CN108175810A - A kind of efficient Chlortetracycline premix of 10% content and preparation method thereof - Google Patents
A kind of efficient Chlortetracycline premix of 10% content and preparation method thereof Download PDFInfo
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- CN108175810A CN108175810A CN201711429468.2A CN201711429468A CN108175810A CN 108175810 A CN108175810 A CN 108175810A CN 201711429468 A CN201711429468 A CN 201711429468A CN 108175810 A CN108175810 A CN 108175810A
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- chlortetracycline premix
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- chlortetracycline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Abstract
The present invention relates to a kind of efficient Chlortetracycline premix of 10% content, each raw material weight percentage is：The Chlortetracycline premix pretreatment fine powder 40-80% of more than 15% content, vine polyphenol 1-10%, microcrystalline cellulose 5-15%, maltodextrin 1-3%, adhesive 0.2-0.5%, surplus are starch.In inventive formulation, the Chlortetracycline premix pretreatment fine powder of more than 15% content of raw material is intracellular aureomycin to be made to be released from intracellular, needs not move through the broken wall effect of hydrochloric acid in gastric juice by wall breaking enzyme enzymolysis processing Aureomycin fermentation liquor, more there are the absorption using animal intestinal tract, good feeding effect.
Description
Technical field
The invention belongs to pre-mixing agent technical fields, and in particular to the efficient Chlortetracycline premix and its system of a kind of 10% content
Preparation Method.
Background technology
At present, commercially available Chlortetracycline premix product is that Aureomycin fermentation liquor addition calcium carbonate is complexed, aureomycin
Still in the cell, during feeding, Chlortetracycline premix is acted on by the broken wall of hydrochloric acid in gastric juice, is released, then in enteron aisle
It plays a role.Since the acidity of hydrochloric acid in gastric juice is limited, residence time of the Chlortetracycline premix in stomach is short, and the sporoderm-broken rate of aureomycin only has
40-70%, subsequent be absorbed and utilized will be less.The present invention carries out part broken wall to the Aureomycin fermentation liquor that fermentation latter stage obtains
Processing then adds in calcium carbonate and carries out high-content（>15%）The production of Chlortetracycline premix.Simultaneously in 10% Chlortetracycline premix
In production, functional auxiliary material vine polyphenol is added in, can not only slow down the oxidation of free aureomycin, while can be to pathogenic microorganisms
There are control and influence, the effect of alimentary canal microbe colony is adjusted so as to play it.Therefore generally, the present invention can be bright
It is aobvious to improve the absorption rate of aureomycin in animal body.
Invention content
Present invention aims to overcome that prior art defect, provides a kind of efficient Chlortetracycline premix of 10% content, the gold
The absorption rate of mycin in animal body is high, good feeding effect.
The present invention also provides the preparation methods of the efficient Chlortetracycline premix of above-mentioned 10% content.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of efficient Chlortetracycline premix of 10% content, which is characterized in that each raw material weight percentage is：More than 15% content
Chlortetracycline premix pretreatment fine powder 40-80%, vine polyphenol 1-10%, microcrystalline cellulose 5-15%, maltodextrin 1-3%,
Adhesive 0.2-0.5%, surplus are starch.
Specifically, described adhesive is 2 by mass ratio:1:2 starch, lactose, sodium carboxymethylcellulose mix.
Specifically, the Chlortetracycline premix pretreatment fine powder of more than 15% content is obtained through following step：Using ability
Domain routine techniques prepares Aureomycin fermentation liquor；0.2mg/L wall breaking enzymes are added in into Aureomycin fermentation liquor, then in 35-38
DEG C heat preservation 30-90min；Calcium carbonate complexing is added in after heat preservation, most afterwards through plate-frame filtering, drying, sieving to get gold is mould
Plain effective content is in 15-30%.
It is further preferred that the wall breaking enzyme is 1 by mass ratio:1 lysozyme and glusulase mixing composition；Per 1m3Gold
Calcium carbonate 40-100kg is added in mycin zymotic fluid.The enzyme activity of lysozyme and glusulase is 20 KU/mg.
The invention discloses the preparation methods of the efficient Chlortetracycline premix of above-mentioned 10% content, include the following steps：
1）The Chlortetracycline premix of more than 15% content of raw material is taken to pre-process fine powder, vine polyphenol, microcrystalline cellulose, wheat in proportion
Bud dextrin, starch, sieve with 100 mesh sieve respectively, spare；
2）Adhesive boils 10-20min in boiling water, cools, and obtains the binder solution of concentration 5-20g/L, spare；
3）By step 1）The Chlortetracycline premix pretreatment fine powder of more than 15% content of gained, vine polyphenol, microcrystalline cellulose, wheat
Bud dextrin and starch are put into wet mixing pelletizer, and after mixing, side, which is stirred, adds in binder solution, is through drying after mixing
.
In pelletization, the strictly flow acceleration of control binder solution is needed while stirring, because this is the key that granulation,
Female effect is influenced.Simultaneously by adjusting the mixing speed of wet mixing pelletizer and cutter speed, it is done directly aureomycin
Then particle is dried in fluid bed for the production of pre-mixing agent particle, shines net whole grain after dry.Specifically, step 3）In
During granulation, the flow acceleration of binder solution is controlled as 1.5-2L/min, mixing speed 250-300r/min, cutter rotating velocity
For 2500-3000 r/min；Adhesive add in after, continue stir 40-60s after discharge, subsequently enter in fluid bed into
Row drying, inlet air temperature are 80 DEG C, drying time 20-25min.
In the present invention, vine polyphenol（Purchased from Xi'an Quan Ao bio tech ltd）It is a kind of plant polyphenol kind active matter
Matter is primarily present among grape pip and Grape Skin.In numerous plant polyphenols, with vine polyphenol oxidation and removing free radicals
Ability it is most strong, oxidation resistance VE50 times, VC20 times.In addition, vine polyphenol also has preventing hypertension, resists and move
Pulse atherosclerosis, antithrombotic, anti-gastric-ulcer, anti-inflammatory, antitumor, reducing blood lipid, prevent chronic complicating diseases of diabetes, anti-mutation life
Object activity and the functions such as skin care and beauty.Vine polyphenol is in addition to the direct effect to human body or animal tissue cell's metabolism
Outside, the control to pathogenic microorganisms and influence are further included, the effect of alimentary canal microbe colony is adjusted so as to play it.Portugal
The main function of grape polyphenol in the present invention is as follows：1）Aureomycin by broken wall act on, be discharged into it is extracellular, production, storage
Deposit, stability can decline in transportational process, add in vine polyphenol after, can inhibit aureomycin occur oxidation；2）It is raised in animal
During feeding, vine polyphenol also has the function of to inhibit intestinal pathogenic micro other than with anti-inflammatory, antioxidation, from
And it plays it and adjusts the effect of alimentary canal microorganism species.
The master of the Chlortetracycline premix pretreatment fine powder and traditional Chlortetracycline premix fine powder of more than 15% content of the invention
It will be difference lies in：Traditional Chlortetracycline premix fine powder manufacturing process is：S. aurefaciens strain pure-blood ferment is sent out in aureomycin
Calcium carbonate complexing, plate-frame filtering, drying are directly added into zymotic fluid, be sieved to get.In traditional Chlortetracycline premix fine powder effectively
It is intracellular that ingredient aureomycin is mostly present in S. aurefaciens strain, and during detoxification, intracellular aureomycin needs
The broken wall effect that pass through hydrochloric acid in gastric juice releases, and could play a role in enteron aisle.Since the acidity of hydrochloric acid in gastric juice is limited, aureomycin premix
Residence time of the agent in stomach is short, and the sporoderm-broken rate of aureomycin only has 40-70%, and subsequent be absorbed and utilized will be less, therefore, passes
The Chlortetracycline premix fine powder of system can influence the absorption of animal.The Chlortetracycline premix pretreatment of more than 15% content in the present invention
The advantage of fine powder is：After wall breaking enzyme enzymolysis processing, intracellular aureomycin releases Aureomycin fermentation liquor from intracellular,
The broken wall effect of hydrochloric acid in gastric juice is needed not move through, more there is the absorption using animal intestinal tract.
Specific embodiment
Technical scheme of the present invention is further discussed in detail with reference to embodiments, but protection scope of the present invention
It is not limited thereto.
In following embodiments, described adhesive is 2 by mass ratio:1:2 starch, lactose, sodium carboxymethylcellulose mixing
It forms.The Chlortetracycline premix pretreatment fine powder of more than 15% content used is obtained through following step：
1）Aureomycin fermentation liquor is prepared using this field routine techniques（Specifically it can refer to CN201611199651.3《It is a kind of
Ferment of DM culture medium and the Ferment of DM production method using the culture medium》Disclosed in method prepare aureomycin
Zymotic fluid）；
2）0.2mg/L wall breaking enzymes are added in into Aureomycin fermentation liquor（The wall breaking enzyme is 1 by mass ratio:1 lysozyme and snail
The enzyme activity of enzyme mixing composition, lysozyme and glusulase is 20 KU/mg）, then 60min is kept the temperature in 37 DEG C；After heat preservation
Add in calcium carbonate complexing（Per 1m3Calcium carbonate 40-100kg is added in Aureomycin fermentation liquor）；
3）Through plate-frame filtering, drying, 80-120 mesh sieve is crossed, obtains the Chlortetracycline premix pretreatment fine powder of more than 15% content,
Aureomycin effective content is in 15-30%.
Embodiment 1
A kind of efficient Chlortetracycline premix of 10% content, each raw material weight percentage are：The Chlortetracycline premix of 15% content
Pre-process 66.67 kg of fine powder, 2.0 kg of vine polyphenol, 10.0 kg of microcrystalline cellulose, 3.0 kg of maltodextrin, starch 18.33
Kg, 0.2 kg of adhesive.
The preparation method of the efficient Chlortetracycline premix of above-mentioned 10% content, includes the following steps：
1）The Chlortetracycline premix of more than 15% content of raw material is taken to pre-process fine powder, vine polyphenol, microcrystalline cellulose, wheat in proportion
Bud dextrin, starch, sieve with 100 mesh sieve respectively, spare；
2）Adhesive boils 10-20min in boiling water, cools, and obtains the binder solution of concentration 15g/L, spare；
3）By step 1）The Chlortetracycline premix pretreatment fine powder of more than 15% content of gained, vine polyphenol, microcrystalline cellulose, wheat
Bud dextrin and starch are put into wet mixing pelletizer, and after stirring evenly, strictly the stream of control adhesive accelerates while stirring
It spends for 1.5-2L/min, while the mixing speed for adjusting wet mixing pelletizer is 280r/min, cutter rotating velocity is 2800 r/
Min, adhesive complete the production of Chlortetracycline premix particle after adding in.Continue to discharge after stirring 40-60s, then general
Grain is dried in fluid bed（Inlet air temperature is 80 DEG C, drying time 25min）, shine net whole grain after drying to obtain the final product.
Embodiment 2
A kind of efficient Chlortetracycline premix of 10% content, each raw material weight percentage are：The Chlortetracycline premix of 18% content
Pre-process 55.56 kg of fine powder, 3.0 kg of vine polyphenol, 5.0 kg of microcrystalline cellulose, 2.0 kg of maltodextrin, starch 34.44
Kg, 0.3 kg of adhesive.
The preparation method of the efficient Chlortetracycline premix of above-mentioned 10% content, with reference to embodiment 1.
Embodiment 3
A kind of efficient Chlortetracycline premix of 10% content, each raw material weight percentage are：The Chlortetracycline premix of 20% content
Pre-process 50 kg of fine powder, 4.0 kg of vine polyphenol, 8.0 kg of microcrystalline cellulose, 3.0 kg of maltodextrin, 35 kg of starch, bonding
0.4 kg of agent.
The preparation method of the efficient Chlortetracycline premix of above-mentioned 10% content, with reference to embodiment 1.
Embodiment 4
A kind of efficient Chlortetracycline premix of 10% content, each raw material weight percentage are：The Chlortetracycline premix of 30% content
40 kg of fine powder, 8.0 kg of vine polyphenol, 10.0 kg of microcrystalline cellulose, 2.0 kg of maltodextrin, 40 kg of starch are pre-processed, is glued
0.1 kg of mixture.
The preparation method of the efficient Chlortetracycline premix of above-mentioned 10% content, with reference to embodiment 1.
The application examples present invention is made efficient Chlortetracycline premix feeding animals and tests.
Experimental animal：140 28 age in days piglets.
Experimental method：The efficient Chlortetracycline premix of 10% content made from the embodiment of the present invention 1 to 4 is added in daily ration
Product and common 10% Chlortetracycline premix product（Ordinary commercial products, as a control group）, according to adding 1kg in daily ration per ton
Amount be added, one day feeding twice, free water, feed 20 days.It is net to investigate head weightening, feedstuff-meat ratio, head feed intake and head
The situation of the indexs such as profit.Experimental result see the table below.
From the point of view of the experimental result of upper table：Head weightening, feedstuff-meat ratio, head feed intake, four indexs of head net profit comparison in,
The application effect of efficient Chlortetracycline premix product prepared by feeding various embodiments of the present invention is superior to common Chlortetracycline premix
Product control group.
Claims (6)
1. a kind of efficient Chlortetracycline premix of 10% content, which is characterized in that each raw material weight percentage is：More than 15% content
Chlortetracycline premix pretreatment fine powder 40-80%, vine polyphenol 1-10%, microcrystalline cellulose 5-15%, maltodextrin 1-
3%th, adhesive 0.2-0.5%, surplus are starch.
2. the efficient Chlortetracycline premix of 10% content as described in claim 1, which is characterized in that described adhesive is by mass ratio
It is 2:1:2 starch, lactose, sodium carboxymethylcellulose mix.
3. the efficient Chlortetracycline premix of 10% content as described in claim 1, which is characterized in that the gold of more than 15% content
Mycin pre-mixing agent pretreatment fine powder is obtained through following step：Aureomycin fermentation liquor is prepared using this field routine techniques；To
0.2mg/L wall breaking enzymes are added in Aureomycin fermentation liquor, then keep the temperature 30-90min in 35-38 DEG C；Carbonic acid is added in after heat preservation
Calcium be complexed, most afterwards through plate-frame filtering, drying, sieving to get.
4. the efficient Chlortetracycline premix of 10% content as claimed in claim 3, which is characterized in that the wall breaking enzyme is by mass ratio
It is 1:1 lysozyme and glusulase mixing composition；Per 1m3Calcium carbonate 40-100kg is added in Aureomycin fermentation liquor.
5. the preparation method of the efficient Chlortetracycline premix of any 10% content of Claims 1-4, which is characterized in that including
Following steps：
1）The Chlortetracycline premix of more than 15% content of raw material is taken to pre-process fine powder, vine polyphenol, microcrystalline cellulose, wheat in proportion
Bud dextrin, starch, sieve with 100 mesh sieve respectively, spare；
2）Adhesive boils 10-20min in boiling water, cools, and obtains the binder solution of concentration 5-20g/L, spare；
3）By step 1）The Chlortetracycline premix pretreatment fine powder of more than 15% content of gained, vine polyphenol, microcrystalline cellulose, wheat
Bud dextrin and starch are put into wet mixing pelletizer, and after mixing, side, which is stirred, adds in binder solution, is through drying after mixing
.
6. the preparation method of the efficient Chlortetracycline premix of 10% content as claimed in claim 5, which is characterized in that step 3）In
During granulation, the flow acceleration of binder solution is controlled as 1.5-2L/min, mixing speed 250-300r/min, cutter rotating velocity
For 2500-3000 r/min；Adhesive add in after, continue stir 40-60s after discharge, subsequently enter in fluid bed into
Row drying, inlet air temperature are 80 DEG C, drying time 20-25min.
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| CN201711429468.2A CN108175810A (en) | 2017-12-26 | 2017-12-26 | A kind of efficient Chlortetracycline premix of 10% content and preparation method thereof |
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| CN201711429468.2A CN108175810A (en) | 2017-12-26 | 2017-12-26 | A kind of efficient Chlortetracycline premix of 10% content and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641729A (en) * | 2020-12-24 | 2021-04-13 | 金河牧星（重庆）生物科技有限公司 | High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof |
| CN114767637A (en) * | 2022-04-26 | 2022-07-22 | 驻马店华中正大有限公司 | Method for producing finished product of aureomycin premix by one-step method |
| WO2023236507A3 (en) * | 2022-06-09 | 2024-02-01 | 驻马店华中正大有限公司 | Highly stable chlortetracycline premix and preparation method therefor |
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| CN106011212A (en) * | 2016-06-03 | 2016-10-12 | 浦城正大生化有限公司 | Extraction process of chlortetracycline premixed agent |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641729A (en) * | 2020-12-24 | 2021-04-13 | 金河牧星（重庆）生物科技有限公司 | High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof |
| CN112641729B (en) * | 2020-12-24 | 2022-11-18 | 金河牧星（重庆）生物科技有限公司 | High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof |
| CN114767637A (en) * | 2022-04-26 | 2022-07-22 | 驻马店华中正大有限公司 | Method for producing finished product of aureomycin premix by one-step method |
| WO2023236507A3 (en) * | 2022-06-09 | 2024-02-01 | 驻马店华中正大有限公司 | Highly stable chlortetracycline premix and preparation method therefor |
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