CN108186692A - A kind of drug and production method for treating intestinal bacilli illness - Google Patents
A kind of drug and production method for treating intestinal bacilli illness Download PDFInfo
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- CN108186692A CN108186692A CN201810124962.6A CN201810124962A CN108186692A CN 108186692 A CN108186692 A CN 108186692A CN 201810124962 A CN201810124962 A CN 201810124962A CN 108186692 A CN108186692 A CN 108186692A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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Abstract
The invention discloses a kind of drug and production method for treating intestinal bacilli illness, the tablet of one includes following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 1 ~ 5 mass parts；Bifidobacterium is 2 ~ 7 mass parts；Enterococcus faecalis is 1 ~ 2 mass parts；Lactobacillus acidophilus is 4 ~ 6 mass parts；Auxiliary material is that fructose is 1 ~ 3 mass parts；Lactose is 2 ~ 4 mass parts；Superfine silica gel powder is 1 ~ 5 mass parts；Fruit hides essence as 1 ~ 2 mass parts；Purified water is 2 ~ 6 mass parts；Pregelatinized starch is 1 ~ 5 mass parts.Drug of the present invention has of low cost, selected medicinal material is mostly the object of mild in medicine property sum, convenient nursing personnel treat the patient of intestinal bacilli illness, and effect is lasting, do not have irritant smell, to human body without any injury, by the addition of Bifidobacterium with biological barrier, trophism, antitumor action, immunological enhancement, improvement a variety of important physiological functions such as gastrointestinal function and anti-aging.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation technical field, specially a kind of drug for treating intestinal bacilli illness and making
Method.
Background technology
At present, it is existing treatment intestinal bacilli illness drug also there is the place of some shortcomings, such as；It is existing to control
The drug drug of the present invention for treating intestinal bacilli illness is higher with cost, and selected medicinal material is mostly the object of pharmacological property stimulation, it has not been convenient to
Nursing staff treats the patient of intestinal bacilli illness, and irritant smell has human body certain injury, and existing treatment
The drug of intestinal bacilli illness does not have biological barrier, trophism, antitumor action, immunological enhancement, improves gastrointestinal tract work(
A variety of important physiological functions such as energy and anti-aging.
Invention content
The technical problem to be solved by the present invention is to overcome the defects of the prior art, provide a kind of to treat intestinal bacilli illness
Drug and production method, drug of the present invention have it is of low cost, selected medicinal material is mostly the object of mild in medicine property sum, and convenient nursing personnel control
The patient of intestinal bacilli illness is treated, and effect is lasting, does not have irritant smell, to human body without any injury, passes through bifid bar
The addition of bacterium has biological barrier, trophism, antitumor action, immunological enhancement, improves gastrointestinal function and anti-aging
Etc. a variety of important physiological functions.
To solve the above problems, the present invention provides following technical solution：A kind of drug and system for treating intestinal bacilli illness
Make method, the tablet of one includes following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 1 ~ 5 mass parts；
Bifidobacterium is 2 ~ 7 mass parts；Enterococcus faecalis is 1 ~ 2 mass parts；Lactobacillus acidophilus is 4 ~ 6 mass parts；Auxiliary material is that fructose is 1 ~ 3
Mass parts；Lactose is 2 ~ 4 mass parts；Superfine silica gel powder is 1 ~ 5 mass parts；Fruit hides essence as 1 ~ 2 mass parts；Purified water is 2 ~ 6
Mass parts；Pregelatinized starch is 1 ~ 5 mass parts.
As a kind of preferred embodiment of the present invention, the drug of the treatment intestinal bacilli illness, the tablet of one
Including following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Enterococcus faecalis is 2 mass parts；It is thermophilic
Lactobacillus lactis is 4 mass parts；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit is hidden
Essence is 2 mass parts；Purified water is 4 mass parts；Pregelatinized starch is 3 mass parts.
As a kind of preferred embodiment of the present invention, the drug of the treatment intestinal bacilli illness, the tablet of one
Including following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Bifidobacterium is 4 mass parts；Excrement
Enterococcus is 2 mass parts；Lactobacillus acidophilus is 4 mass parts；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Micro mist silicon
Glue is 1 mass parts；Fruit hides essence as 2 mass parts；Purified water is 4 mass parts；Pregelatinized starch is 3 mass parts.
As a kind of preferred embodiment of the present invention, the Bifidobacterium is Gram-positive, and cellular morphology is more
Sample, including rod-short, nearly spherical, long bent pole shape, bifurcated be rod-shaped, club-like or spoon-shaped；Cell is single or arranges forming V-shape, fence
It is shape, starlike；It is not antiacid, do not form gemma, do not move, obligate anaerobic；Bacterium colony is smaller, smooth, dome, edge are complete, in butterfat
Color is to white.Optimum growth temperature is 37-41 DEG C, and minimum growth temperature is 25-28 DEG C, up to 43-45 DEG C；Initial growth is most
Suitable pH is 6.5-7.0, and growth pH ranges are generally 4.5-8.5.
As a kind of preferred embodiment of the present invention, the superfine silica gel powder is nontoxic, it is tasteless, non-ignitable, not quick-fried, non-volatile,
Corrosion-free, large pore volume, surface-active are strong；Chemical property is stablized, and is not acted on acid, alkali（Except hydrofluoric acid）；It is not soluble in water.
As a kind of preferred embodiment of the present invention, the production method of the drug of the treatment intestinal bacilli illness,
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
As a kind of preferred embodiment of the present invention, mixing and stirring in the step b, first by major ingredient and auxiliary material
Mixer is put into, is then carried out again by blender to major ingredient and auxiliary material stirring, temperature during stirring is 30 ~ 40 DEG C, during stirring
Speed be 150r/min, mixing time 10min.
Compared with prior art, beneficial effects of the present invention are as follows：
A kind of drug and production method for treating intestinal bacilli illness of the present invention, drug of the present invention have of low cost, selected medicine
Material is mostly the object of mild in medicine property sum, and convenient nursing personnel treat the patient of intestinal bacilli illness, and effect is lasting, does not have irritant
Smell to human body without any injury, has biological barrier by the addition of Bifidobacterium, trophism, antitumor action, is immunized
Humidification improves a variety of important physiological functions such as gastrointestinal function and anti-aging.
Specific embodiment
Preferably, the drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight point
Number：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 1 ~ 5 mass parts；Bifidobacterium is 2 ~ 7 mass parts；Enterococcus faecalis is 1 ~ 2 mass parts；
Lactobacillus acidophilus is 4 ~ 6 mass parts；Auxiliary material is that fructose is 1 ~ 3 mass parts；Lactose is 2 ~ 4 mass parts；Superfine silica gel powder is 1 ~ 5 mass
Part；Fruit hides essence as 1 ~ 2 mass parts；Purified water is 2 ~ 6 mass parts；Pregelatinized starch is 1 ~ 5 mass parts.
Preferably, the drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight point
Number：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Enterococcus faecalis is 2 mass parts；Lactobacillus acidophilus is 4 mass parts；Auxiliary material
It is 2 mass parts for fructose；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit hides essence as 2 mass parts；Purified water is 4
Mass parts；Pregelatinized starch is 3 mass parts.
Preferably, the drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight point
Number：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Bifidobacterium is 4 mass parts；Enterococcus faecalis is 2 mass parts；Acidophilus breast
Bacillus is 4 mass parts；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit hides essence
For 2 mass parts；Purified water is 4 mass parts；Pregelatinized starch is 3 mass parts.
Preferably, the Bifidobacterium is Gram-positive, and cellular morphology is various, including rod-short, nearly spherical, length
Curved bar shape, bifurcated are rod-shaped, club-like or spoon-shaped；Cell is single or arrangement forming V-shape, paliform, starlike；It is not antiacid, do not form bud
Spore does not move, obligate anaerobic；Bacterium colony is smaller, smooth, dome, edge are complete, in creamy to white.Optimum growth temperature is
37-41 DEG C, minimum growth temperature is 25-28 DEG C, up to 43-45 DEG C；Initial growth optimal pH is 6.5-7.0, grows pH models
Enclose generally 4.5-8.5.
Preferably, the superfine silica gel powder is nontoxic, tasteless, non-ignitable, not quick-fried, non-volatile, corrosion-free, large pore volume, surface-active
By force；Chemical property is stablized, and is not acted on acid, alkali（Except hydrofluoric acid）；It is not soluble in water.
Preferably, the production method of the drug of the treatment intestinal bacilli illness, manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
Preferably, the mixing and stirring in the step b, is put into mixer by major ingredient and auxiliary material first, then again by
Blender is carried out to major ingredient and auxiliary material stirring, and temperature during stirring is 30 ~ 40 DEG C, and speed during stirring is 150r/min, stirring
Time is 10min.
Embodiment 1
The drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight fraction：Major ingredient is freezes
Dry cloth Laplace saccharomycete is 1 ~ 5 mass parts；Bifidobacterium is 2 ~ 7 mass parts；Enterococcus faecalis is 1 ~ 2 mass parts；Lactobacillus acidophilus
For 4 ~ 6 mass parts；Auxiliary material is that fructose is 1 ~ 3 mass parts；Lactose is 2 ~ 4 mass parts；Superfine silica gel powder is 1 ~ 5 mass parts；Fruit is hidden
Essence is 1 ~ 2 mass parts；Purified water is 2 ~ 6 mass parts；Pregelatinized starch is 1 ~ 5 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
In the present embodiment treatment intestinal bacilli illness drug tool have it is of low cost, selected medicinal material be mostly mild in medicine property and
Object, convenient nursing personnel treat the patient of intestinal bacilli illness, and effect is lasting, does not have irritant smell, to human body without
Any injury has biological barrier, trophism, antitumor action, immunological enhancement, improvement by the addition of Bifidobacterium
A variety of important physiological functions such as gastrointestinal function and anti-aging.
Embodiment 2
The drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight fraction：Major ingredient is freezes
Dry cloth Laplace saccharomycete is 3 mass parts；Enterococcus faecalis is 2 mass parts；Lactobacillus acidophilus is 4 mass parts；Auxiliary material is that fructose is 2 matter
Measure part；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit hides essence as 2 mass parts；Purified water is 4 mass parts；Pre- glue
Change starch is 3 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
The drug for the treatment of intestinal bacilli illness in the present embodiment, by the increase of lactobacillus acidophilus, can effectively adjust
Intestinal flora balances, and inhibits the proliferation of enteron aisle undesirable microorganism, also has antagonism to pathogenic microorganisms.
Embodiment 3
The drug of the treatment intestinal bacilli illness, the tablet of one include following raw material and its weight fraction：Major ingredient is freezes
Dry cloth Laplace saccharomycete is 3 mass parts；Bifidobacterium is 4 mass parts；Enterococcus faecalis is 2 mass parts；Lactobacillus acidophilus is 4 mass
Part；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit hides essence as 2 mass parts；It is pure
Change water is 4 mass parts；Pregelatinized starch is 3 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
In the present embodiment treatment intestinal bacilli illness drug, have it is of low cost, selected medicinal material be mostly mild in medicine property and
Object, convenient nursing personnel treat the patient of intestinal bacilli illness, and effect is lasting, does not have irritant smell, to human body without
Any injury has biological barrier, trophism, antitumor action, immunological enhancement, improvement by the addition of Bifidobacterium
A variety of important physiological functions such as gastrointestinal function and anti-aging.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to aforementioned reality
Example is applied the present invention is described in detail, it for those skilled in the art, still can be to aforementioned each implementation
Technical solution recorded in example modifies or carries out equivalent replacement to which part technical characteristic.All essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (7)
1. a kind of drug for treating intestinal bacilli illness, it is characterised in that：The tablet of one includes following raw material and its weight point
Number：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 1 ~ 5 mass parts；Bifidobacterium is 2 ~ 7 mass parts；Enterococcus faecalis is 1 ~ 2 mass parts；
Lactobacillus acidophilus is 4 ~ 6 mass parts；Auxiliary material is that fructose is 1 ~ 3 mass parts；Lactose is 2 ~ 4 mass parts；Superfine silica gel powder is 1 ~ 5 mass
Part；Fruit hides essence as 1 ~ 2 mass parts；Purified water is 2 ~ 6 mass parts；Pregelatinized starch is 1 ~ 5 mass parts.
2. a kind of drug for treating intestinal bacilli illness according to claim 1, it is characterised in that：The tablet of one includes
Following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Enterococcus faecalis is 2 mass parts；Acidophilus breast
Bacillus is 4 mass parts；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Superfine silica gel powder is 1 mass parts；Fruit hides essence
For 2 mass parts；Purified water is 4 mass parts；Pregelatinized starch is 3 mass parts.
3. a kind of drug for treating intestinal bacilli illness according to claim 1, it is characterised in that：The tablet of one includes
Following raw material and its weight fraction：Major ingredient is that freeze-drying cloth Laplace saccharomycete is 3 mass parts；Bifidobacterium is 4 mass parts；Excrement intestines ball
Bacterium is 2 mass parts；Lactobacillus acidophilus is 4 mass parts；Auxiliary material is that fructose is 2 mass parts；Lactose is 3 mass parts；Superfine silica gel powder is 1
Mass parts；Fruit hides essence as 2 mass parts；Purified water is 4 mass parts；Pregelatinized starch is 3 mass parts.
4. a kind of drug for treating intestinal bacilli illness according to claim 1, it is characterised in that：The Bifidobacterium is
Gram-positive, cellular morphology is various, and including rod-short, nearly spherical, long bent pole shape, bifurcated be rod-shaped, club-like or spoon-shaped；
Cell is single or arrangement forming V-shape, paliform, starlike；It is not antiacid, do not form gemma, do not move, obligate anaerobic；Bacterium colony is smaller, light
Cunning, dome, edge are complete, in creamy to white；Optimum growth temperature is 37-41 DEG C, and minimum growth temperature is 25-28 DEG C,
Up to 43-45 DEG C；Initial growth optimal pH is 6.5-7.0, and growth pH ranges are generally 4.5-8.5.
5. a kind of drug for treating intestinal bacilli illness according to claim 1, it is characterised in that：The superfine silica gel powder without
Malicious, tasteless, non-ignitable, not quick-fried, non-volatile, corrosion-free, large pore volume, surface-active are strong；Chemical property is stablized, and is not acted on acid, alkali
（Except hydrofluoric acid）；It is not soluble in water.
6. the production method of the drug of the treatment intestinal bacilli illness according to claim 1 to 5, it is characterised in that：It makes
Processing step is as follows：
A. above-mentioned raw materials are weighed according to parts by weight；
B. after the completion for the treatment of step a, then the major ingredient weighed and auxiliary material mixed and is stirred；
C. after the completion for the treatment of step b, then mixed spice being taken out and is placed on extruding pelletization in twin-screw, extrusion temperature is 30 ~ 50 DEG C,
Engine speed is about 200 ~ 360r/min；
D. after the completion for the treatment of step c, the compound spice particle made at 40 ~ 45 DEG C is dried into 8 ~ 10h, is finally detected, is filled
Bag and mark.
7. the production method of the drug for the treatment of intestinal bacilli illness according to claim 6, it is characterised in that：The step
Mixing and stirring in b, are put into mixer by major ingredient and auxiliary material first, then by blender stir major ingredient and auxiliary material again
It mixes, temperature during stirring is 30 ~ 40 DEG C, and speed during stirring is 150r/min, mixing time 10min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810124962.6A CN108186692A (en) | 2018-02-07 | 2018-02-07 | A kind of drug and production method for treating intestinal bacilli illness |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810124962.6A CN108186692A (en) | 2018-02-07 | 2018-02-07 | A kind of drug and production method for treating intestinal bacilli illness |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108186692A true CN108186692A (en) | 2018-06-22 |
Family
ID=62592736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810124962.6A Withdrawn CN108186692A (en) | 2018-02-07 | 2018-02-07 | A kind of drug and production method for treating intestinal bacilli illness |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108186692A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108641991A (en) * | 2018-07-11 | 2018-10-12 | 江苏恒丰强生物技术有限公司 | A kind of composite viable bacteria preparation and preparation method and its application |
| CN115227728A (en) * | 2022-05-31 | 2022-10-25 | 湖南航天医院 | Intestinal microecological preparation and preparation method thereof |
-
2018
- 2018-02-07 CN CN201810124962.6A patent/CN108186692A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108641991A (en) * | 2018-07-11 | 2018-10-12 | 江苏恒丰强生物技术有限公司 | A kind of composite viable bacteria preparation and preparation method and its application |
| CN115227728A (en) * | 2022-05-31 | 2022-10-25 | 湖南航天医院 | Intestinal microecological preparation and preparation method thereof |
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Application publication date: 20180622 |