CN108159075B - Application of palladium nano material - Google Patents

Application of palladium nano material Download PDF

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CN108159075B
CN108159075B CN201711441168.6A CN201711441168A CN108159075B CN 108159075 B CN108159075 B CN 108159075B CN 201711441168 A CN201711441168 A CN 201711441168A CN 108159075 B CN108159075 B CN 108159075B
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palladium
nano material
octahedral
antibacterial
nanomaterial
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CN108159075A (en
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葛翠翠
方舸
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Suzhou University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • B22F1/0553—Complex form nanoparticles, e.g. prism, pyramid, octahedron
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/07—Metallic powder characterised by particles having a nanoscale microstructure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F9/00—Making metallic powder or suspensions thereof
    • B22F9/16—Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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Abstract

The invention provides an application of a palladium nano material in preparing an antibacterial drug; wherein the palladium nano material is a palladium octahedral nano material or a palladium cubic nano material. The palladium nano material generates active oxygen by exerting the activity of the nano enzyme of the material, so that a more stable and lasting antibacterial effect is realized; furthermore, the palladium cubic nanometer material has obvious effect on gram-positive bacteria, and the palladium octahedral nanometer material has higher activity on gram-negative bacteria.

Description

Application of palladium nano material
Technical Field
The invention relates to the technical field of antibacterial materials, in particular to application of a palladium nano material in preparation of antibacterial drugs.
Background
In recent years, infectious diseases caused by bacteria seriously threaten human health, particularly, the appearance of super bacteria causes more and more attention to microorganisms which harm human survival, so that research and development of various materials with antibacterial and bactericidal properties are of great significance to human protection, disease reduction and green and healthy environment creation, and development of antibacterial materials also forms a huge and wide market.
With the development of nanotechnology and nanoscience, nanomaterials are becoming a great research hotspot for antibacterial materials, including metals, metal oxides and carbon nanomaterials, due to their large specific surface area, excellent antibacterial properties and no drug resistance. Among them, silver nano materials are the most widely studied, but they have high toxicity and poor antibacterial durability and stability.
Some researchers disclosed in the literature (Advanced Materials,2015,27(6): 1097-1104) a method for preparing a gold particle-loaded porous silica nanocomposite (denoted as MSN-AuNPs), wherein gold nanoparticles are loaded into the pores of porous silica by an antibacterial agent, and the material shows excellent oxidase and peroxidase, so that the antibacterial material has high antibacterial performance and antibacterial stability by promoting the generation of active oxygen in bacteria. However, the antibacterial agent requires the synthesis of porous silica in advance, which undoubtedly increases the complexity of the preparation process; meanwhile, the preparation method only loads gold nanoparticles with low oxidase and peroxidase activities in the precious metal nanometer material into the silicon dioxide pore channels, so that the activity of the nanometer enzyme can be only partially improved, the activity of partial enzyme is limited, and the antibacterial effect is finally influenced.
Disclosure of Invention
The invention aims to solve the technical problem of providing the application of the palladium nano material in the preparation of antibacterial drugs, and the palladium nano material has a stable and lasting antibacterial effect.
In view of the above, the present application provides an application of a palladium nanomaterial in the preparation of an antibacterial drug; the palladium nano material is a palladium cubic nano material or a palladium octahedral nano material.
Preferably, the preparation method of the palladium cubic nanometer material comprises the following steps:
and mixing polyvinylpyrrolidone, ascorbic acid and potassium bromide, adding sodium chloropalladate, and reacting to obtain the palladium cubic nano material.
Preferably, the preparation method of the palladium octahedral nanomaterial comprises the following steps:
mixing polyvinylpyrrolidone, ascorbic acid and citric acid, adding sodium chloropalladate, and reacting to obtain the palladium octahedral nanomaterial.
Preferably, the reaction temperature is 80-120 ℃, and the reaction time is 3 hours.
Preferably, the size of the palladium nano material is 8-12 nm.
The application also provides an application of the palladium nano material in preparation of the anti-gram-positive bacteria drug, wherein the palladium nano material is a palladium cubic nano material.
The application also provides an application of the palladium nano material in preparation of the anti-gram-negative bacteria drug, wherein the palladium nano material is a palladium octahedral nano material.
The application also provides an antibacterial preparation which comprises a palladium nano material solution and auxiliary materials, wherein the palladium nano material in the palladium nano material solution is a palladium cubic nano material or a palladium octahedral nano material.
The application also provides an application of the palladium nano material in an antibacterial agent, wherein the palladium nano material is a palladium cubic nano material or a palladium octahedral nano material.
Preferably, the antibacterial agent is an antibacterial dressing or a band-aid.
The application provides an application of a palladium nano material in preparation of an antibacterial drug, and particularly the palladium nano material is a palladium octahedral nano material or a palladium cubic nano material. The palladium nano material provided by the application achieves an antibacterial effect by playing roles of oxidase and peroxidase, and does not release ions, so that the palladium nano material has a stable and lasting antibacterial effect.
Drawings
FIG. 1 is a set of graphs representing cubic nanomaterials of palladium prepared in example 1 of the present invention;
FIG. 2 is a set of graphs representing octahedral nanomaterials of palladium prepared in example 1 of the present invention;
FIG. 3 is a bar graph of the survival rate of gram-positive bacteria at different concentrations of palladium nanomaterial;
FIG. 4 is a bar graph of the survival rate of gram-negative bacteria at different concentrations of palladium nanomaterial;
FIG. 5 is a bar graph of the effect of different concentrations of palladium nanomaterials on cell viability.
Detailed Description
For a further understanding of the invention, reference will now be made to the preferred embodiments of the invention by way of example, and it is to be understood that the description is intended to further illustrate features and advantages of the invention, and not to limit the scope of the claims.
Aiming at the problems of poor antibacterial stability and high toxicity of an antibacterial agent in the prior art, the embodiment of the invention discloses an application of a palladium nano material in preparing an antibacterial drug; the palladium nano material is a palladium cubic nano material or a palladium octahedral nano material. The palladium nano material provided by the invention is a noble metal nano material with two different crystal faces, one with a {111} crystal face and the other with a {100} crystal face. The palladium nano material provided by the application generates active oxygen by exerting the activity of the nano enzyme of the material, and further realizes a more stable and lasting antibacterial effect.
The palladium nano material provided by the invention realizes an antibacterial effect, and is mainly characterized in that the noble metal nano material has oxidase and peroxidase; specifically, the preparation method of the palladium cubic nanometer material comprises the following steps:
and mixing polyvinylpyrrolidone, ascorbic acid and potassium bromide, adding sodium chloropalladate, and reacting to obtain the palladium cubic nano material.
In the process of preparing the palladium cubic nanometer material, the sodium chloropalladate finally obtains the palladium cubic nanometer material under the synergistic action of a protective agent polyvinylpyrrolidone, a reducing agent ascorbic acid and a crystal face mediating agent potassium bromide.
Similarly, the preparation method of the palladium octahedral nanomaterial comprises the following steps:
mixing polyvinylpyrrolidone, ascorbic acid and citric acid, adding sodium chloropalladate, and reacting to obtain the palladium octahedral nanomaterial.
In the process of preparing the palladium octahedral nanomaterial, sodium chloropalladate is subjected to reaction kinetics control under the action of a protective agent polyvinylpyrrolidone, a reducing agent ascorbic acid and citric acid, and finally the palladium octahedral nanomaterial is obtained.
In order to obtain the palladium nano material with higher purity, the preparation method of the palladium nano material comprises the following specific steps:
firstly, adding polyvinylpyrrolidone, ascorbic acid and potassium bromide or citric acid into an aqueous solution, and stirring and reacting for 10min at a certain temperature;
secondly, adding sodium chloropalladate into the solution at a certain speed, and stirring at constant temperature for 3 hours to obtain reaction liquid;
and thirdly, centrifuging the reaction solution obtained in the second step to collect a product, washing the obtained solid with alcohol and water for multiple times, and then resuspending the aqueous solution to obtain the finished product of the antibacterial material.
In the second step of preparing the palladium nano material, the palladium cubic nano material to be obtained needs to be stirred at the constant temperature of 80 ℃, and the palladium octahedral nano material to be obtained needs to be stirred at the constant temperature of 120 ℃.
The size of the palladium nano material prepared by the method is 8-12 nm, no agglomeration occurs among particles, and the dispersibility is good. The antibacterial effect of the palladium nano material prepared by the method is influenced by the size and the concentration, and the smaller the size is, the higher the concentration is, and the better the antibacterial effect is.
According to the invention, in the two palladium nano materials, the palladium cubic nano material is preferentially selected for gram-positive bacteria, and the palladium octahedral nano material is preferentially selected for gram-negative bacteria; more specifically, the palladium cubic nanomaterial has a remarkable effect on staphylococcus aureus, and the palladium octahedral nanomaterial has a remarkable effect on escherichia coli. For gram-positive bacteria, the cell wall is thicker, the endocytosis difference of the material is not obvious, and the antibacterial activity difference is derived from the activity difference of the nanometer enzyme; for gram-negative bacteria, endocytosis difference of the two materials is dominant, and the octahedron can penetrate through cell membranes more easily to enter bacteria in a short time to exert antibacterial effect, so that reversed antibacterial effect is achieved.
The application also provides a preparation, which comprises a palladium nano material solution and an auxiliary material, wherein the palladium nano material in the palladium nano material solution is a palladium cubic nano material or a palladium octahedral nano material.
The palladium nano material provided by the invention not only has an application effect in preparing antibacterial drugs, but also has an application effect in antibacterial agents. In particular, the palladium nanomaterial provided by the application can be carried out in a band-aid or an antibacterial dressing.
The invention provides application of a palladium nano material in preparation of antibacterial drugs, the palladium nano material achieves an antibacterial effect by playing roles of oxidase and peroxidase, and the problem of poor stability of a silver nano material is solved without ion release, so that a lasting and stable antibacterial effect is realized. In addition, the palladium nano material is safe below 200ug/ml, and the concentration of the palladium nano material used in the antibacterial application is lower than the concentration, so the palladium nano material has low toxicity.
For further understanding of the present invention, the following examples are given to illustrate the application of the palladium nanomaterial provided by the present invention, and the scope of the present invention is not limited by the following examples.
Example 1
Preparing a Pd cubic nanometer material: dissolving 105mg of polyvinylpyrrolidone, 60mg of ascorbic acid and 300mg of potassium bromide in 8ml of water, adding the mixture into a flask, stirring and preheating the mixture at 80 ℃ for 10min, quickly adding 3ml of aqueous solution in which 57mg of sodium chloropalladate is dissolved, continuously stirring and reacting for 3h at constant temperature, centrifuging the mixture, adding water to wash the solid for 3 times, and re-suspending the aqueous solution to obtain the Pd cubic nanomaterial.
Preparing a Pd octahedral nanomaterial: dissolving 105mg of polyvinylpyrrolidone, 60mg of ascorbic acid and 60mg of citric acid in 8ml of water, adding the mixture into a flask, stirring and preheating the mixture at 80 ℃ for 10min, injecting 3ml of aqueous solution in which 57mg of sodium chloropalladate is dissolved into the solution at a constant speed by using a syringe pump, continuously stirring and reacting for 3h at a constant temperature, adding water to wash the solid for 3 times after centrifugation, and re-suspending the aqueous solution to obtain the Pd octahedral nanomaterial.
Fig. 1 is a group diagram showing the characteristics of the cubic palladium nanomaterial prepared in this example 1, and fig. 2 is a group diagram showing the characteristics of the octahedral palladium nanomaterial prepared in this example.
And (3) antibacterial experiment: respectively preparing Pd cubic nanometer material and Pd octahedral nanometer material (surface atom concentration: 1x 10)16One/ml) and 1 × 106Bacteria at CFU/ml were incubated in water for 20min and diluted 103After doubling, coating the bacteria on a plate to observe the antibacterial effect; the results show that: the sterilization rate of the Pd cubic nanometer material to staphylococcus aureus is 60%, and the sterilization rate of the Pd octahedral nanometer material to staphylococcus aureus is 20%; the sterilization rate of the Pd cubic nanometer material to the coliform bacteria is 55 percent, and the sterilization rate of the Pd octahedral nanometer material to the coliform bacteria is 90 percent. This indicates that: the Pd octahedral nanomaterial has a more excellent antibacterial effect on gram-negative bacteria, and the Pd cubic nanomaterial has a more excellent antibacterial effect on gram-positive bacteria.
Fig. 3 is a bar graph of the survival rate of gram-positive bacteria under different concentrations of palladium nanomaterial, and fig. 4 is a bar graph of the survival rate of gram-negative bacteria under different concentrations of palladium nanomaterial, further illustrating: the Pd octahedral nanomaterial has a more excellent antibacterial effect on gram-negative bacteria, and the Pd cubic nanomaterial has a more excellent antibacterial effect on gram-positive bacteria.
Fig. 5 is a bar graph of the effect of the palladium nanomaterial at different concentrations on the cell viability, and it can be seen from fig. 5 that the palladium nanomaterial still has a high cell viability at a concentration of 200 μ g/ml, and thus the palladium nanomaterial is safe within the application concentration range.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (3)

1. The application of the palladium nano material in preparing the anti-escherichia coli medicine is characterized in that the palladium nano material is a palladium octahedral nano material;
the preparation method of the palladium octahedral nanomaterial comprises the following steps:
mixing polyvinylpyrrolidone, ascorbic acid and citric acid, adding sodium chloropalladate, and reacting to obtain the palladium octahedral nanomaterial.
2. The use according to claim 1, wherein the reaction temperature is 80-120 ℃ and the reaction time is 3 h.
3. The use according to claim 1, wherein the palladium nanomaterial is 8-12 nm in size.
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CN113477936A (en) * 2021-06-30 2021-10-08 海南深远海新能源科技有限公司 Method and device for preparing palladium and palladium alloy nanocrystals
CN113499773A (en) * 2021-07-08 2021-10-15 辽宁大学 Nano enzyme of nano zinc oxide supported palladium nanoparticles and preparation method and application thereof
CN114908359A (en) * 2022-06-22 2022-08-16 杭州师范大学 Method for preparing Pd-octahedral nano catalyst with high yield, product and application thereof
CN115581732A (en) * 2022-09-30 2023-01-10 长春师范大学 Application of palladium nano material in preparation of antibacterial drugs
CN115646486A (en) * 2022-11-10 2023-01-31 辽宁大学 Graphene-supported palladium nanoenzyme as well as preparation method and application thereof
CN116058385A (en) * 2022-11-18 2023-05-05 辽宁大学 Palladium zinc oxide nano enzyme material with double enzyme activities, and preparation method and application thereof
CN115737810A (en) * 2022-11-25 2023-03-07 国科温州研究院(温州生物材料与工程研究所) Polyphenol-palladium nano reactor for treating bacterial/fungal infection and preparation method and application thereof

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