CN108159227A - A kind of medicine for relieving pain composition - Google Patents
A kind of medicine for relieving pain composition Download PDFInfo
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- CN108159227A CN108159227A CN201810242343.7A CN201810242343A CN108159227A CN 108159227 A CN108159227 A CN 108159227A CN 201810242343 A CN201810242343 A CN 201810242343A CN 108159227 A CN108159227 A CN 108159227A
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Abstract
The present invention relates to medicine for relieving pain compositions, include the component of following parts by weight：Common St.Paulswort Herb 20~30, lopseed 65~80, Caulis Spatholobi 36~44, lotus pod 15~30, ramulus mori 20~30, Jehol Ligusticum Rhizome 35~55, Rhizoma Et Radix Notopterygii 20~25, safflower 35~45, aconiti preparata,radix 40~60, rhizoma cyperi 22~30, silkworm excrement 9~18, folium artemisiae argyi 36~48；Compared with prior art, folium artemisiae argyi can be for monarch drug in a prescription with eliminating cold to stop pain, promoting blood circulation and removing blood stasis, warming meridian in this programme；Lopseed, Caulis Spatholobi, ramulus mori, rhizoma cyperi, aconiti preparata,radix, lotus pod can with expelling wind and clearing away cold, activate blood and relax tendons, be for ministerial drug；Common St.Paulswort Herb, lotus pod, Jehol Ligusticum Rhizome, Rhizoma Et Radix Notopterygii, safflower can be for adjutant with blood-activating analgetic, detoxicating, relieving inflammation；Silkworm excrement can reconcile monarch drug in a prescription, ministerial drug and adjutant, be to make medicine；The effect of whole composition all medicines share receives relaxing tendons and activating collaterals altogether, and dispersing blood stasis relieves pain can effectively treat neck, shoulder, waist and leg and all diseases of arthralgia caused by wind-cold damp pathogen numbness resistance channels and collaterals.
Description
Technical field
The present invention relates to tcm field, a kind of more particularly to medicine for relieving pain composition.
Background technology
Osteoarthropathy is also known as osteoarthritis, retrogression arthritis, hypertrophic arthritis, senescent arthritis etc.；This disease
It is general it is more refractory more main therapy is to subtract pauciarticular heavy burden and excessive significantly movable, with delay lesion into
Journey, and during treatment, because of the presence of inflammation, such state of an illness will be along with pain, and pain normally behaves as holding
Long property is ached, it is not easy to be subsided, patient will be tormented for a long time by pain or even in spirit also can be by larger shadow
It rings, also will appear severe pain once in a while, it is most likely that cause physiological dysfunction or even shock.
In order to solve problem above, the method for such state of an illness pain is handled in the prior art as hot compress massage method, medical care people
Member uses the hot towel hot compress of 75-80 degree at sufferer, and carries out the massage of appropriateness for patient using both hands, to relieve pain,
Though certain mitigation can be played, the labor intensity of medical staff is larger, and when stopping massaging and removing towel, patient
It can feel the pain of pain again quickly, lenitive effect is not obvious.
Invention content
The invention is intended to provide a kind of medicine for relieving pain combination that preferable mitigation can be played to arthralgia
Object.
A kind of medicine for relieving pain composition in this programme includes the component of following parts by weight：Common St.Paulswort Herb 20~30,
Lopseed 65~80, Caulis Spatholobi 36~44, lotus pod 15~30, ramulus mori 20~30, Jehol Ligusticum Rhizome 35~55, Rhizoma Et Radix Notopterygii 20~25, safflower 35
~45, aconiti preparata,radix 40~60, rhizoma cyperi 22~30, silkworm excrement 9~18, folium artemisiae argyi 36~48.
The technical principle of this programme is：Common St.Paulswort Herb life taste bitter and cold, dispelling wind and eliminating dampness are its this work(, and effect is very aobvious, are people
It is praised, and energy clearing away heat and eliminating dampeness is so that skin pruritus；It steams then then to be warm, energy strong muscles and bones are suitable for the paralysis all diseases of Impotence numbness；To closing
Section muscles and bones has preferable strong effect.
Lopseed dispelling wind and eliminating dampness, the product pungent-warm, it is pungent can manage it dissipate, temperature overcome the coldness it is wet, because wind-cold damp pathogen invasion limbs channels and collaterals due to lead
Limbs pain is caused, the product can be selected in numb, joint stuffiness, and expelling wind and clearing away cold victory is wet, and disease and evil is gone, then all disease self-healing；Lopseed can also
Relaxing tendons and activating collaterals, enters Liver Channel, and liver governing tendons, therefore the product have the effect of relaxing tendons and activating collaterals.
Caulis Spatholobi bitter but slightly sweet taste, warm-natured, Return liver, the heart, kidney channel；Color it is red enter blood, matter profit row dissipate；With activating blood and relaxing tendons, blood-nourishing
The effect of menstruation regulating；Arthralgia pain due to rheumatism is cured mainly, numb in every limb, quadriplegia, irregular menstruation, blockage of menstruation, dysmenorrhoea, Amenorrhea, leucocyte
Reduce disease；Also the diseases such as the waist and knee arthralgia caused by treatment rheumatism, arthralgia pain due to rheumatism, extremity numbness, with lopseed compatibility tonifying liver benefit
Kidney, promoting blood circulation and stopping pain；It is the most suitable that long numbness belongs to void person.
The warm-natured bitter of lotus pod, puckery, return liver warp；Removing blood stasis and hemostasis has certain effect to joint siltation difference, can weaken joint
Pain.
Ramulus mori bitter, micro-pungent, it is mild-natured；Return liver, lung channel；Clearing heat and expelling damp dredging collateral, for beriberoid pyretic arthralgia, extremities joint pain,
The product energy dispelling wind and removing obstruction in the meridians profit joint can individually reuse the arthropathy that product treatment redness and swelling of joints heat pain etc. belongs to hot numbness, can also match
Lopseed is closed with using, two medicines share, wind-expelling pain-stopping, and it is most effective to control wandering arthritis, there is good effect to arthralgia.
Jehol Ligusticum Rhizome acrid flavour, it is warm-natured；Return bladder warp, expelling wind and clearing away cold, damp dispelling and pain relieving；For exterior syndrome due to wind-cold, mountain peak top pain, rheumatism numbness
Bitterly, there is good effect to arthralgia, with ramulus mori with using, can more play strong muscles and bones, proceed blood cycle.
Rhizoma Et Radix Notopterygii acrid flavour, it is bitter, it is warm-natured；Return bladder, kidney channel；Dissipate exterior cold, wind-damp dispelling, sharp joint, analgesic；Master catches cold；Head
It is bitterly lossless；Mimeograph cold-dampness numbness；Geomantic omen edema；Sore swollen toxin.With Jehol Ligusticum Rhizome compatibility, diuresis of detoxifying preferably diminishes inflammation, alleviates pain
Bitterly.
Safflower is pungent, and taste temperature enters the heart, Liver Channel；Invigorate blood circulation, stasis eliminatings analgesic；Controlling through closing, abdominal mass, difficult labour, stillborn foetus, postpartum
Lochia, hemostasis are had a pain, carbuncle swells, injury from falling down.With Rhizoma Et Radix Notopterygii compatibility, there is good promoting blood circulation and stopping pain.
Aconiti preparata,radix acrid flavour, hardship, property heat, the thoughts of returning home, liver,kidney,spleen warp, dispelling wind and eliminating dampness, antalgic for wind-cold-dampness arthralgia, close
Crymodynia is saved, cold hernia is had a pain and narcotic analgesic.
The pungent taste micro-sweet of rhizoma cyperi property, flat, slight bitter；Return liver, spleen, tri-jiao channel；Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving；For
Stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is bored, turgor pain, irregular menstruation, Amenorrhea
Dysmenorrhoea.With lopseed compatibility, similar phase is from bringing out the best in each other, liver kidney is with controlling, and qi and blood is all adjusted, promoting blood circulation and stopping pain.
It is silkworm excrement acrid flavour, sweet, it is warm-natured；Return stomach, spleen, Liver Channel；Dispelling wind and eliminating dampness, regulating the function of the stomach to resolve the turbidity, invigorate blood circulation；For main rheumatism numbness
Bitterly, limbs are unsuccessful, rubella itch, convulsion of vomiting and diarrhoea, amenorrhoea, uterine bleeding.There is reconciliation drug effect.
Folium artemisiae argyi is warm-natured, acrid flavour, hardship, Return liver, spleen, kidney channel；Warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin.Match with rhizoma cyperi
5, promote the drug effect of rhizoma cyperi, can more alleviate arthralgia.
Compared with prior art, this programme has the beneficial effect that：In this programme folium artemisiae argyi can with eliminating cold to stop pain, it is promoting blood circulation and removing blood stasis,
Warming meridian is for monarch drug in a prescription；Lopseed, Caulis Spatholobi, ramulus mori, rhizoma cyperi, aconiti preparata,radix, lotus pod can with expelling wind and clearing away cold, activate blood and relax tendons, auxiliary
Folium artemisiae argyi is helped to be alleviated well to extremities joint pain jointly, is for ministerial drug；Common St.Paulswort Herb, lotus pod, Jehol Ligusticum Rhizome, Rhizoma Et Radix Notopterygii, safflower can
With blood-activating analgetic, detoxicating, relieving inflammation, the effect of relieving pain of monarch drug in a prescription and ministerial drug can be enhanced, be for adjutant；Silkworm excrement can be to monarch drug in a prescription, ministerial drug
It is reconciled with adjutant, plays the drug effect of composition bigger, be to make medicine；Whole composition all medicines share, receives relaxing tendons and activating collaterals altogether, disappears
The effect of stasis of blood relieves pain can effectively treat neck, shoulder, waist and leg and all diseases of arthralgia caused by wind-cold damp pathogen numbness resistance channels and collaterals.
Further, include the component of following parts by weight：Common St.Paulswort Herb 24~26, lopseed 70~75, Caulis Spatholobi 40~42,
Lotus pod 18~24, ramulus mori 24~26, Jehol Ligusticum Rhizome 40~50, Rhizoma Et Radix Notopterygii 22~24, safflower 38~42, aconiti preparata,radix 48~54, rhizoma cyperi 24~
28th, silkworm excrement 12~16, folium artemisiae argyi 40~44.This ratio is better.
Further, include the component of following parts by weight：Common St.Paulswort Herb 25, lopseed 72, Caulis Spatholobi 40, lotus pod 20, ramulus mori
24th, Jehol Ligusticum Rhizome 46, Rhizoma Et Radix Notopterygii 24, safflower 40, aconiti preparata,radix 52, rhizoma cyperi 25, silkworm excrement 14, folium artemisiae argyi 40.This ratio has better effect.
Further, the component of following parts by weight is further included：Cattail pollen 8~17.Property sugariness put down, Return liver, pericardium channel, hemostasis,
Stagnation resolvation, it is treating stranguria；For spitting blood, bleeding from five sense organs or subcutaneous tissue is spat blood, uterine bleeding, traumatic hemorrhage, Amenorrhea promoting menstruation, chest and abdomen shouting pain, tumbling and swelling, and blood strangury is puckery
Bitterly.With silkworm excrement coordination to make medicine, play the role of common coordinating the drug actions of a prescription.
Further, the component of following parts by weight is further included：The root of Chinese clematis 12~28.It is warm-natured, it is acrid flavour, salty；Return bladder warp；It dispels
Wind dehumidifying is removed obstruction in channels to relieve pain；Belong to the wind-damp-dispelling and cold-dissipating medicinal of wind-dispelling diseases caused by dampness subordinate classification, with Jehol Ligusticum Rhizome compatibility, the logical muscle for enhancing Jehol Ligusticum Rhizome is lived
The effect of network, anti-inflammatory analgetic is all adjutant, assists monarch drug in a prescription and ministerial drug, plays better analgesic effect.
Further, the component of following parts by weight is further included：60~70 parts of yellow rice wine of the alcoholic strength between 16~20 degree.It is yellow
Wine plays the role of efficacy-enhancing ingredient so that monarch more fully brings drug effect into play.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail：
Related data is as shown in table 1 in embodiment：
Table 1：Unit (g)
By taking embodiment 4 as an example, a kind of medicine for relieving pain composition is specifically described, a kind of lenitive medicine
The application method of compositions is：
(1) it cleans：Xuan Qu Common St.Paulswort Herbs 25g, lopseed 72g, Caulis Spatholobi 40g, lotus pod 20g, ramulus mori 24g, Jehol Ligusticum Rhizome 46g, Qiang
Live 24g, safflower 40g, aconiti preparata,radix 52g, rhizoma cyperi 25g, silkworm excrement 14g, folium artemisiae argyi 40g, and more than medicinal material is cleaned using clear water；
(2) it grinds：More than medicinal material is ground into medicinal powder, the grain size of medicinal powder is 2~3mm；
(3) frying：More than medicinal powder is uniformly mixed, and is put into marmite, pours into yellow rice wine, slow boiling frying 15 minutes；
(4) it packs：Dry in the air it is cool after, the good medicinal powder of frying is encased in the sand pocket that can be applied with.
Difference lies in the changes of relevant parameter as shown in table 1 for embodiment 1-3,5-7 and embodiment 4.
Difference lies in embodiment 8 does not add in folium artemisiae argyi to embodiment 8 with embodiment 4.
Difference lies in embodiment 9 does not add in lopseed to embodiment 9 with embodiment 4.
Difference lies in embodiment 10 does not add in Jehol Ligusticum Rhizome to embodiment 10 with embodiment 4.
Difference lies in 11 each component parts by weight of embodiment are all higher than the weight of instant component to embodiment 11 with embodiment 4
Measure number.
Difference lies in comparative example 1 is to carry out lenitive example in background technology to comparative example 1 with embodiment 4.
Difference lies in comparative example 2 is the example pasted using ten thousand pain muscles and bones to comparative example 2, and ten thousand pain muscles and bones patch is wrapped with embodiment 4
Include the component Rhizoma Chuanxiong 25g of following parts by weight, radix cyathulae 36g, root of Dahurain angelica 23g, corydalis tuber 12g, safflower 22g, Chinese cassia tree 18g, cloves
26g, menthol 7g, borneol 5g, application method are consistent with a kind of application method of medicine for relieving pain composition of the present invention.
1st, experimental subjects and method
1.1 experimental subjects
400 patients are invited in Zun Yi somewhere, wherein man 212, female 188,43~75 years old age, the state of an illness 2 years~20
Year.Wherein cervical spondylosis 123, scapulohumeral periarthritis 89, the protrasion of the lumbar intervertebral disci 101, knee joint osseous arthritis 87.By its with
Machine is assigned as 8 groups, every group 50.
1.2 experimental method
1.2.1 above 8 groups of patients take Wantongjingu pill, and one time 2 (every 0.28g) 2~3 times on the one, 30 days is
1 course for the treatment of, takes 2 course for the treatment of altogether.
1.2.2 above 1~7 group of patient uses example 3 below, embodiment 4, embodiment 8~11 respectively during medication
And the medicine for external application that comparative example 2 obtains is applied with, the 8th group of patient corresponds to comparative example 1, only takes Wantongjingu pill, with above example
Son is compared.
2nd, experimental result and analysis
2.1 experimenters carry out the patient of more than 1-8 groups the comparison of clinical efficacy, as shown in table 2：
Table 2：
| Group number | Total number of persons | Clinic control | It is effective | Effectively | In vain | Cure-remarkable-effectiveness rate (%) |
| 1 | 50 | 32 | 14 | 3 | 1 | 92 |
| 2 | 50 | 36 | 12 | 2 | 0 | 96 |
| 3 | 50 | 24 | 12 | 5 | 5 | 72 |
| 4 | 50 | 27 | 14 | 7 | 2 | 82 |
| 5 | 50 | 30 | 13 | 5 | 2 | 86 |
| 6 | 50 | 25 | 8 | 13 | 4 | 66 |
| 7 | 50 | 21 | 11 | 10 | 8 | 64 |
| 8 | 50 | 17 | 13 | 10 | 10 | 60 |
From Table 2, it can be seen that the medicine for relieving pain composition of the present invention, assists the recovery of patient to be substantially better than pair
Ten thousand pain muscles and bones of ratio are pasted, and folium artemisiae argyi is not added in the medicine for external application that the present composition makes has large effect to patient's treatment,
It is slightly weak to be not added with the influence that lopseed and Jehol Ligusticum Rhizome treat patient.
The comparison of 2.2 8 groups of pretherapy and post-treatment WOMAC, as shown in table 3：
Table 3：
As known from Table 3, the medicine for external application that the present invention produces, hence it is evident that better than comparative example 1, comparative example 2 and embodiment 11；This hair
Folium artemisiae argyi is not added in the medicine for external application that bright composition makes to the influence that patient treat more than being not added with lopseed and Jehol Ligusticum Rhizome to patient
The influence for the treatment of.
The comparison of 2.3 8 groups of pretherapy and post-treatment IL-l β, TNF-α, as shown in table 4：
Table 4：
As known from Table 4, the medicine for external application produced of the present invention, can significantly assist oral Wantongjingu pill control IL-l β,
TNF-α reduces more preferable.
3rd, conclusion
From the result shows that, the present invention produce medicine for external application clinical efficacy, reduce WOMAC scoring, lower IL-l β,
TNF-α level etc. is superior to embodiment 11, comparative example 1 and comparative example 2, and difference is statistically significant；Show system of the present invention
The medicine for external application made can preferably assist oral Wantongjingu pill by reducing cell factor in knee osteoarthritis patient articular
The content of IL-l β, TNF-α, so as to achieve the purpose that auxiliary cures knee osteoarthritis, the present composition is produced outer
The topical application of drug has not only acted as lenitive effect, and play the role of it is lenitive also clearly.
Claims (6)
1. a kind of medicine for relieving pain composition, which is characterized in that include the component of following parts by weight：Common St.Paulswort Herb 20~
30th, lopseed 65~80, Caulis Spatholobi 36~44, lotus pod 15~30, ramulus mori 20~30, Jehol Ligusticum Rhizome 35~55, Rhizoma Et Radix Notopterygii 20~25, safflower
35~45, aconiti preparata,radix 40~60, rhizoma cyperi 22~30, silkworm excrement 9~18, folium artemisiae argyi 36~48.
2. medicine for relieving pain composition according to claim 1, it is characterised in that：Include the group of following parts by weight
Point：Common St.Paulswort Herb 24~26, lopseed 70~75, Caulis Spatholobi 40~42, lotus pod 18~24, ramulus mori 24~26, Jehol Ligusticum Rhizome 40~50, Qiang
Live 22~24, safflower 38~42, aconiti preparata,radix 48~54, rhizoma cyperi 24~28, silkworm excrement 12~16, folium artemisiae argyi 40~44.
3. medicine for relieving pain composition according to claim 2, it is characterised in that：Include the group of following parts by weight
Point：Common St.Paulswort Herb 25, lopseed 72, Caulis Spatholobi 40, lotus pod 20, ramulus mori 24, Jehol Ligusticum Rhizome 46, Rhizoma Et Radix Notopterygii 24, safflower 40, aconiti preparata,radix 52, perfume
Attached 25, silkworm excrement 14, folium artemisiae argyi 40.
4. medicine for relieving pain composition according to claim 1, it is characterised in that：Further include following parts by weight
Component：Cattail pollen 8~17.
5. medicine for relieving pain composition according to claim 4, it is characterised in that：Further include following parts by weight
Component：The root of Chinese clematis 12~28.
6. medicine for relieving pain composition according to claim 1, it is characterised in that：Further include following parts by weight
Component：60~70 parts of yellow rice wine of the alcoholic strength between 16~20 degree.
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Application publication date: 20180615 |