CN108127911A - The biological 3D printing nozzle and method of self-defined subregion temperature control - Google Patents
The biological 3D printing nozzle and method of self-defined subregion temperature control Download PDFInfo
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- CN108127911A CN108127911A CN201711136525.8A CN201711136525A CN108127911A CN 108127911 A CN108127911 A CN 108127911A CN 201711136525 A CN201711136525 A CN 201711136525A CN 108127911 A CN108127911 A CN 108127911A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
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Abstract
The present invention discloses the biological 3D printing nozzle and method of a kind of self-defined subregion temperature control, it is related to 3D printing technique field, the technical issues of different process process can not match corresponding suitable relevant parameter and cause quality of item relatively low is undergone to solve existing 3D printer when bio-ink prints.The biological 3D printing nozzle of self-defined subregion temperature control of the present invention, including：Barrel and the syringe needle connected with the end of barrel, and be tightly connected between barrel and syringe needle and form one using syringe needle as the structure of slot；Wherein, the outside of barrel is from top to bottom wrapped up by storing area temperature control element, transition region temperature control element, extrusion zone temperature control element successively, and extrusion zone temperature control element package extends to the stage casing of syringe needle；Also, shaping area state modulator element is installed below extrusion zone temperature control element.
Description
Technical field
The present invention relates to 3D printing technique field, the biological 3D printing nozzle of more particularly to a kind of self-defined subregion temperature control and
Method.
Background technology
Biological 3D printing be using 3D printing it is discrete/basic principle and method of accumulation molding, to bio-ink (including life
Object material and cell suspension etc.) carry out controlled printing, formed required biologically active implantation material, cell three-dimensional structure or
Artificial organ organ etc..
During bio-ink is printed as corresponding product, several mistakes such as storage, extrusion, accumulation/curing are undergone
Journey, the state of bio-ink also occur to change several times therewith, therefore to control the parameter of different zones that material is made to enter accordingly
State transformation.
In order to maintain the parameter of bio-ink and the stabilization of character as possible in storage, by control of material low as possible
Under temperature condition, the environment of sealing low temperature is stored in using liquid nitrogen cryopreservation cell strain, by Biodegradable polymer material；In order to
Bio-ink during extrusion is made to reach the flow regime of suitable for printing, again arrives temperature control under corresponding transition temperature,
Such as high molecular material heating is made into its melting；In order to make bio-ink accumulation molding after extrusion, also to control certain specific
External condition, such as temperature drop is low, the illumination of crosslinking agent, specific band etc..
Existing 3D printer does not consider above-mentioned change procedure completely in design, only individually additional discrete
Corresponding function is realized in device.Such as Germany's 3D-Bioplotter biology 3D printers, though it is set for different materials melting
Counted different types of nozzle, but a nozzle storage, squeeze out when and with a temperature parameter, by room temperature or print platform
Temperature control certain material is made to reach the cured effect of accumulation, ranging from 30 DEG C -250 DEG C of high temperature print head temperature control, low temperature nozzle
It is 0 DEG C -70 DEG C, and some other external condition then goes to realize using additional independent structure, and 365nmUV irradiation heads are such as configured.
However, present inventor has found, such as certain easy degradations are printed using 3D-Bioplotter high temperature print heads
High molecular material, the defects of because of state modulator, the material being finally extruded necessarily causes due to high temperature degradation with being initially squeezed
Difference occurs in the material molecule amount gone out；Such as certain is printed using 3D-Bioplotter low temperature print head cooperation 365nm irradiation heads
A little thin photo-sensitive hydrogel materials, then because print head can not irradiate UV light simultaneously to material surface in printing, then thin water-setting
Glue material can not cure into silk after the extrusion.
Invention content
The purpose of the present invention is to provide the biological 3D printing nozzles and method of a kind of self-defined subregion temperature control, existing to solve
Some 3D printers, which undergo different process process when bio-ink prints, can not match corresponding suitable relevant parameter and cause
The technical issues of quality of item is relatively low.
The present invention provides a kind of biological 3D printing nozzle of self-defined subregion temperature control, including：Barrel and with the barrel
End connection syringe needle, and between the barrel and the syringe needle be tightly connected formed one using the syringe needle as the knot of slot
Structure；The outside of the barrel is from top to bottom successively by storing area temperature control element, transition region temperature control element, extrusion zone temperature control element packet
It wraps up in, and extrusion zone temperature control element package extends to the stage casing of the syringe needle；The lower section installation of the extrusion zone temperature control element
There is shaping area state modulator element.
Wherein, the storing area temperature control element is the cooling module for generating low temperature.
Specifically, the storing area temperature control element is semiconductor chilling plate or cryogenic heat exchanger.
Wherein, the transition region temperature control element is the heating element for generating high temperature.
Wherein, the extrusion zone temperature control element is the heating element for generating high temperature.
During practical application, the storing area temperature control element is the heating element for generating high temperature；The transition region temperature control
Element is heat insulating element or cooling module；The extrusion zone temperature control element is warm keeping element or cooling module.
Wherein, the shaping area state modulator element is light source；Or, the shaping area state modulator element is for spraying
The spraying device or fluidic device of crosslinking agent；Or, the shaping area state modulator element is and the extrusion zone temperature control element one
Heating element, warm keeping element or the cooling module of cause.
Specifically, the inside of the barrel is from top to bottom followed successively by pushing meanss and piston, and the outer surface of the piston
Sealing space is formed with the barrel；Material in the sealing space is from top to bottom followed successively by storing area material, transition region material
Material, extrusion zone material and shaping area material.
Relative to the prior art, the biological 3D printing nozzle of self-defined subregion temperature control of the present invention is with following excellent
Gesture：
The biological 3D printing nozzle of self-defined subregion temperature control provided by the invention, including：Barrel and the end with barrel
The syringe needle of connection, and be tightly connected between barrel and syringe needle and form one using syringe needle as the structure of slot；Wherein, the outside of barrel
It is from top to bottom wrapped up successively by storing area temperature control element, transition region temperature control element, extrusion zone temperature control element, and extrusion zone temperature control member
Part wraps up the stage casing for extending to syringe needle；Also, shaping area state modulator element is installed below extrusion zone temperature control element.Thus
Analysis is it is found that the biological 3D printing nozzle of self-defined subregion temperature control provided by the invention, in overall structure, is integrated with multiple controls
Warm element and process parameter control element can carry out the bio-ink of different process position timely and different parameter tune
It is whole, so as to which bio-ink be controlled to be converted to current most rational state, and then effectively improve printing product in corresponding process station
State.
The present invention also provides a kind of biological 3D printing method of self-defined subregion temperature control, including：Confirm material module, confirm
Block of state, parameter chosen module, control execution module and parameters measurement module, and include the following steps：The confirmation material
Module confirms material property, and material characteristic parameter is exported to the parameter chosen module；The acknowledgement state module confirms
The execution state of nozzle subregion temperature control, and temperature control is performed into state output to the parameter chosen module；The parameter selectes mould
Block performs state to material characteristic parameter and temperature control and handles, and obtains selected parameter, and selected parameter is input to parameter ratio
Compared with device, the parameter of the parameter of input and monitoring feedback is compared by the parameter comparator, and exports control parameter described in
Execution module is controlled, the control execution module is regulated and controled；The control execution module performs control parameter, and
Subregion temperature control is carried out to printing head, the printing head gives the parameter feedback for monitoring feedback during subregion temperature control
The parameters measurement module；The parameters measurement module monitors the subregion temperature control situation of the printing head in real time, and
Monitoring parameters are inputed into the parameter comparison device.
Wherein, storage condition, extrusion condition and the condition of molding for confirming material property and including material.
Specifically, the storage condition includes storage temperature and transition temperature；The extrusion condition include transition temperature and
Extrusion temperature；The condition of molding includes molding parameter, and the molding parameter is the ginseng of sample intensity of illumination in forming process
It is several, crosslinking agent to use parameter or the temperature parameter of sample formation.
Further, the acknowledgement state module includes selected function and inventory function；The selected function includes printing
And stopping；The inventory function includes suspend mode and preheating.
Further, the parameter chosen module includes suspend mode/halted state, pre- Warm status and print state；It is described
Suspend mode/halted state, the pre- Warm status and the print state include storage region, transitional region, expulsion area and into
Type region.
The biological 3D printing method of the self-defined subregion temperature control and the biological 3D printing of above-mentioned self-defined subregion temperature control are sprayed
Head is identical relative to advantage possessed by the prior art, and details are not described herein.
In addition, the biological 3D printing nozzle and method of self-defined subregion temperature control provided by the invention, join due to subregion control and spray
The independence of each parameter spatially so that printed material can be saved in memory block with the state that optimum stores, energy
It is enough to be extruded in extrusion zone with the parameter most useful for extrusion molding, have greatly compared to traditional technology to the friendly of material
It improves；It is alternative when the nozzle is in pause/not wire vent due to the independence of each parameter of subregion control ginseng nozzle in time
Stopping extrusion zone and transition region temperature control, and continue memory block temperature control, so that material keeps better service life/vigor etc. to have
Sharp character；When needing to continue wire vent, due to only needing to heat extrusion zone material, heated perimeter is than the prior art (entire material
Cylinder) smaller, therefore under equal conditions faster material can be made to be restored to extrudable condition；Since subregion control ginseng nozzle is respectively joined
The continuity of number spatially so that printed material can more timely be exposed to the work of the conditions of molding such as light/chemical cross-linking agent
Under, reduce traditional technology switching time between equipment, working efficiency and installation cost are all obtained compared with traditional technology
Optimization.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution of the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is the structure diagram of the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention；
Fig. 2 is the temperature control flow chart of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention；
Fig. 3 is the material property control ginseng of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention
Number schematic diagram；
Fig. 4 is the output state control ginseng of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention
Number schematic diagram.
In figure：101- barrels；102- syringe needles；103- pistons；104- pushing meanss；201- storing areas temperature control element；
202- transition region temperature control elements；203- extrusion zone temperature control elements；204- shaping areas state modulator element；301- storing areas material
Material；302- transition region materials；303- extrusion zone materials；304- shaping areas material.
Specific embodiment
Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's all other embodiments obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " " center ", " on ", " under ", "left", "right", " vertical ",
The orientation or position relationship of the instructions such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to
Convenient for the description present invention and simplify description rather than instruction or imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is only used for description purpose, and it is not intended that instruction or hint relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected；It can
To be mechanical connection or be electrically connected；It can be directly connected, can also be indirectly connected by intermediary, it can be with
It is the connection inside two elements.For the ordinary skill in the art, it can understand that above-mentioned term exists with concrete condition
Concrete meaning in the present invention.
Fig. 1 is the structure diagram of the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention.
The embodiment of the present invention provides a kind of biological 3D printing nozzle of self-defined subregion temperature control, as shown in Figure 1, including：Material
Cylinder 101 and the syringe needle 102 connected with the end of barrel 101, and be tightly connected between barrel 101 and syringe needle 102 and form one
Structure with syringe needle 102 for slot；The outside of barrel 101 is from top to bottom successively by storing area temperature control element 201, transition region temperature control
Element 202, extrusion zone temperature control element 203 are wrapped up, and extrusion zone temperature control element 203 wraps up the stage casing for extending to syringe needle 102；It squeezes out
The lower section of area's temperature control element 203 is equipped with shaping area state modulator element 204.
Relative to the prior art, the biological 3D printing nozzle of the self-defined subregion temperature control described in the embodiment of the present invention have with
Lower advantage：
As shown in Figure 1, the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention, including：Barrel
101 and the syringe needle 102 that is connected with the end of barrel 101, and be tightly connected between barrel 101 and syringe needle 102 formed one with
Syringe needle 102 is the structure of slot；Wherein, the outside of barrel 101 is from top to bottom successively by storing area temperature control element 201, transition region
Temperature control element 202, extrusion zone temperature control element 203 are wrapped up, and extrusion zone temperature control element 203 wraps up the stage casing for extending to syringe needle 102；
Also, the lower section of extrusion zone temperature control element 203 is equipped with shaping area state modulator element 204.From this analysis, the present invention is real
The biological 3D printing nozzle of the self-defined subregion temperature control of example offer is provided, in overall structure, is integrated with multiple temp-controlling elements and work
Skill state modulator element can carry out the bio-ink of different process position timely and different parameter adjustment, so as to control
Bio-ink is converted to current most rational state in corresponding process station, and then effectively improves the state of printing product.
Herein it should be added that, the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention
In, barrel 101 is cylinder-like structure；Also, according to the material printed, material should be resistant to for barrel 101 and syringe needle 102
Corresponding temperature and chemical environmental conditions；In addition, the pattern of syringe needle 102 can choose corresponding section shape according to actual requirement
Shape/size/material and suitable runner type.
In addition, extrusion zone temperature control element 203 can improve temperature control precision close proximity to the region of the needle point of syringe needle 102；
Expulsion area spatial volume should be small as possible, and the power of element should be big as possible, reaches extrudable to ensure that material is interior when most fast
State.
Wherein, above-mentioned storing area temperature control element 201 can be the cooling module for generating low temperature, so as to pass through the refrigeration
Element is in low-temperature condition for material in control area.
Specifically, above-mentioned storing area temperature control element 201 can be semiconductor chilling plate or cryogenic heat exchanger.
Wherein, above-mentioned transition region temperature control element 202 can be the heating element for generating high temperature, so as to pass through the heating
Element is for material in heating region tentatively to change the flowing character of material.
Wherein, above-mentioned extrusion zone temperature control element 203 can be the heating element for generating high temperature, so as to pass through the heating
Element is for the material in heating region so that material is in the optimum state that can be extruded.
During practical application, above-mentioned storing area temperature control element 201 or the heating element for generating high temperature；Above-mentioned mistake
Cross area's temperature control element 202 or heat insulating element or cooling module；Above-mentioned extrusion zone temperature control element 203 or heat preservation member
Part or cooling module.
Herein it should be added that, the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention
In, above-mentioned storing area temperature control element 201, transition region temperature control element 202, extrusion zone temperature control element 203 specific element versions,
It will be depending on the flow behavior of respective material and molding mode after extrusion.
Wherein, above-mentioned shaping area state modulator element 204 can depending on the shaping characteristic of specific material, such as
Material with light sensitive characteristic, then shaping area state modulator element 204 can be that a pair answers light source；Or, such as material is by changing
It learns crosslinked mode to be molded, then shaping area state modulator element 204 can be the spraying device or jet stream for spraying crosslinking agent
Device；Or, such as material only by temperature become cure, then shaping area state modulator element 204 can be and above-mentioned extrusion zone
The consistent heating element of temperature control element 203, warm keeping element or cooling module, i.e. shaping area state modulator element 204 is squeeze out
One extension of area's temperature control element 203.
Specifically, as shown in Figure 1, the inside of above-mentioned barrel 101 can from top to bottom be followed successively by pushing meanss 104 and piston
103, and the outer surface of piston 103 forms sealing space with barrel 101；Also, the material in the sealing space from top to bottom according to
It is secondary to be wrapped up by different temp-controlling elements or state modulator element, storing area material 301 can be divided into, transition region material 302, squeezed
Go out area's material 303 and shaping area material 304.
Herein it should be added that, the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention
In, practical above-mentioned storing area material 301, transition region material 302, extrusion zone material 303 are a kind of material, and only material is in difference
Under the conditions of character it is different, shaping area material 304 exposure, material under corresponding condition of molding may produce this
The variation of matter.
Further, above-mentioned pushing meanss 104 can be pushed by the power source of the forms such as gas, push rod；Above-mentioned piston 103
According to the material printed, material should be resistant to corresponding temperature and chemical environmental conditions.
Fig. 2 is the temperature control flow chart of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention.
The embodiment of the present invention also provides a kind of biological 3D printing method of self-defined subregion temperature control, including：Confirm material mould
Block, acknowledgement state module, parameter chosen module, control execution module and parameters measurement module, and as shown in Fig. 2, including as follows
Step：Confirm that material module confirms material property, and material characteristic parameter is exported and gives parameter chosen module；Acknowledgement state module
Confirm the execution state of nozzle subregion temperature control, and give temperature control execution state output to parameter chosen module；Parameter chosen module pair
Material characteristic parameter and temperature control perform state and are handled, and obtain selected parameter, and selected parameter is input to parameter comparator,
Parameter comparator by the parameter of input and monitoring feedback parameter be compared, and export control parameter to control execution module,
Control execution module is regulated and controled；Control execution module performs control parameter, and carries out subregion control to printing head
Temperature, printing head will monitor the parameter feedback of feedback to parameters measurement module during subregion temperature control；Parameters measurement module
The subregion temperature control situation of printing head is monitored, and monitoring parameters are inputed to parameter comparison device in real time.
Fig. 3 is the material property control ginseng of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention
Number schematic diagram.
Wherein, as shown in Fig. 2 combinations Fig. 3, above-mentioned confirmation material property can include storage condition, the extrusion condition of material
And condition of molding.
Specifically, as shown in figure 3, above-mentioned storage condition can include storage temperature and transition temperature；Above-mentioned extrusion condition
It can include transition temperature and extrusion temperature；Above-mentioned condition of molding can include molding parameter, and above-mentioned molding parameter can be sample
Product in forming process the parameter of intensity of illumination, crosslinking agent using the temperature parameter of parameter or sample formation and conducive to sample
Product are molded required other parameters.
Fig. 4 is the output state control ginseng of the biological 3D printing method of self-defined subregion temperature control provided in an embodiment of the present invention
Number schematic diagram.
Further, as shown in figure 4, above-mentioned acknowledgement state module can include selected function and inventory function；Wherein, it selects
Printing can be included and stop by determining function；Inventory function can include suspend mode and preheating.
Further, above-mentioned parameter chosen module includes suspend mode/halted state, pre- Warm status and print state；Also,
Suspend mode/halted state, pre- Warm status and print state may each comprise storage region, transitional region, expulsion area and shaping area
Domain.
The biological 3D printing nozzle and method of self-defined subregion temperature control provided in an embodiment of the present invention are joined due to subregion control and are sprayed
The independence of each parameter spatially so that printed material can be saved in memory block with the state that optimum stores, energy
It is enough to be extruded in extrusion zone with the parameter most useful for extrusion molding, have greatly compared to traditional technology to the friendly of material
It improves；It is alternative when the nozzle is in pause/not wire vent due to the independence of each parameter of subregion control ginseng nozzle in time
Stopping extrusion zone and transition region temperature control, and continue memory block temperature control, so that material keeps better service life/vigor etc. to have
Sharp character；When needing to continue wire vent, due to only needing to heat extrusion zone material, heated perimeter is than the prior art (entire material
Cylinder) smaller, therefore under equal conditions faster material can be made to be restored to extrudable condition；Since subregion control ginseng nozzle is respectively joined
The continuity of number spatially so that printed material can more timely be exposed to the work of the conditions of molding such as light/chemical cross-linking agent
Under, reduce traditional technology switching time between equipment, working efficiency and installation cost are all obtained compared with traditional technology
Optimization.
Herein it should be added that, the biological 3D printing nozzle of self-defined subregion temperature control provided in an embodiment of the present invention
And method, it can apply in photocuring nozzle, aggregation nozzle, low-temp. spraying head etc., but be not limited to above-mentioned cited printing
Nozzle.
Specific embodiment 1：Photocuring nozzle printing metering system acid gelatin Gel MA (50%)
Implementation process：
Confirm material：Biomaterial metering system acid gelatin Gel MA (50%)
Each region parameter is determined by material property：
1st, storage temperature：Character stabilization can be kept at 4 DEG C before photo-crosslinking, i.e. its best storage temperature is 4 DEG C；
2nd, extrusion temperature：There is the mobility for being relatively suitble to printing at 37 DEG C, i.e. its best extrusion temperature is 37 DEG C；
3rd, transition temperature：One 20 DEG C of transition temperature is selected by above-mentioned condition, has certain flowing in this material temperature
Property, while convenient for being rapidly heated to 37 DEG C；
4th, condition of molding：In 365nm, 300mw/cm2, ultraviolet light 20S cross mouldings；
5th, other restrictions：Gel MA are long placed at 37 DEG C can occur heat cross-linking, lead to not squeeze out；
Each region output parameter is selected with reference to output state and material property, see the table below：
| Region state | Suspend mode/stopping | Preheating | Printing |
| Memory block | 4℃ | 4℃ | 4℃ |
| Transition region | 4℃ | 20℃ | 20℃ |
| Extrusion zone | 4℃ | 20℃ | 37℃ |
| Shaping area | It closes ultraviolet | It closes ultraviolet | It opens ultraviolet |
The output parameter in each region under each state is specified by the table, subsequent feedback output flow is carried out, carries out nozzle subregion
Temperature control.
As a result：
Material is in suspend mode and stops being rapidly introduced into the storage temperature suitable for preservation during printing so that material character obtains surely
It is fixed to maintain.At pre- Warm status (will start to print), transition region material is heated in advance so that the heating stand-by period is big
Big to shorten, in print state, the material of extrusion is exposed under ultraviolet irradiation in time, at the same make material be in 37 DEG C when
Between greatly shorten.So that material is molded in precalculated position by predetermined way, preferable printing effect is achieved.
Specific embodiment 2：Polymer nozzle printing l-lactic acid PLLA (molecular weight 80000)
Implementation process：
Confirm material：L-lactic acid PLLA (molecular weight 80000)
Each region parameter is determined by material property：
1st, storage temperature：It can relatively stablize preservation under room temperature or lower temperature, it is 25 DEG C to select storage temperature；
2nd, extrusion temperature：There is the mobility for being relatively suitble to printing at 185 DEG C, i.e. its best extrusion temperature is 185 DEG C；
3rd, transition temperature：One 140 DEG C of transition temperature is selected by above-mentioned condition, has certain stream compared with material in this temperature
Dynamic property, while convenient for being rapidly heated to 185 DEG C；
4th, condition of molding：It is i.e. plastic that room temperature is exposed to after extrusion；
5th, other restrictions：Gel MA easily degrade under long term high temperature, and molecular weight becomes smaller, and property changes；
Each region output parameter is selected with reference to output state and material property, see the table below：
| Region state | Suspend mode/stopping | Preheating | Printing |
| Memory block | 25℃ | 25℃ | 25℃ |
| Transition region | 25℃ | 140℃ | 140℃ |
| Extrusion zone | 25℃ | 140℃ | 185℃ |
| Shaping area | It closes ultraviolet | It closes ultraviolet | It opens ultraviolet |
The output parameter in each region under each state is specified by the table, subsequent feedback output flow is carried out, carries out nozzle subregion
Temperature control.
As a result：
Material is in suspend mode and stops being rapidly introduced into the storage temperature suitable for preservation during printing so that material character obtains surely
It is fixed to maintain.At pre- Warm status (will start to print), transition region material is heated in advance so that the heating stand-by period is big
It is big to shorten, in print state, greatly shorten the time that material is in 185 DEG C；Substantially reduce the degradation rate of material so that
Material is molded in precalculated position by predetermined way, achieves preferable printing effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (13)
1. a kind of biological 3D printing nozzle of self-defined subregion temperature control, which is characterized in that including：Barrel and with the barrel
End connection syringe needle, and between the barrel and the syringe needle be tightly connected formed one using the syringe needle as the knot of slot
Structure；
The outside of the barrel is from top to bottom successively by storing area temperature control element, transition region temperature control element, extrusion zone temperature control element
Package, and extrusion zone temperature control element package extends to the stage casing of the syringe needle；The lower section peace of the extrusion zone temperature control element
Equipped with shaping area state modulator element.
2. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 1, which is characterized in that the storing area
Temperature control element is the cooling module for generating low temperature.
3. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 2, which is characterized in that the storing area
Temperature control element is semiconductor chilling plate or cryogenic heat exchanger.
4. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 2, which is characterized in that the transition region
Temperature control element is the heating element for generating high temperature.
5. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 4, which is characterized in that the extrusion zone
Temperature control element is the heating element for generating high temperature.
6. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 1, which is characterized in that the storing area
Temperature control element is the heating element for generating high temperature；
The transition region temperature control element is heat insulating element or cooling module；
The extrusion zone temperature control element is warm keeping element or cooling module.
7. the biological 3D printing nozzle of the self-defined subregion temperature control according to any one of claim 1-6, feature exist
In the shaping area state modulator element is light source；
Or, the shaping area state modulator element is the spraying device or fluidic device for spraying crosslinking agent；
Or, the shaping area state modulator element for the heating element consistent with the extrusion zone temperature control element, warm keeping element or
Cooling module.
8. the biological 3D printing nozzle of self-defined subregion temperature control according to claim 7, which is characterized in that the barrel
Inside is from top to bottom followed successively by pushing meanss and piston, and the outer surface of the piston forms sealing space with the barrel；
Material in the sealing space is from top to bottom followed successively by storing area material, transition region material, extrusion zone material and molding
Area's material.
A kind of 9. biological 3D printing method of self-defined subregion temperature control, which is characterized in that including：Confirm material module, confirm shape
Morphotype block, parameter chosen module, control execution module and parameters measurement module, and include the following steps：
The confirmation material module confirms material property, and material characteristic parameter is exported to the parameter chosen module；
The acknowledgement state module confirms the execution state of nozzle subregion temperature control, and temperature control is performed state output to the parameter
Chosen module；
The parameter chosen module performs state to material characteristic parameter and temperature control and handles, and obtains selected parameter, and will choosing
To determine parameter and be input to parameter comparator, the parameter of input and the parameter of monitoring feedback are compared by the parameter comparator, and
Control parameter is exported to the control execution module, the control execution module is regulated and controled；
The control execution module performs control parameter, and carry out subregion temperature control, the printing head to printing head
During subregion temperature control, the parameter feedback of feedback will be monitored to the parameters measurement module；
The parameters measurement module monitors, and monitoring parameters are inputted the subregion temperature control situation of the printing head in real time
To the parameter comparison device.
10. the biological 3D printing method of self-defined subregion temperature control according to claim 9, which is characterized in that the confirmation
Material property includes storage condition, extrusion condition and the condition of molding of material.
11. the biological 3D printing method of self-defined subregion temperature control according to claim 10, which is characterized in that the storage
Condition includes storage temperature and transition temperature；
The extrusion condition includes transition temperature and extrusion temperature；
The condition of molding includes molding parameter, the molding parameter parameter of intensity of illumination, friendship in forming process for sample
Connection agent uses parameter or the temperature parameter of sample formation.
12. the biological 3D printing method of self-defined subregion temperature control according to claim 9, which is characterized in that the confirmation
Block of state includes selected function and inventory function；
The selected function includes printing and stops；
The inventory function includes suspend mode and preheating.
13. the biological 3D printing method of self-defined subregion temperature control according to claim 9, which is characterized in that the parameter
Chosen module includes suspend mode/halted state, pre- Warm status and print state；
Suspend mode/the halted state, the pre- Warm status and the print state include storage region, transitional region, extrusion
Region and forming area.
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