CN108144014A - A kind of drug for treating vascular headache - Google Patents

A kind of drug for treating vascular headache Download PDF

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Publication number
CN108144014A
CN108144014A CN201810159749.9A CN201810159749A CN108144014A CN 108144014 A CN108144014 A CN 108144014A CN 201810159749 A CN201810159749 A CN 201810159749A CN 108144014 A CN108144014 A CN 108144014A
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parts
drug
headache
vascular headache
honey
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刘四新
孙颖
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals

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Abstract

The invention discloses a kind of drug for treating vascular headache, the drug composition includes：10 15 parts of Rhizoma Chuanxiong, 12 15 parts of Rhizoma Gastrodiae, 10 13 parts of fructus viticis, 10 20 parts of Radix Paeoniae Alba, 10 13 parts of corydalis tuber, 15 18 parts of the root of Dahurain angelica, 12 15 parts of Radix Salviae Miltiorrhizae, 13 16 parts of Jehol Ligusticum Rhizome, 10 15 parts of peach kernel, 8 12 parts of safflower, 10 15 parts of radix bupleuri, 35 parts of full worm, 12 18 parts of cape jasmine, 24 parts of centipede, 10 13 parts of curcuma zedoary and honey.Drug of the present invention for treatment vascular headache, is all made of pure Chinese medicine, without any side effects, and onset time is 57 days, according to course of disease length, adheres to taking 13 months, can achieve the purpose that healing.Follow up time up to 10 years no relapse.

Description

A kind of drug for treating vascular headache
Technical field
The present invention relates to drug field, specially a kind of drug for treating vascular headache.
Background technology
Headache is clinical common symptom, usually will be limited to the head first half, outer grand including geisoma, helix upper limb and pillow Prominent line is referred to as headache with the pain of upper bit.Headache is because various, neuralgia, intracranial infection, intracranial space-occupying lesion, the cerebrovascular Maxillofacial disease and general disease such as acute infection, poisoning etc. can cause to have a headache outside disease, cranium.Age of onset is common in Young, middle age and old age.Headache is common disease, frequently-occurring disease, and pathogenesis is also very complicated.Most patient is come meeting when seeing the doctor The reason of various is spoken of, other than certain organic diseases, such as brain tumor, encephalitis, cerebrovascular disease, cervical spondylosis, more What is dwelt on is certain external environmental factors, these factors have been counted as the risk factor that headache occurs.Cause headache Common environmental is because being known as Changes in weather:Solar glare, which is irradiated, dried, cold irritates can induce headache.In China, spring and summer section header Pain incidence is significantly high.Autumn and winter, this may be related with temperature height.Bad life habits are also to induce the factor of headache, such as raw Living, irregular, sleep insufficiency, operating pressure is big, overstrain one's nerves, easily has a headache.In addition, to be infected with some bad thermophilic by some people It is good, such as smoke, headache can also be induced by drinking.
There are many drug for treating headache currently on the market, belong to mostly and suit the remedy to the case, and based on analgesic, usually take stopgap measures and do not control This, high recurrence rate, it is also possible to patient be made to generate the dependence to drug.Of short duration headache once in a while, because medication effect is fast and apparent, But Western medicine is taken in long-term headache, can cause the side effect of body, is unfavorable for the health of human body.
Invention content
It is an object of the invention in view of the above-mentioned problems, overcome the shortage of prior art, disclose a kind of to treat vascular head The drug of pain is made of and without any side effects pure Chinese medicine.
A kind of drug for treating vascular headache, the drug composition include：10-15 parts of Rhizoma Chuanxiong, it is 12-15 parts of Rhizoma Gastrodiae, climing 10-13 parts of Jing Zi, 10-20 parts of Radix Paeoniae Alba, 10-13 parts of corydalis tuber, 15-18 parts of the root of Dahurain angelica, 12-15 parts of Radix Salviae Miltiorrhizae, 13-16 parts of Jehol Ligusticum Rhizome, peach 10-15 parts of benevolence, 8-12 parts of safflower, 10-15 parts of radix bupleuri, worm 3-5 parts complete, 12-18 parts of cape jasmine, 2-4 parts of centipede, 10-13 parts of curcuma zedoary And honey.
Preferably, the preparation process includes：The drug is ground into 100 mesh, pill of the honey refining for weight 0.05g.
Preferably, the sweet refining process includes the drug after crushing and honey according to 10:3 ratios are mixed well, pill mechanism It is standby.
The main function of wherein each herbal raw material ingredient is：
Rhizoma Chuanxiong：Pungent-warm, which rises, to be dissipated, can " the uplink head ", wind-expelling pain-stopping, to control headache key medicine, no matter chill, wind-heat, rheumatism, The deficiency of blood, blood stasis headache can with card compatibility with it, therefore Li Dong Yuan speech " have a headache palpus Rhizoma Chuanxiong ".Anemofrigid headache is controlled, with Rhizoma Et Radix Notopterygii, carefully The pungent, root of Dahurain angelica, as Chuanxiong Chatiao San (《The formulary of peaceful benevolent dispensary》)；If with chrysanthemum, gypsum, stiff silkworm, headache due to pathogenic wind-heat can be controlled, as Rhizoma Chuanxiong dissipates (《It defends Raw health care》)；If controlling headache due to wind-wetness evil, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, windproof can be matched, as Decoction of Notopterygium for Rheumatism (《Differentiation on endogenous》)；With Radix Angelicae Sinensis, Radix Paeoniae Alba takes the work(of this product wind-expelling pain-stopping, can control headache due to deficiency of blood, such as plus taste Siwu Tang (《The deficient wing of gold》)；If controlling blood stasis headache, can match The radix paeoniae rubrathe, Moschus, as TONGQIAOHUOXUE Decoction (《The correction of the errors of medical works》)
Rhizoma Gastrodiae：Rhizoma Gastrodiae has coronary artery, peripheral blood vessel a degree of dilating effect, and Gastrodia Injection can make rabbit blood Drops, decreased heart rate, cardiac output increase, and myocardial oxygen consumption declines Rhizoma Gastrodiaes and is known as promotion myocardial cell energy metabolism, especially It is in addition the effect for obtaining energy under anaerobic conditions still has antiinflammatory immunity function.
Fructus viticis：Fructus viticis water decoction has apparent analgesic activity.Intraperitoneal injection can significantly improve the threshold of pain of mouse.Health product Effect be better than parched medicinal material, alcohol extract is better than water extract.Aqueous extracts have apparent sedation, and Vitex rotundifolia is better than wild pepper Son.Fructus viticis alcohol immersion liquid can significantly reduce the blood pressure of anesthetized cat.Have preferably to the microcirculation disorder of experimental periphery and internal organ Improvement is remarkably improved the blood flow velocity of the microcirculation of lagophthalmos bulbar conjunctiva
Radix Paeoniae Alba：Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improves myocardial nutritional flow, expansion blood Pipe, inhibits platelet aggregation, calmness, analgesia, spasmolysis, antiulcer, the effect for adjusting blood glucose at confrontation acute myocardial ischemia.Radix Paeoniae Alba Decoction can inhibit shigella dysenteriae, streptococcus pneumonia, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa.
Corydalis tuber：Corydalis tuber has good analgesic effect, can treat kinds cancer.Clinical practice is except compound prescription decoctum, levigation Outside swallowing, also extract tetrahydropalmatine and be used for analgesic.
The root of Dahurain angelica：The root of Dahurain angelica and Radix angelicae dahuricae alcohol extracting ether soluble components exempt from ear blood vessel and have a notable dilating effect to leaving one's post, and the root of Dahurain angelica The Coumarins ingredient byak-angelicin that water soluble ingredient has the vasoconstrictor effects roots of Dahurain angelica has coronary vasodilator in the different Europe of dilating effect Peucedanin has the power effect of reduction isolated frog heart shrink.
Jehol Ligusticum Rhizome：For anemofrigid cold, top of the head pain.Jehol Ligusticum Rhizome pungent-warm perfume (or spice) is dry, and nature and flavor all rise, and medicine gesture is magnificent, Starch 1500 mountain peak top, with Diverging Taiyang channel wind-cold damp pathogen is good at, therefore with sun chill is controlled, follow through upper criminal symptoms include headache, have a stuffy nose, parietal headache notably, often with With using, such as refreshing art dissipates the wind-expelling pain-stoppings medicines such as ginger work, rhizoma atractylodis, four rhizomes of chuanxiong；If catching cold damp evil, all over the body to the greatest extent pain, and often with it is windproof, only Work, the root of Chinese clematis, rhizoma atractylodis are equally used, and with cold dispelling of dispelling, damp dispelling and pain relieving, win wet soup as ginger lives.
Peach kernel：Peach kernel bitter but sweet flavor and it is mild-natured, the heart, liver, large intestine can be entered, promoting blood circulation effect is very wide, can be with controlling stagnation of blood stasis Various rheumatisms.
Safflower：Safflower has the effect of swelling and pain relieving, suitable for a variety of Blood stasis, such as chest impediment and cardialgia, rib abdomen pain, subcutaneous blueness The diseases such as purple, hemiplegia.In addition, four limbs numbness pain or stasis caused pain caused by the strain of traumatic injury, metal-inflicted wound, using safflower effect very Significantly.
Radix bupleuri：Saturating table expels the heat-evil, and soothing liver-qi stagnation rises and lifts yang-energy.Saturating table expels the heat-evil, and soothing liver-qi stagnation rises and lifts yang-energy.Inflammation is caused to a variety of Ankle-joint caused by agent swells has inhibiting effect with desmoplastic inflammation.
Full worm：Inducing cortical potential to splanchnodynia, skin scorch pain and trigeminal neuralgia has stronger inhibiting effect；But in vitro Action potential conduction has no significant effect.
Cape jasmine：The fruit of cape jasmine is traditional Chinese medicine, belongs to the l batches of medicine-food two-purpose resources that the Ministry of Public Health promulgates, has protect liver, profit The effects that courage, decompression, calmness, hemostasis, detumescence.
Centipede：It is warm-natured for medicinal herbs most in use, acrid flavour.There is ceases wind solution antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain.For Child convulsion, twitch spasm, apoplexy facial paralysis, hemiplegia, lockjaw disease, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.
Curcuma zedoary：Cure mainly " qi and blood stagnation, trusted subordinate's distending pain, abdominal mass, accumulation, place food does not disappear, women's blood stasis, traumatic injury Have a pain.
Beneficial effects of the present invention are：The drug for the treatment of headache prepared by the present invention is made of pure Chinese herbal medicine, clinical real Trample observation prove honeyed bolus preparation be more advantageous to drug effect and therapeutic effect more preferably, in addition without it is any chemistry addition, onset time It is 5-7 days, according to course of disease length, adheres to taking 1-3 months, can achieve the purpose that healing.Simultaneously in terms of curative effect, to trident god Dysmenorrhoea and post-herpetic neuralgia are also relieved effect.
Specific embodiment
A kind of drug for treating vascular headache, drug composition include：10-15 parts of Rhizoma Chuanxiong, 12-15 parts of Rhizoma Gastrodiae, fructus viticis 10-13 parts, 10-20 parts of Radix Paeoniae Alba, 10-13 parts of corydalis tuber, 15-18 parts of the root of Dahurain angelica, 12-15 parts of Radix Salviae Miltiorrhizae, 13-16 parts of Jehol Ligusticum Rhizome, peach kernel 10- 15 parts, 8-12 parts of safflower, 10-15 parts of radix bupleuri, worm 3-5 parts complete, 12-18 parts of cape jasmine, 2-4 parts of centipede, 10-13 parts of curcuma zedoary and bee Honey.
Wherein preparation process includes：The drug is ground into 100 mesh, pill of the honey refining for weight 0.05g.Wherein honey refining Process includes the drug after crushing and honey according to 10:3 ratios are mixed well, prepared by pellet processing machine.
Specifically used method takes orally, each taking 15-20g, three times a day.
During specifically used 10 years, 700 many cases vascular headache patients are treated altogether, are cured up to 650 many cases, cure rate Reach more than 90%, wherein to the patient having a headache in shouting pain, referred pain, cure rate is up to 100%.The present invention is treatment vascular head The drug of pain, is all made of pure Chinese medicine, without any side effects, and onset time is 5-7 days, according to course of disease length, adheres to taking With 1-3 months, it can achieve the purpose that healing.Follow up time up to 10 years no relapse.
Above-described embodiment, only presently preferred embodiments of the present invention, is not used for limiting the scope of the present invention, therefore all with this The equivalence changes that content described in invention claim is done should all be included within scope of the invention as claimed.

Claims (3)

1. a kind of drug for treating vascular headache, which is characterized in that the drug composition includes：10-15 parts of Rhizoma Chuanxiong, Rhizoma Gastrodiae 12-15 parts, 10-13 parts of fructus viticis, 10-20 parts of Radix Paeoniae Alba, 10-13 parts of corydalis tuber, 15-18 parts of the root of Dahurain angelica, 12-15 parts of Radix Salviae Miltiorrhizae, Jehol Ligusticum Rhizome 13-16 parts, 10-15 parts of peach kernel, 8-12 parts of safflower, 10-15 parts of radix bupleuri, worm 3-5 parts complete, 12-18 parts of cape jasmine, 2-4 parts of centipede, cowherb 10-13 parts of art and honey.
A kind of 2. drug for treating vascular headache according to claim 1, which is characterized in that the preparation process packet It includes：The drug is ground into 100 mesh, pill of the honey refining for weight 0.05g.
3. a kind of drug for treating vascular headache according to claim 2, which is characterized in that the honey refining process includes By the drug after crushing and honey according to 10:3 ratios are mixed well, and later prepared by pellet processing machine.
CN201810159749.9A 2018-02-26 2018-02-26 A kind of drug for treating vascular headache Pending CN108144014A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101972455A (en) * 2010-11-04 2011-02-16 刘四新 Medicament for treating vascular headache and preparation method thereof
CN104491759A (en) * 2015-01-15 2015-04-08 张士红 Traditional Chinese medicine composition for treating cephalagra and preparation method thereof
WO2015074494A1 (en) * 2013-11-22 2015-05-28 富力 Use of ginsenoside-rg3 in preparing medicine for preventing or/and treating dementia and medicine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101972455A (en) * 2010-11-04 2011-02-16 刘四新 Medicament for treating vascular headache and preparation method thereof
WO2015074494A1 (en) * 2013-11-22 2015-05-28 富力 Use of ginsenoside-rg3 in preparing medicine for preventing or/and treating dementia and medicine
CN104491759A (en) * 2015-01-15 2015-04-08 张士红 Traditional Chinese medicine composition for treating cephalagra and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
魏霞: "芎芷芍甘汤治疗血管性头痛34例", 《湖南中医杂志》 *

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Application publication date: 20180612