CN108144117A - A kind of tooth-implanting base station - Google Patents
A kind of tooth-implanting base station Download PDFInfo
- Publication number
- CN108144117A CN108144117A CN201711422765.4A CN201711422765A CN108144117A CN 108144117 A CN108144117 A CN 108144117A CN 201711422765 A CN201711422765 A CN 201711422765A CN 108144117 A CN108144117 A CN 108144117A
- Authority
- CN
- China
- Prior art keywords
- base station
- tooth
- metronidazole
- implanting
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
The invention discloses a kind of tooth-implanting base stations, and including base station ontology, base station ontology is pure titanium material, there is cerium/Metronidazole coating on base station ontology, and coating production is 1. pure titanium-based platform body surface sanding and polishing, immersion NaOH aqueous solutions, cleaning, drying；2. impregnates step 1. treated base station using a concentration of 5.0mol/L cerous nitrate solutions, cleaning, dry；3. the salpeter solution, teos solution and water of Metronidazole are stirred reaction 20 hours by ice-water bath, centrifuge, washing, vacuum freeze drying obtains nano anti-biotic material, nano anti-biotic material is added in gelatin solution under stiring；4. step 1. treated base station ontology is immersed in 3. colloidal sol that step obtains 23 hours, then take out, clean up to get.Antibacterial tooth-implanting base station of the present invention obtains having both long-acting and sustained release antibacterial functions tooth-implanting base stations.The success rate of tooth-planting is improved, shortens treatment time.
Description
Technical field
The present invention relates to a kind of tooth-implanting base stations, belong to tooth-planting field.
Background technology
Tooth implant and the bone tissue of host, gingival epithelium tissue and the contact of upper subcutaneous connective tissue, while part exposure
Have in collarium border in oral cavity.Behind planting body implantation oral cavity, it is subject to the invasion of microorganism and its toxic product and epithelium occurs
Separation generates deep peri-implant bag.Therefore, implant denture surrounding tissue is easier to bacterium infection, and the bacterial plaque in planting body artificial tooth week is micro-
Biological accumulation may develop into peri-implantitiss, be inflammation or the infection of peri-implant, and with the forfeiture for supporting bone.Cause
This, payes attention to effect of the microorganism in peri-implantitiss morbidity, inhibits oral bacteria in the Abutment for being exposed to oral cavity
The adherency on surface, it is critically important to keep the non-cohesive bacterial plaque of Abutment.At least two methods can inhibit the shape of bacterial plaque
Into first is the initial adherence for inhibiting oral bacteria；Second is the field planting for inhibiting oral bacteria, including antibacterial surface activity.Such as
The long-term opposite gnotobasis in tooth implant week can be created and maintained, will be the pass for the incidence for reducing Colonization in Partial Edentulous Patients with Peri-implantitis
Key.
Oral bacteria starts from the invasion of planting body base station, generates peri-implant inflammation after bacterium infection, can seriously cause
Tooth-implanting fails.So prevent oral bacteria in the adherency of base station and field planting for ensuring that long-term clinical success is most important.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of tooth-implanting base station, contains cerium by the attachment in base station outer surface
With the coating of Metronidazole, obtain having both long-acting and sustained release antibacterial functions tooth-implanting base stations.
The present invention provides a kind of tooth-implanting base station, and including base station ontology, the base station ontology is pure titanium material, and feature exists
In：There is cerium/Metronidazole coating on the base station ontology；
The preparation method of the cerium/Metronidazole coating includes the following steps：
1. pure titanium-based platform body surface sanding and polishing, immerses the NaOH aqueous solutions of a concentration of 16~18mol/L, 50~
55 DEG C are ultrasonically treated 2-3 hours, cleaning, drying；
2. is small using a concentration of 0.05-5.0mol/L cerous nitrate solutions dipping 30-48 by step 1. treated base station
When, cleaning, drying；
3. the salpeter solution, teos solution and water of Metronidazole are stirred reaction 28- by ice-water bath
It 20 hours, centrifuges, washing, vacuum freeze drying obtains nano anti-biotic material, nano anti-biotic material is added under stiring bright
In sol solution；
4. step 2. treated base station ontology is immersed in 3. colloidal sol that step obtains 2-3 hour, then take out, cleaning
Totally to get.
Further, in the above-mentioned technical solutions, step 3. in, the salpeter solution a concentration of 4 of Metronidazole~
A concentration of 10~100mmol/L of 10mmol/L, gelatin solution.
Further, in the above-mentioned technical solutions, step 3. in, Metronidazole, ethyl orthosilicate, gelatin solution dosage
Than for 5-8mg：0.1-0.16mg：1.5-2.5ml.
Further, in the above-mentioned technical solutions, step 3. in, freeze-drying temperature be -10~-15 DEG C.
Further, in the above-mentioned technical solutions, 4. base station that step obtains is repeated 1-3 times and immerses what 2. step obtained
2-3 hours in colloidal sol, then take out, clean up.
Further, in the above-mentioned technical solutions, step 2. in, it is dry 2-7 hours dry for 60-100 DEG C under vacuum.
Invention advantageous effect
Tooth-implanting base station of the present invention by adhering to the coating containing cerium and Metronidazole in base station outer surface, obtains simultaneous
Have long-acting and sustained release antibacterial functions tooth-implanting base stations.The invasion that can effectively inhibit bacteria, it is demonstrated experimentally that the tooth of the present invention
Planting matrix has good anti-microbial property, while inhibit the adherency and survival of periodontal common pathogen, has persistently, efficiently
Sterilization, anti-infection ability, improve the success rate of tooth-planting, shorten treatment time.The dental implant abutment of the present invention
Preparation method is simple, has a good application prospect in tooth-planting field.
Specific embodiment
Following nonlimiting examples can make those of ordinary skill in the art be more fully understood the present invention, but not with
Any mode limits the present invention.
Embodiment 1
A kind of tooth-implanting base station, including base station ontology, the base station ontology is pure titanium material, it is characterised in that：Described
There is cerium/Metronidazole coating on base station ontology；
The preparation method of the cerium/Metronidazole coating includes the following steps：
1. pure titanium-based platform body surface sanding and polishing is immersed the NaOH aqueous solutions of a concentration of 16mol/L, 50 DEG C of ultrasounds by
Processing 2-3 hours, cleaning, drying；
2. step 1. treated base station is used a concentration of 0.05molL by-1Cerous nitrate solution impregnates 30-48 hours,
Cleaning, drying；
3. the salpeter solution, teos solution and water of Metronidazole are stirred reaction 28- by ice-water bath
It 20 hours, centrifuges, washing, vacuum freeze drying obtains nano anti-biotic material, nano anti-biotic material is added under stiring bright
In sol solution；
4. step 2. treated base station ontology is immersed in 3. colloidal sol that step obtains 2-3 hour, then take out, cleaning
Totally to get.
Step 3. in, a concentration of 4~10mmol/L of salpeter solution of Metronidazole, a concentration of the 10 of gelatin solution~
100mmol/L。
Step 3. in, Metronidazole, ethyl orthosilicate, gelatin solution amount ratio be 5mg：0.1mg：1.5ml.
Step 3. in, freeze-drying temperature be -10 DEG C.
2-3 hours in 2. colloidal sol that 4. 1-3 immersion step of base station repetition that step obtains is obtained, then take out, clearly
Wash clean.
Step 2. in, it is dry for 60 DEG C of dryings 7 hours under vacuum.
Embodiment 2
A kind of tooth-implanting base station, including base station ontology, the base station ontology is pure titanium material, it is characterised in that：Described
There is cerium/Metronidazole coating on base station ontology；
The preparation method of the cerium/Metronidazole coating includes the following steps：
1. pure titanium-based platform body surface sanding and polishing is immersed the NaOH aqueous solutions of a concentration of 18mol/L, 55 DEG C of ultrasounds by
Processing 2-3 hours, cleaning, drying；
2. step 1. treated base station is used a concentration of 5.0molL by-1Cerous nitrate solution dipping 30-48 hours, clearly
It washes, dry；
3. the salpeter solution, teos solution and water of Metronidazole are stirred reaction 20 by ice-water bath
Hour, it centrifuges, washing, vacuum freeze drying obtains nano anti-biotic material, nano anti-biotic material is added to gelatin under stiring
In solution；
4. step 2. treated base station ontology is immersed in 3. colloidal sol that step obtains 2-3 hour, then take out, cleaning
Totally to get.
Step 3. in, a concentration of 10mmol/L of salpeter solution of Metronidazole, a concentration of 100mmol/ of gelatin solution
L。
Step 3. in, Metronidazole, ethyl orthosilicate, gelatin solution amount ratio be 8mg：0.16mg：2.5ml.
Step 3. in, freeze-drying temperature be -15 DEG C.
2-3 hours in 2. colloidal sol that 4. 1-3 immersion step of base station repetition that step obtains is obtained, then take out, clearly
Wash clean.
Step 2. in, it is dry for 100 DEG C of dryings 2 hours under vacuum.
Claims (6)
1. a kind of tooth-implanting base station, including base station ontology, the base station ontology is pure titanium material, it is characterised in that：The base
There is cerium/Metronidazole coating on playscript with stage directions body；
The preparation method of the cerium/Metronidazole coating includes the following steps：
1. pure titanium-based platform body surface sanding and polishing, immerses the NaOH aqueous solutions of a concentration of 16~18mol/L, 50~55 DEG C
It is ultrasonically treated 2-3 hours, cleaning, drying；
2. step 1. treated base station is impregnated 30-48 hours by using a concentration of 0.05-5.0mol/L cerous nitrate solutions, clearly
It washes, dry；
3. by the salpeter solution, teos solution and water of Metronidazole be stirred in ice-water bath reaction 28-20 it is small
When, it centrifuges, washing, vacuum freeze drying obtains nano anti-biotic material, it is molten that nano anti-biotic material is added to gelatin under stiring
In liquid；
4. step 2. treated base station ontology is immersed in 3. colloidal sol that step obtains 2-3 hour, then take out, cleaning is done
Only to get.
2. tooth-implanting base station according to claim 1, it is characterised in that：Step 3. in, the salpeter solution of Metronidazole is dense
Spend a concentration of 10~100mmol/L for 4~10mmol/L, gelatin solution.
3. tooth-implanting base station according to claim 2, it is characterised in that：Step 3. in, Metronidazole, ethyl orthosilicate,
Gelatin solution amount ratio is 5-8mg：0.1-0.16mg：1.5-2.5ml.
4. tooth-implanting base station according to claim 2, it is characterised in that：Step 3. in, freeze-drying temperature be -10~-15
℃。
5. tooth-implanting base station according to claim 2, it is characterised in that：4. base station that step is obtained repeats 1-3 immersion
2-3 hours in 2. colloidal sol that step obtains, then take out, clean up.
6. tooth-implanting base station according to claim 1, it is characterised in that：Step 2. in, dry is 60-100 DEG C under vacuum
It is 2-7 hours dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711422765.4A CN108144117A (en) | 2017-12-25 | 2017-12-25 | A kind of tooth-implanting base station |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711422765.4A CN108144117A (en) | 2017-12-25 | 2017-12-25 | A kind of tooth-implanting base station |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108144117A true CN108144117A (en) | 2018-06-12 |
Family
ID=62462059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711422765.4A Pending CN108144117A (en) | 2017-12-25 | 2017-12-25 | A kind of tooth-implanting base station |
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| Country | Link |
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| CN (1) | CN108144117A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197689A (en) * | 2021-05-08 | 2021-08-03 | 山东恒泰医疗器械有限公司 | Dental implant abutment for inhibiting adhesion of dental bacteria and surface treatment method thereof |
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| CN101073675A (en) * | 2007-05-29 | 2007-11-21 | 中国科学院上海硅酸盐研究所 | Antiseptic biological active titanium coating and its production |
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2017
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Cited By (1)
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| CN113197689A (en) * | 2021-05-08 | 2021-08-03 | 山东恒泰医疗器械有限公司 | Dental implant abutment for inhibiting adhesion of dental bacteria and surface treatment method thereof |
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Application publication date: 20180612 |