CN108137543B - 选择性nr2b拮抗剂 - Google Patents
选择性nr2b拮抗剂 Download PDFInfo
- Publication number
- CN108137543B CN108137543B CN201680060583.4A CN201680060583A CN108137543B CN 108137543 B CN108137543 B CN 108137543B CN 201680060583 A CN201680060583 A CN 201680060583A CN 108137543 B CN108137543 B CN 108137543B
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- CN
- China
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- water
- mobile phase
- acetonitrile
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3308/DEL/2015 | 2015-10-14 | ||
| IN3308DE2015 | 2015-10-14 | ||
| PCT/US2016/056714 WO2017066366A1 (en) | 2015-10-14 | 2016-10-13 | Selective nr2b antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108137543A CN108137543A (zh) | 2018-06-08 |
| CN108137543B true CN108137543B (zh) | 2021-11-23 |
Family
ID=57223768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680060583.4A Active CN108137543B (zh) | 2015-10-14 | 2016-10-13 | 选择性nr2b拮抗剂 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10344020B2 (enExample) |
| EP (1) | EP3362441B1 (enExample) |
| JP (1) | JP6938485B2 (enExample) |
| KR (1) | KR20180063306A (enExample) |
| CN (1) | CN108137543B (enExample) |
| AU (1) | AU2016340237A1 (enExample) |
| BR (1) | BR112018006537A2 (enExample) |
| CA (1) | CA3001890A1 (enExample) |
| EA (1) | EA201890946A1 (enExample) |
| ES (1) | ES2818254T3 (enExample) |
| IL (1) | IL258603A (enExample) |
| MX (1) | MX2018004256A (enExample) |
| WO (1) | WO2017066366A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3203144A1 (en) * | 2020-12-04 | 2022-06-09 | Novartis Ag | Dosage regimen for a nr2b-nmda receptor nam for the treatment of depression |
| US11646085B2 (en) | 2021-06-17 | 2023-05-09 | Sandisk Technologies Llc | Toggle mode frequency optimization by dynamic ODT matching for non-volatile memory |
| CN116354923B (zh) * | 2021-12-27 | 2025-05-09 | 江苏恩华药业股份有限公司 | 一种含氮杂环化合物及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015105929A1 (en) * | 2014-01-09 | 2015-07-16 | Bristol-Myers Squibb Company | (r)-3-((3s,4s)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| WO2015105772A1 (en) * | 2014-01-09 | 2015-07-16 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022728B2 (en) * | 2001-03-09 | 2006-04-04 | Abbott Laboratories | Benzimidazoles that are useful in treating male sexual dysfunction |
| US6960589B2 (en) | 2001-03-09 | 2005-11-01 | Abbott Laboratories | Benzimidazoles that are useful in treating sexual dysfunction |
| MXPA05013151A (es) | 2003-06-04 | 2006-03-17 | Merck & Co Inc | 3-fluoro-piperidinas como antagonistas de n-metil-d-aspartato/nr2b. |
| JPWO2007099828A1 (ja) * | 2006-02-23 | 2009-07-16 | 塩野義製薬株式会社 | 環式基で置換された含窒素複素環誘導体 |
| WO2009006437A1 (en) | 2007-06-29 | 2009-01-08 | Emory University | Nmda receptor antagonists for neuroprotection |
| JP2009067784A (ja) * | 2007-08-21 | 2009-04-02 | Shionogi & Co Ltd | 環式基で置換された含窒素複素環誘導体を含有する鎮痛剤 |
| EP2163541A1 (en) | 2008-09-12 | 2010-03-17 | Bayer Schering Pharma Aktiengesellschaft | Piperazine derivatives for binding and imaging amyloid plaques and their use |
| CN102933226A (zh) | 2010-02-11 | 2013-02-13 | 西北大学 | 二级结构稳定化的nmda受体调节剂及其用途 |
| US9624170B2 (en) * | 2013-12-26 | 2017-04-18 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors |
| EP3362447B1 (en) * | 2015-10-14 | 2020-08-26 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
-
2016
- 2016-10-13 JP JP2018519321A patent/JP6938485B2/ja active Active
- 2016-10-13 US US15/767,386 patent/US10344020B2/en active Active
- 2016-10-13 WO PCT/US2016/056714 patent/WO2017066366A1/en not_active Ceased
- 2016-10-13 EP EP16790475.4A patent/EP3362441B1/en active Active
- 2016-10-13 BR BR112018006537A patent/BR112018006537A2/pt not_active Application Discontinuation
- 2016-10-13 MX MX2018004256A patent/MX2018004256A/es unknown
- 2016-10-13 EA EA201890946A patent/EA201890946A1/ru unknown
- 2016-10-13 KR KR1020187013126A patent/KR20180063306A/ko not_active Abandoned
- 2016-10-13 AU AU2016340237A patent/AU2016340237A1/en not_active Abandoned
- 2016-10-13 CA CA3001890A patent/CA3001890A1/en not_active Abandoned
- 2016-10-13 CN CN201680060583.4A patent/CN108137543B/zh active Active
- 2016-10-13 ES ES16790475T patent/ES2818254T3/es active Active
-
2018
- 2018-04-10 IL IL258603A patent/IL258603A/en unknown
-
2019
- 2019-07-03 US US16/502,684 patent/US10961229B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015105929A1 (en) * | 2014-01-09 | 2015-07-16 | Bristol-Myers Squibb Company | (r)-3-((3s,4s)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| WO2015105772A1 (en) * | 2014-01-09 | 2015-07-16 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017066366A1 (en) | 2017-04-20 |
| CA3001890A1 (en) | 2017-04-20 |
| IL258603A (en) | 2018-06-28 |
| AU2016340237A1 (en) | 2018-05-31 |
| US20180312491A1 (en) | 2018-11-01 |
| JP6938485B2 (ja) | 2021-09-22 |
| US20200071304A1 (en) | 2020-03-05 |
| US10344020B2 (en) | 2019-07-09 |
| KR20180063306A (ko) | 2018-06-11 |
| CN108137543A (zh) | 2018-06-08 |
| BR112018006537A2 (pt) | 2018-10-16 |
| JP2018536637A (ja) | 2018-12-13 |
| US10961229B2 (en) | 2021-03-30 |
| EA201890946A1 (ru) | 2018-09-28 |
| ES2818254T3 (es) | 2021-04-09 |
| MX2018004256A (es) | 2018-05-16 |
| EP3362441B1 (en) | 2020-08-12 |
| EP3362441A1 (en) | 2018-08-22 |
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Legal Events
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |