CN108201635A - Bone Defect Repari stent under a kind of articular cartilage - Google Patents
Bone Defect Repari stent under a kind of articular cartilage Download PDFInfo
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
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Abstract
Bone Defect Repari stent under a kind of articular cartilage, is made of from top to bottom porous salt deposit and porous metal material layer, and porous metal material layer is gradient porous metal material layer.It is bionical that the stent of this kind of structure has effectively achieved artificial articular cartilage sending down the fishbone, subchondral bone is enable to bear complicated, big load, and with good pooling feature, realize the transmission of good power, intensity is higher than porous non-metallic stent, the problem of overcoming the high porosity porous metal material rigidity deficiency of single hole, porous salt deposit is conducive to merge with cartilage layers again, this kind of stent also has good seepage characteristic, its aperture design not only improves cell, nutrient solution migration, and helps that intra-articular liquid is maintained to have appropriate pressure；The aperture of this kind of stent, design of material contribute to the migration of cell, live away from home, break up, rising in value again, it is Bone Defect Repari, regeneration support under real articular cartilage.
Description
Technical field
The present invention relates to prostheses, and in particular to Bone Defect Repari stent under a kind of articular cartilage.
Background technology
Human synovial has a complicated structure, and subchondral bone is the important component in joint, and joint is held during human motion
By larger complex load, when in motion, the load that joint is born is even up to 7-9 times or more of the weight of people, this is to joint
Subchondral bone proposes very high requirement.With the incidence of the severe traumas such as the raising of social and economic level, traffic accident
Rapidly increasing.In China, the joint injury about caused by wound about influences the life of hundreds of thousands of them every year, annual big
It needs to carry out artificial joint replacement there are about 100,000 people.The incidence in joint caused by disease and social senilization is also constantly rising
Height, Osteoarthritis etc. can cause damage or the defect in joint, thereby result in damage or the defect of articular cartilage sending down the fishbone, clinical
Upper simple articular cartilage damage is more rare, is more the lesion with subchondral bone, soft as caused by osteochondritis lesion
The necrosis of bone sending down the fishbone, hardening of subchondral bone etc. caused by cartilage degeneration.It is artificial fully closed used by treatment osteoarthropathy at present
Section displacement material is mostly the hard materials such as metal, ceramics, ultra-high molecular weight polyethylene, with the growth of service life, is easily produced
It the problems such as green material failure, aging, causes to wear, loosen and lead to postoperative complications, service life is short, and somewhat expensive.For
This, people have carried out many researchs to Bone Defect Repari stent under articular cartilage.
A kind of bone/cartilage of the preparation method introduction of nano micrometer structure coexistence chitosan double-layer supports of CN103127553A
The bottom of recovery support is three dimensional micron chitosan stent, for providing high porosity and mechanical strength, is suitble to osteoblast
Growth, for repairing subchondral bone.
CN101219069A discloses a kind of for the double of bone repair of cartilage for the two-layer compound stent of bone repair of cartilage
Layer compound rest, simulation subchondral bone layer is using hydroxyapatite, tricalcium phosphate, polyether-ether-ketone, and polyglycolic-polylactic acid is common
The mixture of one or more of polymers, polyglycolic acid, polylactic acid, fibroin；Simulation subchondral bone layer thickness be
2mm -20mm, the porosity of this layer is 50%-75%, and aperture is 200 μm -500 μm.
CN102526809A is a kind of for stent of osteochondral defect reparation and preparation method thereof, and the stent is by with hole
Cartilage layers and subchondral bone layer with hole form, the cartilage layers and subchondral bone layer be closely as one, wherein
The material of subchondral bone layer is POROUS TITANIUM or porous titanium oxide or porous titanium alloy.
Porous tantalum biocomposites for osteochondral defect repair（E.
H.Mrosek et al. Bone Joint Res. 2016；5:403-411) describe with porous tantalum and Self periosteum it is compound into
The repairing test of sheep cartilage-subchondral bone defect is gone.The result shows that the structure fails to effectively facilitate Subchondral drilling.
Although people have carried out many researchs, the structure of Bone Defect Repari stent is still unreasonable under articular cartilage, fails to have
Bionical human synovial is imitated, subchondral bone is easy to cave in, damage with recovery support, and reparation, regeneration effect are bad.
Invention content：
The object of the present invention is to provide a kind of rational in infrastructure, Bone Defect Repari stents under the articular cartilage of favorable regeneration effect.
The object of the invention is achieved through the following technical solutions：
Bone Defect Repari stent under a kind of articular cartilage, is made of from top to bottom porous salt deposit and porous metal material layer successively, institute
Porous metal material layer is stated as gradient porous metal material layer.The material of this kind of structure is had effectively achieved under artificial articular cartilage
Bone is bionical, avoids the problem of single nonmetallic materials intensity is insufficient, and subchondral bone is enable to bear complicated, big load,
In porous structure can transmit nutrient solution, cell, porous salt deposit is conducive to merge with cartilage layers again, and promotion joint prosthesis is repaiied
It is multiple.
Furtherly, Bone Defect Repari stent under the articular cartilage, the porous salt deposit for porous, inorganic salt deposit or/and
Porous organic salt deposit.
Furtherly, Bone Defect Repari stent under the articular cartilage, the porous, inorganic salt deposit use hydroxyapatite,
Or prepared by tricalcium phosphate or hyaluronic acid ammonium or hyaluronic acid tetrabutylammonium, be particularly conducive to merge with cartilage layers.
Furtherly, Bone Defect Repari stent under the articular cartilage, porous organic salt deposit use chondroitin sulfate,
Or phosphoglycerol or fructose phosphate or glucose phosphate or Serine phosphoric acid or adenylic acid or aminoglucose or galactolipin
Amine is particularly conducive to merge with cartilage layers.
Furtherly, Bone Defect Repari stent under the articular cartilage, the porous metal material layer for porous tantalum layer or
POROUS TITANIUM and its alloy-layer or porous niobium layer or porous cobalt-based alloy layer or porous stainless steel layer or porous nickel-titanium alloy-layer,
Or porous composite material layer.
Furtherly, Bone Defect Repari stent under the articular cartilage, the aperture of the porous salt deposit is 3 μm -10 μm,
Furtherly, the joint prosthesis material for repairing, the aperture of the porous salt deposit are 3 μm -10 μm, this kind of structure it is more
Hole salt deposit can make Bone Defect Repari stent under articular cartilage have preferable seepage flow spy with the compound setting of other porous material layers
Property, cell, nutrient solution in marrow etc. can on the one hand passed through, while completely cut off cartilage and subchondral bone to a certain extent, make by
Moderately release buffering does not decline excessively the fluid pressure of articular cavity again during power.
Furtherly, Bone Defect Repari stent under the articular cartilage, the porous metal material layer include upper and lower two layers；
Wherein, the aperture on porous metal material upper strata being connected with the porous salt deposit is 50 μm -100 μm, under porous metal material
The aperture of layer is 100 μm -1000 μm, and the hole inside each layer porous metal material and between layer is mutually communicated.This structure
Material when being repaired for joint prosthesis, the transmission of power, good absorption effect, intensity is high, and its bone tissue of being more convenient for is grown into, and
And be conducive to osteocyte and exported from porous metal material upper strata；Or make the aperture of the porous metal material layer from it is described more
The aperture on the adjacent surface of hole salt deposit gradually increases the porous metals for being transitioned into and deviating from the porous salt deposit from 50 μm -100 μm
Up to 100 μm -1000 μm, the hole inside porous metal material layer is mutually communicated, and is also had in the aperture of the distal surface of material layer
There is the comparable effect of above-mentioned two layers of porous metal material layer.
Furtherly, Bone Defect Repari stent under the articular cartilage, the gradient of the gradient porous metal material layer are more
Mesoporous metal material is makes the porous gold that the hole of aperture bigger formed with the porous metal material of minimal gradient grade by raw material
Belong to material, the hole for forming each gradient grade porous metal material of gradient porous metal material is mutually communicated, this structure
Porous metal material is also substantially reduced between gradients at different levels the effect of the interface that connects not only proximate to subchondral bone structure.Furtherly,
The gradient porous metal material layer makes two layers of bigger using the porous metal material in 3 μm of -10 μm of holes penetrated through as raw material
The material in aperture forms the gradient porous metal material layer for possessing three layers of upper, middle and lower, wherein, with the porous polymer materials layer
The aperture of adjacent upper strata porous metal material layer is 3 μm -10 μm, the aperture of middle layer porous metal material layer for 50 μm -
100 μm, the aperture of lower floor's porous metal material layer is 100 μm -1000 μm, inside each layer porous metal material and between layer
Hole is mutually communicated, the joint prosthesis material for repairing of this kind of structure not only the transmission of power, assimilation effect more preferably, first
Layer, the second layer play the role of cortex bone, bear big load, and third layer plays the role of cancellous bone, have buffering effect, and
With preferable seepage characteristic, promote subchondral bone and repair of cartilage.
Bone Defect Repari stent under articular cartilage provided by the invention with bionical for means, passes through the porous salt of reasonable design
The structure of layer, porous metal material layer carries out bone structure under articular cartilage bionical；The porous metals part of gradient-structure can be held
By complicated, big load, and there is good pooling feature, Bone Defect Repari realizes good power with stent under this kind of articular cartilage
Transmission, there is excellent mechanical property, intensity is higher than porous non-metallic material, and porous non-metallic material often understands intensity not
Enough or toughness is inadequate, moreover, Bone Defect Repari is better than the high porosity porous metals of single hole with stent under this kind of articular cartilage, it is single
The high porosity porous metal material rigidity of one hole is insufficient, can be deformed under big load such as impact loading and excessive cause to collapse
Failures, the porous salt deposit such as collapse are conducive to merge with cartilage layers again, meanwhile, Bone Defect Repari stent has good under this kind of articular cartilage
Seepage characteristic, aperture design not only improves cell, nutrient solution migration, and it is appropriate to help to maintain intra-articular liquid to have
Pressure；Under this kind of articular cartilage the aperture of Bone Defect Repari stent, design of material contribute to again cartilage, the living away from home of osteocyte, point
Change, increment, thus it is Bone Defect Repari, regrown material under real articular cartilage.
Description of the drawings
Below in conjunction with attached drawing, the present invention is further elaborated with embodiment.
Fig. 1 is Bone Defect Repari supporting structure schematic diagram under articular cartilage of the present invention.
Fig. 2 is Bone Defect Repari supporting structure schematic diagram under articular cartilage in embodiment 6.
Specific embodiment
The specific embodiment of the present invention is explained below in conjunction with the accompanying drawings, embodiment is using technical solution of the present invention before
It carries, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited only to following implementation
Mode.
Embodiment 1
Referring to Fig. 1, Bone Defect Repari stent under the articular cartilage of the present embodiment, from top to bottom successively by porous salt deposit 1 and porous gold
Belong to material layer 2 to form.Porous salt deposit 1 is porous, inorganic salt deposit, is prepared using porous hydroxyapatite, and aperture is 3 μm -6 μm,
Porosity is 43%, thickness 0.5mm；Porous metal material layer 1 be porous titanium alloy, material TC4, wherein porous titanium alloy
With two layers, referring to Fig. 1, wherein the aperture of upper strata 2-1 being connected with porous salt deposit is 3 μm -10 μm, porosity 38% is thick
It spends for 2mm, the aperture of lower floor 2-2 is 100 μm -450 μm, porosity 82%, thickness 4mm, inside each layer porous titanium alloy
And the hole between layer is mutually communicated.The preparation method of the artificial joint repair material is as follows：
（1）Porous titanium alloy upper strata is prepared with titanium alloy TC 4 powder and pore creating material mixed compaction sintering.
（2）Porous titanium alloy lower floor is prepared with foam dipping method.
（3）Porous titanium alloy upper strata and porous titanium alloy lower floor are connected as an Integrate porous titanium with vacuum diffusion welding to close
Gold.
（4）With Vacuum Freezing ＆ Drying Technology porous hydroxyl is prepared in the porous titanium alloy upper surface of Integrate porous titanium alloy
Base apatite layer obtains Bone Defect Repari stent under the articular cartilage of the present embodiment after having made.
Embodiment 2
Bone Defect Repari stent is similar to Example 1 under the articular cartilage of the present embodiment, and difference is that porous metal material layer is
Porous niobium, the aperture on upper strata is 75 μm -100 μm, and porosity 43%, the aperture of lower floor is 400 μm -700 μm, and porosity is
78%, the hole between each layer porous niobium inside and layer is mutually communicated, and the aperture of porous hydroxyapatite is 5 μm -10 μm, hole
Gap rate is 36%, preparation method similar embodiment 1.
Embodiment 3
Bone Defect Repari stent is similar to Example 1 under the articular cartilage of the present embodiment, difference for porous metal material layer by
Prepared by Nitinol, the aperture on upper strata is 50 μm -80 μm, porosity 39%, and the aperture of lower floor is 700 μm -1000 μm, hole
Rate is 72%, and the hole inside each layer porous nickel-titanium alloy and between layer is mutually communicated, and porous salt deposit is made using hyaluronic acid ammonium
It is prepared for raw material, aperture is 4 μm -8 μm, porosity 38%, preparation method similar embodiment 1.
Embodiment 4
The porous salt deposit of Bone Defect Repari stent is porous organic salt deposit under the articular cartilage of the present embodiment, using chondroitin sulfate system
Standby, aperture is 3 μm -10 μm, porosity 40%, thickness 0.6mm；Porous metal material layer uses POROUS TITANIUM, the POROUS TITANIUM
For gradient porous material, structure is：Aperture from the aperture on surface being connected with the porous salt deposit for 50 μm -80 μm by
Cumulative great transition is 100 μm -500 μm to the aperture of the distal surface of porous titanium layer deviated from the porous salt deposit, and thickness is
4mm, the hole inside POROUS TITANIUM are mutually communicated.Preparation method is：POROUS TITANIUM model, root are prepared with computer three-dimensional modeling
POROUS TITANIUM is prepared with Selective Laser Sintering according to the model, prepares chondroitin sulfate solution, is 50 μ by POROUS TITANIUM aperture
Chondroitin sulfate solution depth 0.3mm is immersed on m -80 μm of surface, freeze-drying obtain with porous chondroitin sulfate with it is more
Bone Defect Repari stent under the articular cartilage of the assembly of hole titanium, i.e. the present embodiment.
Embodiment 5
Bone Defect Repari stent is similar to Example 4 under the articular cartilage of the present embodiment, difference for porous metal material layer by
Prepared by Stainless steel 316 L, structure is：Aperture from the aperture on surface being connected with the porous salt deposit for 70 μm -100 μm by
Cumulative great transition to the aperture of the distal surface of porous titanium layer deviated from the porous salt deposit be 500 μm -1000 μm, thickness
For 3.5mm, porous salt deposit is prepared using aminoglucose.The preparation method similar embodiment 4 of Bone Defect Repari stent under articular cartilage.
Embodiment 6
Referring to Fig. 2, Bone Defect Repari stent under the articular cartilage of the present embodiment, porous salt 1 is prepared using tricalcium phosphate, and thickness is
0.5mm.Porous metal material layer uses porous C oCrMo alloys, and porous C oCrMo alloys are three layers of gradient porous material of upper, middle and lower
Material, the aperture of the upper strata porous C oCrMo alloy-layer 3 adjacent with porous salt deposit 1 is 3 μm -10 μm, thickness 0.8mm, middle layer 4
Aperture for 50 μm -75 μm, the cavity wall material in hole is the porous C oCrMo alloys that above-mentioned aperture is 3 μm -10 μm, thickness
For 2mm, the aperture of lower floor 5 is 100 μm -650 μm, and cavity wall material is that the porous C oCrMo that above-mentioned aperture is 3 μm -10 μm is closed
Gold, thickness 4mm, the hole between each layer porous C oCrMo alloys inside and layer is mutually communicated.Preparation method is as follows：
（1）The CoCrMo alloyed powders that grain size is 30nm are taken, grain size is 5 μm -15 μm of ethyl cellulose powder, according to volume ratio
CoCrMo alloyed powders：Ethyl cellulose powder is 7：3 mixing, repeatedly stirring make it uniformly mix, mixed powder are put into hard alloy
Mold applies 10MPa pressure and flattens, prepares the green compact of upper strata porous C oCrMo alloys.
（2）The CoCrMo alloyed powders that grain size is 30nm are taken, grain size is 5 μm -15 μm of ethyl cellulose powder, and grain size is 65 μ
M-85 μm of urea, according to volume ratio CoCrMo alloyed powders：Ethyl cellulose powder：Urea is 7：3：25 mixing, repeatedly stirring make
It is uniformly put into the mold containing upper strata porous C oCrMo alloy green compact, applies 10MPa pressure and flattens, it is porous to form upper strata
CoCrMo alloys and the incorporated green compact of middle layer porous C oCrMo alloys.
（3）Take the CoCrMo alloyed powders of grain size 30nm, grain size is 5 μm -15 μm of ethyl cellulose powder, grain size for 180 μm -
750 μm of urea, according to volume ratio CoCrMo alloyed powders：Ethyl cellulose powder：Urea is 7：3：25 mixing, repeatedly stirring make it
Uniformly, the mold containing upper strata porous C oCrMo alloys Yu the incorporated green compact of middle layer porous C oCrMo alloys is put into, is applied
Add 400MPa pressure compactions, it is more to form upper strata porous C oCrMo alloys, middle layer porous C oCrMo alloys and lower floor by pressurize 27s
The incorporated green compact of hole CoCrMo alloys.
（4）Green compact are put into vacuum drying oven, carry out vacuum-sintering and heat treatment to get to the gradient-structure with three layers
Porous C oCrMo alloys.
（5）It is coated in porous C oCrMo alloy upper surfaces with plasma spray and sprays tricalcium phosphate, form porous calcium phosphate three
Calcium layer obtains Bone Defect Repari stent under the articular cartilage of the present embodiment.
Embodiment 7
The present embodiment is similar to Example 6, and difference is prepared for porous salt deposit using hyaluronic acid tetrabutylammonium, porous metals
Layer is prepared using tantalum, and the aperture of middle layer 4 is 70 μm -100 μm, and the aperture of lower floor 5 is 600 μm -1000 μm, and preparation method is similar
Embodiment 6.
Implant and the compound rear implantation sheep shin of sheep Self periosteum is made in the subchondral bone material for repairing of embodiment 7
The cartilage of Bones and joints-subchondral bone fault location 14 weeks shows that bone tissue grows into the 94% of porous tantalum hole by histological observation,
Cartilage defect is also substantially achieved reparation.
Claims (10)
1. a kind of Bone Defect Repari stent under articular cartilage, it is characterised in that：The stent from top to bottom successively by porous salt deposit and
Porous metal material layer is formed, and the porous metal material layer is gradient porous metal material layer.
2. Bone Defect Repari stent under articular cartilage as described in claim 1, it is characterised in that：The porous salt deposit is porous nothing
Machine salt deposit or/and porous organic salt deposit.
3. Bone Defect Repari stent under articular cartilage as claimed in claim 2, it is characterised in that：The porous, inorganic salt deposit uses
Hydroxyapatite or tricalcium phosphate or hyaluronic acid ammonium or hyaluronic acid tetrabutylammonium are prepared.
4. Bone Defect Repari stent under articular cartilage as claimed in claim 2, it is characterised in that：Porous organic salt deposit uses
Chondroitin sulfate or phosphoglycerol or fructose phosphate or glucose phosphate or Serine phosphoric acid or adenylic acid or aminoglucose or half
Lactose amine is prepared.
5. Bone Defect Repari stent under articular cartilage as claimed in claim 1 or 2 or 3 or 4, it is characterised in that：The porous gold
Belong to material layer for porous tantalum layer or POROUS TITANIUM and its alloy-layer or porous niobium layer or porous cobalt-based alloy layer or porous stainless steel layer
Or porous nickel-titanium alloy-layer or porous composite material layer.
6. Bone Defect Repari stent under the articular cartilage as described in claim 1 to 5 any claim, it is characterised in that：It is described
The aperture of porous salt deposit is 3 μm -10 μm.
7. Bone Defect Repari stent under the articular cartilage as described in claim 1 to 6 any claim, it is characterised in that：It is described
Porous metal material layer includes upper and lower two layers；Wherein, the aperture on porous metal material upper strata being connected with the porous salt deposit
Be 50 μm -100 μm, the aperture of porous metal material lower floor is 100 μm -1000 μm, inside each layer porous metal material and layer it
Between hole be mutually communicated.
8. Bone Defect Repari stent under the articular cartilage as described in claim 1 to 6 any claim, it is characterised in that：It is described
The aperture of porous metal material layer gradually increased from the aperture on surface being connected with the porous salt deposit for 50 μm -100 μm
It is 100 μm -1000 μm to cross to the aperture of the distal surface of porous metal material layer deviated from the porous salt deposit, porous gold
Belong to the hole inside material layer to be mutually communicated.
9. Bone Defect Repari stent under the articular cartilage as described in claim 1 to 6 any claim, it is characterised in that：It is described
The gradient porous metal material of gradient porous metal material layer is makes using the porous metal material of minimal gradient grade as raw material
The porous metal material that the hole of aperture bigger is formed forms each gradient grade porous metal material of gradient porous metal material
Hole is mutually communicated.
10. Bone Defect Repari stent under articular cartilage as claimed in claim 9, it is characterised in that：The gradient porous metal material
The bed of material makes the material of two layers of more large aperture using the porous metal material in 3 μm of -10 μm of holes penetrated through as raw material, and formation possesses
The gradient porous metal material layer of three layers of upper, middle and lower, wherein, the upper strata porous metal material layer adjacent with the porous salt deposit
Aperture is 3 μm -10 μm, and the aperture of middle layer porous metal material layer is 50 μm -100 μm, lower floor's porous metal material layer
Aperture is 100 μm -1000 μm, and the hole inside each layer porous metal material and between layer is mutually communicated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611183811.5A CN108201635B (en) | 2016-12-20 | 2016-12-20 | Support for repairing articular subchondral bone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611183811.5A CN108201635B (en) | 2016-12-20 | 2016-12-20 | Support for repairing articular subchondral bone |
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| Publication Number | Publication Date |
|---|---|
| CN108201635A true CN108201635A (en) | 2018-06-26 |
| CN108201635B CN108201635B (en) | 2020-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611183811.5A Active CN108201635B (en) | 2016-12-20 | 2016-12-20 | Support for repairing articular subchondral bone |
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| CN108201635B (en) | 2020-10-23 |
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