CN108175527B - Implant abutment gum penetrating structure with visible light functionalization function and manufacturing method - Google Patents
Implant abutment gum penetrating structure with visible light functionalization function and manufacturing method Download PDFInfo
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- CN108175527B CN108175527B CN201810075415.3A CN201810075415A CN108175527B CN 108175527 B CN108175527 B CN 108175527B CN 201810075415 A CN201810075415 A CN 201810075415A CN 108175527 B CN108175527 B CN 108175527B
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- 239000007943 implant Substances 0.000 title claims abstract description 105
- 230000000149 penetrating effect Effects 0.000 title claims abstract description 43
- 238000007306 functionalization reaction Methods 0.000 title abstract description 10
- 238000004519 manufacturing process Methods 0.000 title abstract description 6
- 239000002071 nanotube Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 9
- 229910052737 gold Inorganic materials 0.000 claims abstract description 8
- 239000010931 gold Substances 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 8
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002086 nanomaterial Substances 0.000 claims abstract description 5
- 230000003287 optical effect Effects 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 18
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
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- 238000010438 heat treatment Methods 0.000 claims description 12
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 12
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- 238000005406 washing Methods 0.000 claims description 11
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- 238000007254 oxidation reaction Methods 0.000 claims description 9
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 6
- 238000007743 anodising Methods 0.000 claims description 6
- 238000001354 calcination Methods 0.000 claims description 6
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- 230000001678 irradiating effect Effects 0.000 claims description 6
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- 244000052616 bacterial pathogen Species 0.000 abstract 1
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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Abstract
The invention discloses a gingival penetrating structure of an implant abutment with a visible light functionalization function and a manufacturing method thereof2A nanostructure of a nanotube, the structure having the property of producing a functionalization of a light upon irradiation with visible light. Preparing the nanometer gold particle-loaded TiO by an anodisation method and a self-assembly method for a base station gum-penetrating structure2A nanotube structure. The base station gum penetrating structure of the invention generates optical mechanical functionalization under visible light irradiation, and the generated superoxide radical and hydroxyl radical can kill pathogenic bacteria of peri-implantitis, destroy bacterial plaque biomembranes and purify the surface of the base station gum penetrating structure of the implant so as to prevent and treat the peri-implantitis.
Description
Technical Field
The invention relates to the technical field of medical implantation, in particular to a gingival penetrating structure of an oral implant abutment and a preparation method thereof.
Background
An oral implant system generally includes three parts: a body part implanted in an alveolar bone, an artificial crown, and an implant abutment functioning as a connection between the body part and the artificial crown.
Causes of peri-implantitis include genetic polymorphisms, microbial infection, smoking, rough implant surfaces, improper base selection, and the like. The gum penetrating structure of the implant abutment is an important part for the occurrence and development of peri-implantitis, and bacterial plaque microorganism accumulation around the implant denture can develop into the peri-implantitis, so that the peri-implantitis is caused by inflammation or infection, the loss of supporting bones is accompanied, and finally the implantation fails. The current clinically common methods for treating peri-implantitis mainly include surgical treatment, ultrasonic scaling, local medicine single or combined treatment, photodynamic therapy and the like. The conventional methods such as operation treatment, ultrasonic scaling and the like are invasive or minimally invasive treatment processes, and have no effect on the prevention of peri-implantitis.
Photodynamic therapy is the latest method applied to peri-implantitis, requiring photosensitizers and lasers. A photosensitizer is a chemical substance that selectively concentrates itself on target cells, and can produce a photodynamic effect to destroy the target cells when excited by light of an appropriate wavelength.
In some in vitro experiments, Hass explains the photodynamic bactericidal effect of peri-implantitis, such as Aa, Pg and Pi can adhere to the surface of a titanium plate with different characteristics, bacteria can be hatched on the titanium plate, scanning analysis of an electron microscope shows that the photodynamic therapy can kill the bacteria without damaging the surface structure of the implant, Shibli proves that the photodynamic antibacterial treatment can reduce the number of bacteria such as prevotella intermedia, black producing bacillus, fusiform bacillus, β -hemolytic streptococcus and the like on the surface of the implant.
According to the existing research, photodynamic therapy is a more potential adjuvant therapy method for periimplantitis due to the exact action of photodynamic therapy in antibiosis and the sterilization mechanism of photodynamic therapy which is different from antibiotics. It can overcome the defects of mechanical treatment and drug treatment, shorten the treatment time, reduce the pain of patients in treatment and relieve the damage to surrounding tissues.
At present, clinical photodynamic therapy has some defects, and the patient needs to purchase expensive photosensitizer and special equipment to finish the therapy, so that the treatment expense of the patient is greatly increased; secondly, the photosensitizer is only selectively combined with a type of bacteria and singly destroys the bacteria, the influence on inflammatory factors of peri-implantitis is not reported, and the anti-inflammatory range is single and limited. Therefore, the method has important significance for optimizing the gum penetrating structure of the implant abutment.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides an implant abutment transgingival structure with a visible light function and a manufacturing method thereof, so that the abutment transgingival structure can generate light machine functionalization under the irradiation of visible light, pathogen can be killed and decomposed indifferently, inflammatory factors are decomposed, the surface of the abutment transgingival structure is purified, a biological basis is provided for the recovery of inflammation and the re-attachment of epithelium, and the implant abutment transgingival structure is used for preventing and treating peri-implantitis.
The invention relates to a gingival penetrating structure of an implant abutment with a visible light function, which comprises the implant abutment, wherein the implant abutment is made of titanium, the implant abutment comprises an abutment upper part, an abutment gingival penetrating structure and an abutment lower part, the abutment gingival penetrating structure is positioned between the abutment upper part and the abutment lower part, and the surface of the abutment gingival penetrating structure is provided with TiO loaded with nano-gold particles2Nanostructures of nanotubes.
The manufacturing method of the implant abutment gum penetrating structure with the visible light functionalization function comprises the following steps:
1) sequentially polishing the implant base table by water sand paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: preparing self-assembled TiO on the surface of a base station gum penetrating structure of an implant base station by using a glycerol solution with a volume percentage concentration of 75%, using a 0.01-1mol/L ammonium fluoride system as an electrolyte and setting an anode voltage to be 10V-60V2A nanotube; the oxidation time is set to be 1-10 h; ultrasonically cleaning the oxidized implant base station in an ethanol solution, and naturally drying in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01-0.5 mol/L; TiO is loaded on the surface of the base station gum penetrating structure 22Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; placing for 30min, directly irradiating with ultraviolet light provided by 300W high-pressure mercury lamp with wavelength of 350-420 nm, and loading TiO on the high-pressure mercury lamp and the base station gum penetrating structure 2 surface2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is 10-180 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) cleaning the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature; TiO loaded with nano gold particles on the surface of the base penetrating gum structure 2 of the manufactured implant base2The nanotube structure has the characteristic of generating optical function in the visible light region with the wavelength of 430-485 nm.
Drawings
Fig. 1 is a front view of a transgingival structure of an implant abutment with a visible light functionalization function according to the present invention.
Fig. 2 is an image of a transgingival structure of an implant abutment with visible light functionalization according to the present invention.
Detailed Description
As shown in figure 1, the implant abutment gum penetrating structure with visible light function of the invention comprises an implant abutment, the implant abutment is made of titanium, the implant abutment comprises an abutment upper part 1, an abutment gum penetrating structure 2 and an abutment lower part 3, the abutment gum penetrating structure 2 is positioned between the abutment upper part 1 and the abutment lower part 3, and the surface of the abutment gum penetrating structure 2 is provided with TiO loaded with nano gold particles2Nanostructures of nanotubes. TiO of loading nano gold particle2The nanostructure of the nanotubes is shown in figure 2.
The manufacturing method of the implant abutment gum penetrating structure with the visible light functionalization function comprises the following steps:
1) sequentially polishing the implant base table by water sand paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: preparing self-assembled TiO on the surface of a base station gum penetrating structure 2 of an implant abutment by using a glycerol solution with a volume percentage concentration of 75% and an ammonium fluoride system of 0.01-1mol/L as an electrolyte and setting an anode voltage to be 10V-60V2A nanotube; the oxidation time is set to be 1-10 h; ultrasonically cleaning the oxidized implant base station in an ethanol solution, and naturally drying in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01-0.5 mol/L; TiO is loaded on the surface of the base station gum penetrating structure 22Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; placing for 30min, directly irradiating with ultraviolet light provided by 300W high-pressure mercury lamp with wavelength of 350-420 nm, and loading TiO on the high-pressure mercury lamp and the base station gum penetrating structure 2 surface2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is 10-180 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) sequentially washing the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively; drying at room temperature; TiO loaded with nano gold particles on the surface of the base penetrating gum structure 2 of the manufactured implant base2The nanotube structure has the characteristic of generating optical function in the visible light region with the wavelength of 430-485 nm.
The implant abutment is made of titanium.
Example 1: the implant abutment is made of titanium.
1) Sequentially polishing the implant base table by 1000# to 5000# waterproof abrasive paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: the volume percent concentration of glycerol solution is 75 percent, a 0.27mol/L ammonium fluoride system is used as electrolyte, the anode voltage is 10V, 30V or 60V, and the self-assembled TiO is prepared on the surface of the base penetrating gum structure 2 of the implant abutment2A nanotube; the oxidation time is set to be 3h, and after the oxidation is finished, the implant base station is ultrasonically cleaned in an ethanol solution and naturally dried in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01 mol/L; TiO is loaded on the surface of the base station gum penetrating structure 22Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; placing for 30min, directly irradiating with ultraviolet light provided by 300W high-pressure mercury lamp with wavelength of 350-420 nm, and loading TiO on the high-pressure mercury lamp and the base station gum penetrating structure 2 surface2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is 20 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) sequentially washing the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively; drying at room temperature.
Example 2: the implant abutment is made of titanium.
1) Sequentially polishing the implant base table by 1000# to 5000# waterproof abrasive paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: the volume percent concentration of glycerol solution is 75 percent, a 0.27mol/L ammonium fluoride system is used as electrolyte, the anode voltage is 30V, and the self-assembled TiO is prepared on the surface of the base penetrating gingival structure 2 of the implant base2A nanotube; setting the oxidation time to be 1h, 5h and 10h, and after the oxidation is finished, ultrasonically cleaning the implant base platform in an ethanol solution and naturally drying the implant base platform in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01 mol/L; TiO is loaded on the surface of the base station gum penetrating structure 22Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; placing for 30min, directly irradiating with ultraviolet light provided by 300W high-pressure mercury lamp with wavelength of 350-420 nm, and loading TiO on the high-pressure mercury lamp and the base station gum penetrating structure 2 surface2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is 20 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) sequentially washing the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively; drying at room temperature.
Example 3: the implant abutment is made of titanium.
1) Sequentially polishing the implant base table by 1000# to 5000# waterproof abrasive paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: the volume percent concentration of glycerol solution is 75 percent, a 0.27mol/L ammonium fluoride system is used as electrolyte, the anode voltage is 30V, and the self-assembled TiO is prepared on the surface of the base penetrating gingival structure 2 of the implant base2A nanotube; setting the oxidation time to be 1h, 5h and 10h, and after the oxidation is finished, ultrasonically cleaning the implant base platform in an ethanol solution and naturally drying the implant base platform in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01 mol/L; TiO is loaded on the surface of the base station gum penetrating structure 22Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; placing for 30min, directly irradiating with ultraviolet light provided by 300W high-pressure mercury lamp with wavelength of 350-420 nm, and loading TiO on the high-pressure mercury lamp and the base station gum penetrating structure 2 surface2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is
10min, 30min, 60min and 180 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) sequentially washing the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively; drying at room temperature.
Claims (1)
1. A preparation method of a gingival penetrating structure of an implant abutment with a visible light function comprises the steps of preparing a titanium implant abutment, and preparing a titanium substrate; the implant abutment is composed of an abutment upper part (1), an abutment gum penetrating structure (2) and an abutment lower part (3), wherein the abutment gum penetrating structure (2) is positioned between the abutment upper part (1) and the abutment lower part (3), and the surface of the abutment gum penetrating structure (2) is provided with TiO loaded with nano gold particles2A nanostructure of a nanotube;
the method is characterized in that: the method comprises the following steps:
1) sequentially polishing the implant base table by water sand paper until the surface is smooth and has no obvious defect;
2) then, ultrasonic cleaning the polished implant base station in acetone, ethanol and distilled water for 5-6min respectively in sequence; drying at room temperature;
3) and arranging electrodes: the anode is an implant base station, and the cathode is a platinum ring;
4) and anodizing: preparing self-assembled TiO on the surface of a base station gum penetrating structure (2) of an implant base station by using a glycerol solution with a volume percentage concentration of 75%, a 0.01-1mol/L ammonium fluoride system as an electrolyte and setting an anode voltage to be 10V-60V2A nanotube; the oxidation time is set to be 1-10 h; ultrasonically cleaning the oxidized implant base station in an ethanol solution, and naturally drying in the air;
5) and (3) heat treatment: calcining the implant base table oxidized and air-dried in the step 4) in a box type furnace in the air at the temperature of 400 ℃, reducing the temperature by 5 ℃ per minute, and gradually cooling the implant base table to the room temperature for 3 hours;
6) firstly, dissolving solid chloroauric acid in isopropanol to prepare a chloroauric acid solution of 0.01-0.5 mol/L; TiO is loaded on the surface of the base station gum penetrating structure (2)2Vertically inserting the implant base station of the nanotube into a small beaker filled with chloroauric acid solution, and sealing the small beaker by using a preservative film; directly irradiating with ultraviolet light after placing for 30min, wherein the ultraviolet light is provided by a 300W high-pressure mercury lamp, the wavelength lambda of the ultraviolet light is 350-420 nm, and TiO is loaded on the surface of the high-pressure mercury lamp and the base station gum penetrating structure (2)2The distance between the implant bases of the nano tube is about 20cm, and the ultraviolet irradiation time is 10-180 min; after the irradiation is finished, repeatedly washing the irradiated implant base platform with deionized water, and then drying for 4h on a heating plate at the temperature of 80 ℃;
7) sequentially washing the implant base station treated in the step 6) in acetone, ethanol and distilled water for 5-6min respectively; drying at room temperature; the surface of the base penetrating gum structure (2) of the manufactured implant base is provided with TiO loaded with nano gold particles2The nanotube structure has the characteristic of generating optical function in the visible light region with the wavelength of 430-485 nm.
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| CN103876943A (en) * | 2013-12-27 | 2014-06-25 | 柳州市工人医院 | Implant tooth base, implant tooth and preparation method of implant tooth base |
| CN105935317A (en) * | 2016-04-05 | 2016-09-14 | 中国人民解放军第四军医大学 | Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof |
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| EP3049017B1 (en) * | 2013-09-27 | 2020-05-20 | Vita Zahnfabrik H. Rauter GmbH & Co. KG | Implants with a removable coating |
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| CN103876943A (en) * | 2013-12-27 | 2014-06-25 | 柳州市工人医院 | Implant tooth base, implant tooth and preparation method of implant tooth base |
| CN105935317A (en) * | 2016-04-05 | 2016-09-14 | 中国人民解放军第四军医大学 | Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| TiO2 nanotubes modified with Au nanoparticles for visible-light enhanced antibacterial and anti-inflammatory capabilities;Xu Wenzhou等;《Journal of Electroanalytical Chemistry》;20190426;第842卷;66-73 * |
| 钛基种植体表面抗菌改性的研究进展;孙磊等;《国际口腔医学杂志》;20150730;第42卷(第4期);475-479 * |
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