CN108181477A - A kind of test paper instrument and method for detecting blood clotting INR parameters - Google Patents
A kind of test paper instrument and method for detecting blood clotting INR parameters Download PDFInfo
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- CN108181477A CN108181477A CN201810097312.7A CN201810097312A CN108181477A CN 108181477 A CN108181477 A CN 108181477A CN 201810097312 A CN201810097312 A CN 201810097312A CN 108181477 A CN108181477 A CN 108181477A
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- blood
- blood clotting
- inr
- test strips
- stent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/224—Haemostasis or coagulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
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- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
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- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to in-vitro diagnosis medical equipment fields, specially a kind of test paper instrument and method for detecting blood clotting INR parameters, the apparatus structure is simple, at low cost, and it is accurate to measure, it takes short, and the size of blood coagulation detection device is reduced, using with more feasibility, meet the needs of consumer is to market, convenient for being promoted in family, have wide practical use.Detection method of the present invention using process is simple, testing result is accurate, meets the needs of consumer is to market.
Description
Technical field
The present invention relates to in-vitro diagnosis medical equipment field, specially a kind of test paper instrument for detecting blood clotting INR parameters and
Method.
Background technology
In recent years, with the development of laboratory medicine, clinically gradually increase in relation to hemostasis and thrombus detection project, fibrin ferment
Former time (PT) as diagnosis disorders of blood coagulation basic detection project, accurate, reliable testing result to clinical detection with
Observation of curative effect provides valuable index.Result to measure different thromboplastin reagents is comparable, and spy draws state
Border standadized ratio INR(International Normalized Ratio).With the reference blood plasma measured by thromboplastin with
The ISI values that the PT ratios and agents useful for same of normal plasma mark can calculate INR values.The value of INR is higher, needed for blood clotting
Time it is longer.Apoplexy caused by thrombosis, such as thrombus can be prevented in this way.But if when INR values are very high, just
It will appear uncontrollable bleeding risk.INR can also effectively monitor the effect using anti-freezing " hemodilution " drug simultaneously, such as
Warfarin(Warfarin).Usually using the apoplexy of anticoagulant therapy prevention atrial fibrillation patient;Also it is used for preventing quiet
The recurrence of arteries and veins thrombus.But once using warfarin, just answer the monitoring INR of regularity.Such as patient it will be appreciated that their blood
Pressure value is the same, they also will be appreciated that oneself warfarin dosage and INR values.
INR parameters, but the generally bulky needs of blood coagulation analyzer detect using blood coagulation analyzer in most of medical institutions
Flushing liquor, holding vessel etc. are equipped with, and expensive, complicated for operation, use is popularized to hemorrhagic and thrombotic diseases patient's household
Also there are certain difficulties.So the device of a detection blood clotting INR parameters simple to operation of exploitation is urgently to be resolved hurrily asks
Topic.
Invention content
The problem to be solved in the present invention is to provide a kind of test paper instrument and method for facilitating detection blood clotting INR parameters.
The present invention is achieved by the following technical solutions:
A kind of test paper instrument for detecting blood clotting INR parameters, including the rectangular support frame horizontal by 45 ° of angles, the stent
On be equipped with white celluloid fiber blood clotting test strips along its length, the cross section of the blood clotting test strips is circular hole honeycomb knot
Structure, the cross-sectional unit Circularhole diameter of the blood clotting test strips is 0.1mm, and the blood clotting test strips side is equipped with what is aligned
INR graduated scales, the pedestal lower end are equipped with the blood collection pond for immersing the blood clotting test strips bottom end, the blood collection pond
Capacity is 0.025ml, and the blood collection pond is equipped with the graduation mark for representing 0.02ml capacity;Protection is provided on the stent
With the transparent outer cover of observation blood clotting test strips.It is so designed that, blood collection pond is put into the blood of the acquisition of 0.02ml, passes through 45 °
The cellular circular hole of the blood clotting reagent paper slip of angle, due to capillary phenomenon principle, blood rises and then solidifies constant corresponding INR
Scale value is exactly what is needed the INR detected values wanted.
Further, the groove of the embedded blood clotting test strips, the groove and the blood are provided on the stent
The bottom perforation of collecting pit, the groove penetrate through the cantilever tip.It is so designed that, facilitates fixed blood clotting test strips, Yi Jichong
Tap touches the blood for absorbing blood collection pond, facilitates and replaces blood clotting test strips.
Further, it is pasted with celluloid fiber hardboard under the blood clotting test strips.It is so designed that, facilitates blood in blood clotting
It is absorbed in test strips, anti-Hemostatic Oral Liquid is sticked on stent cover.
Further, the length of the blood clotting test strips is 50 ~ 60mm, width is 3 ~ 4mm, thickness is 1 ~ 2mm.So set
Meter, size design are reasonable.
The detection method of the test paper instrument of the detection blood clotting INR parameters, specific steps are followed successively by down:
1st, finger finger is wiped with alcohol swab;
2nd, blood needle is taken to take blood on the finger by alcohol wipe with sterile;
3rd, the blood taken in blood needle is injected in blood collection pond, and filled to graduation mark position;
4th, when blood is drawn onto blood clotting test strips from collecting pit, the white surface of paper slip band reddens, and 3min is waited for, until blood
When red in solidifying test strips is unchanged, the reading on INR scales is write down.
It is of the present invention detection blood clotting INR parameters test paper instrument compared with prior art, acquired advantageous effect
It is:The present invention is put into the blood of the acquisition of 0.02ml by blood collection pond, by the cellular circular hole of blood clotting reagent paper slip, by
In capillary phenomenon principle, blood, which rises and then solidifies constant corresponding INR scale values, is exactly what is needed the INR detected values wanted, the instrument
Device is simple in structure, at low cost, and it is accurate to measure, time-consuming short, and reduces the size of blood coagulation detection device, using with more feasible
Property, meet the needs of consumer is to market, convenient for being promoted in family, have wide practical use.
Detection method of the present invention using process is simple, testing result is accurate, meets need of the consumer to market
It asks, convenient for being promoted in family, has wide practical use.
Description of the drawings
Fig. 1 is the test paper instrument main structure diagram of detection blood clotting INR parameters of the present invention;
Fig. 2 is the test paper instrument left view structural representation of detection blood clotting INR parameters of the present invention;
Fig. 3 is the schematic cross-sectional view of supporting structure shown in Fig. 1;
In figure:1st, stent, 2, blood clotting test strips, 3, INR graduated scales, 4, blood collection pond, 5, shell, 6, groove, 7, hardboard.
Specific embodiment
The specific embodiment of the present invention is described in further detail below in conjunction with the accompanying drawings.
As Fig. 1 ~ 3 detection blood clotting INR parameters test paper instrument, including the rectangular support frame horizontal by 45 ° of angles
1, white celluloid fiber blood clotting test strips 2, the length of 50mm, width 3mm, thickness are equipped on stent 1 along its length
For 1mm, the cross section of blood clotting test strips 2 is circular hole honeycomb, and the cross-sectional unit Circularhole diameter of blood clotting test strips 2 is
0.1mm, 2 side of blood clotting test strips are equipped with the INR graduated scales 3 aligned, and 1 lower end of stent, which is equipped with, immerses 2 bottom of blood clotting test strips
The blood collection pond 4 at end, the capacity in blood collection pond 4 is 0.025ml, and blood collection pond 4, which is equipped with, represents 0.02ml capacity
Graduation mark;In order to facilitate fixing blood clotting test strips and coming into full contact with the blood in absorption blood collection pond, it is provided on stent 1
The groove 6 of embedded blood clotting test strips 2, groove 6 and the bottom in blood collection pond 2 penetrate through, and groove 6 penetrates through 1 top of stent, so may be used
Used blood clotting test strips are replaced to facilitate;Protection is provided on stent 1 and observes the transparent outer cover 5 of blood clotting test strips.
It is absorbed in blood clotting test strips in order to facilitate blood, anti-Hemostatic Oral Liquid is sticked on stent cover, the 2 times stickups of blood clotting test strips
There is celluloid fiber hardboard 7.
The specific detection method body step of the test paper instrument of present invention detection blood clotting INR parameters is followed successively by down:
1st, finger finger is wiped with alcohol swab;
2nd, blood needle is taken to take blood on the finger by alcohol wipe with sterile;
3rd, the blood taken in blood needle is injected in blood collection pond, and filled to graduation mark position;
4th, when blood is drawn onto blood clotting test strips from collecting pit, the white surface of paper slip band reddens, etc.
It treats 3min, when the red in blood clotting test strips is unchanged, writes down INR
Reading on scale.
It should be noted last that more than specific embodiment is merely illustrative of the technical solution of the present invention and unrestricted,
Although the present invention is described in detail with reference to preferred embodiment, it will be understood by those of ordinary skill in the art that, it can be right
Technical scheme of the present invention is modified or replaced equivalently, equal without departing from the spirit and scope of technical solution of the present invention
It is intended to be within the scope of the claims of the invention.
Claims (5)
1. a kind of test paper instrument for detecting blood clotting INR parameters, which is characterized in that including the rectangle horizontal by 45 ° of angles
Stent(1), the stent(1)On be equipped with white celluloid fiber blood clotting test strips along its length(2), the blood clotting test strips
(2)Cross section be circular hole honeycomb, the blood clotting test strips(2)Cross-sectional unit Circularhole diameter for 0.1mm, the blood
Solidifying test strips(2)Side is equipped with the INR graduated scales aligned(3), the stent(1)Lower end, which is equipped with, immerses the blood clotting examination
Paper slip(2)The blood collection pond of bottom end(4), the blood collection pond(4)Capacity for 0.025ml, the blood collection pond(4)
It is equipped with the graduation mark for representing 0.02ml capacity;The stent(1)On be provided with protection and observe the transparent outer of blood clotting test strips
Shell(5).
2. the test paper instrument of detection blood clotting INR parameters according to claim 1, which is characterized in that the stent(1)On set
It is equipped with the embedded blood clotting test strips(2)Groove(6), the groove(6)With the blood collection pond(2)Bottom perforation,
The groove(6)Penetrate through the stent(1)Top.
3. the test paper instrument of detection blood clotting INR parameters according to claim 1, which is characterized in that the blood clotting test strips
(2)Under be pasted with celluloid fiber hardboard(7).
4. the test paper instrument of detection blood clotting INR parameters according to claim 1, which is characterized in that the blood clotting test strips
(2)Length be 50 ~ 60mm, width is 3 ~ 4mm, thickness is 1 ~ 2mm.
5. the detection method of the test paper instrument using detection blood clotting INR parameters described in claim 1, which is characterized in that specific
Step is followed successively by down:
1st, finger finger is wiped with alcohol swab;
2nd, blood needle is taken to take blood on the finger by alcohol wipe with sterile;
The blood taken in blood needle is injected in blood collection pond, and is filled to graduation mark position;
4th, when blood is drawn onto blood clotting test strips from collecting pit, the white surface of paper slip band reddens, and waits for 3 min, until
When red in blood clotting test strips is unchanged, write down on INR scales
Reading.
Priority Applications (1)
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CN201810097312.7A CN108181477A (en) | 2018-01-31 | 2018-01-31 | A kind of test paper instrument and method for detecting blood clotting INR parameters |
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CN201810097312.7A CN108181477A (en) | 2018-01-31 | 2018-01-31 | A kind of test paper instrument and method for detecting blood clotting INR parameters |
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CN108181477A true CN108181477A (en) | 2018-06-19 |
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CN201810097312.7A Pending CN108181477A (en) | 2018-01-31 | 2018-01-31 | A kind of test paper instrument and method for detecting blood clotting INR parameters |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113740326A (en) * | 2021-09-06 | 2021-12-03 | 中国人民解放军军事科学院军事医学研究院 | Device and method for rapidly detecting concentration of fibrinogen in whole blood |
Citations (3)
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WO2014091262A1 (en) * | 2012-12-14 | 2014-06-19 | Subotics Innovációs Kft (Subotics Innovation Ltd.) | Disposable ivd device for home self-checking of inr value, characterising blood clotting |
CN105647930A (en) * | 2016-01-21 | 2016-06-08 | 武汉慧禹信息科技有限公司 | Gold-labeled strip based on nucleic acid aptamers of progesterone in saliva and used for detection |
CN207798855U (en) * | 2018-01-31 | 2018-08-31 | 山东兰桥医学科技有限公司 | A kind of test paper instrument of detection blood clotting INR parameters |
-
2018
- 2018-01-31 CN CN201810097312.7A patent/CN108181477A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014091262A1 (en) * | 2012-12-14 | 2014-06-19 | Subotics Innovációs Kft (Subotics Innovation Ltd.) | Disposable ivd device for home self-checking of inr value, characterising blood clotting |
CN105008922A (en) * | 2012-12-14 | 2015-10-28 | 海默环球股份有限公司 | Disposable IVD device for home self-checking of INR value, characterising blood clotting |
CN105647930A (en) * | 2016-01-21 | 2016-06-08 | 武汉慧禹信息科技有限公司 | Gold-labeled strip based on nucleic acid aptamers of progesterone in saliva and used for detection |
CN207798855U (en) * | 2018-01-31 | 2018-08-31 | 山东兰桥医学科技有限公司 | A kind of test paper instrument of detection blood clotting INR parameters |
Non-Patent Citations (1)
Title |
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林发全, 李明芬: "不同血凝分析仪的检测结果可比性探讨", 第三军医大学学报, no. 17 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113740326A (en) * | 2021-09-06 | 2021-12-03 | 中国人民解放军军事科学院军事医学研究院 | Device and method for rapidly detecting concentration of fibrinogen in whole blood |
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