≤10/g
Yeast and mold number≤10/g
Control bacterium and mite living must not be detected.
Claims (3)
1. a kind of Chinese medicine bulbus fritilariae snow pear lozenge, it is characterised in that including the following raw material in parts by weight：Pyrus nivalis 100 ~ 120
Part,
8 ~ 10 parts of tendril-leaved fritillary bulb, 5 ~ 8 parts of Radix Ophiopogonis, 6 ~ 9 parts of campanulaceae, 4 ~ 8 parts of tussilago, 50 ~ 60 parts of granulated sugar, 2 ~ 4 parts of film-coating liquid.
2. Chinese medicine bulbus fritilariae snow pear lozenge according to claim 1, it is characterised in that the film-coating liquid is included according to weight
Measure part
The following raw material of number meter：12 ~ 18 parts of hydroxypropyl methyl cellulose, 4 ~ 8 parts of glycerine, 10 ~ 20 parts of propylene glycol, magnesium stearate 5 ~
10 parts, 600 ~ 700 parts of deionized water.
3. the preparation method of Chinese medicine bulbus fritilariae snow pear lozenge as described in claim 1, it is characterised in that include the following steps：
Step（1）, traditional Chinese medicine extraction：Tendril-leaved fritillary bulb, Radix Ophiopogonis, campanulaceae and tussilago are crushed to 150 ~ 200 mesh together, with deionized water
Percolation extraction is carried out as solvent is leached, extracting solution is stood, takes supernatant liquor, obtains Chinese medicine extract；
Step（2）, pear syrup processed：Pyrus nivalis is cleaned up and is squeezed the juice, pears slag adds water to cook 2 ~ 3 hours, and amount of water is pears slag quality
1 ~ 2 times, filtering, filtrate, pear juice and step（1）Obtained Chinese medicine extract merges, and is concentrated under reduced pressure, obtains pear syrup；
Step（3）, sugar refinery：Granulated sugar is taken, is incorporated as the water of saccharic amount 50 ~ 60%, heating is dissolved, and is boiled, and is tempered to liquid glucose in gold
Yellow is degree, obtains sugar refinery；
Step（4）, granulation：By step（2）Obtained pear syrup and step（3）Obtained sugar refinery is separately dried with baking oven, Ran Houyong
High speed disintegrator is respectively crushed into fine powder, then with one-step-granulating method be respectively prepared can tabletting particle, finally with three-dimensional mixed
Conjunction machine
Particle obtained is uniformly mixed, obtains hybrid particles；
Step（5）, coating：By step（4）Obtained hybrid particles tabletting, then places it in high-efficiency coating pot, use is thin
Film clothing liquid is to step（7）It obtains snow pear slice plain piece and carries out film coating, coating temperature is 50~60 DEG C, is finally wrapped
Fill to get to the present invention Chinese medicine bulbus fritilariae snow pear lozenge.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611160222.5A CN108210709A (en) | 2016-12-15 | 2016-12-15 | A kind of Chinese medicine bulbus fritilariae snow pear lozenge and preparation method thereof |
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| CN201611160222.5A CN108210709A (en) | 2016-12-15 | 2016-12-15 | A kind of Chinese medicine bulbus fritilariae snow pear lozenge and preparation method thereof |
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| CN108210709A true CN108210709A (en) | 2018-06-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116077601A (en) * | 2023-04-07 | 2023-05-09 | 江西草珊瑚药业有限公司 | Lozenge for clearing heat, relieving cough and reducing sputum and preparation method thereof |
-
2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116077601A (en) * | 2023-04-07 | 2023-05-09 | 江西草珊瑚药业有限公司 | Lozenge for clearing heat, relieving cough and reducing sputum and preparation method thereof |
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Application publication date: 20180629 |