CN108184845A - A kind of fomesafen microemulsion and preparation method thereof - Google Patents
A kind of fomesafen microemulsion and preparation method thereof Download PDFInfo
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- CN108184845A CN108184845A CN201810035114.8A CN201810035114A CN108184845A CN 108184845 A CN108184845 A CN 108184845A CN 201810035114 A CN201810035114 A CN 201810035114A CN 108184845 A CN108184845 A CN 108184845A
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- Prior art keywords
- fomesafen
- microemulsion
- ether
- alcohol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/06—Sulfonic acid amides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of fomesafen microemulsions and preparation method thereof, its fomesafen microemulsion is a kind of novel, efficiently, low toxicity, it is pollution-free, fowl safety is stored to people and weeds are not likely to produce the novel form of drug resistance, the dosage form by surfactant effect, fomesafen is dissolved in organic solvent, it is dispersed in water to form transparent preparation, manufactured fomesafen microemulsion forms fomesafen 1 20% by following weight percents, surfactant 5 25%, cosolvent 5 15%, stabilizer 0.01 5%, synergist 0.5 5%, promote infiltration 0.1 5%, water supplies 100%, raw material availability of the present invention is high, it is simple for process, production cost is low, it is a kind of novel agricultural weeding dosage form.
Description
Technical field
The present invention relates to a kind of pesticide herbicides more particularly to a kind of fomesafen microemulsion and preparation method thereof.
Background technology
Fomesafen (Fomesafen), chemical name：5- [2- chloro- 4- (trifluoromethyl) phenoxy group]-N- (methyl sulphurs
Acyl group) -2- nitrobenzamides, molecular structural formula：
Fomesafen is selective diphenyl ether herbicide, is mainly used to prevent and kill off soybean in field broad leaved weed, as Tong fiber crops,
Amaranth, lamb's-quarters, Siberian cocklebur, volume stem smartweed, iron amaranth, bur beggar-ticks, black nightshade, purslane etc., have grassy weed certain inhibiting effect.
It is frequently used due to a large amount of of chemical synthetic pesticide, results in pesticide residue, the generation of disease pest and weed resistance.
In recent years, it is increasingly strict to the limitation for using organic solvent in the developed countries such as Great Britain and America, pesticidal preparations, certain country's dimethylbenzene
Have the tendency that banned for pesticide solvent, so as to promote the formulations of pesticide that must constantly update, wherein Water-borne modification is exactly Agrochemicals
One of important directions, the microemulsion using water as solvent can not only reduce the pollution of pesticide, but also can reduce the cost of pesticide producing,
A kind of particularly important dosage form in pesticide manufacturing is become.
Invention content
The purpose of the present invention is disclose a kind of fomesafen microemulsion and preparation method thereof.
What the purpose of the present invention was achieved through the following technical solutions：Using fomesafen as active constituent, by emulsifier
Effect, and add auxiliary agent, make its it is homodisperse form transparent fomesafen microemulsion in water, be oil-in-water type (W/
O), the content of fomesafen therein is 1-20%.
Above-mentioned fomesafen microemulsion is made of following weight percents：
Surfactant of the present invention is aliphatic alcohol sulfate, alkylol polyoxyethanyl ether sodium sulfate, alkylbenzenesulfonate, alkane
Base naphthalene sulfonate, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol formaldehyde condensation product ethylene oxide adduct sulfonate, fat
Fat alcohol polyoxyethylene ether, alkylphenol-polyethenoxy base ether, dehydration sorbic alcohol aliphatic ester, sorbitan fatty polyoxyethylene
Base ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, alkylphenol formaldehyde condensation product polyoxyethylene ether, ethylene oxide nonyl phenol
One or more of condensation product.
Stabilizer of the present invention is 3- chloro- 1, and 2 propylene oxide, butyl glycidyl ether, phenyl glycidyl ether, tolyl contract
One or more of water glycerin ether, polyethylene glycol diglycidyl ether, sodium sorbate.Antifreezing agent is ethylene glycol, third
One or more of glycol, glycerine, polyethylene glycol, sorbierite.
Permeation enhancers of the present invention are azone, Laurocapram.
Cosolvent of the present invention for methanol, DMF, dimethylbenzene, cyclohexanone, ethyl alcohol, isoamyl alcohol, phenol, acetone, ethyl acetate,
One or more of dimethyl sulfoxide (DMSO).
Synergist of the present invention is Butacide, sulfoxide, formaldehyde, castor oil, chlorinated aliphatic, one kind in piperonyl butoxide or
It is several.
The preparation method of above-mentioned fomesafen microemulsion, which is characterized in that first by fomesafen active compound and hydrotropy
Agent is mixed evenly, and then proportionally adds in surfactant, stabilizer, synergist, antifreezing agent, permeation enhancers, stirs,
It is sufficiently mixed uniformly, is eventually adding deionized water, is uniformly mixed, stand, you can microemulsion is made, packs.
The present invention provides it is a kind of it is novel, efficient, less toxic, pollution-free, people's fowl poultry safety and weeds are not easy to produce resistance
Fomesafen microemulsion, the dosage form is with water section or all instead of the microemulsion of the organic solvent in missible oil.It is by table
The effect of face activity, fomesafen oil is homogeneously dispersed in, transparent preparation is formed in water, adds appropriate increasing wherein
Agent, permeation enhancers and stabilizer are imitated, so as to which the herbicide products of high-quality and high-efficiency be made, raw material availability of the present invention is high, technique letter
Single, production cost is low, is a kind of herbicide products of novel dosage forms.
The invention has the advantages that：It is decentralized medium as a result, thus having because of the miniaturization of preparation drop and using water
1. flash-point is high, does not burn and do not explode, production storage and it is safe to use；2. environmental pollution is small, to the producer and user and ring
Border safety；3. a pair plant has good permeability, absorptivity is high, thus low dosage can obtain higher preventive effect；4. using water as
Matrix, resourceful, the low packaging of product cost is easy；5 can be significantly reduced the peculiar smell of pesticide, reduce the wound in itself to crop
Evil.
Specific implementation
Example one
5% fomesafen microemulsion.95% fomesafen active compound 5.3kg is taken, is placed in the methanol solvate cosolvent of 5kg
In, the phenethyl phenol polyoxyethylene poly-oxygen propylene aether of input 8kg, 6kg alkylbenzenesulfonates, 12kg dehydration sorbic alcohol fat after dissolving
Fatty acid ester surface active agent, 0.5kg Butacides, 0.5kg phenyl glycidyl ethers are thrown after stirring, then by solvent
Enter and mix and homogenize strongly into the homogenizer equipped with 58.7kg decentralized medium waters and 4kg ethylene glycol antifreezes, obtain appearance
For limpid 5% transparent fomesafen microemulsion.
Example two
10% fomesafen microemulsion.95% fomesafen active compound 10.6kg is taken, the cyclohexanone solvent for being placed in 8kg helps
In solvent, the alkylphenol-polyethenoxy base ether of 7kg, 5kg alkylbenzenesulfonates, 13kg ethylene oxide nonyl phenols are put into after dissolving
Condensation product surfactant, 0.5kg Butacides, 0.5kg sodium sorbates put into dress after stirring, then by solvent
It mixes and homogenizes strongly in the homogenizer for having 51.4kg decentralized medium waters and 4kg propylene glycol antifreezing agents, it is limpid to obtain appearance
10% transparent fomesafen microemulsion.
Example three
15% fomesafen microemulsion.95% fomesafen active compound 15.8kg is taken, the acetone solvent for being placed in 10kg helps
In solvent, the fat alcohol ethylene oxide adduct sulfonate of 6kg, 7kg alkylnaphthalene sulfonates, 12kg ethylene oxide nonyls are put into after dissolving
Base phenol condensate surfactant, 0.5kg castor oil, 0.5kg sodium sorbates are thrown after stirring, then by solvent
Enter and mix and homogenize strongly into the homogenizer equipped with 44.2kg decentralized medium waters and 4kg propylene glycol antifreezing agents, obtain appearance
For limpid 15% transparent fomesafen microemulsion.
Example four
20% fomesafen microemulsion.95% fomesafen active compound 21.1kg is taken, is placed in the xylene solvent of 13kg
In cosolvent, the aliphatic alcohol sulfate of 10kg, 5kg aliphatic alcohol polyethenoxy base ethers, 12kg ethylene oxide nonyls are put into after dissolving
Phenol condensate surfactant, 0.5kg castor oil, 0.5kg sodium sorbates are put into after stirring, then by solvent
It mixes and homogenizes strongly into the homogenizer equipped with 33.9kg decentralized medium waters and 4kg glycerine antifreezing agents, obtaining appearance is
Limpid 20% transparent fomesafen microemulsion.
Claims (8)
1. a kind of fomesafen microemulsion and preparation method thereof, weight percent is formed as fomesafen 1-20%, table
Face activating agent 5-25%, cosolvent 5-15%, stabilizer 0.01-5%, synergist 0.5-5%, permeation enhancers 0.1-5% are antifreeze
Agent 1-4%, water supply 100%.
2. fomesafen microemulsion according to claim 1, which is characterized in that surfactant is fatty alcohol sulphuric acid
Salt, alkylol polyoxyethanyl ether sodium sulfate, alkylbenzenesulfonate, alkylnaphthalene sulfonate, fatty alcohol ethylene oxide adduct sulfonic acid
Salt, alkylphenol formaldehyde condensation product ethylene oxide adduct sulfonate, aliphatic alcohol polyethenoxy base ether, alkylphenol-polyethenoxy base
Ether, dehydration sorbic alcohol aliphatic ester, sorbitan fatty polyoxyethylene ether, alkylphenol formaldehyde condensation product polyoxyethylene groups
One or more of ether, ethylene oxide nonyl phenol condensation product.
3. fomesafen microemulsion according to claim 1, which is characterized in that stabilizer is chloro- 1,2 epoxies third of 3-
Alkane, butyl glycidyl ether, phenyl glycidyl ether, cresyl glycidyl ether, polyethylene glycol diglycidyl ether,
One or more of sodium sorbate.
4. fomesafen microemulsion according to claim 1, which is characterized in that antifreezing agent is ethylene glycol, propylene glycol, third
One or more of triol, polyethylene glycol, sorbierite.
5. fomesafen microemulsion according to claim 1, which is characterized in that permeation enhancers are azone, bay nitrogen is tall and erect
Ketone.
6. fomesafen microemulsion according to claim 1, which is characterized in that cosolvent is ethyl alcohol, isoamyl alcohol, benzene
One or more of phenol, acetone, ethyl acetate, dimethyl sulfoxide (DMSO).
7. fomesafen microemulsion according to claim 1, which is characterized in that synergist is Butacide, sulfoxide, first
One or more of aldehyde, castor oil, chlorinated aliphatic, piperonyl butoxide.
8. a kind of preparation method of fomesafen microemulsion as described in claim 1, which is characterized in that first by fluorine sulfanilamide (SN) grass
Ether active compound is mixed evenly with cosolvent, then proportionally adds in surfactant, stabilizer, synergist, antifreezing agent, rush
Bleeding agent, stirring are sufficiently mixed uniformly, are eventually adding deionized water, are uniformly mixed, and stand, you can microemulsion is made, wraps
Dress.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810035114.8A CN108184845A (en) | 2018-01-15 | 2018-01-15 | A kind of fomesafen microemulsion and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810035114.8A CN108184845A (en) | 2018-01-15 | 2018-01-15 | A kind of fomesafen microemulsion and preparation method thereof |
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| CN108184845A true CN108184845A (en) | 2018-06-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111713491A (en) * | 2020-07-27 | 2020-09-29 | 江西禾益化工股份有限公司 | Dimethachlon suspending agent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554156A (en) * | 2008-04-11 | 2009-10-14 | 北京绿色农华生物工程技术有限公司 | Fomesafen microemulsion and preparation method thereof |
| CN102726414A (en) * | 2012-06-29 | 2012-10-17 | 四川贝尔化工集团有限公司 | Microemulsion containing fomesafen and quizalofop-p-ethyl, and preparation method thereof |
-
2018
- 2018-01-15 CN CN201810035114.8A patent/CN108184845A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554156A (en) * | 2008-04-11 | 2009-10-14 | 北京绿色农华生物工程技术有限公司 | Fomesafen microemulsion and preparation method thereof |
| CN102726414A (en) * | 2012-06-29 | 2012-10-17 | 四川贝尔化工集团有限公司 | Microemulsion containing fomesafen and quizalofop-p-ethyl, and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111713491A (en) * | 2020-07-27 | 2020-09-29 | 江西禾益化工股份有限公司 | Dimethachlon suspending agent and preparation method thereof |
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