CN108144110A - A kind of preparation method of promoting healing type head injury titanium net composite material - Google Patents
A kind of preparation method of promoting healing type head injury titanium net composite material Download PDFInfo
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- CN108144110A CN108144110A CN201711316509.7A CN201711316509A CN108144110A CN 108144110 A CN108144110 A CN 108144110A CN 201711316509 A CN201711316509 A CN 201711316509A CN 108144110 A CN108144110 A CN 108144110A
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2430/00—Materials or treatment for tissue regeneration
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Abstract
The present invention relates to a kind of promoting healing type head injury preparation methods of titanium net composite material, belong to medical material tech field.The present invention is by based on titanium net, since titanium net has stronger compressive property in numerous materials for use in skull-fixing, histocompatbility is good, after being implanted into human body, fibroblast can grow into the micropore of titanium net, titanium net is made to combine together with tissue, with calcification and ossified trend, and gel layer is coated to its surface, since gel uses soybean protein isolate as raw material, it can effectively be decomposed to form polypeptide in human body and be absorbed by the body, effectively facilitate wound healing and cell growth, and the present invention is coagulant liquid main body by chitosan, it effectively coats icariin and is discharged after being implanted into human body, since icariin can effectively facilitate osteoblast differentiation and proliferation, inhibit the differentiation of osteoclast, reduce the bone information area of osteoclast, effectively improve reparation and regeneration that skull is damaged position, it is further reduced the time of skull wound healing.
Description
Technical field
The present invention relates to a kind of preparation methods of promoting healing type head injury titanium net composite material, belong to medical material technology neck
Domain.
Background technology
In neurosurgery clinical position, because of the purpose of decompression or one phase of bone flap can not often be resetted, lead to skull defeci.Skull
Defect influences beauty, causes the symptoms such as headache and dizzy and its existing potential danger factor, is caused to patient certain
Psychological burden.After stable disease, based on protection, support brain tissue, the stabilization of intracranial pressure is kept, restores original structure and appearance
The reason of, the later stage needs row cranioplasty more.Titanium and its alloy are extensive due to good mechanical performance and biocompatibility
Applied to bone defect and tooth-planting field.But since its elasticity modulus (110GPa or so) (is less than much larger than bone tissue
30GPa), the bone tissue after implanting around its implant is likely to stress shielding and absorbs, so as to cause implant
It loosens.Implantation material porous can not only effectively reduce the elasticity modulus of implant, moreover it is possible in hole and its surrounding tissue provides
Good nutrition and waste exchange channel are conducive to sticking, be proliferated and breaking up for cell, so as to promote the knot of bone tissue and material
It closes.
With material science and biomedical engineering advancement of science, the development of cranioplasty is not only promoted, simultaneously
Higher requirement is proposed to the quality of material.Ideal materials for use in skull-fixing should have no cytotoxicity, no or low immunogene
Property, it is biodegradable and can be replaced within a certain period of time by self area of new bone, can random-shaping, have sufficient intensity and toughness,
It is nonmagnetic, can in body solidified forming, be easier to prepare and promote and apply, convenient for CT, MRI scan check the advantages that.It selects different
During body patching material, to consider protection intensity, good appearance whether there is rejection, patching material whether aging, deformation and youngster
The factors such as the change after virgin period repairing in developmental process, but although existing titanium net meets its strength and toughness and compatibility
Deng, but the healing at patient's skull position can not be effectively facilitated, wound recovery time is slow, is effectively facilitated more so preparing one kind
The composite titanium net materials of conjunction are necessary.
Invention content
The technical problems to be solved by the invention：Patient's skull position can not be effectively facilitated for existing material for repairing skull
Healing, the defects of wound recovery time is slow, provide a kind of preparation method of alkaline-resisting vegetation type ecological slop protection material.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
（1）In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixing
Powder；
（2）In mass ratio 1:8, mixed-powder and sodium hydroxide solution are stirred, ultrasonic disperse obtains dispersion liquid, by weight
Number meter weighs 75~80 parts of dispersion liquids, 10~15 parts of chitosans and 25~30 parts of N-N '-methylene-bisacrylamides and is placed in respectively
In three-necked flask, lead to nitrogen and exclude air, heating heating and insulation reaction, stand cooling and rotary evaporation, obtain cladding coagulant liquid；
（3）It takes titanium net and with carborundum paper grinding process, treats after the completion of polishing completely, with high pressure air rifle to the titanium net after polishing
Blast cleaning is carried out, after the completion of for clearance, titanium net is dipped in absolute ethyl alcohol, coagulant liquid spray gun will be coated after naturally dry
It uniformly sprays to titanium net surface, sprays processing and drying, sterilizing, you can be prepared into a kind of promoting healing type head injury and answered with titanium net
Condensation material.
Step（2）The nitrogen is passed through rate as 45~50mL/min.
Step（2）The rotating evaporation temperature is 55~60 DEG C.
Step（3）The layer thickness that sprays for spraying processing is 0.5~0.8mm.
Step（3）It is 0.5~1.0MPa that the blast cleaning condition, which is jet-stream wind pressure, nozzle from test specimen for 5~
8mm, injection angle are 90 °.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention is by based on titanium net, since titanium net has stronger compressive property in numerous materials for use in skull-fixing,
Histocompatbility is good, and after being implanted into human body, fibroblast can grow into the micropore of titanium net, and titanium net is made to combine together with tissue, tool
There are calcification and ossified trend, and gel layer is coated to its surface, since gel uses soybean protein isolate as raw material, in human body
Polypeptide can be effectively decomposed to form and be absorbed by the body, effectively facilitated wound healing and cell growth, effectively facilitate wound healing；
（2）The present invention is coagulant liquid main body by chitosan, effectively coats icariin and is discharged after being implanted into human body, due to excessive sheep
Leaves of pulse plants glycosides can effectively facilitate osteoblast differentiation and proliferation, increase alkaline phosphatase activities, make secretion and the mineralising of osteocalcin, drop
Low superoxide anion and actin inhibit the differentiation of osteoclast, and then reduce the bone information area of osteoclast, so as to
Reparation and regeneration that skull is damaged position are effectively improved, is further reduced the time of skull wound healing.
Specific embodiment
In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixing
Powder, in mass ratio 1:8, mixed-powder and 5% sodium hydroxide solution of mass fraction are stirred, surpassed under 200~300W
Sound disperses 10~15min, obtains dispersion liquid and counts in parts by weight, weighs 75~80 parts of dispersion liquids, 10~15 parts of chitosans respectively
It is placed in three-necked flask with 25~30 parts of N-N '-methylene-bisacrylamides, leads to nitrogen and exclude air, in 45~50mL/min nitrogen
Gas is passed through under rate, and heating is heated to 75~80 DEG C, and after 2~3h of insulation reaction, standing is cooled to 55~60 DEG C and rotary evaporations
To the 1/5 of original volume, cladding coagulant liquid is obtained；It takes titanium net and is beaten successively with 240 mesh, 280 mesh and 360 mesh carborundum papers
Mill, is treated after the completion of polishing completely, and blast cleaning is carried out to the titanium net after polishing with high pressure air rifle, sprays gas when controlling blast cleaning
Stream pressure is 0.5~1.0MPa, and nozzle is 5~8mm from test specimen, and injection angle is 90 °, and after the completion of for clearance, titanium net is impregnated
3~5h into absolute ethyl alcohol then takes out titanium net and naturally dry, then cladding coagulant liquid is uniformly sprayed with spray gun to titanium net table
Face, control spray thickness as 0.5~0.8mm, spray pressure as 0.2~0.3MPa, wait after the completion of spraying, vacuum freeze drying is simultaneously
It is placed in 25~30min of sterilization treatment under ultraviolet sterilization lamp, you can be prepared into a kind of promoting healing type head injury titanium net composite wood
Material.
Example 1
In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixed powder
End, in mass ratio 1:8, mixed-powder and 5% sodium hydroxide solution of mass fraction are stirred, the ultrasonic disperse under 200W
10min obtains dispersion liquid and counts in parts by weight, weighs 75 parts of dispersion liquids, 10 parts of chitosans and 25 parts of N-N '-di-2-ethylhexylphosphine oxides respectively
Acrylamide is placed in three-necked flask, is led to nitrogen and is excluded air, and in the case where 45mL/min nitrogen is passed through rate, heating is heated to 75
DEG C, after insulation reaction 2h, standing is cooled to 55 DEG C and rotary evaporation to the 1/5 of original volume, obtains cladding coagulant liquid；Take titanium net and according to
It is secondary to be polished with 240 mesh, 280 mesh and 360 mesh carborundum papers, treat completely polish after the completion of, with high pressure air rifle to polishing after
Titanium net carry out blast cleaning, jet-stream wind pressure is 0.5MPa when controlling blast cleaning, and nozzle is 5mm from test specimen, is blown angle
It is 90 ° to spend, and after the completion of for clearance, titanium net is dipped to 3h in absolute ethyl alcohol, then takes out titanium net and naturally dry, then will cladding
Coagulant liquid is uniformly sprayed with spray gun to titanium net surface, and control sprays thickness as 0.5mm, is sprayed pressure as 0.2MPa, is waited to have sprayed
Cheng Hou, vacuum freeze drying are placed in sterilization treatment 25min under ultraviolet sterilization lamp, you can are prepared into a kind of promoting healing type skull damage
Wound titanium net composite material.
Example 2
In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixed powder
End, in mass ratio 1:8, mixed-powder and 5% sodium hydroxide solution of mass fraction are stirred, the ultrasonic disperse under 250W
12min obtains dispersion liquid and counts in parts by weight, weighs 77 parts of dispersion liquids, 12 parts of chitosans and 27 parts of N-N '-di-2-ethylhexylphosphine oxides respectively
Acrylamide is placed in three-necked flask, is led to nitrogen and is excluded air, and in the case where 47mL/min nitrogen is passed through rate, heating is heated to 77
DEG C, after insulation reaction 3h, standing is cooled to 57 DEG C and rotary evaporation to the 1/5 of original volume, obtains cladding coagulant liquid；Take titanium net and according to
It is secondary to be polished with 240 mesh, 280 mesh and 360 mesh carborundum papers, treat completely polish after the completion of, with high pressure air rifle to polishing after
Titanium net carry out blast cleaning, jet-stream wind pressure is 0.7MPa when controlling blast cleaning, and nozzle is 6mm from test specimen, is blown angle
It is 90 ° to spend, and after the completion of for clearance, titanium net is dipped to 4h in absolute ethyl alcohol, then takes out titanium net and naturally dry, then will cladding
Coagulant liquid is uniformly sprayed with spray gun to titanium net surface, and control sprays thickness as 0.7mm, is sprayed pressure as 0.3MPa, is waited to have sprayed
Cheng Hou, vacuum freeze drying are placed in sterilization treatment 27min under ultraviolet sterilization lamp, you can are prepared into a kind of promoting healing type skull damage
Wound titanium net composite material.
Example 3
In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixed powder
End, in mass ratio 1:8, mixed-powder and 5% sodium hydroxide solution of mass fraction are stirred, the ultrasonic disperse under 300W
15min obtains dispersion liquid and counts in parts by weight, weighs 80 parts of dispersion liquids, 15 parts of chitosans and 30 parts of N-N '-di-2-ethylhexylphosphine oxides respectively
Acrylamide is placed in three-necked flask, is led to nitrogen and is excluded air, and in the case where 50mL/min nitrogen is passed through rate, heating is heated to 80
DEG C, after insulation reaction 3h, standing is cooled to 60 DEG C and rotary evaporation to the 1/5 of original volume, obtains cladding coagulant liquid；Take titanium net and according to
It is secondary to be polished with 240 mesh, 280 mesh and 360 mesh carborundum papers, treat completely polish after the completion of, with high pressure air rifle to polishing after
Titanium net carry out blast cleaning, jet-stream wind pressure is 1.0MPa when controlling blast cleaning, and nozzle is 8mm from test specimen, is blown angle
It is 90 ° to spend, and after the completion of for clearance, titanium net is dipped to 5h in absolute ethyl alcohol, then takes out titanium net and naturally dry, then will cladding
Coagulant liquid is uniformly sprayed with spray gun to titanium net surface, and control sprays thickness as 0.8mm, is sprayed pressure as 0.3MPa, is waited to have sprayed
Cheng Hou, vacuum freeze drying are placed in sterilization treatment 30min under ultraviolet sterilization lamp, you can are prepared into a kind of promoting healing type skull damage
Wound titanium net composite material.
It is tested for the property, has in titanium net composite material and pure common titanium net Materials Plant animal body prepared by the present invention
Test result is as follows for body shown in table table 1：
The 1 performance table of comparisons of table
As seen from the above table, the titanium net composite material compatibility that prepared by the present invention is preferable, and effectively facilitates skull healing.
Claims (5)
1. a kind of preparation method of promoting healing type head injury titanium net composite material, it is characterised in that specifically preparation process is：
（1）In mass ratio 1:5, icariin is stirred with soybean protein isolate, is crushed and is ground, and is crossed 200 mesh and is sieved to obtain mixing
Powder；
（2）In mass ratio 1:8, mixed-powder and sodium hydroxide solution are stirred, ultrasonic disperse obtains dispersion liquid, by weight
Number meter weighs 75~80 parts of dispersion liquids, 10~15 parts of chitosans and 25~30 parts of N-N '-methylene-bisacrylamides and is placed in respectively
In three-necked flask, lead to nitrogen and exclude air, heating heating and insulation reaction, stand cooling and rotary evaporation, obtain cladding coagulant liquid；
（3）It takes titanium net and with carborundum paper grinding process, treats after the completion of polishing completely, with high pressure air rifle to the titanium net after polishing
Blast cleaning is carried out, after the completion of for clearance, titanium net is dipped in absolute ethyl alcohol, coagulant liquid spray gun will be coated after naturally dry
It uniformly sprays to titanium net surface, sprays processing and drying, sterilizing, you can be prepared into a kind of promoting healing type head injury and answered with titanium net
Condensation material.
2. a kind of promoting healing type head injury preparation method of titanium net composite material according to claim 1, feature
It is：Step（2）The nitrogen is passed through rate as 45~50mL/min.
3. a kind of promoting healing type head injury preparation method of titanium net composite material according to claim 1, feature
It is：Step（2）The rotating evaporation temperature is 55~60 DEG C.
4. a kind of promoting healing type head injury preparation method of titanium net composite material according to claim 1, feature
It is：Step（3）The layer thickness that sprays for spraying processing is 0.5~0.8mm.
5. a kind of promoting healing type head injury preparation method of titanium net composite material according to claim 1, feature
It is：Step（3）The blast cleaning condition is that jet-stream wind pressure is 0.5~1.0MPa, and nozzle is 5~8mm from test specimen,
It is 90 ° to be blown angle.
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| CN201711316509.7A CN108144110A (en) | 2017-12-12 | 2017-12-12 | A kind of preparation method of promoting healing type head injury titanium net composite material |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559240A (en) * | 2008-04-17 | 2009-10-21 | 杨立群 | Skull repairing material and preparation method thereof |
| CN101843924A (en) * | 2010-03-16 | 2010-09-29 | 温州医学院眼视光研究院 | Bone repairing bracket material with controllable and slow-releasing traditional Chinese medicine and preparation method thereof |
| CN102218159A (en) * | 2010-09-29 | 2011-10-19 | 上海双申医疗器械有限公司 | Skull defect restoration titanium mesh with nonsticking coating and preparation method thereof |
| CN104826172A (en) * | 2015-03-06 | 2015-08-12 | 赵红斌 | Scaffold used for bone injury recovery and having tissue inductive function |
| CN105435305A (en) * | 2015-12-17 | 2016-03-30 | 西南交通大学 | Porous titanium composite material and preparation method thereof |
-
2017
- 2017-12-12 CN CN201711316509.7A patent/CN108144110A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559240A (en) * | 2008-04-17 | 2009-10-21 | 杨立群 | Skull repairing material and preparation method thereof |
| CN101843924A (en) * | 2010-03-16 | 2010-09-29 | 温州医学院眼视光研究院 | Bone repairing bracket material with controllable and slow-releasing traditional Chinese medicine and preparation method thereof |
| CN102218159A (en) * | 2010-09-29 | 2011-10-19 | 上海双申医疗器械有限公司 | Skull defect restoration titanium mesh with nonsticking coating and preparation method thereof |
| CN104826172A (en) * | 2015-03-06 | 2015-08-12 | 赵红斌 | Scaffold used for bone injury recovery and having tissue inductive function |
| CN105435305A (en) * | 2015-12-17 | 2016-03-30 | 西南交通大学 | Porous titanium composite material and preparation method thereof |
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